Published in J Cell Biol on December 01, 1992
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev (2005) 3.38
Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol (1995) 3.16
Origin of cardiac fibroblasts and the role of periostin. Circ Res (2009) 2.33
An extensive 3' regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo. Genetics (1998) 1.70
Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol (2002) 1.68
A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice. J Cell Biol (1996) 1.42
Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. J Clin Invest (1995) 1.30
Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice. J Cell Biol (1994) 1.28
Evidence for three major transcription activation elements in the proximal mouse proalpha2(I) collagen promoter. Nucleic Acids Res (1996) 0.95
Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis. J Biomed Res (2013) 0.93
JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction. Nucleic Acids Res (2009) 0.93
Distinct regulatory elements control muscle-specific, fiber-type-selective, and axially graded expression of a myosin light-chain gene in transgenic mice. Mol Cell Biol (1996) 0.92
Distinct regions control transcriptional activation of the alpha1(VI) collagen promoter in different tissues of transgenic mice. J Cell Biol (1996) 0.89
Regulation of the human alpha 2(1) procollagen gene by sequences adjacent to the CCAAT box. Biochem J (1997) 0.83
COL1A2 polymorphic markers confer an increased risk of neovascular age-related macular degeneration in a Han Chinese population. Mol Vis (2012) 0.80
Transcriptional activation of the minimal human Proalpha1(I) collagen promoter: obligatory requirement for Sp1. Biochem J (1997) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell (1987) 15.79
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14
The transforming growth factor-beta family. Annu Rev Cell Biol (1990) 10.62
Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature (1990) 4.64
Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene. Nature (1983) 4.14
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72
Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes. J Cell Biol (1989) 3.55
Role of transforming growth factor-beta in the development of the mouse embryo. J Cell Biol (1987) 3.48
Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol (1991) 3.38
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29
Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. J Biol Chem (1987) 3.25
Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J Clin Invest (1987) 2.74
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors. Science (1988) 2.68
In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Development (1990) 2.53
The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron (1991) 2.37
Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. Proc Natl Acad Sci U S A (1984) 2.30
Appearance and distribution of collagens and laminin in the early mouse embryo. Dev Biol (1980) 2.27
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell (1990) 2.22
Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis. Development (1991) 2.21
Expression of the mouse alpha 1(II) collagen gene is not restricted to cartilage during development. Development (1991) 2.14
Selective activation of transcription by a novel CCAAT binding factor. Science (1988) 2.12
Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis. Recent Prog Horm Res (1988) 1.99
A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding. J Biol Chem (1988) 1.93
Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in transfected primary thyrotropes. J Biol Chem (1989) 1.84
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem (1992) 1.69
Transcriptional control of the mouse alpha 2(I) collagen gene: functional deletion analysis of the promoter and evidence for cell-specific expression. Mol Cell Biol (1986) 1.60
The localization and synthesis of some collagen types in developing mouse embryos. Cell (1979) 1.51
Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells. J Cell Biol (1992) 1.48
An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice. Mol Cell Biol (1991) 1.36
Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.34
Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter. J Biol Chem (1988) 1.30
TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Development (1990) 1.26
Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development (1990) 1.23
Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity. Mech Dev (1991) 1.16
Transforming-growth-factor-beta activation elements in the distal promoter regions of the rat alpha 1 type I collagen gene. Biochem J (1991) 1.09
Conservation of binding sites for regulatory factors in the coordinately expressed alpha 1 (I) and alpha 2 (I) collagen promoters. Biochem Biophys Res Commun (1991) 1.06
Temporal and spatial patterns of transforming growth factor-beta 1 expression in developing rat molars. Arch Oral Biol (1990) 0.89
The role of TGF beta in mouse development. Ann N Y Acad Sci (1990) 0.85
Evidence for two functional gal promoters in intact Escherichia coli cells. J Biol Chem (1981) 17.42
Cyclic AMP receptor protein: role in transcription activation. Science (1984) 8.37
Sox9 is required for cartilage formation. Nat Genet (1999) 7.89
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol (1997) 5.72
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell (1980) 5.51
Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interspersed promoters. Cell (1977) 5.29
Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol (1987) 5.25
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15
Structure of the promoter for chicken alpha 2 type I collagen gene. Proc Natl Acad Sci U S A (1981) 4.89
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A (2001) 4.13
The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell (2001) 4.11
Interaction site of Escherichia coli cyclic AMP receptor protein on DNA of galactose operon promoters. Proc Natl Acad Sci U S A (1979) 3.83
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.80
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72
The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell (1980) 3.66
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem (1996) 3.30
Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol (1995) 3.16
The family of collagen genes. Annu Rev Biochem (1990) 2.98
Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci (1998) 2.71
Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A (1977) 2.57
Unusual methylation pattern of the alpha 2 (l) collagen gene. Cell (1982) 2.36
Unusual location and function of the operator in the Escherichia coli galactose operon. Nature (1979) 2.35
Mutations in the Escherichia coli operon that define two promoters and the binding site of the cyclic AMP receptor protein. J Mol Biol (1982) 2.30
Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J Biol Chem (1998) 2.21
Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene. Proc Natl Acad Sci U S A (1980) 2.18
Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc Natl Acad Sci U S A (1995) 2.17
Mutation of PAX9 is associated with oligodontia. Nat Genet (2000) 2.13
Selective activation of transcription by a novel CCAAT binding factor. Science (1988) 2.12
