Published in J Biol Chem on January 23, 2004
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest (2013) 2.48
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hear Res (2006) 1.71
TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res (2010) 1.65
Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med (2009) 1.61
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem (2008) 1.43
Myofibroblasts: trust your heart and let fate decide. J Mol Cell Cardiol (2013) 1.25
Calcineurin A-alpha but not A-beta is required for normal kidney development and function. Am J Pathol (2004) 1.24
Preservation and expansion of the primate keratocyte phenotype by downregulating TGF-beta signaling in a low-calcium, serum-free medium. Invest Ophthalmol Vis Sci (2006) 1.04
Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. J Biol Chem (2010) 1.00
Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. Mol Endocrinol (2011) 1.00
IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells. Am J Physiol Cell Physiol (2011) 0.97
NFATc is required for TGFbeta-mediated transcriptional regulation of fibronectin. Biochem Biophys Res Commun (2007) 0.93
NFAT as cancer target: mission possible? Biochim Biophys Acta (2014) 0.91
Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. J Cell Mol Med (2011) 0.90
Tiotropium bromide inhibits TGF-β-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro. Int J Chron Obstruct Pulmon Dis (2010) 0.89
Calreticulin regulates transforming growth factor-β-stimulated extracellular matrix production. J Biol Chem (2013) 0.88
Therapeutic targets for treating fibrotic kidney diseases. Transl Res (2014) 0.88
Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway. Cell Cycle (2012) 0.84
A fluorimetric method for determination of calcineurin activity. Cell Calcium (2007) 0.83
FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus. Anat Cell Biol (2014) 0.83
Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose. J Biol Chem (2013) 0.81
Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 gene. Comp Hepatol (2007) 0.80
Cardiac valve cells and their microenvironment--insights from in vitro studies. Nat Rev Cardiol (2014) 0.79
Regulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice. Korean J Physiol Pharmacol (2011) 0.76
Prevention of TGF-β-induced early liver fibrosis by a maleic acid derivative anti-oxidant through suppression of ROS, inflammation and hepatic stellate cells activation. PLoS One (2017) 0.75
FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression. Int J Clin Exp Pathol (2015) 0.75
Calreticulin Is Required for TGF-β-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells. Stem Cell Reports (2017) 0.75
Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent. J Cell Mol Med (2014) 0.75
MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet (2008) 9.50
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem (2005) 2.98
Subcellular localization of Nox4 and regulation in diabetes. Proc Natl Acad Sci U S A (2009) 2.73
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis. Am J Kidney Dis (2008) 2.02
Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol (2003) 1.91
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. Diabetes (2009) 1.87
NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. J Am Soc Nephrol (2009) 1.80
Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes (2007) 1.79
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J Biol Chem (2010) 1.60
Aiding and abetting roles of NOX oxidases in cellular transformation. Nat Rev Cancer (2012) 1.57
Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation. Am J Physiol Renal Physiol (2002) 1.45
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem (2008) 1.43
NAD(P)H oxidases regulate HIF-2alpha protein expression. J Biol Chem (2007) 1.37
Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem J (2004) 1.31
Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int (2005) 1.31
Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci (2008) 1.29
Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells. Cell Signal (2004) 1.28
Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation. Biochem J (2011) 1.25
Genome scan for determinants of serum uric acid variability. J Am Soc Nephrol (2007) 1.25
Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes (2007) 1.25
Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Diabetes (2008) 1.24
Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy. Am J Kidney Dis (2011) 1.19
Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species. J Biol Chem (2013) 1.15
ZO-1 expression and phosphorylation in diabetic nephropathy. Diabetes (2006) 1.14
Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans. J Clin Endocrinol Metab (2008) 1.13
Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. J Biol Chem (2011) 1.12
Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans. Diabetes (2007) 1.11
microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion. PLoS One (2012) 1.11
Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes (2013) 1.08
A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS. Nephrol Dial Transplant (2008) 1.08
The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes. J Am Soc Nephrol (2011) 1.07
Ethical issues associated with conducting genetic family studies of complex disease. Ann Epidemiol (2005) 1.06
Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. Am J Physiol Cell Physiol (2011) 1.04
Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol (2007) 1.03
Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression. Mol Cell Biol (2013) 1.03
P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans. Diabetes (2007) 1.01
Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. PLoS One (2012) 1.01
Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species. Am J Physiol Renal Physiol (2005) 1.01
Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB. Antioxid Redox Signal (2006) 1.00
Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes. Am J Physiol Cell Physiol (2011) 1.00
Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy. Kidney Int Suppl (2002) 1.00
Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors. Mol Cancer (2008) 1.00
Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. Am J Physiol Renal Physiol (2005) 1.00
Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts. Free Radic Biol Med (2010) 0.99
Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. J Biol Chem (2011) 0.99
Morphological insights into the origin of glomerular endothelial and mesangial cells and their precursors. J Histochem Cytochem (2003) 0.98
Differential expression of calcineurin A isoforms in the diabetic kidney. J Am Soc Nephrol (2004) 0.97
IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells. Am J Physiol Cell Physiol (2011) 0.97
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin. Am J Pathol (2010) 0.95
ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice. Am J Physiol Renal Physiol (2013) 0.95
Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells. Carcinogenesis (2010) 0.93
Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans. Diab Vasc Dis Res (2008) 0.93
NFκB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation. Cell Signal (2013) 0.92
TSC2 deficiency increases PTEN via HIF1alpha. J Biol Chem (2009) 0.92
The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. Am J Physiol Renal Physiol (2013) 0.91
Examination of association with candidate genes for diabetic nephropathy in a Mexican American population. Clin J Am Soc Nephrol (2010) 0.91
Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J (2008) 0.91
Expression of apoptosis-related genes in chronic cyclosporine nephrotoxicity in mice. Am J Transplant (2002) 0.90
Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J Am Soc Nephrol (2007) 0.90
The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling. Diabetes (2012) 0.89
Regulation of STIM1, store-operated Ca2+ influx, and nitric oxide generation by retinoic acid in rat mesangial cells. Am J Physiol Renal Physiol (2006) 0.89
The Ser(326)Cys polymorphism of 8-oxoguanine glycosylase 1 (OGG1) is associated with type 2 diabetes in Mexican Americans. Hum Hered (2010) 0.88
Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes. PLoS One (2012) 0.88
Impaired mitochondrial complex III and melatonin responsive reactive oxygen species generation in kidney mitochondria of db/db mice. J Pineal Res (2011) 0.87
Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy. J Biol Chem (2013) 0.87
Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line. Am J Physiol Cell Physiol (2008) 0.86
Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans. Hum Genet (2008) 0.86
Veterans' experience in using the online Surgeon General's family health history tool. Per Med (2011) 0.86
Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. Diabetes Metab Res Rev (2009) 0.86
Nephrogenic systemic fibrosis: evidence for oxidative stress and bone marrow-derived fibrocytes in skin, liver, and heart lesions using a 5/6 nephrectomy rodent model. Am J Pathol (2012) 0.86
Diabetic nephropathy among Mexican Americans. Clin Nephrol (2012) 0.86
PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells. Cell Signal (2003) 0.85
Relation of low glomerular filtration rate to metabolic disorders in individuals without diabetes and with normoalbuminuria. Clin J Am Soc Nephrol (2008) 0.85
The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans. Mol Cell Biochem (2009) 0.85
Heat shock protein 90beta1 is essential for polyunsaturated fatty acid-induced mitochondrial Ca2+ efflux. J Biol Chem (2008) 0.85
Regulation of protein synthesis by IGF-I in proximal tubular epithelial cells. Am J Physiol Renal Physiol (2002) 0.85
Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation. Kidney Int (2004) 0.84
beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP. Am J Physiol Cell Physiol (2005) 0.84
PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression. Cell Signal (2005) 0.84