Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.

PubWeight™: 3.80‹?› | Rank: Top 1%

🔗 View Article (PMID 14623723)

Published in Arch Neurol on November 01, 2003

Authors

Robert H Dworkin1, Miroslav Backonja, Michael C Rowbotham, Robert R Allen, Charles R Argoff, Gary J Bennett, M Catherine Bushnell, John T Farrar, Bradley S Galer, Jennifer A Haythornthwaite, David J Hewitt, John D Loeser, Mitchell B Max, Mario Saltarelli, Kenneth E Schmader, Christoph Stein, David Thompson, Dennis C Turk, Mark S Wallace, Linda R Watkins, Sharon M Weinstein

Author Affiliations

1: Department of Anesthesiology, University of Rochester School of Meedicine and Dentistry, Rochester, NY 14642. robert_dworkin@urmc.rochester.edu

Articles citing this

(truncated to the top 100)

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol (2015) 5.57

Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci (2009) 5.00

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med (2008) 3.83

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex. Nat Med (2008) 2.82

Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society. Pain Res Manag (2007) 2.59

Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther (2010) 2.27

Targeting astrocyte signaling for chronic pain. Neurotherapeutics (2010) 1.88

Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients. Psychosom Med (2008) 1.88

Neuropathic pain: a practical guide for the clinician. CMAJ (2006) 1.79

Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs (2008) 1.50

Tolerance and withdrawal from prolonged opioid use in critically ill children. Pediatrics (2010) 1.46

Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury. Anesthesiology (2008) 1.39

A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res (2008) 1.26

Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain. Pain (2006) 1.22

Activation of JNK pathway in persistent pain. Neurosci Lett (2008) 1.19

Current aproach to cancer pain management: Availability and implications of different treatment options. Ther Clin Risk Manag (2007) 1.17

Enhancement of Antinociception by Co-administrations of Nefopam, Morphine, and Nimesulide in a Rat Model of Neuropathic Pain. Korean J Pain (2012) 1.16

Issues in long-term opioid therapy: unmet needs, risks, and solutions. Mayo Clin Proc (2009) 1.14

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. Glia (2010) 1.09

The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness. Obstet Gynecol (2009) 1.06

The impact of morphine after a spinal cord injury. Behav Brain Res (2007) 1.05

Use of gabapentin for perioperative pain control -- a meta-analysis. Pain Res Manag (2007) 1.03

The prevalence of neuropathic pain: clinical evaluation compared with screening tools in a community population. Pain Med (2009) 1.01

The pharmacotherapy of chronic pain: a review. Pain Res Manag (2006) 1.01

Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci (2009) 0.99

The role of tramadol in current treatment strategies for musculoskeletal pain. Ther Clin Risk Manag (2007) 0.98

Evaluation of quality of life and neuropathic pain in patients with low back pain using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire. Eur Spine J (2014) 0.97

Phenotypic Identification of Spinal Cord-Infiltrating CD4(+) T Lymphocytes in a Murine Model of Neuropathic Pain. J Pain Relief (2014) 0.97

TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. Pain (2014) 0.95

Diabetic neuropathy in older adults. Clin Geriatr Med (2008) 0.94

Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings. Rheumatol Int (2009) 0.92

A systematic comparison between subjects with no pain and pain associated with active myofascial trigger points. PM R (2013) 0.92

The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats. J Neural Transm (Vienna) (2011) 0.91

Evidence-based guideline for neuropathic pain interventional treatments: spinal cord stimulation, intravenous infusions, epidural injections and nerve blocks. Pain Res Manag (2012) 0.91

Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. Psychopharmacology (Berl) (2005) 0.91

Pharmacological treatment of neuropathic pain in older persons. Clin Interv Aging (2008) 0.90

Treatment of localized post-traumatic neuropathic pain in scars with 5% lidocaine medicated plaster. Local Reg Anesth (2010) 0.90

Systemic inflammatory mediators in post-traumatic complex regional pain syndrome (CRPS I) - longitudinal investigations and differences to control groups. Eur J Med Res (2009) 0.89

An evidence-based algorithm for the treatment of neuropathic pain. MedGenMed (2007) 0.89

The determination and application of fixed-dose analgesic combinations for treating multimodal pain. J Pain (2010) 0.89

The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice. PLoS One (2011) 0.89

Guidelines in the management of diabetic nerve pain: clinical utility of pregabalin. Diabetes Metab Syndr Obes (2013) 0.88

Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Front Cell Neurosci (2014) 0.88

Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Mol Pain (2012) 0.88

New treatments for chronic prostatitis/chronic pelvic pain syndrome. Nat Rev Urol (2010) 0.87

Spinal cord stimulation for neuropathic pain: an evidence-based analysis. Ont Health Technol Assess Ser (2005) 0.87

Physiotherapy movement based classification approaches to low back pain: comparison of subgroups through review and developer/expert survey. BMC Musculoskelet Disord (2012) 0.86

Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury. Neurochem Res (2011) 0.85

