Cyclin D1 affects epithelial-mesenchymal transition in epithelial ovarian cancer stem cell-like cells.

Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application. J Hematol Oncol (2014) 1.20

Mesenchymal Stromal Cells Epithelial Transition Induced by Renal Tubular Cells-Derived Extracellular Vesicles. PLoS One (2016) 0.86

Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer. PLoS One (2015) 0.80

Small putative NANOG, SOX2, and SSEA-4-positive stem cells resembling very small embryonic-like stem cells in sections of ovarian tissue in patients with ovarian cancer. J Ovarian Res (2016) 0.79

Inhibitory effects of metformin at low concentration on epithelial-mesenchymal transition of CD44(+)CD117(+) ovarian cancer stem cells. Stem Cell Res Ther (2015) 0.78

IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation. Int J Gynecol Cancer (2015) 0.75

CDK4/6 inhibition is more active against the glioblastoma proneural subtype. Oncotarget (2017) 0.75

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17

Identification of human brain tumour initiating cells. Nature (2004) 38.87

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80

Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene (2010) 9.66

Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97

Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev (1993) 7.40

Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression. J Cell Physiol (2007) 7.34

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70

Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res (2008) 6.38

Integrins and anoikis. Curr Opin Cell Biol (1997) 5.38

Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness. Proc Natl Acad Sci U S A (2006) 4.66

Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature (2009) 3.90

Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res (2009) 3.76

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer (2007) 3.28

Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res (2006) 3.12

Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS One (2008) 2.90

Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma. Int J Cancer (2010) 2.54

Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res (2006) 2.32

Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. Clin Cancer Res (2005) 2.13

A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. Cancer Res (2007) 2.11

Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell (2010) 1.92

Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer. Curr Cancer Drug Targets (2010) 1.91

The early detection of ovarian cancer: from traditional methods to proteomics. Can we really do better than serum CA-125? Am J Obstet Gynecol (2008) 1.86

Multicellular spheroids in ovarian cancer metastases: Biology and pathology. Gynecol Oncol (2009) 1.82

Bmi-1 is essential for the tumorigenicity of neuroblastoma cells. Am J Pathol (2007) 1.59

Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma. Cancer Res (2008) 1.50

Cell-cell adhesion in the normal ovary and ovarian tumors of epithelial origin; an exception to the rule. Mol Cell Endocrinol (2003) 1.45

In vitro propagation and characterization of neoplastic stem/progenitor-like cells from human prostate cancer tissue. Prostate (2009) 1.33

Cadherin switching in ovarian cancer progression. Int J Cancer (2003) 1.25

Identification of cancer stem cell-like cells from human epithelial ovarian carcinoma cell line. Cell Mol Life Sci (2010) 1.21

Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling. Carcinogenesis (2008) 1.18

The role of cancer stem cells and the side population in epithelial ovarian cancer. Histol Histopathol (2010) 1.08

CD133-expressing stem cells associated with ovarian metastases establish an endothelial hierarchy and contribute to tumor vasculature. Stem Cells (2009) 1.08

The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers. Am J Pathol (2010) 1.07

Analysis of OCT4 expression in an extended panel of human tumor cell lines from multiple entities and in human mesenchymal stem cells. Cell Mol Life Sci (2009) 0.97

Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis. Cell Death Differ (2009) 0.96

Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp (Warsz) (2008) 0.95

Inhibition of tumor growth and metastasis by non-small cell lung cancer cells transfected with cyclin D1-targeted siRNA. Oligonucleotides (2009) 0.88

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33

HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96

Recovery of learning and memory is associated with chromatin remodelling. Nature (2007) 6.72

Many paths to methyltransfer: a chronicle of convergence. Trends Biochem Sci (2003) 5.65

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49

Structural basis for the product specificity of histone lysine methyltransferases. Mol Cell (2003) 4.42

