Published in Immunol Today on September 01, 1988
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 5.90
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc Natl Acad Sci U S A (1992) 5.55
T cell genetic background determines default T helper phenotype development in vitro. J Exp Med (1995) 3.18
Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model. Infect Immun (1993) 3.04
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med (1989) 3.03
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci U S A (2007) 2.46
Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect Immun (1994) 2.45
Effective immunization against Bordetella pertussis respiratory infection in mice is dependent on induction of cell-mediated immunity. Infect Immun (1993) 2.36
Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol Cell Biol (1993) 2.30
T cell-mediated immunity in the lung: a Cryptococcus neoformans pulmonary infection model using SCID and athymic nude mice. Infect Immun (1991) 2.17
Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice. J Exp Med (1991) 2.16
Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J Exp Med (1994) 1.88
Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis. Infect Immun (1993) 1.84
The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype. J Exp Med (1989) 1.76
Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J Virol (1995) 1.71
Effects of preinduced Candida-specific systemic cell-mediated immunity on experimental vaginal candidiasis. Infect Immun (1994) 1.68
"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype. J Exp Med (1994) 1.60
Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Infect Immun (1989) 1.56
Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution. Infect Immun (1990) 1.55
Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development. Proc Natl Acad Sci U S A (1995) 1.51
Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells. Proc Natl Acad Sci U S A (1995) 1.49
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. J Exp Med (1991) 1.41
Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness. Thorax (1993) 1.41
Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens. Proc Natl Acad Sci U S A (1990) 1.40
Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action. J Exp Med (1990) 1.35
Pertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine. Infect Immun (1996) 1.33
Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infect Immun (1994) 1.21
A repetitive peptide of Leishmania can activate T helper type 2 cells and enhance disease progression. J Exp Med (1990) 1.21
Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies. J Exp Med (1989) 1.20
Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes. Infect Immun (1989) 1.17
MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage. Mol Cell Biol (1993) 1.13
Anti-interferon gamma treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses. J Exp Med (1991) 1.12
T lymphocyte interferon-gamma production induced by Plasmodium falciparum antigen is high in recently infected non-immune and low in immune subjects. Clin Exp Immunol (1990) 1.09
Effect of adoptive transfer of cloned Actinobacillus actinomycetemcomitans-specific T helper cells on periodontal disease. Infect Immun (1991) 1.02
Differential requirement for protein synthesis in cytolysis mediated by class I and class II MHC-restricted cytotoxic T cells. Immunology (1990) 1.02
Th17 cells in inflammatory conditions. Rev Diabet Stud (2006) 1.00
Increase of IgA-specific switch T cells in patients with IgA nephropathy. Clin Exp Immunol (1989) 0.97
Murine T-cell response to native and recombinant protein antigens of Rickettsia tsutsugamushi. Infect Immun (1993) 0.96
Francisella tularensis-specific T-cell clones are human leukocyte antigen class II restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production. Infect Immun (1989) 0.93
Expression of surface antigens distinguishing "naive" and previously activated lymphocytes in bronchoalveolar lavage fluid. Thorax (1990) 0.91
Immunosuppressive properties of the Mycoplasma arthritidis T-cell mitogen in vivo: inhibition of proliferative responses to T-cell mitogens. Infect Immun (1990) 0.90
CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset. J Exp Med (1990) 0.90
Selective deficiency of interferon-gamma production in the hyper-IgE syndrome. Relationship to in vitro IgE synthesis. Clin Exp Immunol (1991) 0.90
In vivo effects of anticytokine antibodies on isotype restriction in Mesocestoides corti-infected BALB/c mice. Infect Immun (1991) 0.89
Ciprofloxacin enhances T cell function by modulating interleukin activities. Clin Exp Immunol (1991) 0.86
An investigation of T-cell subset phenotype and function in the rheumatoid synovium using in situ hybridization for IL-2 mRNA. Immunology (1991) 0.85
Immune responses in newly developed short-lived SAM mice. III. Genetic control of defective helper T-cell activity in in vitro primary antibody response. Immunology (1989) 0.85
The demonstration of an essential role for macrophages in the in vivo generation of IgG2a antibodies. Clin Exp Immunol (1994) 0.85
HLA-B27 misfolding and spondyloarthropathies. Prion (2009) 0.84
Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells. Clin Exp Immunol (1998) 0.84
A novel strategy for targeting CD4+ PPD-reactive T cells against tumour cells using PPD monoclonal antibody heteroconjugates. Clin Exp Immunol (1990) 0.84
T-helper subset function in the gut of rats: differential stimulation of eosinophils, mucosal mast cells and antibody-forming cells by OX8- OX22- and OX8- OX22+ cells. Immunology (1990) 0.83
Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells. Immunology (1991) 0.83