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia. Neuroscience (2010) 0.85

Results of a randomized controlled trial to examine the efficacy of a chronic pain self-management group for older adults [ISRCTN11899548]. Pain (2007) 0.84

Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury. J Neuroinflammation (2015) 0.84

An uncommonly common: Glossopharyngeal neuralgia. Ann Indian Acad Neurol (2013) 0.84

Pain Management Doesn't have to be a Pain: Working and Communicating Effectively with Patients who have Chronic Pain. Perm J (2005) 0.84

Comparison of antinociceptive effect of the antiepileptic drug gabapentin to that of various dosage combinations of gabapentin with lamotrigine and topiramate in mice and rats. J Neurosci Rural Pract (2011) 0.84

The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model. Evid Based Complement Alternat Med (2012) 0.84

Neuropathic cancer pain: What we are dealing with? How to manage it? Onco Targets Ther (2014) 0.83

Anti-hyperalgesic effect of CaMKII inhibitor is associated with downregulation of phosphorylated CREB in rat spinal cord. J Anesth (2010) 0.83

Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux). Mol Pain (2007) 0.83

Potential Therapeutic Benefits of Maintaining Mitochondrial Health in Peripheral Neuropathies. Curr Neuropharmacol (2016) 0.83

Descending facilitation maintains long-term spontaneous neuropathic pain. J Pain (2013) 0.83

Activated polymorphonuclear cells promote injury and excitability of dorsal root ganglia neurons. Exp Neurol (2007) 0.83

Antiallodynic effect of herbal medicine yokukansan on peripheral neuropathy in rats with chronic constriction injury. Evid Based Complement Alternat Med (2012) 0.82

Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion. Sleep (2014) 0.82

Antinociceptive and cytotoxic activities of an epiphytic medicinal orchid: Vanda tessellata Roxb. BMC Complement Altern Med (2014) 0.81

Treating chronic pain: new knowledge, more choices. Perm J (2005) 0.81

The diagnosis and management of neuropathic pain in daily practice in Belgium: an observational study. BMC Public Health (2007) 0.80

Pain management part II: pharmacologic management of chronic orofacial pain. Anesth Prog (2010) 0.80

Ziconotide Monotherapy: A Systematic Review of Randomised Controlled Trials. Curr Neuropharmacol (2017) 0.79

Phytochemical investigation and evaluation of antinociceptive activity of ethanolic extract of Dalbergia sissoo (Roxb.) bark. J Nat Sci Biol Med (2011) 0.79

Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1. PLoS One (2013) 0.79

Management of cancer pain: 1. Wider implications of orthodox analgesics. Int J Gen Med (2014) 0.79

Effect of electroacupuncture on rats with chronic constriction injury-induced neuropathic pain. ScientificWorldJournal (2014) 0.79

Effectiveness of pregabalin as monotherapy or combination therapy for neuropathic pain in patients unresponsive to previous treatments in a Spanish primary care setting. Clin Drug Investig (2013) 0.79

Treatment of postherpetic neuralgia: focus on pregabalin. Clin Interv Aging (2009) 0.79

An Epidemiological Study of Neuropathic Pain Symptoms in Canadian Adults. Pain Res Manag (2016) 0.79

Relation between injury of the periaqueductal gray and central pain in patients with mild traumatic brain injury: Observational study. Medicine (Baltimore) (2016) 0.78

Computational modeling of Adelta-fiber-mediated nociceptive detection of electrocutaneous stimulation. Biol Cybern (2015) 0.78

Are treatment benefits in neuropathic pain reflected in the Self Assessment of Treatment questionnaire? Health Qual Life Outcomes (2013) 0.78

Prescribing cannabis for harm reduction. Harm Reduct J (2012) 0.78

Neuropathic Pain Treatment: Still a Challenge. Neurol Int (2016) 0.78

Conceptual Conditioning: Mechanisms Mediating Conditioning Effects on Pain. Psychol Sci (2015) 0.77

Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis. Neuropsychiatr Dis Treat (2013) 0.77

Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. Iran J Basic Med Sci (2014) 0.77

Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain. J Neuroinflammation (2015) 0.77

The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation. J Korean Med Sci (2008) 0.77

The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine. Neurochem Int (2014) 0.77

Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy. J Neurophysiol (2014) 0.76

Transcranial Direct Current Stimulation in Neuropathic Pain. J Pain Relief (2013) 0.76

Neuropathic pain in hereditary peripheral neuropathy. J Exerc Rehabil (2013) 0.76

Pain associated with diabetic peripheral neuropathy: a review of available treatments. P T (2008) 0.76

A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation. BJOG (2016) 0.76

Feasibility of Early and Repeated Low-dose Interscalene Brachial Plexus Block for Residual Pain in Acute Cervical Radiculopathy Treated with NSAIDS. Korean J Pain (2014) 0.76

Awareness of Fabry disease among rheumatologists--current status and perspectives. Clin Rheumatol (2011) 0.76

