Published in ScientificWorldJournal on November 02, 2007
Ibudilast in the Treatment of Medication Overuse Headache | NCT01317992
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
Cytokine and chemokine regulation of sensory neuron function. Handb Exp Pharmacol (2009) 1.70
Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66
"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev (2007) 1.62
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun (2008) 1.58
Glia in pathological pain: a role for fractalkine. J Neuroimmunol (2008) 1.39
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun (2008) 1.34
Toll-like receptors in chronic pain. Exp Neurol (2011) 1.29
Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. J Neurosci (2011) 1.22
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience (2010) 1.22
Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology (2010) 1.17
Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats. Mol Pain (2010) 1.08
Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience (2010) 1.07
The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain Behav Immun (2009) 1.07
Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice. Neurosci Lett (2010) 1.04
Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. Immunol Invest (2011) 1.04
Intrathecal morphine attenuates recovery of function after a spinal cord injury. J Neurotrauma (2009) 1.02
The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse. Eur J Pharmacol (2010) 1.02
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience (2009) 1.02
Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses. Br J Clin Pharmacol (2008) 1.01
Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss. Sleep (2011) 1.01
Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4. Br J Pharmacol (2013) 0.99
The therapeutic potential of interleukin-10 in neuroimmune diseases. Neuropharmacology (2014) 0.98
Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms. Pain (2014) 0.98
Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. J Neuroinflammation (2012) 0.97
Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains. Brain Behav Immun (2011) 0.97
Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine. J Neurosci (2013) 0.97
Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities. Front Psychiatry (2015) 0.96
Morphine-enhanced apoptosis in selective brain regions of neonatal rats. Int J Dev Neurosci (2013) 0.94
Combination drug therapy for chronic pain: a call for more clinical studies. J Pain (2010) 0.94
Targeting Toll-like receptors with small molecule agents. Chem Soc Rev (2013) 0.93
An IL-1 receptor antagonist blocks a morphine-induced attenuation of locomotor recovery after spinal cord injury. Brain Behav Immun (2010) 0.93
Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. PLoS One (2014) 0.92
Gabapentin improves cold-pressor pain responses in methadone-maintained patients. Drug Alcohol Depend (2010) 0.92
New perspectives in the diagnosis and management of enteric neuropathies. Nat Rev Gastroenterol Hepatol (2013) 0.92
Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients. PLoS One (2012) 0.91
Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proc Natl Acad Sci U S A (2016) 0.91
Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6. J Immunol (2014) 0.89
Why is neuroimmunopharmacology crucial for the future of addiction research? Neuropharmacology (2013) 0.89
The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats. Neuropsychopharmacology (2010) 0.87
Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury. Front Neural Circuits (2014) 0.87
Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy. Brain Behav Immun (2012) 0.87
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. Psychopharmacology (Berl) (2013) 0.87
Medications development for opioid abuse. Cold Spring Harb Perspect Med (2013) 0.86
Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats. Neurosci Lett (2010) 0.85
Glutamatergic transmission in drug reward: implications for drug addiction. Front Neurosci (2015) 0.84
Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques. Brain Behav Immun (2015) 0.84
Design, synthesis, and evaluation of biotinylated opioid derivatives as novel probes to study opioid pharmacology. Bioconjug Chem (2008) 0.84
Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances. Expert Opin Investig Drugs (2012) 0.83
Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats. Gene Ther (2011) 0.83
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. J Neuroimmunol (2012) 0.82
Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine. J Neurosci (2017) 0.81
Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4). Psychopharmacology (Berl) (2015) 0.81
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats. Anesthesiology (2012) 0.81
Dose escalation during the first year of long-term opioid therapy for chronic pain. Pain Med (2014) 0.81
Molecular and contextual markers of hepatitis C virus and drug abuse. Mol Diagn Ther (2009) 0.80
New directions in migraine. BMC Med (2011) 0.80
Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling. Neuropsychopharmacology (2016) 0.80
Analgesic tolerance to morphine is regulated by PPARγ. Br J Pharmacol (2014) 0.79
Opioid administration following spinal cord injury: implications for pain and locomotor recovery. Exp Neurol (2013) 0.79
Opioid-induced central immune signaling: implications for opioid analgesia. Headache (2015) 0.79
Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives. Curr Drug Abuse Rev (2012) 0.79
The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology (2017) 0.78
Pioglitazone prevents morphine antinociception tolerance and withdrawal symptoms in rats. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.78
Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP. Front Integr Neurosci (2014) 0.78
Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Transl Psychiatry (2014) 0.78
