Published in Proc Natl Acad Sci U S A on December 10, 2003
ER chaperones in mammalian development and human diseases. FEBS Lett (2007) 4.40
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity (2007) 4.17
Aminoacyl tRNA synthetases and their connections to disease. Proc Natl Acad Sci U S A (2008) 2.41
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med (2008) 2.04
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62
Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin. Blood (2008) 1.55
Heat shock proteins: linking danger and pathogen recognition. Med Microbiol Immunol (2007) 1.45
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J Immunol (2009) 1.43
CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol (2009) 1.39
Interactions of tumor cells with dendritic cells: balancing immunity and tolerance. Cell Death Differ (2007) 1.35
Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants. Cell Stress Chaperones (2010) 1.31
Effect of adenovirus-mediated heat shock protein expression and oncolysis in combination with low-dose cyclophosphamide treatment on antitumor immune responses. Cancer Res (2006) 1.23
Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ (2013) 1.11
Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells. J Immunol (2011) 1.07
ER Stress Proteins in Autoimmune and Inflammatory Diseases. Front Immunol (2012) 1.04
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. J Cell Physiol (2015) 1.04
MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells. J Virol (2005) 1.00
Identification of gp96 as a novel target for treatment of autoimmune disease in mice. PLoS One (2010) 1.00
A clear and present danger: endogenous ligands of Toll-like receptors. Neuromolecular Med (2009) 0.99
Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept. Proc Natl Acad Sci U S A (2009) 0.98
Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus. Cell Mol Immunol (2012) 0.95
The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity. Front Immunol (2013) 0.94
Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation. Arthritis Res Ther (2010) 0.94
Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases. Am J Pathol (2007) 0.93
Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. J Immunol (2010) 0.92
Molecular mechanisms of regulation of Toll-like receptor signaling. J Leukoc Biol (2016) 0.89
Role of hsp90 in systemic lupus erythematosus and its clinical relevance. Autoimmune Dis (2012) 0.88
Angiogenic transforming capacity of IgG purified from plasma of type 1 diabetic patients. J Cell Mol Med (2008) 0.87
Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. J Biol Chem (2009) 0.86
A New-Age for Biologic Therapies: Long-Term Drug-Free Therapy with BiP? Front Immunol (2012) 0.83
T cells as vehicles for cancer vaccination. J Biomed Biotechnol (2011) 0.82
Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors. J Biol Chem (2012) 0.82
Functions of heat shock proteins in pathways of the innate and adaptive immune system. J Immunol (2014) 0.82
Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity. FASEB J (2011) 0.81
The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes. PLoS Pathog (2013) 0.81
Structural insights into complexes of glucose-regulated Protein94 (Grp94) with human immunoglobulin G. relevance for Grp94-IgG complexes that form in vivo in pathological conditions. PLoS One (2014) 0.81
Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications. Front Immunol (2016) 0.80
Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease. Gut (2005) 0.80
Human α1-Antitrypsin Binds to Heat-Shock Protein gp96 and Protects from Endogenous gp96-Mediated Injury In vivo. Front Immunol (2013) 0.80
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94. Curr Top Med Chem (2016) 0.79
Role of chaperones and FcgammaR in immunogenic death. Curr Opin Immunol (2008) 0.79
The role of glycoprotein 96 in the persistent inflammation of rheumatoid arthritis. Arch Biochem Biophys (2012) 0.79
Heat shock proteins in the kidney. Pediatr Nephrol (2016) 0.78
Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota. Pathogens (2014) 0.78
Degradation of AIMP1/p43 induced by hepatitis C virus E2 leads to upregulation of TGF-β signaling and increase in surface expression of gp96. PLoS One (2014) 0.78
Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells. J Immunol (2014) 0.78
Toll-like receptors 4 and 9 are responsible for the maintenance of the inflammatory reaction in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis. J Neuroinflammation (2012) 0.77
The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics. Front Oncol (2015) 0.76
Low-variance RNAs identify Parkinson's disease molecular signature in blood. Mov Disord (2015) 0.75
Detection of novel auto-antigens in patients with recurrent miscarriage: description of an approach and preliminary findings. Croat Med J (2014) 0.75
Malaria DNA vaccine gp96NTD-CSP elicits both CSP-specific antibody and CD8(+) T cell response. Parasitol Res (2015) 0.75
The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum (1982) 67.54
Dendritic cells and the control of immunity. Nature (1998) 56.54
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Toll-like receptors. Annu Rev Immunol (2001) 26.06
Toll-like receptors and innate immunity. Nat Rev Immunol (2001) 16.50
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature (2002) 11.05
