Published in Biochemistry on November 25, 2003
Stretch-activated ion channels: what are they? Physiology (Bethesda) (2010) 1.85
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. J R Soc Interface (2009) 1.77
G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects. J Gen Physiol (2007) 1.64
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49
Docosahexaenoic acid alters bilayer elastic properties. Proc Natl Acad Sci U S A (2007) 1.48
Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs. J Gen Physiol (2008) 1.45
Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms. Am J Physiol Cell Physiol (2013) 1.42
Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol (2014) 1.39
Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci (2012) 1.28
Amphiphile regulation of ion channel function by changes in the bilayer spring constant. Proc Natl Acad Sci U S A (2010) 1.26
Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. J Am Chem Soc (2009) 1.24
Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods. Proc Natl Acad Sci U S A (2004) 1.23
Membrane-thinning effect of curcumin. Biophys J (2008) 1.12
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. Mol Pharmacol (2004) 1.11
Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator. Br J Pharmacol (2008) 1.09
Screening for small molecules' bilayer-modifying potential using a gramicidin-based fluorescence assay. Assay Drug Dev Technol (2010) 1.08
The bound states of amphipathic drugs in lipid bilayers: study of curcumin. Biophys J (2008) 1.06
Structure and water permeability of fully hydrated diphytanoylPC. Chem Phys Lipids (2010) 1.04
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery. J Gen Physiol (2011) 0.96
Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases. Am J Physiol Heart Circ Physiol (2005) 0.93
Small-molecule photostabilizing agents are modifiers of lipid bilayer properties. Biophys J (2013) 0.90
Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling. Proc Natl Acad Sci U S A (2011) 0.90
Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases. Br J Pharmacol (2010) 0.89
Structure and elasticity of lipid membranes with genistein and daidzein bioflavinoids using X-ray scattering and MD simulations. J Phys Chem B (2012) 0.89
Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. Faraday Discuss (2013) 0.87
Direct inhibition of the pacemaker (If) current in rabbit sinoatrial node cells by genistein. Br J Pharmacol (2006) 0.85
Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly. J Gen Physiol (2006) 0.83
The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels. Biochim Biophys Acta (2008) 0.82
The sodium-calcium exchanger is a mechanosensitive transporter. J Physiol (2008) 0.82
Molecular basis for genistein-induced inhibition of Kir2.3 currents. Pflugers Arch (2007) 0.80
Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications. Curr Pharm Des (2013) 0.80
X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranes. Chem Phys Lipids (2013) 0.80
Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties. FEBS Lett (2011) 0.80
The interaction of dipole modifiers with polyene-sterol complexes. PLoS One (2012) 0.79
Genistein inhibits the activity of kv1.3 potassium channels in human T lymphocytes. J Membr Biol (2005) 0.79
Bilayer elasticity at the nanoscale: the need for new terms. PLoS One (2012) 0.78
Lipid microdomain formation: characterization by infrared spectroscopy and ultrasonic velocimetry. Biophys J (2008) 0.78
Inhibition of Kv4.3 by genistein via a tyrosine phosphorylation-independent mechanism. Am J Physiol Cell Physiol (2010) 0.78
A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics. J Gen Physiol (2015) 0.78
The interaction of dipole modifiers with amphotericin-ergosterol complexes. Effects of phospholipid and sphingolipid membrane composition. Eur Biophys J (2014) 0.77
Bilayer Effects of Antimalarial Compounds. PLoS One (2015) 0.76
Investigation of channel-forming activity of polyene macrolide antibiotics in planar lipid bilayers in the presence of dipole modifiers. Acta Naturae (2014) 0.76
Mechanical transduction by ion channels: A cautionary tale. World J Neurol (2015) 0.75
Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties. Proc Natl Acad Sci U S A (2017) 0.75
Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism. Sci Rep (2017) 0.75