A combinational effect of acetaminophen and oriental herbs on the regulation of inflammatory mediators in microglia cell line, BV2. Anat Cell Biol (2015) 0.77
Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation. ChemMedChem (2015) 0.77
Evaluation of the effects of specific opioid receptor agonists in a rodent model of spinal cord injury. Spinal Cord (2016) 0.77
Sex differences in motivational responses to dietary fat in Syrian hamsters. Physiol Behav (2015) 0.76
Opioid treatment of experimental pain activates nuclear factor-κB. J Opioid Manag (2015) 0.76
Hysterectomy and predictors for opioid prescription in a chronic pain clinic sample. Pain Med (2011) 0.76
An emerging new paradigm in opioid withdrawal: a critical role for glia-neuron signaling in the periaqueductal gray. ScientificWorldJournal (2012) 0.76
Immunoadolescence: Neuroimmune development and adolescent behavior. Neurosci Biobehav Rev (2016) 0.76
Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. J Med Chem (2015) 0.76
Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci (2015) 0.75
The protective effect of hydromorphone to ischemia in rat glial cells. Springerplus (2016) 0.75
The Opioid Challenge. Anesth Prog (2016) 0.75
The effect of gut microbiome on tolerance to morphine mediated antinociception in mice. Sci Rep (2017) 0.75
Sterile Neuroinflammation and Strategies for Therapeutic Intervention. Int J Inflam (2017) 0.75
Sex differences in innate immunity and its impact on opioid pharmacology. J Neurosci Res (2017) 0.75
Ceasing intrathecal therapy in chronic non-cancer pain: an invitation to shift from biomedical focus to active management. PLoS One (2012) 0.75
Complement factor C5a and C5a receptor contribute to morphine tolerance and withdrawal-induced hyperalgesia in rats. Exp Ther Med (2012) 0.75
Effects of Opioids on Esophageal Dysfunction. Gastroenterol Hepatol (N Y) (2016) 0.75
Role of phosphodiesterase inhibitor Ibudilast in morphine-induced hippocampal injury. J Inj Violence Res (2013) 0.75
Withdrawal-associated injury site pain (WISP): a descriptive case series of an opioid cessation phenomenon. Pain (2016) 0.75
Effects of Ibudilast on the Subjective, Reinforcing and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence. Neuropsychopharmacology (2017) 0.75
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proc Natl Acad Sci U S A (2002) 4.34
Regulation of Wnt signaling during adipogenesis. J Biol Chem (2002) 3.94
Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol (2003) 3.80
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev (2005) 3.25
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. Cell Metab (2012) 2.76
Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev (2002) 2.75
Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biol Psychiatry (2006) 2.70
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65
Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes (2003) 2.36
"Brain-specific" nutrients: a memory cure? Nutrition (2003) 2.29
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci (2004) 2.11
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J Neurosci (2006) 2.07
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging (2006) 2.06
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00
Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists. Psychopharmacology (Berl) (2007) 1.94
Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci (2012) 1.93
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci (2003) 1.91
Glia: novel counter-regulators of opioid analgesia. Trends Neurosci (2005) 1.86
Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology (Berl) (2007) 1.86
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol (2003) 1.84
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav Immun (2002) 1.82
Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
Glial activation and pathological pain. Neurochem Int (2004) 1.80
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology (Berl) (2007) 1.74
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73
Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nat Chem Biol (2011) 1.70
Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68
The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors. Neuropsychopharmacology (2005) 1.68
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain (2005) 1.66
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain (2006) 1.66
Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan. Cephalalgia (2010) 1.63
"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev (2007) 1.62
Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J Neurosci Methods (2005) 1.61
In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity. Neuropsychopharmacology (2012) 1.61
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun (2008) 1.58
Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behav Brain Res (2002) 1.58
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain (2010) 1.58
Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain Behav Immun (2009) 1.58
CRF system recruitment mediates dark side of compulsive eating. Proc Natl Acad Sci U S A (2009) 1.57
Behavioral control, the medial prefrontal cortex, and resilience. Dialogues Clin Neurosci (2006) 1.56
5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry (2009) 1.55
Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci (2003) 1.53
Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci (2005) 1.53
Role of the medial prefrontal cortex in coping and resilience. Brain Res (2010) 1.52
Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol (2004) 1.52
Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs (2007) 1.45
Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology (2002) 1.45
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. Behav Neurosci (2004) 1.44
The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biol (2006) 1.43