Published in J Biol Chem on November 21, 2008
Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages. Cell Metab (2010) 2.95
Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab (2012) 2.70
Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A (2012) 2.62
Genetic variation in ANGPTL4 provides insights into protein processing and function. J Biol Chem (2009) 1.64
Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem (2009) 1.64
Genetic determinants of plasma triglycerides. J Lipid Res (2010) 1.63
Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology (2011) 1.19
A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J Biol Chem (2009) 1.12
Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity. J Biol Chem (2011) 1.03
Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation. J Biol Chem (2013) 1.03
Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. J Biol Chem (2010) 1.03
Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J Lipid Res (2011) 0.96
Regulation of triglyceride metabolism by glucocorticoid receptor. Cell Biosci (2012) 0.91
Transcriptional analysis of abdominal fat in genetically fat and lean chickens reveals adipokines, lipogenic genes and a link between hemostasis and leanness. BMC Genomics (2013) 0.88
Determination of lipoprotein lipase activity using a novel fluorescent lipase assay. J Lipid Res (2011) 0.85
ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion. EBioMedicine (2017) 0.84
Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. J Biol Chem (2012) 0.83
Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation. Biosci Rep (2014) 0.83
Genetics of lipid traits and relationship to coronary artery disease. Curr Cardiol Rep (2013) 0.82
A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase. Sci Rep (2015) 0.81
The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking. Open Biol (2016) 0.81
Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases. Drug Discov Today (2016) 0.80
Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans. BMC Complement Altern Med (2014) 0.79
Angiopoietin-like gene expression in the mouse uterus during implantation and in response to steroids. Cell Tissue Res (2012) 0.78
Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia. J Lipid Res (2013) 0.78
The role of ANGPTL3 in controlling lipoprotein metabolism. Endocrine (2016) 0.77
Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration. BMC Evol Biol (2017) 0.75
Genetics of non-conventional lipoprotein fractions. Curr Genet Med Rep (2015) 0.75
Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry. J Lipid Res (2016) 0.75
Stabilizing lipoprotein lipase. J Lipid Res (2009) 0.75
The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3. Mol Genet Metab (2016) 0.75
Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise. PLoS One (2017) 0.75
Angiopoietin-like 3 in lipoprotein metabolism. Nat Rev Endocrinol (2017) 0.75
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet (2007) 13.78
Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists. Methods Biochem Anal (2005) 5.37
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab (2007) 5.04
Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J Lipid Res (2002) 4.94
Lipoprotein lipase: genetics, lipid uptake, and regulation. J Lipid Res (2002) 4.09
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res (1996) 4.01
Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology (2005) 3.83
Angptl3 regulates lipid metabolism in mice. Nat Genet (2002) 3.52
The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem (2005) 3.51
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc Natl Acad Sci U S A (2006) 2.90
Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation. Arterioscler Thromb Vasc Biol (2006) 2.55
ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. J Biol Chem (2002) 2.29
GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Curr Opin Lipidol (2007) 2.01
Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4. J Biol Chem (2003) 1.89
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci U S A (2007) 1.88
Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler Thromb Vasc Biol (2006) 1.87
Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. J Biol Chem (2003) 1.81
Differential regulation and properties of angiopoietin-like proteins 3 and 4. J Lipid Res (2005) 1.80
Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4. J Lipid Res (2004) 1.69
Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arterioscler Thromb Vasc Biol (2007) 1.56
Validation and diagnostic efficacy of a lipase assay using the substrate 1,2-o-dilauryl-rac-glycero glutaric acid-(6' methyl resorufin)-ester for the diagnosis of acute pancreatitis in dogs. Vet Clin Pathol (2005) 1.45
A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res (2003) 1.40
Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysis. J Biol Chem (1994) 1.33
Studies on inactivation of lipoprotein lipase: role of the dimer to monomer dissociation. Biochemistry (1985) 1.30
Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochem J (1992) 1.30
Measurement of pancreatic lipase activity in serum by a kinetic colorimetric assay using a new chromogenic substrate. Ann Clin Biochem (2001) 1.18
Down-regulation of adipose tissue lipoprotein lipase during fasting requires that a gene, separate from the lipase gene, is switched on. J Biol Chem (2002) 1.14
A molecular biology-based approach to resolve the subunit orientation of lipoprotein lipase. Proc Natl Acad Sci U S A (1997) 1.11
The distribution of lipoprotein lipase in rat adipose tissue. Changes with nutritional state engage the extracellular enzyme. J Biol Chem (2003) 1.09
Heterozygous lipoprotein lipase deficiency: frequency in the general population, effect on plasma lipid levels, and risk of ischemic heart disease. Circulation (1997) 1.06
Rapid subunit exchange in dimeric lipoprotein lipase and properties of the inactive monomer. J Biol Chem (2004) 1.04
Human lipoprotein lipase. Analysis of the catalytic triad by site-directed mutagenesis of Ser-132, Asp-156, and His-241. J Biol Chem (1992) 1.04
Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain. Eur J Biochem (2002) 1.01
Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects. J Vasc Res (2006) 0.98
Human lipoprotein lipase: production in vitro, purification, and generation of polyclonal antibody. Methods Enzymol (1996) 0.82
A tale of two angiopoietin-like proteins. Curr Opin Lipidol (2007) 0.82
A kinetic study of the irreversible inhibition of an enzyme measured in the presence of coupled enzymes. Fluorescein isothiocyanate as inhibitor of the adenosinetriphosphatase activity from sarcoplasmic reticulum. Biochim Biophys Acta (1986) 0.79
A kinetic study of an unstable enzyme measured through coupling reactions. Application to the self-inactivation of detergent-solubilized Ca(2+)-ATPase from sarcoplasmic reticulum. Biochim Biophys Acta (1993) 0.78
Ancestral polyploidy in seed plants and angiosperms. Nature (2011) 7.00
Lrp5 functions in bone to regulate bone mass. Nat Med (2011) 5.33
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A (2003) 4.70
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A (2011) 4.52
Comparison of next generation sequencing technologies for transcriptome characterization. BMC Genomics (2009) 2.60
An algorithm that improves speech intelligibility in noise for normal-hearing listeners. J Acoust Soc Am (2009) 2.52
Three immunomarker support vector machines-based prognostic classifiers for stage IB non-small-cell lung cancer. J Clin Oncol (2009) 1.91
Highly similar microbial communities are shared among related and trophically similar ant species. Mol Ecol (2012) 1.81
Exploring intracellular space: function of the Min system in round-shaped Escherichia coli. EMBO J (2002) 1.69
Speech recognition by bilateral cochlear implant users in a cocktail-party setting. J Acoust Soc Am (2009) 1.67
Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem (2009) 1.64
Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol (2009) 1.64
A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Blood (2011) 1.62
Subcarinal node metastasis in thoracic esophageal squamous cell carcinoma. Ann Thorac Surg (2011) 1.61
Objective measures for predicting speech intelligibility in noisy conditions based on new band-importance functions. J Acoust Soc Am (2009) 1.58
Conservation and divergence in the AGAMOUS subfamily of MADS-box genes: evidence of independent sub- and neofunctionalization events. Evol Dev (2006) 1.57
Ideal permissive hypotension to resuscitate uncontrolled hemorrhagic shock and the tolerance time in rats. Anesthesiology (2011) 1.55
Floral gene resources from basal angiosperms for comparative genomics research. BMC Plant Biol (2005) 1.54
LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling. Mol Cell Biol (2012) 1.48
