Published in J Am Soc Nephrol on November 19, 2009
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma (ECMA) | NCT03388359
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res (2012) 3.02
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol (2012) 2.03
TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities. Cell Signal (2012) 1.82
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology (2012) 1.49
Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther (2011) 1.48
Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol (2014) 1.47
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci (2012) 1.44
Molecular and cellular mechanisms of pulmonary fibrosis. Fibrogenesis Tissue Repair (2012) 1.37
Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem (2010) 1.36
Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells. Free Radic Biol Med (2012) 1.31
Role of triglyceride-rich lipoproteins in diabetic nephropathy. Nat Rev Nephrol (2010) 1.22
NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PLoS One (2012) 1.17
Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy. J Am Soc Nephrol (2014) 1.14
Oxidative stress in obstructive nephropathy. Int J Exp Pathol (2010) 1.10
NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury. J Am Soc Nephrol (2012) 1.10
Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal (2014) 1.10
Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells. PLoS One (2011) 1.07
NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses. Redox Biol (2014) 1.04
TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves. Cardiovasc Res (2013) 1.04
RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species. Am J Physiol Renal Physiol (2014) 1.02
Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes. Am J Physiol Cell Physiol (2011) 1.00
Functional implications of microRNA-215 in TGF-β1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1. PLoS One (2013) 0.99
Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med (2013) 0.98
Myofibroblasts. Curr Opin Rheumatol (2013) 0.98
IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells. Am J Physiol Cell Physiol (2011) 0.97
Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells. Cell Commun Signal (2012) 0.95
Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension. Am J Physiol Renal Physiol (2014) 0.95
ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice. Am J Physiol Renal Physiol (2013) 0.95
Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass. Am J Physiol Renal Physiol (2012) 0.93
TRPV1 potentiates TGFβ-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop. PLoS One (2013) 0.93
TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway. Am J Physiol Renal Physiol (2013) 0.92
The balance of powers: Redox regulation of fibrogenic pathways in kidney injury. Redox Biol (2015) 0.91
Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis. BMC Nephrol (2013) 0.91
Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD. J Am Soc Nephrol (2013) 0.90
Nox2 is required for macrophage chemotaxis towards CSF-1. PLoS One (2013) 0.89
Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer (2014) 0.88
Therapeutic targets for treating fibrotic kidney diseases. Transl Res (2014) 0.88
Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling. PLoS One (2013) 0.87
The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol (2016) 0.86
Neutrophils: game changers in glomerulonephritis? Trends Mol Med (2010) 0.86
Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease. Oxid Med Cell Longev (2012) 0.85
Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease. Mol Cells (2015) 0.85
Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease. Biomed Res Int (2014) 0.84
Inhibiting TGFβ1 has a protective effect on mouse bone marrow suppression following ionizing radiation exposure in vitro. J Radiat Res (2013) 0.84
Role of NADPH oxidases in the redox biology of liver fibrosis. Redox Biol (2015) 0.84
Diabetes and Kidney Disease: Role of Oxidative Stress. Antioxid Redox Signal (2016) 0.83
Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis. Redox Biol (2015) 0.83
NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ. Curr Eye Res (2011) 0.82
Redox-relevant aspects of the extracellular matrix and its cellular contacts via integrins. Antioxid Redox Signal (2014) 0.81
Remnant nephron physiology and the progression of chronic kidney disease. Pediatr Nephrol (2013) 0.80
Nox2 and Nox4 influence neonatal c-kit(+) cardiac precursor cell status and differentiation. Am J Physiol Heart Circ Physiol (2013) 0.80
Oxidative Stress and Skin Fibrosis. Curr Pathobiol Rep (2014) 0.80
Inhibitory role of the KEAP1-NRF2 pathway in TGFβ1-stimulated renal epithelial transition to fibroblastic cells: a modulatory effect on SMAD signaling. PLoS One (2014) 0.80
The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. J Biol Chem (2016) 0.80
GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway. Cell Death Dis (2016) 0.80
The AMPK agonist AICAR inhibits TGF-β1 induced activation of kidney myofibroblasts. PLoS One (2014) 0.80
Influence of glycosaminoglycan identity on vocal fold fibroblast behavior. Acta Biomater (2011) 0.80
Inhibition of breast cancer invasion by TIS21(/BTG2/Pc3)-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes. Oncogene (2015) 0.79
Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. J Am Soc Nephrol (2015) 0.79
Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle. Nutr Rev (2016) 0.78
Lung extracellular matrix and redox regulation. Redox Biol (2016) 0.78
Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. J Biol Chem (2015) 0.78
Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis. Am J Pathol (2016) 0.77
The fate of the primary cilium during myofibroblast transition. Mol Biol Cell (2014) 0.77
The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int (2017) 0.77
Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE. J Biol Chem (2015) 0.77
Redox-sensitive MAPK and Notch3 regulate fibroblast differentiation and activation: a dual role of ERK1/2. Oncotarget (2016) 0.77
Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. PLoS One (2014) 0.77
Centrality of bone marrow in the severity of gadolinium-based contrast-induced systemic fibrosis. FASEB J (2016) 0.76
Grape seed extract attenuates arsenic-induced nephrotoxicity in rats. Exp Ther Med (2013) 0.76