Novel Treatment of Radicular Pain With a Multi-Mechanistic Combination Topical Agent: A Case Series and Literature Review. Anesth Pain Med (2016) 0.76

Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides (2014) 0.76

Neuroplasticity of ascending and descending pathways after somatosensory system injury: reviewing knowledge to identify neuropathic pain therapeutic targets. Spinal Cord (2016) 0.75

Antinociceptive and Anti-Inflammatory Activities of Teucrium persicum Boiss. Extract in Mice. Scientifica (Cairo) (2015) 0.75

Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. Sci Rep (2016) 0.75

Predictive factors and clinical biomarkers for treatment in patients with chronic pain caused by osteoarthritis with a central sensitisation component. Int J Clin Pract (2015) 0.75

Brain morphological alternation in chronic pain patients with neuropathic characteristics. Mol Pain (2016) 0.75

Articles by these authors

Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain (2005) 11.80

Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain (2007) 8.89

Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain (2005) 7.80

Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain (2007) 6.98

The prevention and treatment of missing data in clinical trials. N Engl J Med (2012) 6.92

Effects of Testosterone Treatment in Older Men. N Engl J Med (2016) 6.66

Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet (2004) 5.87

Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53

Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet (2007) 5.20

The biopsychosocial approach to chronic pain: scientific advances and future directions. Psychol Bull (2007) 5.09

Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations. J Pain (2008) 4.59

Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis (2008) 4.46

Recommendations for the management of herpes zoster. Clin Infect Dis (2007) 4.33

Comparison of logistic regression versus propensity score when the number of events is low and there are multiple confounders. Am J Epidemiol (2003) 4.27

On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection. N Engl J Med (2015) 4.26

Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. J Oral Facial Pain Headache (2014) 4.25

Core outcome domains for chronic pain clinical trials: IMMPACT recommendations. Pain (2003) 4.24

NeuPSIG guidelines on neuropathic pain assessment. Pain (2010) 4.04

Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc (2010) 3.92

Modifying dyspepsia management in primary care: a cluster randomised controlled trial of educational outreach compared with passive guideline dissemination. Br J Gen Pract (2003) 3.88

Surgery for low back pain: a review of the evidence for an American Pain Society Clinical Practice Guideline. Spine (Phila Pa 1976) (2009) 3.80

An internet survey of 2,596 people with fibromyalgia. BMC Musculoskelet Disord (2007) 3.71

The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome. Gastroenterology (2003) 3.59

A new definition of neuropathic pain. Pain (2011) 3.57

Implementation of self management support for long term conditions in routine primary care settings: cluster randomised controlled trial. BMJ (2013) 3.49

Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA (2004) 3.47

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ (2010) 3.46

Interventional therapies, surgery, and interdisciplinary rehabilitation for low back pain: an evidence-based clinical practice guideline from the American Pain Society. Spine (Phila Pa 1976) (2009) 3.45

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34

Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev (2005) 3.25

How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive-behavioral clinical trials literature. Sleep Med Rev (2004) 3.25

Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base. J Pain (2010) 2.90

Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89

Conducting indirect-treatment-comparison and network-meta-analysis studies: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 2. Value Health (2011) 2.88

Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87

Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain (2006) 2.75

Interventional management of neuropathic pain: NeuPSIG recommendations. Pain (2013) 2.75

Safety of herpes zoster vaccine in the shingles prevention study: a randomized trial. Ann Intern Med (2010) 2.73

The role of fear of movement in subacute whiplash-associated disorders grades I and II. Pain (2012) 2.72

Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum (2005) 2.71

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65

Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain (2004) 2.60

NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol (2008) 2.60

Abuse liability measures for use in analgesic clinical trials in patients with pain: IMMPACT recommendations. Pain (2013) 2.58

How neuroimaging studies have challenged us to rethink: is chronic pain a disease? J Pain (2009) 2.58

Informed Consent. N Engl J Med (2017) 2.56

What does it mean to call chronic pain a brain disease? J Pain (2013) 2.54

The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep (2007) 2.53

Development and initial validation of an expanded and revised version of the Short-form McGill Pain Questionnaire (SF-MPQ-2). Pain (2009) 2.53

American pain society recommendations for improving the quality of acute and cancer pain management: American Pain Society Quality of Care Task Force. Arch Intern Med (2005) 2.52

Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction. Pain (2006) 2.51

Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations. Pain (2009) 2.49

Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer (2003) 2.48

Identifying important outcome domains for chronic pain clinical trials: an IMMPACT survey of people with pain. Pain (2007) 2.47

Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options. Pain Med (2008) 2.44

Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41

Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medications. Am J Gastroenterol (2002) 2.39

Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? J Neurosci (2007) 2.38

Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37

An interdisciplinary expert consensus statement on assessment of pain in older persons. Clin J Pain (2007) 2.37

Duration of sleep contributes to next-day pain report in the general population. Pain (2008) 2.35

Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain (2004) 2.34

Poor functional status as a risk factor for surgical site infection due to methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol (2008) 2.33

ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell (2006) 2.26

Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendations. Pain (2006) 2.23