Published in J Biol Chem on February 02, 2004
Model for the peptide-free conformation of class II MHC proteins. PLoS One (2008) 1.17
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Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Immunol Rev (2012) 1.00
Peptide-conjugation induced conformational changes in human IgG1 observed by optimized negative-staining and individual-particle electron tomography. Sci Rep (2013) 0.99
HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis. J Immunol (2014) 0.91
DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms. Immunology (2010) 0.91
Characterization of structural features controlling the receptiveness of empty class II MHC molecules. PLoS One (2011) 0.90
Functional analysis of monocyte MHC class II compartments. FASEB J (2008) 0.87
Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide. J Biol Chem (2014) 0.84
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Structural basis of metal hypersensitivity. Immunol Res (2013) 0.81
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Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules. Immunology (2010) 0.77
Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange. Curr Top Biochem Res (2011) 0.76
Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation. Front Immunol (2017) 0.75
Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proc Natl Acad Sci U S A (2016) 0.75
A triad of molecular regions contribute to the formation of two distinct MHC class II conformers. Mol Immunol (2016) 0.75
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Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Microautophagy of cytosolic proteins by late endosomes. Dev Cell (2011) 3.51
Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med (2003) 3.46
MHC class II proteins and disease: a structural perspective. Nat Rev Immunol (2006) 2.66
The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc Natl Acad Sci U S A (2003) 2.56
Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci U S A (2002) 2.32
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. J Am Chem Soc (2010) 2.30
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells. Nat Chem Biol (2007) 2.04
A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands. Immunity (2011) 2.00
IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells. J Immunol (2004) 1.99
Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. J Immunol (2005) 1.98
TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells. Proc Natl Acad Sci U S A (2007) 1.91
Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest (2002) 1.83
Human decidual NK cells form immature activating synapses and are not cytotoxic. Proc Natl Acad Sci U S A (2005) 1.82
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol (2008) 1.79
Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells. Nat Immunol (2005) 1.76
CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol (2003) 1.76
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med (2002) 1.74
Viral evasion of natural killer cells. Nat Immunol (2002) 1.74
Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med (2009) 1.73
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry (2006) 1.68
NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand. Proc Natl Acad Sci U S A (2005) 1.67
CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res (2008) 1.64
Towards patient-based cancer therapeutics. Nat Biotechnol (2010) 1.63
CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells. Proc Natl Acad Sci U S A (2006) 1.59
Myosin IIA is required for cytolytic granule exocytosis in human NK cells. J Exp Med (2007) 1.59
Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity. Proc Natl Acad Sci U S A (2007) 1.58
Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J Immunol (2003) 1.54
Methamphetamine inhibits antigen processing, presentation, and phagocytosis. PLoS Pathog (2008) 1.53
Noble metals strip peptides from class II MHC proteins. Nat Chem Biol (2006) 1.53
Disulfide bond-mediated dimerization of HLA-G on the cell surface. Proc Natl Acad Sci U S A (2002) 1.52
Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling. J Cell Biol (2006) 1.47
Class II major histocompatibility complex tetramer staining: progress, problems, and prospects. Immunology (2008) 1.47
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. Mol Cell Biol (2003) 1.44
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol (2011) 1.42
HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. Proc Natl Acad Sci U S A (2009) 1.41
Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2005) 1.34
Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infect Immun (2009) 1.34
The lipid kinase PI4KIIIβ preserves lysosomal identity. EMBO J (2012) 1.32
CD1d and invariant NKT cells at the human maternal-fetal interface. Proc Natl Acad Sci U S A (2002) 1.30
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A (2004) 1.29
Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clin Cancer Res (2005) 1.27
The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia. Blood (2003) 1.27
The killer's kiss: the many functions of NK cell immunological synapses. Curr Opin Cell Biol (2008) 1.26
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat Struct Mol Biol (2012) 1.25
Oxidative stress, inflamm-aging and immunosenescence. J Proteomics (2011) 1.24
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood (2007) 1.24
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc Natl Acad Sci U S A (2011) 1.23
Mediators of the inflammatory response to joint replacement devices. Nat Rev Rheumatol (2011) 1.23
HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimulatory microarrays. Proc Natl Acad Sci U S A (2005) 1.21
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells. Cell Signal (2007) 1.21
Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Blood (2007) 1.20
Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection. PLoS Pathog (2007) 1.20
The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. J Immunol (2007) 1.18
Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunity. Immunobiology (2004) 1.18
Two unique human decidual macrophage populations. J Immunol (2011) 1.17
JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity. Proc Natl Acad Sci U S A (2008) 1.17
Model for the peptide-free conformation of class II MHC proteins. PLoS One (2008) 1.17
Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J Biol Chem (2002) 1.17
Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol (2002) 1.17
Methamphetamine enhances histoplasmosis by immunosuppression of the host. J Infect Dis (2009) 1.16
MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A (2004) 1.16
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain. J Immunol (2004) 1.15
Nomenclature for Factors of the HLA System, 2004. Hum Immunol (2005) 1.14
Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping. Biochemistry (2005) 1.13
LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids. J Biol Chem (2002) 1.13
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med (2003) 1.13
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. ACS Med Chem Lett (2011) 1.12
Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. J Biol Chem (2006) 1.11
Labeling antigen-specific CD4(+) T cells with class II MHC oligomers. J Immunol Methods (2002) 1.11
Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules. Hum Immunol (2003) 1.10
MHC class II compartment subtypes: structure and function. Curr Opin Immunol (2005) 1.10
NK cell activity during human cytomegalovirus infection is dominated by US2-11-mediated HLA class I down-regulation. J Immunol (2002) 1.10
Human CD4+ T cell response to human herpesvirus 6. J Virol (2012) 1.10
Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett (2011) 1.10
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. Proc Natl Acad Sci U S A (2004) 1.09
WIP is essential for lytic granule polarization and NK cell cytotoxicity. Proc Natl Acad Sci U S A (2008) 1.09
Cutting edge: TCR engagement and triggering in the absence of large-scale molecular segregation at the T cell-APC contact site. J Immunol (2002) 1.09
Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am J Pathol (2008) 1.08
Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity. Proc Natl Acad Sci U S A (2002) 1.08
Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis. Mol Immunol (2009) 1.08
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc Natl Acad Sci U S A (2004) 1.08
Adapters in lymphocyte signaling. J Clin Invest (2002) 1.08
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules. Proc Natl Acad Sci U S A (2002) 1.07
CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement. J Immunol (2006) 1.06
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules. Proc Natl Acad Sci U S A (2002) 1.06
CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion. Proc Natl Acad Sci U S A (2003) 1.06
Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. PLoS Pathog (2013) 1.05
Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc Natl Acad Sci U S A (2008) 1.04
Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. J Immunol (2002) 1.04