Published in J Immunol on September 01, 1990
Turnover of naive- and memory-phenotype T cells. J Exp Med (1994) 8.07
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc Natl Acad Sci U S A (1992) 5.55
Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol (2001) 2.78
Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med (1999) 2.33
Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med (2007) 2.29
Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J Exp Med (2004) 2.23
Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood (2011) 2.16
Antigen-independent changes in naive CD4 T cells with aging. J Exp Med (1996) 2.14
In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity. J Exp Med (2000) 1.60
Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis. Infect Immun (1994) 1.40
Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J Exp Med (1996) 1.34
CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med (1996) 1.32
The effect of age on the cognate function of CD4+ T cells. Immunol Rev (2005) 1.32
Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol (2005) 1.30
Aging leads to disturbed homeostasis of memory phenotype CD8(+) cells. J Exp Med (2002) 1.24
In vivo induction of tolerance in murine CD4+ cell subsets. J Exp Med (1993) 1.22
Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol (2008) 1.19
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway. Aging Cell (2010) 1.12
Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses. J Immunol (2008) 1.02
Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects. J Immunol (2008) 1.00
Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med (1995) 0.98
Age-related Deficiencies in Antigen-Specific CD4 T cell Responses: Lessons from Mouse Models. Aging Dis (2011) 0.92
Decreased resistance to primary intravenous Cryptococcus neoformans infection in aged mice despite adequate resistance to intravenous rechallenge. Infect Immun (1998) 0.90
Changes in adipose tissue macrophages and T cells during aging. Crit Rev Immunol (2014) 0.90
Age-associated parallel increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in SJL/J mice. Cell Immunol (2009) 0.89
Tolerance of T cell receptor gamma/delta cells in the intestine. J Exp Med (1993) 0.86
Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches. Semin Immunopathol (2008) 0.86
Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. PLoS One (2013) 0.85
Role of mRNA stability in the different patterns of cytokine production by CD4+ cells from young and old mice. Immunology (1998) 0.84
Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection. Immunology (1999) 0.83
Regeneration of dendritic cells in aged mice. Cell Mol Immunol (2010) 0.81
Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation. Best Pract Res Clin Haematol (2011) 0.80
Superantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signaling. Cell Immunol (2012) 0.80
Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency. J Neurol Sci (2010) 0.79
The aged lymphoid tissue environment fails to support naïve T cell homeostasis. Sci Rep (2016) 0.78
Ex vivo enzymatic treatment of aged CD4 T cells restores antigen-driven CD69 expression and proliferation in mice. Immunobiology (2010) 0.78
Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans. J Clin Immunol (1997) 0.78
Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance. Int Immunol (2010) 0.76
3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance. Int Immunopharmacol (2010) 0.75
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med (1991) 10.87
IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J Immunol (1980) 10.30
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity (1996) 8.27
B cell development pathways. Annu Rev Immunol (2001) 6.94
Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol (1997) 5.95
The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med (1983) 5.74
Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J (1996) 5.17
Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci U S A (1984) 5.15
An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT. J Immunol Methods (1991) 4.55
A functional dichotomy in CD4+ T lymphocytes. Immunol Today (1988) 4.18
Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J Exp Med (1985) 4.16
Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science (1971) 4.13
A modification of the hemolytic plaque assay for use with protein antigens. J Immunol (1968) 4.02
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med (1995) 3.98
Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol (2001) 3.92
Signals and signs for lymphocyte responses. Cell (1994) 3.66
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem (1997) 3.66
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med (1993) 3.57
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes. J Immunol (1998) 3.48
A new murine CD4+ T cell subset with an unrestricted cytokine profile. J Immunol (1989) 3.43
Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils. J Clin Invest (1975) 3.39
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci U S A (1994) 3.34
Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell (1986) 3.34
Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med (1997) 3.33
Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature (1991) 3.32
Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature (1986) 3.24
Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities. J Immunol (1975) 3.18
Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science (1999) 3.10
Cellular sites of immunologic unresponsiveness. Proc Natl Acad Sci U S A (1970) 3.01
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev (1994) 3.00
Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines. J Exp Med (1980) 3.00
Positive selection of natural autoreactive B cells. Science (1999) 2.91
Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med (1995) 2.80
Immunological unresponsiveness. Adv Immunol (1973) 2.75
Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc Natl Acad Sci U S A (1996) 2.68
Rheumatoid factor secretion from human Leu-1+ B cells. Science (1987) 2.65
Identification of the earliest B lineage stage in mouse bone marrow. Immunity (1996) 2.62
Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity. Proc Natl Acad Sci U S A (1973) 2.61
Patterns of cytokine gene expression by CD4+ T cells from young and old mice. J Immunol (1993) 2.56
Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells. J Immunol (1987) 2.53
Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage? Annu Rev Immunol (1988) 2.50
Recent observations and concepts in immunological unresponsiveness and autoimmunity. Clin Exp Immunol (1971) 2.45
Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice. Nature (2000) 2.41
Distinct functional phenotypes of cloned Ia-restricted helper T cells. J Exp Med (1985) 2.39
Characterization and genetic analysis of a mutant of Escherichia coli K-12 with rounded morphology. J Bacteriol (1973) 2.36
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med (1987) 2.34
Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages. J Immunol (1989) 2.32
Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression. Eur J Immunol (1986) 2.30
B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo. J Immunol (1995) 2.29
Both E12 and E47 allow commitment to the B cell lineage. Immunity (1997) 2.27
Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv Immunol (1980) 2.27
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. J Exp Med (1986) 2.25
Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science (1986) 2.24
Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation. J Immunol (1989) 2.24
Immunologic properties of bacterial lipopolysaccharide (LPS). II. The unresponsiveness of C3H/HeJ Mouse spleen cells to LPS-induced mitogenesis is dependent on the method used to extract LPS. J Exp Med (1975) 2.22
Mental retardation associated with congenital heart disease, blepharophimosis, blepharoptosis, and hypoplastic teeth. J Med Genet (1986) 2.22
Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells. J Exp Med (1990) 2.21
The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells. Cell (1993) 2.19
Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J Exp Med (1973) 2.15
Reconstitution of functional receptor for human interleukin-2 in mouse cells. Nature (1986) 2.14
Development and physiology of Ly-1 B and its human homolog, Leu-1 B. Immunol Rev (1986) 2.12
Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells. J Immunol (1988) 2.12
Properties of antigen-specific suppressive T cell factor in the regulation of antibody response of the mouse. II. In vitro activity and evidence for the I region gene product. J Immunol (1976) 2.12
Transfer of experimental autoimmune thyroiditis by serum from thyroidectomized donors. J Exp Med (1969) 2.12
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood (2000) 2.12
B-cell subpopulations identified by two-colour fluorescence analysis. Nature (1982) 2.06
A single VH gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells. Definition of the VH11 family. J Immunol (1989) 2.05
CD4+ T cells: specificity and function. Immunol Rev (1988) 2.04
The heritability of body mass index among an international sample of monozygotic twins reared apart. Int J Obes Relat Metab Disord (1996) 1.98
Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2. Science (1999) 1.97
Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science (1993) 1.97
A developmental switch in B lymphopoiesis. Proc Natl Acad Sci U S A (1991) 1.96
The production of thyroiditis and antibody following injection of unaltered thyroglobulin without adjuvant into rabbits previously stimulated with altered thyroglobulin. J Exp Med (1965) 1.96
Developmental switches in chemokine response profiles during B cell differentiation and maturation. J Exp Med (2000) 1.96
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. J Immunol (1982) 1.95
Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. J Exp Med (1996) 1.95
IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol (1998) 1.92
Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. J Immunol (1997) 1.90
Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice. J Exp Med (1978) 1.89
The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. J Immunol (1993) 1.88
The site and stage of anti-DNA B-cell deletion. Nature (1995) 1.87
Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression. J Exp Med (1979) 1.86
T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med (1999) 1.85
Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo. J Immunol (1993) 1.82
T-cell lines which cooperate in generation of specific cytolytic activity. Nature (1979) 1.82