Use of recombinant plasmids to characterize collagen RNAs in normal and transformed chick embryo fibroblasts. J Biol Chem (1979) 2.07
Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene. Proc Natl Acad Sci U S A (1987) 2.07
Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA. Cell (1980) 2.02
Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis. Recent Prog Horm Res (1988) 1.99
Transcriptional activation encoded by the v-fos gene. Proc Natl Acad Sci U S A (1986) 1.99
L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage (2001) 1.96
A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding. J Biol Chem (1988) 1.93
A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. J Cell Sci (1995) 1.90
Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J Biol Chem (2000) 1.86
Regulation of a collagen gene promoter by the product of viral mos oncogene. Nature (1985) 1.85
Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene. J Biol Chem (1995) 1.85
Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med (2002) 1.84
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A (2000) 1.82
A sequence conserved in both the chicken and mouse alpha 2(I) collagen promoter contains sites sensitive to S1 nuclease. J Biol Chem (1984) 1.81
Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA. J Biol Chem (1981) 1.79
Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene, which codes for both dentin sialoprotein and dentin phosphoprotein. J Biol Chem (1998) 1.73
Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts. J Biol Chem (1985) 1.71
The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300. J Biol Chem (1999) 1.70
Toward understanding SOX9 function in chondrocyte differentiation. Matrix Biol (1998) 1.70
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem (1992) 1.69
Molecuar model of the DNA interaction site for the cyclic AMP receptor protein. Proc Natl Acad Sci U S A (1981) 1.69
Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing. J Biol Chem (1991) 1.67
Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences. J Biol Chem (1980) 1.65
Isolation of genomic DNA clones spanning the entire fibronectin gene. Proc Natl Acad Sci U S A (1983) 1.65
An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes. Mol Cell Biol (1996) 1.64
The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor. Proc Natl Acad Sci U S A (1990) 1.63
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol (2000) 1.63
Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo. J Biol Chem (1998) 1.61
Transcriptional control of the mouse alpha 2(I) collagen gene: functional deletion analysis of the promoter and evidence for cell-specific expression. Mol Cell Biol (1986) 1.60
Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence. Proc Natl Acad Sci U S A (1978) 1.59
On the mechanism of action of lac repressor. Nat New Biol (1971) 1.55
Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Nat Genet (1996) 1.54
Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. Biochem Biophys Res Commun (1970) 1.51
Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor. J Biol Chem (1990) 1.49
Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex. Mol Cell Biol (1996) 1.49
Sequence rearrangement and duplication of double stranded fibronectin cDNA probably occurring during cDNA synthesis by AMV reverse transcriptase and Escherichia coli DNA polymerase I. Nucleic Acids Res (1980) 1.48
Identification of the promoter and first exon of the mouse alpha 1 (III) collagen gene. J Biol Chem (1985) 1.48
Specificity of the bacteriophage lambda N gene product (pN): nut sequences are necessary and sufficient for antitermination by pN. Cell (1979) 1.47
Separate binding sites for nuclear factor 1 and a CCAAT DNA binding factor in the mouse alpha 2(I) collagen promoter. J Biol Chem (1987) 1.47
Three different polypeptides are necessary for DNA binding of the mammalian heteromeric CCAAT binding factor. J Biol Chem (1992) 1.47
Regulation or procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts. Biochemistry (1981) 1.46
ATPase activity required for termination of transcription by the Escherichia coli protein factor rho. J Biol Chem (1976) 1.45
Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts. J Biol Chem (1978) 1.44
Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts. J Biol Chem (1982) 1.44
The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli. Proc Natl Acad Sci U S A (1974) 1.44
Isolation and characterization of genomic DNA coding for alpha 2 type I collagen. Nucleic Acids Res (1980) 1.43
Studies on transcription activation by the multimeric CCAAT-binding factor CBF. J Biol Chem (1995) 1.41
Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene. J Biol Chem (1981) 1.41
DNA sequence comparison of the regulatory signals at the 5' end of the mouse and chick alpha 2 type I collagen genes. J Biol Chem (1984) 1.40
Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene. J Biol Chem (1990) 1.39
A conserved nucleotide sequence, coding for a segment of the C-propeptide, is found at the same location in different collagen genes. Nucleic Acids Res (1983) 1.37
Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.34
Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family. J Biol Chem (2001) 1.33
Transcription in vitro of bacteriophage lambda 4S RNA: studies on termination and rho protein. Nucleic Acids Res (1977) 1.33
Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen. J Cell Biol (1995) 1.32
Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. Proc Natl Acad Sci U S A (1996) 1.31
Differential binding of a CCAAT DNA binding factor to the promoters of the mouse alpha 2(I) and alpha 1(III) collagen genes. J Biol Chem (1986) 1.31
Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development. J Biol Chem (1983) 1.31
A uniquely conserved regulatory signal is found around the translation initiation site in three different collagen genes. J Biol Chem (1983) 1.30
Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter. J Biol Chem (1988) 1.30
A novel mutation in human PAX9 causes molar oligodontia. J Dent Res (2002) 1.29
Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. A DNA-binding domain and a subunit interaction domain are specified by two separate segments. J Biol Chem (1992) 1.28
Isolation, characterization and immunolocalization of a 53-kDal dentin sialoprotein (DSP). Matrix (1992) 1.27
Normal long bone growth and development in type X collagen-null mice. Nat Genet (1994) 1.26
A repetitive structure in the chick alpha 2-collagen gene. Cold Spring Harb Symp Quant Biol (1981) 1.26
Conservation of the sizes for one but not another class of exons in two chick collagen genes. Nature (1984) 1.22
Decrease in the levels of nuclear RNA precursors for alpha 2 collagen in Rous sarcoma virus transformed fibroblasts. Nucleic Acids Res (1981) 1.22
Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. J Biol Chem (1997) 1.18
Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain. J Cell Biol (1992) 1.16
TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. Mol Cell Biol (1993) 1.16
The transcriptional activity of the CCAAT-binding factor CBF is mediated by two distinct activation domains, one in the CBF-B subunit and the other in the CBF-C subunit. J Biol Chem (1996) 1.15