Characterization of rat T-cell clones with bacterial specificity. Immunology (1990) 0.83
Characterization of rat T helper cell clones specific for Bacteroides gingivalis antigen. Infect Immun (1990) 0.83
Melatonin provides signal 3 to unprimed CD4(+) T cells but failed to stimulate LPS primed B cells. Clin Exp Immunol (2001) 0.83
Humoral and cellular immune responses induced by 3a DNA vaccines against severe acute respiratory syndrome (SARS) or SARS-like coronavirus in mice. Clin Vaccine Immunol (2008) 0.82
Potential role of B7-1 and CD28 molecules in immunosuppression in leprosy. Clin Exp Immunol (1998) 0.81
Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis. Clin Exp Immunol (1991) 0.81
Rational live oral carrier vaccine design by mutating virulence-associated genes of Yersinia enterocolitica. Infect Immun (1999) 0.81
Immunological cells and functions in Gaucher disease. Crit Rev Oncog (2013) 0.80
Phenotypic and functional characterization of T cells from patients with myasthenia gravis. J Clin Invest (1990) 0.80
High copy number I-Ab transgenes induce production of IgE through an interluekin 4-dependent mechanism. Proc Natl Acad Sci U S A (1996) 0.79
Effects of interferon-gamma and tumour necrosis factor-alpha on the development of cytotoxic T lymphocytes in autologous mixed lymphocyte tumour cultures with human melanoma. Clin Exp Immunol (1991) 0.79
Effect of nutrient starvation on proliferation and cytokine secretion of peripheral blood lymphocytes. Mol Clin Oncol (2016) 0.78
IL-2-like activity in lymph fluid following in vivo antigen challenge. Immunology (1990) 0.78
Single exposure of mice to Borrelia burgdorferi elicits immunoglobulin G antibodies characteristic of secondary immune response without production of interleukin-4 by immune T cells. Infect Immun (1995) 0.78
Circulating lymphocyte subsets linked to intracellular cytokine profiles in normal humans. Clin Exp Immunol (2003) 0.77
Cytokine regulation of low-affinity IgE receptor (CD23) on monocytes from asthmatic subjects. Clin Exp Immunol (1994) 0.77
A majority of proliferating T cells in cutaneous malignant T cell lymphomas may lack the high affinity IL-2 receptor (CD25). Arch Dermatol Res (1993) 0.77
Correlation of interleukin-17-producing effector memory T cells and CD4+CD25+Foxp3 regulatory T cells with the phosphate levels in chronic hemodialysis patients. ScientificWorldJournal (2014) 0.77
TH1 cells trigger tumor necrosis factor alpha-mediated hypersensitivity to Pseudomonas aeruginosa after adoptive transfer into SCID mice. Infect Immun (1995) 0.77
Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats. Environ Health Perspect (1993) 0.75
L3T4+ and Lyt-2+ cell-surface antigens as indicators of an allergic contact hypersensitivity response. Arch Dermatol Res (1990) 0.75
The targeting of T-helper cells and tumourcidal macrophages to a B-cell lymphoma using a PPD-monoclonal antibody heteroconjugate. Immunology (1992) 0.75
A limited role of IL-1 in immune-enhancement by adjuvants. Immunology (1990) 0.75
A functional dichotomy in CD4+ T lymphocytes. Immunol Today (1988) 0.75
Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol (1997) 5.95
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med (1995) 3.98
Signals and signs for lymphocyte responses. Cell (1994) 3.66
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem (1997) 3.66
Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med (1997) 3.33
Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med (1995) 2.80
Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells. J Immunol (1987) 2.53
Distinct functional phenotypes of cloned Ia-restricted helper T cells. J Exp Med (1985) 2.39
Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages. J Immunol (1989) 2.32
B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo. J Immunol (1995) 2.29
Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation. J Immunol (1989) 2.24
Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells. J Exp Med (1990) 2.21
The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells. Cell (1993) 2.19
Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells. J Immunol (1988) 2.12
CD4+ T cells: specificity and function. Immunol Rev (1988) 2.04
IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol (1998) 1.92
Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. J Immunol (1997) 1.90
Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice. J Exp Med (1978) 1.89
Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression. J Exp Med (1979) 1.86
T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med (1999) 1.85
Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo. J Immunol (1993) 1.82
Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol (1990) 1.79
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Absence of an antigen-specific helper T cell required for the expression of the T 15 idiotype in mice treated with anti-mu antibody. Eur J Immunol (1980) 1.62
Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J Immunol (1997) 1.61
Differential activation of cytokine genes in normal CD4-bearing T cells is stimulus dependent. Eur J Immunol (1989) 1.57
Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding. J Immunol (1997) 1.56
MHC control of CD4+ T cell subset activation. J Exp Med (1989) 1.45
Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu. J Immunol (1999) 1.42
STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science (1999) 1.38
CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. J Virol (2001) 1.35
The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery. Dev Immunol (1992) 1.34
