Published in J Biol Chem on December 08, 2003
Mulan: multiple-sequence local alignment and visualization for studying function and evolution. Genome Res (2004) 2.91
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res (2012) 2.74
Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest (2005) 2.50
Notch1 regulates the fate of cardiac progenitor cells. Proc Natl Acad Sci U S A (2008) 2.22
Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol (2006) 1.82
Role of the GATA family of transcription factors in endocrine development, function, and disease. Mol Endocrinol (2008) 1.81
Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. J Clin Invest (2008) 1.80
Early cardiac development: a view from stem cells to embryos. Cardiovasc Res (2012) 1.18
Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest (2012) 1.10
RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression. Nat Genet (2007) 1.09
Bone morphogenetic protein signaling modulates myocardin transactivation of cardiac genes. Circ Res (2005) 1.09
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. PLoS One (2009) 1.05
T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. Proc Natl Acad Sci U S A (2009) 1.04
GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways. J Bone Miner Res (2014) 1.04
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet (2012) 1.03
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad Sci U S A (2011) 1.02
GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis. Dev Biol (2007) 0.99
Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development (2013) 0.94
Cardiomyogenic stem and progenitor cell plasticity and the dissection of cardiopoiesis. J Mol Cell Cardiol (2008) 0.94
Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease. Genetica (2010) 0.94
Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules. Proc Natl Acad Sci U S A (2005) 0.93
Developmental signaling in myocardial progenitor cells: a comprehensive view of Bmp- and Wnt/beta-catenin signaling. Pediatr Cardiol (2008) 0.93
Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proc Natl Acad Sci U S A (2008) 0.91
NADPH oxidase 4 regulates cardiomyocyte differentiation via redox activation of c-Jun protein and the cis-regulation of GATA-4 gene transcription. J Biol Chem (2013) 0.89
Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells. PLoS One (2010) 0.87
Examining the cardiac NK-2 genes in early heart development. Pediatr Cardiol (2009) 0.86
Transcription factors in heart: promising therapeutic targets in cardiac hypertrophy. Curr Cardiol Rev (2011) 0.86
CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice. Hum Mol Genet (2013) 0.84
Genetic networks governing heart development. Cold Spring Harb Perspect Med (2014) 0.83
Heart failure and pulmonary hypertension. Heart Fail Clin (2010) 0.82
PIAS1 is a GATA4 SUMO ligase that regulates GATA4-dependent intestinal promoters independent of SUMO ligase activity and GATA4 sumoylation. PLoS One (2012) 0.82
BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH. Development (2014) 0.80
Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4. J Mol Cell Cardiol (2013) 0.80
Phosphorylation of Shox2 is required for its function to control sinoatrial node formation. J Am Heart Assoc (2014) 0.79
The functional diversity of essential genes required for mammalian cardiac development. Genesis (2014) 0.79
Unique functions of Gata4 in mouse liver induction and heart development. Dev Biol (2015) 0.78
Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis. Brief Funct Genomics (2013) 0.78
Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1. J Clin Immunol (2009) 0.77
Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation. Tissue Eng Part B Rev (2015) 0.77
Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts. Biochem Biophys Res Commun (2013) 0.76
Evolutionary conservation of Nkx2.5 autoregulation in the second heart field. Dev Biol (2012) 0.76
Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. Stem Cell Reports (2015) 0.76
Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene. Biol Open (2016) 0.75
Prediction and validation of protein-protein interactors from genome-wide DNA-binding data using a knowledge-based machine-learning approach. Open Biol (2016) 0.75
Constitutive Expression of GATA4 Dramatically Increases the Cardiogenic Potential of D3 Mouse Embryonic Stem Cells. Open Biotechnol J (2016) 0.75
Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5. PLoS One (2015) 0.75
Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development (2017) 0.75
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell (2008) 4.70
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res (2006) 4.41
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature (2006) 4.35
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development (2005) 2.92
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature (2009) 2.74
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
Multiple roles for Sox2 in the developing and adult mouse trachea. Development (2009) 2.62
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell (2010) 2.52
Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest (2005) 2.50
Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis. Mol Genet Metab (2003) 2.42
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal (2011) 2.38
Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell (2003) 2.28
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis. Nature (2012) 2.11
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res (2006) 2.08
Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc Natl Acad Sci U S A (2004) 2.07
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity (2007) 2.07
Fgf8 is required for anterior heart field development. Development (2006) 2.03
COUP-TFII is essential for radial and anteroposterior patterning of the stomach. Development (2005) 2.00