Triptolide mitigates radiation-induced pulmonary fibrosis via inhibition of axis of alveolar macrophages-NOXes-ROS-myofibroblasts. Cancer Biol Ther (2016) 0.76
Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles. Redox Biol (2016) 0.76
Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update. Oxid Med Cell Longev (2016) 0.75
Myofibroblast secretome and its auto-/paracrine signaling. Expert Rev Cardiovasc Ther (2016) 0.75
Loss of IκB kinase β promotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop. Protein Cell (2016) 0.75
Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury. J Diabetes Res (2017) 0.75
Hierarchy of molecules in TGF-β1 signaling relevant to myofibroblast activation and renal fibrosis. Am J Physiol Renal Physiol (2014) 0.75
The metabolic syndrome and chronic kidney disease. Transl Res (2016) 0.75
NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury. Sci Rep (2016) 0.75
NADPH Oxidase 4 at the Nexus of Diabetes, Reactive Oxygen Species, and Renal Metabolism. J Am Soc Nephrol (2015) 0.75
Role of redoximiRs in fibrogenesis. Redox Biol (2015) 0.75
SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway. Am J Transl Res (2017) 0.75
TGF-β1 regulates the expression and transcriptional activity of TAZ via a Smad3-independent, myocardin-related transcription factor-mediated mechanism. J Biol Chem (2017) 0.75
Decoding NADPH oxidase 4 expression in human tumors. Redox Biol (2017) 0.75
Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol (2002) 14.80
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol (1993) 8.36
Signal transduction by the TGF-beta superfamily. Science (2002) 5.61
The logic of TGFbeta signaling. FEBS Lett (2006) 5.26
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol (2008) 5.06
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res (2005) 4.66
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2003) 4.56
Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res (1999) 3.78
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65
The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol (1998) 3.65
Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med (2007) 3.44
Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators. Circ Res (2002) 3.32
Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci U S A (1993) 3.16
Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest (1990) 3.15
Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension (2003) 3.15
Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2006) 3.13
Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol (2002) 3.10
Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem (2001) 3.07
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem (2005) 2.98
Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2005) 2.62
Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J Clin Invest (1990) 2.56
Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest (2003) 2.27
Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept (2000) 2.11
Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am J Pathol (1996) 1.92
Reactive oxygen species-regulated signaling pathways in diabetic nephropathy. J Am Soc Nephrol (2003) 1.92
Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol (2003) 1.91
Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. Kidney Int (2005) 1.83
Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II. Proc Natl Acad Sci U S A (1997) 1.80
Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis. Am J Pathol (2005) 1.64
Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy. Biochem Biophys Res Commun (2003) 1.55
Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am J Pathol (1991) 1.55
Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment. Diabetologia (2003) 1.53
Novel NAD(P)H oxidases in the cardiovascular system. Heart (2004) 1.44
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem (2008) 1.43
It's a Smad world: regulation of TGF-beta signaling in the kidney. J Am Soc Nephrol (2002) 1.39
Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochem Biophys Res Commun (2002) 1.35
Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes (2003) 1.35
Functional association of nox1 with p22phox in vascular smooth muscle cells. Free Radic Biol Med (2004) 1.34
Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway. J Biol Chem (2000) 1.32
Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem J (2004) 1.31
The reactive adventitia: fibroblast oxidase in vascular function. Arterioscler Thromb Vasc Biol (2002) 1.31
Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1. Cardiovasc Res (2006) 1.30
Redox control of vascular smooth muscle proliferation. J Lab Clin Med (1998) 1.29
NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology (2005) 1.29
Transforming growth factor-beta regulates the splicing pattern of fibronectin messenger RNA precursor. FEBS Lett (1990) 1.28
Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration. Hypertension (2008) 1.26
Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. Kidney Int (2007) 1.25
NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation. Biochem Biophys Res Commun (2005) 1.14
H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts. FEBS Lett (2005) 1.13
Nox regulation of smooth muscle contraction. Free Radic Biol Med (2007) 1.09
Angiotensin II, TGF-beta and renal fibrosis. Contrib Nephrol (2001) 1.06
Adventitial delivery of dominant-negative p67phox attenuates neointimal hyperplasia of the rat carotid artery. Am J Physiol Heart Circ Physiol (2006) 1.03
Sequential expression of cellular fibronectin by platelets, macrophages, and mesangial cells in proliferative glomerulonephritis. Am J Pathol (1994) 1.02
Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF-beta1 induction of p21WAF1/Cip1. Cell Signal (2005) 1.01
NADPH oxidases: new regulators of old functions. Antioxid Redox Signal (2006) 1.01
ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts. J Cell Physiol (2004) 0.99
Involvement of reactive oxygen species in the activation of tyrosine kinase and extracellular signal-regulated kinase by angiotensin II. Endocrinology (2000) 0.96
Activation of Erk1/2 and Akt following unilateral ureteral obstruction. Kidney Int (2008) 0.96
NADPH oxidase in human lung fibroblasts. J Biomed Sci (2004) 0.90