A one-dimensional continuum elastic model for membrane-embedded gramicidin dimer dissociation. PLoS One (2011) 0.75
Modifiers of the Dipole Potential of Lipid Bilayers. Acta Naturae (2016) 0.75
Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes. Elife (2016) 0.75
Two types of syringomycin E channels in sphingomyelin-containing bilayers. Eur Biophys J (2015) 0.75
Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs. Acad Med (2010) 6.51
Bilayer thickness and membrane protein function: an energetic perspective. Annu Rev Biophys Biomol Struct (2007) 3.52
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature (2004) 3.12
Energetics of ion conduction through the gramicidin channel. Proc Natl Acad Sci U S A (2003) 2.67
Geometry and intrinsic tilt of a tryptophan-anchored transmembrane alpha-helix determined by (2)H NMR. Biophys J (2002) 2.01
Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR. Biophys J (2004) 1.98
Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions. Biochemistry (2003) 1.92
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol (2004) 1.83
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. J R Soc Interface (2009) 1.77
Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity. Mol Pharmacol (2005) 1.70
Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data. J Am Chem Soc (2003) 1.61
Ion permeation through a narrow channel: using gramicidin to ascertain all-atom molecular dynamics potential of mean force methodology and biomolecular force fields. Biophys J (2006) 1.61
Molecular dynamics - potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels. Biophys Chem (2006) 1.57
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Chem Biol (2012) 1.49
Docosahexaenoic acid alters bilayer elastic properties. Proc Natl Acad Sci U S A (2007) 1.48
Models and mechanistic insight. J Gen Physiol (2008) 1.44
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer Res (2007) 1.42
Changes in transmembrane helix alignment by arginine residues revealed by solid-state NMR experiments and coarse-grained MD simulations. J Am Chem Soc (2010) 1.41
Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol (2014) 1.39
Curcumin is a modulator of bilayer material properties. Biochemistry (2007) 1.34
Hydrophobic mismatch between helices and lipid bilayers. Biophys J (2003) 1.28
Amphiphile regulation of ion channel function by changes in the bilayer spring constant. Proc Natl Acad Sci U S A (2010) 1.26
Comparison of "Polarization inversion with spin exchange at magic angle" and "geometric analysis of labeled alanines" methods for transmembrane helix alignment. J Am Chem Soc (2008) 1.24
Charged or aromatic anchor residue dependence of transmembrane peptide tilt. J Biol Chem (2010) 1.20
Orientation and motion of tryptophan interfacial anchors in membrane-spanning peptides. Biochemistry (2007) 1.20
Hydrophobic coupling of lipid bilayer energetics to channel function. J Gen Physiol (2003) 1.20
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophys J (2011) 1.15
Influence of hydrophobic mismatch on structures and dynamics of gramicidin a and lipid bilayers. Biophys J (2012) 1.15
The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels. J Biol Chem (2008) 1.14
Gramicidin channels. IEEE Trans Nanobioscience (2005) 1.12
Screening for small molecules' bilayer-modifying potential using a gramicidin-based fluorescence assay. Assay Drug Dev Technol (2010) 1.08
Single-molecule methods for monitoring changes in bilayer elastic properties. Methods Mol Biol (2007) 1.01
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. PLoS One (2013) 1.01
On the combined analysis of ²H and ¹⁵N/¹H solid-state NMR data for determination of transmembrane peptide orientation and dynamics. Biophys J (2011) 1.00
2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties. Mol Pharmacol (2006) 0.99
Alcohol's effects on lipid bilayer properties. Biophys J (2011) 0.99
Tyrosine replacing tryptophan as an anchor in GWALP peptides. Biochemistry (2012) 0.99
Buried lysine, but not arginine, titrates and alters transmembrane helix tilt. Proc Natl Acad Sci U S A (2013) 0.99
Comment on "Free energy simulations of single and double ion occupancy in gramicidin A" [J. Chem. Phys. 126, 105103 (2007)]. J Chem Phys (2008) 0.98
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery. J Gen Physiol (2011) 0.96
Influence of proline upon the folding and geometry of the WALP19 transmembrane peptide. Biochemistry (2009) 0.94