Mouse and human dendritic cell subtypes. Nat Rev Immunol (2002) 10.01
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science (2001) 8.14
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol (2000) 5.13
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol (2000) 4.48
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity (2001) 4.16
CD91: a receptor for heat shock protein gp96. Nat Immunol (2000) 3.78
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat Cell Biol (2001) 3.60
Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol (2002) 3.55
The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol (2002) 3.47
Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med (2002) 3.35
From T to B and back again: positive feedback in systemic autoimmune disease. Nat Rev Immunol (2001) 3.02
The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med (2002) 2.93
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J Biol Chem (2002) 2.39
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim Biophys Acta (2002) 2.26
Predominance of Th1 immune response in diffuse proliferative lupus nephritis. Arthritis Rheum (2001) 1.61
The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor. Eur J Immunol (2000) 1.59
Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity. J Immunol (2001) 1.31
Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med (2001) 1.17
Evidence that glycoprotein 96 (B2), a stress protein, functions as a Th2-specific costimulatory molecule. J Immunol (2002) 1.11
Immunity or tolerance? That is the question for dendritic cells. Nat Immunol (2001) 1.09
Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosus. J Autoimmun (1992) 1.08
GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. J Biol Chem (2003) 1.05
Dendritic cells in autoimmune diseases. Curr Opin Immunol (2001) 1.00
Overcoming immune tolerance to cancer by heat shock protein vaccines. Mol Cancer Ther (2002) 0.84
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity (2007) 4.17
Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med (2012) 3.52
In situ proteolysis for protein crystallization and structure determination. Nat Methods (2007) 3.05
Statins and the risk of herpes zoster: a population-based cohort study. Clin Infect Dis (2013) 2.74
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat Med (2003) 2.62
IL-10 elicits IFNγ-dependent tumor immune surveillance. Cancer Cell (2011) 2.57
Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One (2011) 2.57
Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell (2013) 2.34
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07
Evolution and metabolic significance of the urea cycle in photosynthetic diatoms. Nature (2011) 2.06
Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet (2010) 1.98
Longitudinal results of intratympanic injection of budesonide for otitis media with effusion in children over 12 years and adults. Otol Neurotol (2014) 1.96
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet (2012) 1.91
The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J (2010) 1.83
The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest (2013) 1.76
Roles of heat shock protein gp96 in the ER quality control: redundant or unique function? Mol Cells (2005) 1.64
Frequency of Takotsubo cardiomyopathy in postmenopausal women presenting with an acute coronary syndrome. Am J Cardiol (2013) 1.64
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62
Density of tobacco retailers near schools: effects on tobacco use among students. Am J Public Health (2009) 1.59
Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry. Cancer Res (2011) 1.59
Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol (2011) 1.56
Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood (2011) 1.55
Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. Hum Mol Genet (2011) 1.55
Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites. Infect Immun (2007) 1.55
Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin. Blood (2008) 1.55
Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits. Cardiovasc Res (2006) 1.53
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49
Stapled Golgi cisternae remain in place as cargo passes through the stack. Elife (2013) 1.47
Unfolded protein response in cancer: the physician's perspective. J Hematol Oncol (2011) 1.45
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44
Heart failure-induced changes of voltage-gated Ca2+ channels and cell excitability in rat cardiac postganglionic neurons. Am J Physiol Cell Physiol (2013) 1.44
17 AAG for HSP90 inhibition in cancer--from bench to bedside. Curr Mol Med (2009) 1.40
Feasibility of using a liver infected with Clonorchis sinensis for liver transplantation: fourteen cases. Liver Transpl (2010) 1.40
MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer. J Pathol (2014) 1.33
An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset. Clin Cancer Res (2009) 1.30
Functional SNP in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification. Proc Natl Acad Sci U S A (2011) 1.28
Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development. Autophagy (2011) 1.28
Aspirin use and breast cancer risk: a meta-analysis. Breast Cancer Res Treat (2011) 1.28
Sensations from initial exposure to nicotine predicting adolescent smoking in China: a potential measure of vulnerability to nicotine. Nicotine Tob Res (2003) 1.27
