IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.

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Published in J Immunol on October 15, 1998

Authors

L Cohn1, J S Tepper, K Bottomly

Author Affiliations

1: Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011, USA. lauren.cohn@yale.edu

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1984: all idiotypes are equal, but some are more equal than others. Immunol Rev (1984) 1.03

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Responses of T cells to ligands for the T-cell receptor. Semin Immunol (1996) 0.85

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Antigen presentation by B cells. Nature (1989) 0.84

A polymerase chain reaction assay for the detection and quantitation of cytokine gene expression in small numbers of cells. J Immunol Methods (1992) 0.84

Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells. Immunology (1991) 0.83

Characterization of gamma/delta T cell clones isolated from human fetal liver and thymus. Eur J Immunol (1990) 0.83

Adaptation to ozone in rats and its association with ascorbic acid in the lung. Fundam Appl Toxicol (1996) 0.83

Selected populations of alloreactive T cells contain helper T cells but lack ThId, an antigen-specific helper T cell required for dominant production of the T15 idiotype. Eur J Immunol (1981) 0.83

Pulmonary response of Fischer 344 rats to acute nose-only inhalation of indium trichloride. Environ Res (1994) 0.83

Characterization of upper respiratory disease in rats following neonatal inoculation with a rat-adapted influenza virus. Vet Pathol (1996) 0.82