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15

The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93

Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol (2008) 3.53

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature (2008) 3.28

MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol (2008) 3.20

Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00

Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87

In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem (2004) 2.86

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55

Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol (2002) 2.51

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50

Update of TTD: Therapeutic Target Database. Nucleic Acids Res (2009) 2.35

Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem (2007) 2.34

Regulation of integrin activation. Annu Rev Cell Dev Biol (2011) 2.32

Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure (2003) 2.30

A common mode of recognition for methylated CpG. Trends Biochem Sci (2013) 2.28

The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol (2002) 2.24

Objective assessment of deformable image registration in radiotherapy: a multi-institution study. Med Phys (2008) 2.15

Image guidance for precise conformal radiotherapy. Int J Radiat Oncol Biol Phys (2003) 2.09

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol (2010) 2.07

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem (2002) 2.06

Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency. Hepatology (2009) 2.03

Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J Biol Chem (2002) 1.99

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP. J Biol Chem (2002) 1.94

Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4. J Biol Chem (2003) 1.89

Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res (2011) 1.76

Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol (2004) 1.74

Structure of the SET domain histone lysine methyltransferase Clr4. Nat Struct Biol (2002) 1.70

Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med (2007) 1.69

Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia. Am J Hum Genet (2012) 1.65

Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily megavoltage computed tomography and deformable image registration. Int J Radiat Oncol Biol Phys (2008) 1.63

Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women. Int J Cancer (2009) 1.63

The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60

Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29. J Pathol (2011) 1.57

Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry (2007) 1.55

A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding. Blood (2014) 1.55

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol (2010) 1.52

miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol (2011) 1.52

Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating I{kappa}B kinase. Cancer Res (2005) 1.48

miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression. Clin Cancer Res (2013) 1.47

Comprehensive alanine-scanning mutagenesis of Escherichia coli CsrA defines two subdomains of critical functional importance. J Biol Chem (2006) 1.47

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res (2008) 1.46

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol (2012) 1.46

Effects of experience on fetal voice recognition. Psychol Sci (2003) 1.45

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics (2009) 1.45

Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction. Anal Biochem (2009) 1.44

Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43

Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation. Mol Endocrinol (2007) 1.42

Solution-processed graphene/MnO2 nanostructured textiles for high-performance electrochemical capacitors. Nano Lett (2011) 1.41

Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res (2004) 1.41

High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell Rep (2013) 1.40

Impact of inborn errors of metabolism on admission in a neonatal intensive care unit--a prospective cohort study. Indian J Pediatr (2011) 1.40

Reduced expression of NDUFS3 and its clinical significance in serous ovarian cancer. Int J Gynecol Cancer (2013) 1.40

Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A (2007) 1.40

An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38

Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38

Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol (2010) 1.37

Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration. Radiother Oncol (2008) 1.37

Green tea and the prevention of breast cancer: a case-control study in Southeast China. Carcinogenesis (2006) 1.36

Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell (2005) 1.36

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res (2012) 1.35

A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat Neurosci (2007) 1.35

Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol (2008) 1.34

PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner. J Control Release (2007) 1.34

The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. J Biol Chem (2004) 1.33

Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci U S A (2005) 1.33

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem (2011) 1.32

Basic amino-acid side chains regulate transmembrane integrin signalling. Nature (2011) 1.30

A simple fixed-point approach to invert a deformation field. Med Phys (2008) 1.28

Infants' first feeds in Hangzhou, PR China. Asia Pac J Clin Nutr (2007) 1.27

Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell (2009) 1.27

Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A (2012) 1.27

Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase. J Mol Biol (2006) 1.27

Prevalence and risk profile of cervical Human papillomavirus infection in Zhejiang Province, southeast China: a population-based study. Virol J (2010) 1.25

microRNAs are biomarkers of oncogenic human papillomavirus infections. Proc Natl Acad Sci U S A (2014) 1.25

Tomographic subvolume alignment and subvolume classification applied to myosin V and SIV envelope spikes. J Struct Biol (2008) 1.24