Published in Nature on July 11, 2010
microRNA-34c is a novel target to treat dementias. EMBO J (2011) 2.44
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov (2012) 2.44
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med (2011) 2.17
MicroRNAs in neuronal function and dysfunction. Trends Neurosci (2012) 1.94
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med (2012) 1.92
Adult-specific functions of animal microRNAs. Nat Rev Genet (2013) 1.89
Structural plasticity upon learning: regulation and functions. Nat Rev Neurosci (2012) 1.88
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell (2011) 1.86
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Calorie restriction and sirtuins revisited. Genes Dev (2013) 1.79
Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci (2013) 1.77
Context-dependent functions of specific microRNAs in neuronal development. Neural Dev (2010) 1.74
MicroRNAs shape the neuronal landscape. Neuron (2012) 1.64
Epigenetic regulation of memory formation and maintenance. Learn Mem (2013) 1.62
LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron (2015) 1.61
Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet (2012) 1.60
CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem (2010) 1.58
Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling. Neuron (2014) 1.56
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55
Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol (2012) 1.45
Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. Dis Model Mech (2013) 1.42
Sirtuins at a glance. J Cell Sci (2011) 1.41
Plasticity and specificity of the circadian epigenome. Nat Neurosci (2010) 1.41
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nat Neurosci (2013) 1.31
Epigenetic mechanisms in learned fear: implications for PTSD. Neuropsychopharmacology (2012) 1.30
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci (2013) 1.30
'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol (2012) 1.28
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol (2011) 1.27
Histone H2A.Z subunit exchange controls consolidation of recent and remote memory. Nature (2014) 1.24
MicroRNA networks direct neuronal development and plasticity. Cell Mol Life Sci (2011) 1.23
The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders. Front Psychiatry (2012) 1.22
SIRT1 in neurodevelopment and brain senescence. Neuron (2014) 1.22
MicroRNA Regulation of SIRT1. Front Physiol (2012) 1.21
Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction. Cell Death Dis (2012) 1.19
Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol (2014) 1.18
G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation. J Neurosci (2012) 1.18
The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. J Neurotrauma (2011) 1.17
Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS Lett (2011) 1.17
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16
Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex. Neural Dev (2011) 1.16
Sirtuins and disease: the road ahead. Front Pharmacol (2012) 1.15
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology. J Cell Biol (2011) 1.14
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nat Neurosci (2011) 1.13
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci (2013) 1.12
MicroRNA-182 regulates amygdala-dependent memory formation. J Neurosci (2013) 1.11
MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev (2013) 1.11
The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes Obes Metab (2013) 1.10
The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci (2012) 1.08
Targeting HDACs: a promising therapy for Alzheimer's disease. Oxid Med Cell Longev (2011) 1.08
The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies. Front Genet (2013) 1.08
MicroRNA regulation of the synaptic plasticity-related gene Arc. PLoS One (2012) 1.07
Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology. PLoS One (2014) 1.07
The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134. Genes Dev (2013) 1.06
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A (2011) 1.05
Epigenetic treatments for cognitive impairments. Neuropsychopharmacology (2011) 1.05
Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. J Neurosci (2011) 1.05
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nat Cell Biol (2013) 1.03
miRNA-132: a dynamic regulator of cognitive capacity. Brain Struct Funct (2012) 1.02
MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease. PLoS One (2015) 1.02
MicroRNAs tune cerebral cortical neurogenesis. Cell Death Differ (2012) 0.99
Epigenetic memory: the Lamarckian brain. EMBO J (2014) 0.99
Consolidation and translation regulation. Learn Mem (2012) 0.99
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat Neurosci (2012) 0.99
Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes. Oxid Med Cell Longev (2012) 0.98
The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders. Front Genet (2012) 0.98
Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annu Rev Physiol (2012) 0.98
Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell (2013) 0.97
A time to remember: the role of circadian clocks in learning and memory. Behav Neurosci (2014) 0.97
Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiol Learn Mem (2012) 0.97
Transcriptome analysis of microRNAs in developing cerebral cortex of rat. BMC Genomics (2012) 0.96
Widespread regulation of miRNA biogenesis at the Dicer step by the cold-inducible RNA-binding protein, RBM3. PLoS One (2011) 0.96
Epigenetic mechanisms in memory and synaptic function. Epigenomics (2011) 0.96
Non-coding RNA networks underlying cognitive disorders across the lifespan. Trends Mol Med (2011) 0.96
NMDA mediated contextual conditioning changes miRNA expression. PLoS One (2011) 0.96
Up-regulation of microRNA-142 in simian immunodeficiency virus encephalitis leads to repression of sirtuin1. FASEB J (2013) 0.96
Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Mol Cancer (2014) 0.96
Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. J Neurosci (2013) 0.95
Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. Cell Death Differ (2014) 0.95
The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p. Cell Mol Neurobiol (2013) 0.95
MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Mol Psychiatry (2014) 0.95
Sirt1: def-eating senescence? Cell Cycle (2012) 0.94
The regulation of transcription in memory consolidation. Cold Spring Harb Perspect Biol (2014) 0.94
Evidence demonstrating role of microRNAs in the etiopathology of major depression. J Chem Neuroanat (2011) 0.94
SIRT1 in the brain-connections with aging-associated disorders and lifespan. Front Cell Neurosci (2015) 0.93
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders. Curr Pharm Des (2013) 0.93
Aging and brain rejuvenation as systemic events. J Neurochem (2014) 0.93
MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review. Front Mol Neurosci (2013) 0.93
miR-153 regulates SNAP-25, synaptic transmission, and neuronal development. PLoS One (2013) 0.92
Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders. Pharmacol Ther (2014) 0.92
SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression. Epigenetics (2012) 0.92
The epigenetic landscape of alcoholism. Int Rev Neurobiol (2014) 0.91
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci (2014) 0.91
CREB and leukemogenesis. Crit Rev Oncog (2011) 0.91
New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs. Front Neurosci (2012) 0.91
Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med (2011) 0.91
Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis. J Trauma Acute Care Surg (2014) 0.91