Positive transforming growth factor-β activated kinase-1 expression has an unfavorable impact on survival in T3N1-3M0 esophageal squamous cell carcinomas. Ann Thorac Surg (2012) 1.46
Prognostic relevance of Id-1 expression in patients with resectable esophageal squamous cell carcinoma. Ann Thorac Surg (2012) 1.46
Expression of floral MADS-box genes in basal angiosperms: implications for the evolution of floral regulators. Plant J (2005) 1.44
Homolog interaction during meiotic prophase I in Arabidopsis requires the SOLO DANCERS gene encoding a novel cyclin-like protein. EMBO J (2002) 1.43
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem (2008) 1.35
GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4. J Lipid Res (2009) 1.33
Uncovering symbiont-driven genetic diversity across North American pea aphids. Mol Ecol (2013) 1.22
Characterization of meiotic crossovers and gene conversion by whole-genome sequencing in Saccharomyces cerevisiae. BMC Genomics (2009) 1.22
The Arabidopsis ATK1 gene is required for spindle morphogenesis in male meiosis. Development (2002) 1.22
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PLoS One (2012) 1.22
Sustainable sources of biomass for bioremediation of heavy metals in waste water derived from coal-fired power generation. PLoS One (2012) 1.18
MiR-101 is involved in human breast carcinogenesis by targeting Stathmin1. PLoS One (2012) 1.17
Glucose biosensor based on Au nanoparticles-conductive polyaniline nanocomposite. Biosens Bioelectron (2005) 1.14
Fatal infection with influenza A (H5N1) virus in China. N Engl J Med (2006) 1.13
Subspace algorithms for noise reduction in cochlear implants. J Acoust Soc Am (2005) 1.13
Nonparaxial Mathieu and Weber accelerating beams. Phys Rev Lett (2012) 1.11
Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett (2009) 1.11
Ebola Virus Outbreak Investigation, Sierra Leone, September 28-November 11, 2014. Emerg Infect Dis (2015) 1.10
EST database for early flower development in California poppy (Eschscholzia californica Cham., Papaveraceae) tags over 6,000 genes from a basal eudicot. Plant Mol Biol (2006) 1.07
Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase. Bioorg Med Chem Lett (2009) 1.05
A SNP site in pri-miR-124 changes mature miR-124 expression but no contribution to Alzheimer's disease in a Mongolian population. Neurosci Lett (2012) 1.04
Regulation of migration in Mythimna separata (Walker) in China: a review integrating environmental, physiological, hormonal, genetic, and molecular factors. Environ Entomol (2011) 1.02
Demethylation of miR-9-3 and miR-193a genes suppresses proliferation and promotes apoptosis in non-small cell lung cancer cell lines. Cell Physiol Biochem (2013) 1.00
Two Dictyostelium orthologs of the prokaryotic cell division protein FtsZ localize to mitochondria and are required for the maintenance of normal mitochondrial morphology. Eukaryot Cell (2003) 0.99
Female reproductive success decreases with display size in monkshood, Aconitum kusnezoffii (Ranunculaceae). Ann Bot (2009) 0.99
Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. J Biomol Screen (2009) 0.97
Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem (2009) 0.97
MicroRNA-181b and microRNA-9 mediate arsenic-induced angiogenesis via NRP1. J Cell Physiol (2012) 0.97
Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders. J Med Chem (2009) 0.95
Longitudinal trends in prostate cancer incidence, mortality, and survival of patients from two Shanghai city districts: a retrospective population-based cohort study, 2000-2009. BMC Public Health (2014) 0.94
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A (2014) 0.93
The GAOLAOZHUANGREN1 gene encodes a putative glycosyltransferase that is critical for normal development and carbohydrate metabolism. Plant Cell Physiol (2004) 0.93
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors. Bioorg Med Chem Lett (2009) 0.93
Statin use and risk of lung cancer: a meta-analysis of observational studies and randomized controlled trials. PLoS One (2013) 0.93
Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone. Nature (2015) 0.93
Gene discovery in Plasmodium vivax through sequencing of ESTs from mixed blood stages. Mol Biochem Parasitol (2005) 0.93
Removable, fully covered, self-expandable metal stents for the treatment of refractory benign esophagogastric anastomotic strictures. Dysphagia (2011) 0.93
A homogeneous G protein-coupled receptor ligand binding assay based on time-resolved fluorescence resonance energy transfer. Assay Drug Dev Technol (2008) 0.92
