Published in J Biol Chem on October 21, 2003
Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest (2008) 5.05
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc Natl Acad Sci U S A (2006) 2.90
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci U S A (2005) 2.63
Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med (2010) 2.32
Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A (2013) 1.96
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart. Proc Natl Acad Sci U S A (2005) 1.82
Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. Proc Natl Acad Sci U S A (2006) 1.79
Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ Res (2006) 1.73
Genetic variation in ANGPTL4 provides insights into protein processing and function. J Biol Chem (2009) 1.64
Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. Diabetes (2008) 1.48
Microbial regulation of intestinal radiosensitivity. Proc Natl Acad Sci U S A (2005) 1.44
The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms. J Biol Chem (2008) 1.44
A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J Biol Chem (2009) 1.12
Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity. J Biol Chem (2011) 1.03
Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation. J Biol Chem (2013) 1.03
The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk. Arterioscler Thromb Vasc Biol (2010) 1.00
A motif in LILRB2 critical for Angptl2 binding and activation. Blood (2014) 0.99
Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. Invest Ophthalmol Vis Sci (2008) 0.93
Role of Angptl4 in vascular permeability and inflammation. Inflamm Res (2013) 0.88
Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes. J Lipid Res (2016) 0.87
Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. PLoS One (2012) 0.85
Angiopoietin-like 4 confers resistance to hypoxia/serum deprivation-induced apoptosis through PI3K/Akt and ERK1/2 signaling pathways in mesenchymal stem cells. PLoS One (2014) 0.84
The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4. Angiogenesis (2013) 0.83
Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. J Biol Chem (2012) 0.83
Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly. Diabetes (2011) 0.83
The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking. Open Biol (2016) 0.81
Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. J Biol Chem (2015) 0.79
Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance. PLoS One (2015) 0.78
Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol (2015) 0.78
Cytokines and Hormones That Contribute to the Positive Association between Fat and Bone. Front Endocrinol (Lausanne) (2014) 0.77
Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4. J Lipid Res (2013) 0.76
Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer. Oncol Lett (2015) 0.75
Bugging the intestinal response to radiation. Proc Natl Acad Sci U S A (2005) 0.75
Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway. PPAR Res (2017) 0.75
Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease. Front Endocrinol (Lausanne) (2017) 0.75
High Concentrations of Angiopoietin-Like Protein 4 Detected in Serum from Patients with Rheumatoid Arthritis Can Be Explained by Non-Specific Antibody Reactivity. PLoS One (2017) 0.75
A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell (2012) 4.49
AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab (2009) 4.30
Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science (2010) 2.78
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes (2006) 2.63
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A (2007) 2.50
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
Update of TTD: Therapeutic Target Database. Nucleic Acids Res (2009) 2.35
MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med (2012) 2.13
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev Cell (2006) 2.11
Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency. Hepatology (2009) 2.03
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem (2003) 1.89
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart. Proc Natl Acad Sci U S A (2005) 1.82
Differential regulation and properties of angiopoietin-like proteins 3 and 4. J Lipid Res (2005) 1.80
Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol (2004) 1.74
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology (2007) 1.73
The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming. Genome Res (2011) 1.70
Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4. J Lipid Res (2004) 1.69
Genomic diversity and evolution of the head crest in the rock pigeon. Science (2013) 1.68
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A (2008) 1.68
Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia. Am J Hum Genet (2012) 1.65
Intestinal ischemia/reperfusion enhances microglial activation and induces cerebral injury and memory dysfunction in rats. Crit Care Med (2012) 1.54
The draft genome of a socially polymorphic halictid bee, Lasioglossum albipes. Genome Biol (2013) 1.52
Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation. Am J Physiol Endocrinol Metab (2009) 1.51
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proc Natl Acad Sci U S A (2011) 1.43
Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell (2009) 1.27
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc Natl Acad Sci U S A (2009) 1.26
Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway. Am J Pathol (2004) 1.26
Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database. BMC Cancer (2006) 1.20
Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem (2002) 1.19
Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms. Am J Hum Genet (2013) 1.19
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Eur J Pharmacol (2009) 1.13