MicroRNAs in addiction: adaptation's middlemen? Mol Psychiatry (2011) 0.91
SIRT1 regulates dendritic development in hippocampal neurons. PLoS One (2012) 0.90
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
A brain-specific microRNA regulates dendritic spine development. Nature (2006) 10.18
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science (1995) 5.19
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci (2008) 5.12
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci U S A (2004) 3.82
Everything you have ever wanted to know about Yin Yang 1...... Biochim Biophys Acta (1997) 3.48
Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron (1993) 3.44
A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron (2008) 3.40
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron (2009) 2.97
Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem (2007) 2.27
The amygdala, fear, and memory. Ann N Y Acad Sci (2003) 2.05
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev (2009) 1.97
CREB: a mediator of long-term memory from mollusks to mammals. Cell (1994) 1.96
MicroRNA function in neuronal development, plasticity and disease. Biochim Biophys Acta (2008) 1.84
Comparative evaluation of synaptophysin-based methods for quantification of synapses. J Neurocytol (1996) 1.80
MicroRNAs in neurodegeneration. Curr Opin Neurobiol (2008) 1.62
BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol Cell Neurosci (2007) 1.39
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature (2011) 8.03
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Recovery of learning and memory is associated with chromatin remodelling. Nature (2007) 6.72
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
Trekking across the brain: the journey of neuronal migration. Cell (2007) 3.90
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry (2010) 3.55
Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. Stem Cells (2010) 3.48
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron (2004) 3.33
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron (2003) 2.97
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron (2008) 2.88
Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron (2005) 2.68
An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature (2012) 2.67
G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell (2005) 2.64
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61
Constructive episodic simulation of the future and the past: distinct subsystems of a core brain network mediate imagining and remembering. Neuropsychologia (2008) 2.61
Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57
Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Neuron (2007) 2.53
Life is a journey: a genetic look at neocortical development. Nat Rev Genet (2002) 2.46
Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron (2011) 2.42
Math5 determines the competence state of retinal ganglion cell progenitors. Dev Biol (2003) 2.36
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet (2003) 2.27
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell (2011) 2.24
Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest (2011) 2.23
APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol (2003) 2.21
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron (2010) 2.08
Cyclin-dependent kinases in brain development and disease. Annu Rev Cell Dev Biol (2011) 2.08
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol (2004) 2.06
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell (2011) 1.95
Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci (2010) 1.94
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol (2010) 1.82
Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. J Neurosci (2004) 1.81
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci (2006) 1.80
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat Neurosci (2012) 1.79
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell Stem Cell (2013) 1.77
Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci (2013) 1.77
Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med (2004) 1.76
Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression. Neuron (2006) 1.74
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron (2011) 1.67
Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol Rev (2011) 1.66
Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron (2010) 1.60
A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin Neurobiol (2004) 1.60
Par-4 links dopamine signaling and depression. Cell (2005) 1.58
Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. Neuron (2003) 1.57
White matter plasticity and enhanced remyelination in the maternal CNS. J Neurosci (2007) 1.54
The potential of HDAC inhibitors as cognitive enhancers. Annu Rev Pharmacol Toxicol (2013) 1.52
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron (2004) 1.51
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A (2010) 1.49
Expression levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion kinase in patients with multiple myeloma and their relationship to clinical stage and extramedullary infiltration. Leuk Lymphoma (2012) 1.45
Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. J Comp Neurol (2004) 1.45
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Mol Biol Cell (2005) 1.45
Protein phosphatase 1 regulates the histone code for long-term memory. J Neurosci (2009) 1.44
Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance. Trends Pharmacol Sci (2006) 1.40
Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron (2004) 1.40
Episodic simulation of past and future events in older adults: Evidence from an experimental recombination task. Psychol Aging (2010) 1.39
A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat Neurosci (2007) 1.35
Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci (2008) 1.31
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nat Neurosci (2013) 1.31
Cdk5: one of the links between senile plaques and neurofibrillary tangles? J Alzheimers Dis (2003) 1.30
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron (2007) 1.30
The role of Cdk5 in neuroendocrine thyroid cancer. Cancer Cell (2013) 1.30
The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci (2002) 1.30
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci (2013) 1.30
Centrosome motility is essential for initial axon formation in the neocortex. J Neurosci (2010) 1.29
Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron (2010) 1.26
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest (2014) 1.23
A method for noninvasive detection of fetal large deletions/duplications by low coverage massively parallel sequencing. Prenat Diagn (2013) 1.22
An annotated cDNA library and microarray for large-scale gene-expression studies in the ant Solenopsis invicta. Genome Biol (2007) 1.22
BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem (2003) 1.19
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology (2012) 1.18
Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. J Neurosci (2007) 1.17
Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci (2007) 1.16
Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron (2009) 1.16
Bridging physiology and pathology in AD. Cell (2009) 1.13
Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration. Cereb Cortex (2006) 1.13
Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration. Nat Neurosci (2003) 1.13
Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. J Neurochem (2004) 1.12
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci (2013) 1.12
Mechanism of CDK5/p25 binding by CDK inhibitors. J Med Chem (2005) 1.11