Published in J Biol Chem on September 08, 2003
Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res (2007) 1.93
Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A (2006) 1.68
The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci (2008) 1.60
GnRH signaling, the gonadotrope and endocrine control of fertility. Front Neuroendocrinol (2010) 1.23
Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol (2007) 1.19
Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase. Mol Endocrinol (2010) 1.09
MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway. Glia (2009) 1.09
Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol (2008) 1.06
Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica. Infect Immun (2013) 0.93
Cell-surface receptors transactivation mediated by g protein-coupled receptors. Int J Mol Sci (2014) 0.93
Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder carcinoma cells. J Exp Clin Cancer Res (2010) 0.91
Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells. Gut (2007) 0.86
Occludin is regulated by epidermal growth factor receptor activation in brain endothelial cells and brains of mice with acute liver failure. Hepatology (2011) 0.86
EGFR may couple moderate alcohol consumption to increased breast cancer risk. Breast Cancer (Dove Med Press) (2009) 0.85
Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line. J Biol Chem (2015) 0.85
Expression and function of ErbB receptors and ligands in the pituitary. Endocr Relat Cancer (2011) 0.84
Characterization of a MAPK scaffolding protein logic gate in gonadotropes. Mol Endocrinol (2011) 0.82
Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone. Mol Cancer Res (2009) 0.82
Outside the box signaling: secreted factors modulate GnRH receptor-mediated gonadotropin regulation. Mol Cell Endocrinol (2013) 0.79
LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands. Biol Reprod (2015) 0.77
Developmental consequences of supplementing with matrix metallopeptidase-9 during in vitro maturation of heat-stressed bovine oocytes. J Reprod Dev (2016) 0.75
Expression of tissue inhibitor of matrix metalloproteinases-1 during aging in rat liver. World J Gastroenterol (2005) 0.75
Involvement of Protein Kinase D1 in Signal Transduction from the Protein Kinase C Pathway to the Tyrosine Kinase Pathway in Response to Gonadotropin-releasing Hormone. J Biol Chem (2015) 0.75
Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding. Cell Death Differ (2017) 0.75
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol (2007) 7.20
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet (2006) 5.29
Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A (2002) 3.88
Cell motility through plasma membrane blebbing. J Cell Biol (2008) 3.29
Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol (2005) 3.28
Staying in shape with formins. Dev Cell (2006) 3.21
TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol (2003) 2.45
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
Nucleating actin for invasion. Nat Rev Cancer (2011) 2.22
Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch (2007) 2.17
Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet (2004) 2.17
Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc Natl Acad Sci U S A (2004) 2.17
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol (2007) 2.15
Nuclear actin network assembly by formins regulates the SRF coactivator MAL. Science (2013) 2.13
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol Med (2012) 1.93
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci U S A (2006) 1.89
MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res (2011) 1.79
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev (2007) 1.77
Beta 1 integrin is essential for teratoma growth and angiogenesis. J Cell Biol (1997) 1.75
Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J (2008) 1.71
Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev Cell (2008) 1.70
TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells. BMC Neurosci (2007) 1.69
Get to grips: steering local actin dynamics with IQGAPs. EMBO Rep (2007) 1.68
RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts. Hum Gene Ther (2006) 1.65
N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. J Biol Chem (2003) 1.59
Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. J Biol Chem (2003) 1.57
TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism. Biochim Biophys Acta (2007) 1.51
Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function. J Biol Chem (2005) 1.51
HIV-1 Nef interferes with host cell motility by deregulation of Cofilin. Cell Host Microbe (2009) 1.50
Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung. Eur J Pharm Biopharm (2010) 1.49
Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol (2004) 1.43
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol (2009) 1.42
Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther (2006) 1.41
Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab (2003) 1.40
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch (2005) 1.40
A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes. J Control Release (2006) 1.37
The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells. Lung Cancer (2007) 1.36
Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation. FEBS Lett (1997) 1.30
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J (2008) 1.28
In vivo TRPC functions in the cardiopulmonary vasculature. Cell Calcium (2007) 1.26
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. J Biol Chem (2002) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6. J Biol Chem (2006) 1.23
Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings. Biomacromolecules (2005) 1.22
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes. Toxicol Appl Pharmacol (2009) 1.21
The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. J Biol Chem (2008) 1.20
LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics. Mol Biol Cell (2007) 1.20
Retracted Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Mol Endocrinol (2003) 1.19
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition. J Biol Chem (2001) 1.17
Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.15
G protein-mediated stretch reception. Am J Physiol Heart Circ Physiol (2012) 1.13
HMGA2 gene is a promising target for ovarian cancer silencing therapy. Int J Cancer (2008) 1.13
In vitro MR imaging of regulated gene expression. Radiology (2003) 1.12
Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1. Pflugers Arch (2008) 1.12
Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch (2005) 1.11
Liposome-polyethylenimine complexes for enhanced DNA and siRNA delivery. Biomaterials (2010) 1.09
SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility. J Cell Sci (2007) 1.07
Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. FASEB J (2006) 1.07
Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J Biol Chem (2011) 1.05
PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy. J Drug Target (2008) 1.04
Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity (2009) 1.03
Evolutionary determinants of divergent calcium selectivity of TRPM channels. FASEB J (2007) 1.03
The fibroblast growth factor-binding protein FGF-BP. Int J Biochem Cell Biol (2005) 1.03
The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13. J Cell Biochem (2003) 1.02
A critical role of TRPM channel-kinase for human magnesium transport. J Physiol (2005) 1.01
Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab. J Gene Med (2010) 1.01
TRPM7: a unique channel involved in magnesium homeostasis. Int J Biochem Cell Biol (2012) 1.00
Type IV collagen induces matrix metalloproteinase 2 activation in HT1080 fibrosarcoma cells. Exp Cell Res (2000) 1.00
RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo. Neuro Oncol (2011) 0.99
AT1 receptors as mechanosensors. Curr Opin Pharmacol (2010) 0.98
Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Mol Reprod Dev (2006) 0.98
Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist. J Biol Chem (2009) 0.98
Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK. Neoplasia (2009) 0.97
Renal TRPathies. J Am Soc Nephrol (2010) 0.96
Combined treatment with serine protease inhibitor aprotinin and matrix metalloproteinase inhibitor Batimastat (BB-94) does not prevent invasion of human esophageal and ovarian carcinoma cells in vivo. Anticancer Res (2000) 0.95
Drosophila TRPM channel is essential for the control of extracellular magnesium levels. PLoS One (2010) 0.95
Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma. Neoplasia (2013) 0.94
Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer Chemother Pharmacol (2010) 0.94
Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas. J Neuropathol Exp Neurol (2003) 0.94
Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction. Respir Physiol Neurobiol (2010) 0.94
Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology (2007) 0.94
Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa. PLoS One (2012) 0.93
Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse. Eur J Cell Biol (2010) 0.93
Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. EMBO Mol Med (2013) 0.92
A role for brain-derived neurotrophic factor in B cell development. J Neuroimmunol (2005) 0.92
The temperature-sensitive ion channel TRPV2 is endogenously expressed and functional in the primary sensory cell line F-11. Cell Physiol Biochem (2005) 0.92
Alternative G protein coupling and biased agonism: new insights into melanocortin-4 receptor signalling. Mol Cell Endocrinol (2010) 0.92