ERK and p38 MAP kinase are involved in arachidonic acid release induced by H(2)O(2) and PDGF in mesangial cells. Am J Physiol Renal Physiol (2002) 0.87
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. Am J Physiol Renal Physiol (2003) 0.87
Expression of alternatively spliced fibronectin variants during remodeling in proliferative glomerulonephritis. Am J Pathol (1995) 0.86
Expression of embryonic fibronectin isoform EIIIA parallels alpha-smooth muscle actin in maturing and diseased kidney. J Histochem Cytochem (1999) 0.86
Glomerular oxidative and antioxidative systems in experimental mesangioproliferative glomerulonephritis. J Am Soc Nephrol (2002) 0.83
Renal fibrosis. Methods Mol Med (2005) 0.79
Oxidant stress and regulation of chemokines in the development of renal interstitial fibrosis. Contrib Nephrol (2003) 0.78
MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet (2008) 9.50
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem (2005) 2.98
Subcellular localization of Nox4 and regulation in diabetes. Proc Natl Acad Sci U S A (2009) 2.73
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol (2009) 2.27
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis. Am J Kidney Dis (2008) 2.02
Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol (2003) 1.91
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. Diabetes (2009) 1.87
IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation. Am J Physiol Heart Circ Physiol (2007) 1.82
Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes (2007) 1.79
Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis. Am J Pathol (2005) 1.64
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J Biol Chem (2010) 1.60
Aiding and abetting roles of NOX oxidases in cellular transformation. Nat Rev Cancer (2012) 1.57
Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation. Am J Physiol Renal Physiol (2002) 1.45
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem (2008) 1.43
Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by rapamycin. Am J Pathol (2007) 1.41
NAD(P)H oxidases regulate HIF-2alpha protein expression. J Biol Chem (2007) 1.37
Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation. J Biol Chem (2004) 1.32
Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem J (2004) 1.31
Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int (2005) 1.31
Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci (2008) 1.29
Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells. Cell Signal (2004) 1.28
Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia. Am J Pathol (2009) 1.27
Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation. Biochem J (2011) 1.25
Genome scan for determinants of serum uric acid variability. J Am Soc Nephrol (2007) 1.25
Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes (2007) 1.25
Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Diabetes (2008) 1.24
Calcineurin A-alpha but not A-beta is required for normal kidney development and function. Am J Pathol (2004) 1.24
Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice. J Immunol (2010) 1.22
Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy. Am J Kidney Dis (2011) 1.19
Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species. J Biol Chem (2013) 1.15
ZO-1 expression and phosphorylation in diabetic nephropathy. Diabetes (2006) 1.14
Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans. J Clin Endocrinol Metab (2008) 1.13
Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. J Biol Chem (2011) 1.12
Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans. Diabetes (2007) 1.11
microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion. PLoS One (2012) 1.11
Beyond Bushfires: Community, Resilience and Recovery - a longitudinal mixed method study of the medium to long term impacts of bushfires on mental health and social connectedness. BMC Public Health (2013) 1.08
Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes (2013) 1.08
A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS. Nephrol Dial Transplant (2008) 1.08
The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes. J Am Soc Nephrol (2011) 1.07
Ethical issues associated with conducting genetic family studies of complex disease. Ann Epidemiol (2005) 1.06
Nox as a target for diabetic complications. Clin Sci (Lond) (2013) 1.05
Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus. J Cell Sci (2006) 1.04
Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. Am J Physiol Cell Physiol (2011) 1.04
Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol (2007) 1.03
Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression. Mol Cell Biol (2013) 1.03
P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans. Diabetes (2007) 1.01
Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. PLoS One (2012) 1.01
Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species. Am J Physiol Renal Physiol (2005) 1.01
Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy. Kidney Int Suppl (2002) 1.00
Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB. Antioxid Redox Signal (2006) 1.00
Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors. Mol Cancer (2008) 1.00
Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes. Am J Physiol Cell Physiol (2011) 1.00
Accessing maternal and child health services in Melbourne, Australia: reflections from refugee families and service providers. BMC Health Serv Res (2012) 1.00
Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. Am J Physiol Renal Physiol (2005) 1.00
Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. J Biol Chem (2011) 0.99
Morphological insights into the origin of glomerular endothelial and mesangial cells and their precursors. J Histochem Cytochem (2003) 0.98
Translational regulation of vascular endothelial growth factor expression in renal epithelial cells by angiotensin II. Am J Physiol Renal Physiol (2004) 0.97
Differential expression of calcineurin A isoforms in the diabetic kidney. J Am Soc Nephrol (2004) 0.97
Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion. PLoS One (2011) 0.97
IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells. Am J Physiol Cell Physiol (2011) 0.97
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin. Am J Pathol (2010) 0.95
PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy. J Cell Physiol (2010) 0.95