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J (2006) 1.99
Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A (2004) 1.93
Phospho-control of TGF-beta superfamily signaling. Cell Res (2009) 1.91
SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J Biol Chem (2003) 1.82
Ultraviolet B light-exposed human platelets mediate acute lung injury in a two-event mouse model of transfusion. Transfusion (2011) 1.81
Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells. Ann N Y Acad Sci (2004) 1.80
Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol (2007) 1.77
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A (2006) 1.76
Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev (2010) 1.75
Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J (2004) 1.75
Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.75
Concurrent partnerships, nonmonogamous partners, and substance use among women in the United States. Am J Public Health (2010) 1.75
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proc Natl Acad Sci U S A (2012) 1.72
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J Clin Invest (2004) 1.71
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol (2007) 1.68
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. EMBO J (2004) 1.62
Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem (2009) 1.59
Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity. J Biol Chem (2002) 1.57
Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol Cell (2003) 1.57
Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem (2005) 1.56
Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet (2009) 1.55
The cellular prion protein identifies bipotential cardiomyogenic progenitors. Circ Res (2009) 1.54
Retinoic acid deficiency alters second heart field formation. Proc Natl Acad Sci U S A (2008) 1.51
Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol (2005) 1.50
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J (2007) 1.49
Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen (2012) 1.47
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. J Clin Invest (2014) 1.45
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling. Dev Cell (2009) 1.45
Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A (2008) 1.39
Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem (2005) 1.38
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem (2009) 1.38
Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res (2009) 1.38
Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun (2013) 1.36
Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling. J Biol Chem (2006) 1.35
Msx2 and necdin combined activities are required for smooth muscle differentiation in mesoangioblast stem cells. Circ Res (2004) 1.33
Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation (2003) 1.33
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell (2010) 1.33
Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4. J Biol Chem (2003) 1.32
Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. J Biol Chem (2002) 1.30
TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections. Cardiovasc Res (2010) 1.30
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol (2006) 1.28
SUMO-1 modification activated GATA4-dependent cardiogenic gene activity. J Biol Chem (2004) 1.28
Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res (2009) 1.28
Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1. J Biol Chem (2004) 1.27
Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet (2008) 1.27
Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell (2008) 1.27
Sex ratio, poverty, and concurrent partnerships among men and women in the United States: a multilevel analysis. Ann Epidemiol (2013) 1.24
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development (2011) 1.24
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med (2012) 1.23
Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway. J Biol Chem (2006) 1.22
Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs. Proc Natl Acad Sci U S A (2006) 1.21
Prox1 maintains muscle structure and growth in the developing heart. Development (2008) 1.21
Hydroxyurea therapy for sickle cell disease in community-based practices: a survey of Florida and North Carolina hematologists/oncologists. Am J Hematol (2005) 1.21
Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts. Mol Cell Biol (2006) 1.20
BCL6 represses Smad signaling in transforming growth factor-beta resistance. Cancer Res (2008) 1.19
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt. Nat Commun (2012) 1.18
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol (2007) 1.18
Smad2 positively regulates the generation of Th17 cells. J Biol Chem (2010) 1.17
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development (2008) 1.16
Targeted expression of IGF-1 transgene to skeletal muscle accelerates muscle and motor neuron regeneration. FASEB J (2002) 1.14
Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol (2003) 1.13
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem (2005) 1.11
dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development. J Biol Chem (2003) 1.10
Critical regulation of TGFbeta signaling by Hsp90. Proc Natl Acad Sci U S A (2008) 1.10
Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology (2009) 1.10
Sumoylation and regulation of cardiac gene expression. Circ Res (2010) 1.08
c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Mol Cell (2013) 1.08
Regulation of TGF-beta signalling by protein phosphatases. Biochem J (2010) 1.08
Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor. J Biol Chem (2001) 1.08
Dissection of embryonic mouse kidney, culture in vitro, and imaging of the developing organ. Cold Spring Harb Protoc (2011) 1.07
PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling. Cell (2016) 1.07