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. J Immunol (1997) 1.33
Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am J Respir Crit Care Med (2000) 1.32
Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells. J Immunol (1995) 1.32
Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma. J Immunol (1997) 1.29
Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. Immunity (2001) 1.28
Cytokines in T-cell development. Immunol Today (1991) 1.26
Differential T cell receptor-mediated signaling in naive and memory CD4 T cells. Eur J Immunol (1997) 1.23
Activation status of the CD4-8- gamma delta-T cells recovered from mice with influenza pneumonia. J Immunol (1991) 1.21
Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies. J Exp Med (1989) 1.20
Activation requirements for CD4+ T cells differing in CD45R expression. J Immunol (1992) 1.19
Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype. Eur J Immunol (1992) 1.19
Involvement of gamma delta T cells in respiratory virus infections. Curr Top Microbiol Immunol (1991) 1.18
Functional CD4 T cell subset interplay in an intact immune system. J Immunol (1993) 1.16
Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation. Eur J Immunol (2000) 1.16
Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression. Genes Dev (1990) 1.16
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation. J Exp Med (1996) 1.16
Molecular associations on the T cell surface correlate with immunological memory. Eur J Immunol (1990) 1.15
Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells. J Exp Med (1983) 1.13
Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. Immunity (1994) 1.12
Ly 9, an alloantigenic marker of lymphocyte differentiation. J Immunol (1980) 1.10
Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity. Immunity (1994) 1.10
Isoform-specific associations of CD45 with accessory molecules in human T lymphocytes. Eur J Immunol (1992) 1.09
Bias in the gamma delta T cell response to Listeria monocytogenes. V delta 6.3+ cells are a major component of the gamma delta T cell response to Listeria monocytogenes. J Immunol (1996) 1.09
Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny. Proc Natl Acad Sci U S A (1989) 1.07
Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation. J Immunol (1998) 1.07
Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny. EMBO J (1991) 1.07
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Regulation of naive T cell differentiation by varying the potency of TCR signal transduction. Semin Immunol (1999) 1.05
1984: all idiotypes are equal, but some are more equal than others. Immunol Rev (1984) 1.03
Progesterone and estradiol modulate interleukin-1 beta messenger ribonucleic acid levels in cultured human peripheral monocytes. J Clin Endocrinol Metab (1989) 1.03
Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets. J Immunol (1997) 1.03
CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR. J Immunol (1998) 1.03
IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol (2001) 1.01
Altered splenic T cell function of BALB/cByJ mice infected with mouse hepatitis virus or Sendai virus. J Immunol (1987) 0.98
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The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM. Arch Virol (1991) 0.95
Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J Biol Chem (1992) 0.94
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The selective ablation of interleukin 2-producing cells isolated from transgenic mice. J Exp Med (1993) 0.91
Antigen-specific helper T cells required for dominant production of an idiotype (THId) are not under immune response (Ir) gene control. J Exp Med (1980) 0.90
Granulocyte-macrophage colony stimulating factor produced by cloned L3T4a+, class II-restricted T cells induces HT-2 cells to proliferate. J Immunol (1987) 0.89
Function and regulation of memory CD4 T cells. Immunol Res (1999) 0.89
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Differential effect of interleukin 1 on naive and memory CD4+ T cells. Eur J Immunol (1992) 0.88
Cultured human luteal peripheral monocytes secrete increased levels of interleukin-1. J Clin Endocrinol Metab (1990) 0.86
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A cloned T cell line that selectively augments antibody responses of phosphorylcholine-specific B cells bearing the T15 idiotype. J Mol Cell Immunol (1986) 0.84
A polymerase chain reaction assay for the detection and quantitation of cytokine gene expression in small numbers of cells. J Immunol Methods (1992) 0.84
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Selected populations of alloreactive T cells contain helper T cells but lack ThId, an antigen-specific helper T cell required for dominant production of the T15 idiotype. Eur J Immunol (1981) 0.83
Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells. Immunology (1991) 0.83
Characterization of gamma/delta T cell clones isolated from human fetal liver and thymus. Eur J Immunol (1990) 0.83
CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells. Eur J Immunol (1995) 0.81
Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted. J Exp Med (1981) 0.81
In vivo administration of interleukin 1 elicits increased Ia antigen expression on B cells through the induction of interleukin 4. Eur J Immunol (1989) 0.81
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IL-4 (B cell stimulatory factor 1) exhibits thymocyte growth factor activity in the presence of IL-2. J Immunol (1988) 0.79
Modes of cell:cell communication in the immune system. J Immunol (1985) 0.78
The role of immunoglobulin and B cells in T cell ontogeny and repertoire formation--a commentary. J Mol Cell Immunol (1985) 0.78