Published in Cancer Res on August 15, 2003
The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell (2007) 2.05
TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer. Oncogene (2009) 1.52
The good and the bad of chemokines/chemokine receptors in melanoma. Pigment Cell Melanoma Res (2009) 1.18
Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis. Onco Targets Ther (2014) 0.93
Proteomic approaches and identification of novel therapeutic targets for alcoholism. Neuropsychopharmacology (2013) 0.85
Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. Prog Mol Biol Transl Sci (2011) 0.83
Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription. Exp Cell Res (2006) 0.81
Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants. Oxid Med Cell Longev (2016) 0.77
Proteomic approaches for studying alcoholism and alcohol-induced organ damage. Alcohol Res Health (2008) 0.77
Expression Profiling in Alcoholism Research. Alcohol Clin Exp Res (2005) 0.76
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity (2009) 6.37
The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol (2011) 5.73
Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol (2008) 4.60
NLRX1 is a regulator of mitochondrial antiviral immunity. Nature (2008) 4.55
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe (2007) 3.52
NLRs at the intersection of cell death and immunity. Nat Rev Immunol (2008) 3.48
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A (2006) 3.41
Novel role of PKR in inflammasome activation and HMGB1 release. Nature (2012) 3.13
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev (2008) 2.89
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59
Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc Natl Acad Sci U S A (2007) 2.48
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol (2003) 2.48
NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol (2009) 2.39
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet (2011) 2.36
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Mol Cell Biol (2004) 2.30
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci U S A (2005) 2.23
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol (2002) 2.18
Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination. Mol Cell (2009) 2.18
CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat Immunol (2003) 2.13
Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol (2009) 2.09
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity (2012) 2.07
Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity (2013) 2.02
Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J Immunol (2007) 1.97
Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. J Immunol (2006) 1.84
NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol (2010) 1.73
Epigenetic regulation of MHC-II and CIITA genes. Trends Immunol (2006) 1.73
MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS One (2009) 1.67
Cutting edge: NLRC5-dependent activation of the inflammasome. J Immunol (2010) 1.66
Criteria for effective design, construction, and gene knockdown by shRNA vectors. BMC Biotechnol (2006) 1.60
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol (2010) 1.59
Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Sci Signal (2011) 1.58
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J Immunol (2002) 1.58
Differential induction of type I interferon responses in myeloid dendritic cells by mosquito and mammalian-cell-derived alphaviruses. J Virol (2006) 1.57
Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci U S A (2005) 1.49
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One (2012) 1.48
Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood (2011) 1.48
Inflammasome inhibition as a pathogenic stealth mechanism. Cell Host Microbe (2010) 1.47
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Curr Biol (2005) 1.46
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol (2012) 1.45
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PLoS One (2010) 1.44
Regulation of mitochondrial antiviral signaling pathways. Immunity (2008) 1.44
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18. J Neurosci (2010) 1.37
CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J Biol Chem (2005) 1.35
NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol (2012) 1.34
Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Res (2003) 1.34
Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes. J Immunol (2003) 1.33
The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response. Infect Immun (2006) 1.30
The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem (2011) 1.27
ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. Mol Cell Biol (2007) 1.25
C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9. Am J Pathol (2008) 1.22
Analysis of NLRP3 in the development of allergic airway disease in mice. J Immunol (2012) 1.18
Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells. PLoS Pathog (2013) 1.18
Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci (2003) 1.18
Enhancement of CIITA transcriptional function by ubiquitin. Nat Immunol (2003) 1.18
The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells. Cancer Res (2010) 1.18
Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines. Curr Opin Immunol (2011) 1.17
Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. Mol Cell Biol (2003) 1.16
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes. Curr Opin Immunol (2005) 1.16
Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. J Immunol (2013) 1.15
Microtubule stabilizing agents: their molecular signaling consequences and the potential for enhancement by drug combination. Cancer Treat Rev (2006) 1.14
Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm. J Exp Med (2010) 1.12
Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression. Proc Natl Acad Sci U S A (2005) 1.08
Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. BMC Med Genomics (2010) 1.06
Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. Proc Natl Acad Sci U S A (2011) 1.05
Positive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation. J Biol Chem (2011) 1.04
The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription. Mol Immunol (2008) 1.02
Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. J Biol Chem (2012) 1.01
Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. PLoS One (2013) 0.99
Cryopyrin: in from the cold. Immunity (2006) 0.98
Transfection of macrophage inflammatory protein 1 alpha into B16 F10 melanoma cells inhibits growth of pulmonary metastases but not subcutaneous tumors. J Immunol (2002) 0.97
Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. J Immunol (2007) 0.97
Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination. Glia (2005) 0.97
Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep (2013) 0.96
Identification of PTPsigma as an autophagic phosphatase. J Cell Sci (2011) 0.95
Serine residues 286, 288, and 293 within the CIITA: a mechanism for down-regulating CIITA activity through phosphorylation. J Immunol (2004) 0.95
Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol (2011) 0.94
Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle. J Neurosci Res (2010) 0.94
Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases. J Immunol (2009) 0.93
CATERPILLER (NLR) family members as positive and negative regulators of inflammatory responses. Proc Am Thorac Soc (2007) 0.93
A CIITA-independent pathway that promotes expression of endogenous rather than exogenous peptides in immune-privileged sites. Eur J Immunol (2004) 0.92
Cutting edge: rho activation and actin polarization are dependent on plexin-A1 in dendritic cells. J Immunol (2006) 0.92
Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clin Cancer Res (2002) 0.92
Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses. Proc Natl Acad Sci U S A (2008) 0.92
The protective role of nitric oxide in a neurotoxicant-induced demyelinating model. J Immunol (2002) 0.91
Lymphotoxin beta receptor (Lt betaR): dual roles in demyelination and remyelination and successful therapeutic intervention using Lt betaR-Ig protein. J Neurosci (2007) 0.90
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem (2010) 0.90
Regulation and specificity of MHC2TA promoter usage in human primary T lymphocytes and cell line. J Immunol (2002) 0.90