Published in Dev Immunol on January 01, 1992
Has the microbiota played a critical role in the evolution of the adaptive immune system? Science (2010) 4.29
The gut microbiota regulates bone mass in mice. J Bone Miner Res (2012) 2.92
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat Immunol (2011) 2.81
Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice. Infect Immun (1993) 2.25
Shp1 regulates T cell homeostasis by limiting IL-4 signals. J Exp Med (2013) 1.64
Coordination of tolerogenic immune responses by the commensal microbiota. J Autoimmun (2009) 1.62
Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol (2007) 1.46
Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J Exp Med (1993) 1.44
Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice. BMC Immunol (2008) 1.35
Distinct antimicrobial peptide expression determines host species-specific bacterial associations. Proc Natl Acad Sci U S A (2013) 1.31
Memory T-lymphocyte survival does not require T-cell receptor expression. Proc Natl Acad Sci U S A (2008) 1.12
Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development. Front Immunol (2013) 1.08
Antibody repertoire development in fetal and newborn piglets, III. Colonization of the gastrointestinal tract selectively diversifies the preimmune repertoire in mucosal lymphoid tissues. Immunology (2000) 1.01
Peripheral education of the immune system by the colonic microbiota. Semin Immunol (2013) 0.97
Effect of barrier microbes on organ-based inflammation. J Allergy Clin Immunol (2013) 0.97
Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nat Rev Genet (2015) 0.97
CD4 T cell defects in the aged: causes, consequences and strategies to circumvent. Exp Gerontol (2014) 0.95
Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance. ISME J (2014) 0.93
The commensal microbiota drives immune homeostasis. Front Immunol (2012) 0.88
Interleukin-12 is sufficient to promote antigen-independent interferon-gamma production by CD8 T cells in old mice. Immunology (2009) 0.86
Neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to CD4 T-cell expansion, without altering T-cell repertoire. PLoS One (2012) 0.83
Microbial diversity and activity in the Nematostella vectensis holobiont: insights from 16S rRNA gene sequencing, isolate genomes, and a pilot-scale survey of gene expression. Front Microbiol (2015) 0.76
Antigen-inexperienced memory CD8(+) T cells: where they come from and why we need them. Nat Rev Immunol (2017) 0.75
NFAT2 Regulates Generation of Innate-Like CD8(+) T Lymphocytes and CD8(+) T Lymphocytes Responses. Front Immunol (2016) 0.75
Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol (1997) 5.95
A functional dichotomy in CD4+ T lymphocytes. Immunol Today (1988) 4.18
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med (1995) 3.98
Signals and signs for lymphocyte responses. Cell (1994) 3.66
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem (1997) 3.66
Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med (1997) 3.33
Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia (2006) 3.21
Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med (1995) 2.80
Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells. J Immunol (1987) 2.53
Distinct functional phenotypes of cloned Ia-restricted helper T cells. J Exp Med (1985) 2.39
Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages. J Immunol (1989) 2.32
B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo. J Immunol (1995) 2.29
Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation. J Immunol (1989) 2.24
Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells. J Exp Med (1990) 2.21
The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells. Cell (1993) 2.19
Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells. J Immunol (1988) 2.12
CD4+ T cells: specificity and function. Immunol Rev (1988) 2.04
Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis. Ann Neurol (1999) 1.99
IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol (1998) 1.92
Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. J Immunol (1997) 1.90
Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice. J Exp Med (1978) 1.89
Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression. J Exp Med (1979) 1.86
T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med (1999) 1.85
Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo. J Immunol (1993) 1.82
Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol (1990) 1.79
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J Clin Invest (2000) 1.76
Selective activation of Th1- and Th2-like cells in vivo--response to human collagen IV. Immunol Rev (1991) 1.72
Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol (1999) 1.70
Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. A sequential histological and ultrastructural study in the rat. Lab Invest (1986) 1.64
Absence of an antigen-specific helper T cell required for the expression of the T 15 idiotype in mice treated with anti-mu antibody. Eur J Immunol (1980) 1.62
Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J Immunol (1997) 1.61
Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells bearing a CD3-associated gamma delta T cell receptor. Eur J Immunol (1990) 1.59
Differential activation of cytokine genes in normal CD4-bearing T cells is stimulus dependent. Eur J Immunol (1989) 1.57
Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding. J Immunol (1997) 1.56
The true function of the thymus? Immunol Today (1989) 1.50
MHC control of CD4+ T cell subset activation. J Exp Med (1989) 1.45
Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu. J Immunol (1999) 1.42
Costimulation and autoimmune diabetes in BB rats. Am J Transplant (2006) 1.41
STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science (1999) 1.38
CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. J Virol (2001) 1.35
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. J Immunol (1997) 1.33
Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am J Respir Crit Care Med (2000) 1.32
Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells. J Immunol (1995) 1.32
Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma. J Immunol (1997) 1.29
Origin of neointimal endothelium and alpha-actin-positive smooth muscle cells in transplant arteriosclerosis. J Clin Invest (2001) 1.28
Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. Immunity (2001) 1.28
Cytokines in T-cell development. Immunol Today (1991) 1.26
Differential T cell receptor-mediated signaling in naive and memory CD4 T cells. Eur J Immunol (1997) 1.23
Activation status of the CD4-8- gamma delta-T cells recovered from mice with influenza pneumonia. J Immunol (1991) 1.21
Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies. J Exp Med (1989) 1.20
Enteropathy precedes type 1 diabetes in the BB rat. Gut (2004) 1.19
Activation requirements for CD4+ T cells differing in CD45R expression. J Immunol (1992) 1.19
Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype. Eur J Immunol (1992) 1.19
Involvement of gamma delta T cells in respiratory virus infections. Curr Top Microbiol Immunol (1991) 1.18
Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells. Eur J Immunol (1991) 1.18
CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. Circulation (2007) 1.17
Functional CD4 T cell subset interplay in an intact immune system. J Immunol (1993) 1.16
Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation. Eur J Immunol (2000) 1.16
Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression. Genes Dev (1990) 1.16
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation. J Exp Med (1996) 1.16
Molecular associations on the T cell surface correlate with immunological memory. Eur J Immunol (1990) 1.15
Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc Natl Acad Sci U S A (1990) 1.14
Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells. J Exp Med (1983) 1.13
Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. Immunity (1994) 1.12
Effects of splenectomy on the humoral immune system. A study in neonatally and adult splenectomized mice. Immunology (1978) 1.11
Ly 9, an alloantigenic marker of lymphocyte differentiation. J Immunol (1980) 1.10
Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity. Immunity (1994) 1.10
Isoform-specific associations of CD45 with accessory molecules in human T lymphocytes. Eur J Immunol (1992) 1.09
Bias in the gamma delta T cell response to Listeria monocytogenes. V delta 6.3+ cells are a major component of the gamma delta T cell response to Listeria monocytogenes. J Immunol (1996) 1.09
Osteopontin levels and increased disease activity in relapsing-remitting multiple sclerosis patients. J Neuroimmunol (2004) 1.08
Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny. Proc Natl Acad Sci U S A (1989) 1.07
Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation. J Immunol (1998) 1.07
Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny. EMBO J (1991) 1.07
Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. Immunity (1995) 1.06
Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Diabetologia (2010) 1.06
Improvement of the immunoglobulin subclass response to influenza vaccine in elderly nursing-home residents by the use of high-dose vaccines. Vaccine (1993) 1.05
Regulation of naive T cell differentiation by varying the potency of TCR signal transduction. Semin Immunol (1999) 1.05
1984: all idiotypes are equal, but some are more equal than others. Immunol Rev (1984) 1.03
Progesterone and estradiol modulate interleukin-1 beta messenger ribonucleic acid levels in cultured human peripheral monocytes. J Clin Endocrinol Metab (1989) 1.03
Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets. J Immunol (1997) 1.03
CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR. J Immunol (1998) 1.03
Chemicals trophic for the thymus: risk for immunodeficiency and autoimmunity. Int J Immunopharmacol (1992) 1.02
Transplantation of purified islet cells in diabetic rats. I. Standardization of islet cell grafts. Diabetes (1991) 1.01
Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro. Blood (1998) 1.01
IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol (2001) 1.01
Altered splenic T cell function of BALB/cByJ mice infected with mouse hepatitis virus or Sendai virus. J Immunol (1987) 0.98
Scanning electron microscopy of homing and recirculating lymphocyte populations. Cell Immunol (1975) 0.97
Differential expression of the alternatively spliced exons of murine CD45 in Th1 and Th2 cell clones. Eur J Immunol (1991) 0.97
B lymphocyte-associated antigens on terminal deoxynucleotidyl transferase-positive cells and pre-B cells in bone marrow of the rat. J Immunol (1986) 0.97
T cell-dependent hapten-specific and polyclonal B cell responses require release of interleukin 5. J Immunol (1988) 0.96
Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation. Immunity (1999) 0.95
The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM. Arch Virol (1991) 0.95
Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression. Am J Pathol (1988) 0.95
Dissemination of rat cytomegalovirus through infected granulocytes and monocytes in vitro and in vivo. J Virol (2003) 0.94
Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J Biol Chem (1992) 0.94
T-cell development during ageing in congenitally athymic (nude) rats. Scand J Immunol (1986) 0.93
Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation. Semin Immunol (2001) 0.92
Cell proliferation and cytokine production by CD4+ cells from old mice. J Cell Biochem (1991) 0.92