PubRank

Elizabeth A Winzeler

Author PubWeight™ 149.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Functional profiling of the Saccharomyces cerevisiae genome. Nature 2002 36.10
2 Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 2003 10.57
3 Spiroindolones, a potent compound class for the treatment of malaria. Science 2010 5.94
4 In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A 2008 4.80
5 Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res 2004 3.63
6 Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol 2008 3.23
7 Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science 2011 3.07
8 The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol 2005 3.02
9 A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog 2006 2.92
10 Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science 2005 2.81
11 The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med 2012 2.42
12 Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol 2009 2.23
13 The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J Exp Med 2010 2.08
14 Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe 2012 2.05
15 Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell 2007 1.90
16 Parallel identification of new genes in Saccharomyces cerevisiae. Genome Res 2002 1.89
17 Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J Med Chem 2010 1.84
18 The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc Natl Acad Sci U S A 2002 1.74
19 Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes. Proc Natl Acad Sci U S A 2010 1.74
20 Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob Agents Chemother 2011 1.67
21 Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One 2008 1.61
22 Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A 2002 1.61
23 Antimalarial drug discovery - approaches and progress towards new medicines. Nat Rev Microbiol 2013 1.60
24 Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe 2013 1.58
25 Treasures and traps in genome-wide data sets: case examples from yeast. Nat Rev Genet 2002 1.57
26 Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. PLoS Genet 2013 1.54
27 Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science 2002 1.52
28 A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. Genome Res 2004 1.49
29 In silico discovery of transcription regulatory elements in Plasmodium falciparum. BMC Genomics 2008 1.48
30 In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis 2005 1.46
31 Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A 2011 1.46
32 In silico gene function prediction using ontology-based pattern identification. Bioinformatics 2004 1.44
33 A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito. PLoS Negl Trop Dis 2010 1.31
34 A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. ACS Chem Biol 2011 1.31
35 A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. BMC Genomics 2008 1.27
36 Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. Genome Res 2010 1.27
37 Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. Am J Trop Med Hyg 2002 1.26
38 Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. J Med Chem 2012 1.22
39 Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. J Infect Dis 2013 1.15
40 The paradoxical population genetics of Plasmodium falciparum. Trends Parasitol 2002 1.14
41 Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax. Am J Trop Med Hyg 2014 1.10
42 Large-scale annotation of small-molecule libraries using public databases. J Chem Inf Model 2007 1.08
43 Using genetic methods to define the targets of compounds with antimalarial activity. J Med Chem 2013 1.06
44 KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrob Agents Chemother 2013 1.03
45 Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials. ACS Chem Biol 2014 1.03
46 Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proc Natl Acad Sci U S A 2012 1.02
47 Target identification and validation of novel antimalarials. Future Microbiol 2011 1.00
48 Direct transfer of whole genomes from bacteria to yeast. Nat Methods 2013 0.99
49 Identification of pathogen genomic variants through an integrated pipeline. BMC Bioinformatics 2014 0.97
50 Elucidating genetic diversity with oligonucleotide arrays. Chromosome Res 2005 0.97
51 Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. J Am Chem Soc 2012 0.97
52 Whole genome sequencing analysis of Plasmodium vivax using whole genome capture. BMC Genomics 2012 0.96
53 Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol 2014 0.95
54 Large-scale mutagenesis and functional genomics in yeast. Funct Integr Genomics 2002 0.94
55 In vivo transcriptional profiling of Plasmodium falciparum. Malar J 2004 0.94
56 Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine 2011 0.92
57 Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Res 2004 0.91
58 Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria. Emerg Infect Dis 2013 0.90
59 Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe 2012 0.89
60 Genomics, systems biology and drug development for infectious diseases. Mol Biosyst 2007 0.88
61 A key role for lipoic acid synthesis during Plasmodium liver stage development. Cell Microbiol 2013 0.87
62 Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. PLoS One 2010 0.84
63 Perspectives: The missing pieces. Nature 2012 0.84
64 Using expression information to discover new drug and vaccine targets in the malaria parasite Plasmodium falciparum. Pharmacogenomics 2005 0.82
65 Genomics and systems biology in malaria drug discovery. Curr Opin Investig Drugs 2010 0.81
66 Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes. ACS Infect Dis 2015 0.80
67 Epidemiology: resistance mapping in malaria. Nature 2013 0.79
68 Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malar J 2013 0.78
69 Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum. BMC Biol 2011 0.78
70 Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature 2016 0.77
71 Using the genome to dissect the molecular basis of drug resistance. Future Microbiol 2006 0.76
72 Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. J Med Chem 2016 0.75
73 Antimalarial drug discovery - approaches and progress towards new medicines. Nat Rev Microbiol 2017 0.75