Proteome, phosphoproteome, and hydroxyproteome of liver mitochondria in diabetic rats at early pathogenic stages. Mol Cell Proteomics (2009) 1.27
A novel chimeric Plasmodium vivax circumsporozoite protein induces biologically functional antibodies that recognize both VK210 and VK247 sporozoites. Infect Immun (2006) 1.25
Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure. Am J Physiol Regul Integr Comp Physiol (2008) 1.25
BuildSummary: using a group-based approach to improve the sensitivity of peptide/protein identification in shotgun proteomics. J Proteome Res (2012) 1.24
CXCR6/CXCL16 functions as a regulator in metastasis and progression of cancer. Biochim Biophys Acta (2010) 1.23
The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain. J Biol Chem (2012) 1.23
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res (2006) 1.22
Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. PLoS Pathog (2011) 1.22
Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer. PLoS One (2011) 1.21
Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide. J Immunol (2012) 1.19
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A (2013) 1.19
Assessment of Mandarin-speaking pediatric cochlear implant recipients with the Mandarin Early Speech Perception (MESP) test. Int J Pediatr Otorhinolaryngol (2010) 1.18
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol (2011) 1.18
Nicotinic acid receptor agonists differentially activate downstream effectors. J Biol Chem (2007) 1.16
4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J Immunol (2004) 1.16
Ovarian cancer immunotherapy: opportunities, progresses and challenges. J Hematol Oncol (2010) 1.16
Demographic and clinical characteristics of patients with anaphylactic shock after surgery for cystic echinococcosis. Am J Trop Med Hyg (2011) 1.15
A comprehensive and non-prefractionation on the protein level approach for the human urinary proteome: touching phosphorylation in urine. Rapid Commun Mass Spectrom (2010) 1.14
Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma. J Hematol Oncol (2014) 1.13
Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood (2011) 1.12
Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. Cancer Lett (2009) 1.12
Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans. Dev Cell (2004) 1.11
UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling. Dev Biol (2003) 1.10
Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis. J Clin Invest (2013) 1.10
Peer influences and access to cigarettes as correlates of adolescent smoking: a cross-cultural comparison of Wuhan, China, and California. Prev Med (2002) 1.10
3',6'-Bis(diethyl-amino)-2-phenyl-spiro[isoindoline-1,9'-xanthen]-3-one. Acta Crystallogr Sect E Struct Rep Online (2009) 1.09
Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters. J Physiol (2009) 1.09
CpG oligodeoxynucleotide and Montanide ISA 51 adjuvant combination enhanced the protective efficacy of a subunit malaria vaccine. Infect Immun (2004) 1.09
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest (2008) 1.09
Integrated microRNA network analyses identify a poor-prognosis subtype of gastric cancer characterized by the miR-200 family. Clin Cancer Res (2013) 1.08
Project EX: A Program of Empirical Research on Adolescent Tobacco Use Cessation. Tob Induc Dis (2004) 1.08
A comparative proteomic strategy for subcellular proteome research: ICAT approach coupled with bioinformatics prediction to ascertain rat liver mitochondrial proteins and indication of mitochondrial localization for catalase. Mol Cell Proteomics (2004) 1.08
An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. Front Biosci (2002) 1.07
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol (2011) 1.06
Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. Rapid Commun Mass Spectrom (2004) 1.06
The human plasma proteome: analysis of Chinese serum using shotgun strategy. Proteomics (2005) 1.06
Dendritic peptide release mediates interpopulation crosstalk between neurosecretory and preautonomic networks. Neuron (2013) 1.06
Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts. Invest Ophthalmol Vis Sci (2008) 1.06
Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins. J Immunol (2009) 1.05
The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. J Hematol Oncol (2010) 1.05
Spermatogenesis after scrotal reconstruction. Br J Plast Surg (2003) 1.05
Promoter hypermethylation correlates with the Hsulf-1 silencing in human breast and gastric cancer. Int J Cancer (2009) 1.04
Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure. Am J Physiol Heart Circ Physiol (2010) 1.03
Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer. Stem Cells (2009) 1.03
Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clin Cancer Res (2013) 1.03
On the genesis and prognosis of variant translocations in chronic myeloid leukemia. Cancer Genet Cytogenet (2007) 1.02
Cutting edge: cross-presentation of cell-associated antigens to MHC class I molecule is regulated by a major transcription factor for heat shock proteins. J Immunol (2004) 1.02
Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res (2013) 1.02
Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor. Cancer Lett (2006) 1.02
Family characteristics and smoking among urban and rural adolescents living in China. Prev Med (2005) 1.01
Common genetic risk factors for venous thrombosis in the Chinese population. Am J Hum Genet (2013) 1.01