CyclinD1, p53, E-cadherin, and VEGF discordant expression in paired regional metastatic lymph nodes of esophageal squamous cell carcinoma: a tissue array analysis. J Surg Oncol (2011) 0.92
Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α. Biochem Biophys Res Commun (2011) 0.92
Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene (2002) 0.92
Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways. Am J Physiol Heart Circ Physiol (2014) 0.92
Effects of lexical tone contour on Mandarin sentence intelligibility. J Speech Lang Hear Res (2014) 0.92
Expression and prognostic relevance of MUC1 in stage IB non-small cell lung cancer. Med Oncol (2010) 0.91
New techniques in radiation therapy for head and neck cancer: IMRT, CyberKnife, protons, and carbon ions. Improved effectiveness and safety? Impact on survival? Anticancer Drugs (2011) 0.90
Versatile protein biotinylation strategies for potential high-throughput proteomics. J Am Chem Soc (2004) 0.90
Pd(II)-catalyzed C-H iodination using molecular I2 as the sole oxidant. J Am Chem Soc (2013) 0.89
Generation of linear and nonlinear nonparaxial accelerating beams. Opt Lett (2012) 0.89
Regulatory T cells increase in breast cancer and in stage IV breast cancer. Cancer Immunol Immunother (2011) 0.89
Comparative genomic analyses in Asparagus. Genome (2005) 0.89
PB1-mediated virulence attenuation of H5N1 influenza virus in mice is associated with PB2. J Gen Virol (2011) 0.88
MiR-206 regulates neural cells proliferation and apoptosis via Otx2. Cell Physiol Biochem (2012) 0.88
Prognostic value of HOXB7 mRNA expression in human oesophageal squamous cell cancer. Biomarkers (2013) 0.88
Establishment and biological analysis of the EC109/CDDP multidrug-resistant esophageal squamous cell carcinoma cell line. Oncol Rep (2009) 0.87
Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug". Chembiochem (2002) 0.87
Novel potent inhibitors of deoxycytidine kinase identified and compared by multiple assays. J Biomol Screen (2009) 0.87
Dislocation-induced nanoparticle decoration on a GaN nanowire. ACS Appl Mater Interfaces (2015) 0.86
Metastatic lymph node CHIP expression is a potential prognostic marker for resected esophageal squamous cell carcinoma patients. Ann Surg Oncol (2013) 0.86
Development of an ELISA-array for simultaneous detection of five encephalitis viruses. Virol J (2012) 0.86
Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection. BMC Immunol (2009) 0.86
Schlafen-11 sensitizes colorectal carcinoma cells to irinotecan. Anticancer Drugs (2014) 0.86
Single and multiple microphone noise reduction strategies in cochlear implants. Trends Amplif (2012) 0.86
Correlation of p53 status with the response to chemotherapy-based treatment in esophageal cancer: a meta-analysis. Ann Surg Oncol (2013) 0.85
MicroRNA expression and regulation in the uterus during embryo implantation in rat. FEBS J (2014) 0.85
Extraskeletal Ewing sarcomas in late adolescence and adults: a study of 37 patients. Asian Pac J Cancer Prev (2013) 0.85
Acceleration control of Airy beams with optically induced refractive-index gradient. Opt Lett (2011) 0.85
Microwave frequency performance and high magnetic anisotropy of nanocrystalline Fe70Co30-B films prepared by composition gradient sputtering. J Nanosci Nanotechnol (2013) 0.84
Coagulation property of hyaluronic acid-collagen/chitosan complex film. J Mater Sci Mater Med (2008) 0.84
Embryonic ectoderm development protein is regulated by microRNAs in human neural tube defects. Am J Obstet Gynecol (2011) 0.84
Analysis of LGR4 receptor distribution in human and mouse tissues. PLoS One (2013) 0.84
Expression and significance of ER, PR, VEGF, CA15-3, CA125 and CEA in judging the prognosis of breast cancer. Asian Pac J Cancer Prev (2013) 0.84
Natural products as kinase inhibitors. Nat Prod Rep (2012) 0.84
Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. J Med Chem (2009) 0.84
Adaptive evolution for fast growth on glucose and the effects on the regulation of glucose transport system in Clostridium tyrobutyricum. Biotechnol Bioeng (2011) 0.84
Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter. Neurosci Lett (2009) 0.84
Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. Biochem J (2009) 0.83
Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity. J Biomol Screen (2013) 0.83
Inversion and tight focusing of Airy pulses under the action of third-order dispersion. Opt Lett (2013) 0.83