Importance of tensor asymmetry for the analysis of 2H NMR spectra from deuterated aromatic rings. J Am Chem Soc (2005) 0.92
Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. I: molecular dynamics simulations. J Phys Chem B (2011) 0.90
Small-molecule photostabilizing agents are modifiers of lipid bilayer properties. Biophys J (2013) 0.90
Response of GWALP transmembrane peptides to changes in the tryptophan anchor positions. Biochemistry (2011) 0.90
Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling. Proc Natl Acad Sci U S A (2011) 0.90
Accommodation of a central arginine in a transmembrane peptide by changing the placement of anchor residues. J Phys Chem B (2012) 0.89
The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958). J Gen Physiol (2008) 0.88
Gramicidin-based fluorescence assay; for determining small molecules potential for modifying lipid bilayer properties. J Vis Exp (2010) 0.88
A brief history of the journal of general physiology. J Gen Physiol (2005) 0.87
Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. Faraday Discuss (2013) 0.87
Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors. J Phys Chem B (2010) 0.87
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. J Pharmacol Exp Ther (2013) 0.87
Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins? Biochemistry (2008) 0.86
Comparisons of interfacial Phe, Tyr, and Trp residues as determinants of orientation and dynamics for GWALP transmembrane peptides. Biochemistry (2014) 0.86
Phosphoinositides alter lipid bilayer properties. J Gen Physiol (2013) 0.84
A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide. J Am Chem Soc (2010) 0.83
Assessing smectic liquid-crystal continuum models for elastic bilayer deformations. Chem Phys Lipids (2013) 0.82
Gateways to the Laboratory: How an MD-PhD Program Increased the Number of Minority Physician-Scientists. Acad Med (2017) 0.81
Role of tryptophan residues in gramicidin channel organization and function. Biophys J (2008) 0.80
Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties. FEBS Lett (2011) 0.80
A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics. J Biol Chem (2014) 0.80
Single tryptophan and tyrosine comparisons in the N-terminal and C-terminal interface regions of transmembrane GWALP peptides. J Phys Chem B (2013) 0.80
Concerning tryptophan and protein-bilayer interactions. J Gen Physiol (2007) 0.79
Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. II: nuclear magnetic resonance experiments. J Phys Chem B (2011) 0.79
Properties of membrane-incorporated WALP peptides that are anchored on only one end. Biochemistry (2012) 0.78
Energetics of double-ion occupancy in the gramicidin A channel. J Phys Chem B (2010) 0.78
Proline kink angle distributions for GWALP23 in lipid bilayers of different thicknesses. Biochemistry (2012) 0.78
The membrane interface dictates different anchor roles for "inner pair" and "outer pair" tryptophan indole rings in gramicidin A channels. Biochemistry (2011) 0.78
Membrane organization and dynamics of "inner pair" and "outer pair" tryptophan residues in gramicidin channels. J Phys Chem B (2012) 0.77
The 58th annual meeting and symposium of the society of general physiologists: lipid signaling in physiology. J Gen Physiol (2005) 0.77
Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays (2002) 0.77
Importance of indole N-H hydrogen bonding in the organization and dynamics of gramicidin channels. Biochim Biophys Acta (2013) 0.77
Cells on the MEND: exploring the role of lipidic forces in membrane trafficking. J Gen Physiol (2011) 0.75
Polar groups in membrane channels: consequences of replacing alanines with serines in membrane-spanning gramicidin channels. Biochemistry (2010) 0.75
History and Outcomes of 50 Years of Physician-Scientist Training in Medical Scientist Training Programs. Acad Med (2017) 0.75
The 57th Annual Meeting and Symposium of the Society of General Physiologists: the biology of chloride. J Gen Physiol (2004) 0.75
Quantitative Characterization of Protein-Lipid Interactions by Free Energy Simulation Between Binary Bilayers. J Chem Theory Comput (2019) 0.75
Introduction to Biophysics Week: What is Biophysics? Biophys J (2017) 0.75
Multivariate data analysis for enhanced interpretation of electrochemical impedance spectra of gramicidin-ion interactions in phospholipid monolayers. Langmuir (2007) 0.75