The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells. Antimicrob Agents Chemother (2009) 1.13
Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol (2004) 1.12
Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. J Biol Chem (2006) 1.12
Flexible and transparent electrothermal film heaters based on graphene materials. Small (2011) 1.10
Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system. Mol Biol Cell (2011) 1.08
Aqua-bis(2-amino-1,3-thia-zole-4-acetato-κO,N)nickel(II). Acta Crystallogr Sect E Struct Rep Online (2009) 1.07
Tetra-aqua-bis-[5-(3-pyrid-yl)tetra-zolido-κN]zinc(II) tetra-hydrate. Acta Crystallogr Sect E Struct Rep Online (2010) 1.07
Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis. Transl Res (2007) 1.06
Expression of miR-31, miR-125b-5p, and miR-326 in the adipogenic differentiation process of adipose-derived stem cells. OMICS (2009) 1.06
FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1. J Biol Chem (2008) 1.04
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell (2011) 1.03
Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc Natl Acad Sci U S A (2008) 1.02
Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem (2005) 1.01
Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host. J Basic Microbiol (2009) 1.01
Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. PLoS One (2010) 1.00
Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones. J Agric Food Chem (2005) 0.98
APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol Endocrinol (2011) 0.97
Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles. BMC Evol Biol (2014) 0.96
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol (2009) 0.96
A live Leishmania major vaccine containing CpG motifs induces the de novo generation of Th17 cells in C57BL/6 mice. Eur J Immunol (2010) 0.93
TTRAP is a novel PML nuclear bodies-associated protein. Biochem Biophys Res Commun (2008) 0.93
Pituitary stalk interruption syndrome in Chinese people: clinical characteristic analysis of 55 cases. PLoS One (2013) 0.93
microRNAs regulate adipocyte differentiation. Cell Biol Int (2013) 0.93
Linking type 2 diabetes and Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 0.92
The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair. Biomaterials (2012) 0.91
Not all angiopoietin-like proteins (Angptls) are created equal: insights from molecular, genetic, and pharmacological studies on the mechanism of LPL inhibition by Angptl3 and Angptl4. Curr Opin Lipidol (2009) 0.90
Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Eur J Pharmacol (2009) 0.90
Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance. Mol Cell Biol (2010) 0.90
Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity. Eur J Pharmacol (2009) 0.90
Graphene - a promising material for organic photovoltaic cells. Adv Mater (2011) 0.90
Let-7a functions as a tumor suppressor in Ewing's sarcoma cell lines partly by targeting cyclin-dependent kinase 6. DNA Cell Biol (2014) 0.89
Isolation and identification of a novel cDNA that encodes human yrdC protein. J Hum Genet (2003) 0.89
Hybrid segmentation of left ventricle in cardiac MRI using Gaussian-mixture model and region restricted dynamic programming. Magn Reson Imaging (2012) 0.88
Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation. Exp Mol Pathol (2004) 0.88
Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas. Endocrinology (2010) 0.88
Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation. Shock (2012) 0.88
Low-dose radiation activates Akt and Nrf2 in the kidney of diabetic mice: a potential mechanism to prevent diabetic nephropathy. Oxid Med Cell Longev (2012) 0.87
Attenuation of diabetes-induced cardiac inflammation and pathological remodeling by low-dose radiation. Radiat Res (2010) 0.87
A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signaling in rats with type 2 diabetes induced by high fat-diet and streptozotocin. Int J Biol Macromol (2015) 0.86
A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation. Diabetes (2013) 0.86
Cyclin D1 affects epithelial-mesenchymal transition in epithelial ovarian cancer stem cell-like cells. Onco Targets Ther (2013) 0.86
Transcriptome analysis of head kidney in grass carp and discovery of immune-related genes. BMC Vet Res (2012) 0.86
Diabetes-induced upregulation of urotensin II and its receptor plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction. Am J Physiol Endocrinol Metab (2008) 0.85
Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes. J Biol Chem (2011) 0.85
Aqua-(2,2'-bipyrimidine-κN,N')(succin-ato-κO,O)copper(II) dihydrate. Acta Crystallogr Sect E Struct Rep Online (2009) 0.85
Antioxidant and cardioprotective effects of Danshensu (3-(3, 4-dihydroxyphenyl)-2-hydroxy-propanoic acid from Salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats. Phytomedicine (2011) 0.85
Cellular protein TTRAP interacts with HIV-1 integrase to facilitate viral integration. Biochem Biophys Res Commun (2009) 0.84
Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice. J Lipid Res (2013) 0.84
Regulated expression of TATA-binding protein-related factor 3 (TRF3) during early embryogenesis. Cell Res (2006) 0.84
Experimental demonstration of 110-Gb/s unsynchronized band-multiplexed superchannel coherent optical OFDM/OQAM system. Opt Express (2013) 0.83
Repetitive exposures to low-dose X-rays attenuate testicular apoptotic cell death in streptozotocin-induced diabetes rats. Toxicol Lett (2009) 0.83
Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion. Mol Neurobiol (2014) 0.83
Toll-like receptor 3 agonist Poly I:C protects against simulated cerebral ischemia in vitro and in vivo. Acta Pharmacol Sin (2012) 0.83
Ischemic postconditioning during reperfusion attenuates oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose reductase. Surgery (2012) 0.83