Published in Immunity on November 23, 2011
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. J Exp Med (2012) 1.71
Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci U S A (2013) 1.52
Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood (2012) 1.13
T cells and their eons-old obsession with MHC. Immunol Rev (2012) 1.13
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity. Nat Immunol (2015) 1.03
Reconciling views on T cell receptor germline bias for MHC. Trends Immunol (2012) 0.98
The T-cell receptor is not hardwired to engage MHC ligands. Proc Natl Acad Sci U S A (2012) 0.95
The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule. J Biol Chem (2012) 0.91
A closer look at TCR germline recognition. Immunity (2012) 0.91
Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. Proc Natl Acad Sci U S A (2012) 0.88
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire. Proc Natl Acad Sci U S A (2016) 0.88
A flexible docking approach for prediction of T cell receptor-peptide-MHC complexes. Protein Sci (2013) 0.87
αβ T cell receptors come out swinging. Immunity (2011) 0.84
Identification of multiple public TCR repertoires in chronic beryllium disease. J Immunol (2014) 0.84
The T cell antigen receptor: the Swiss army knife of the immune system. Clin Exp Immunol (2015) 0.82
Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat Immunol (2016) 0.81
Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy. Cancer Immunol Res (2015) 0.81
Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8(+) T cell response. Nat Immunol (2017) 0.80
Duality of the murine CD8 compartment. Proc Natl Acad Sci U S A (2014) 0.79
Affinity for self antigen selects Treg cells with distinct functional properties. Nat Immunol (2016) 0.78
Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity. J Immunol (2014) 0.78
Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity. Sci Rep (2016) 0.78
Indoctrinating T cells to attack pathogens through homeschooling. Trends Immunol (2015) 0.77
A "hotspot" for autoimmune T cells in type 1 diabetes. J Clin Invest (2016) 0.75
Response to Garcia et al. Immunity (2012) 0.75
MHC Bias by T Cell Receptors: Genetic Evidence for MHC and TCR Coevolution. Trends Immunol (2016) 0.75
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions. JCI Insight (2017) 0.75
T-cell antigen receptor genes and T-cell recognition. Nature (1988) 16.77
T cell tolerance by clonal elimination in the thymus. Cell (1987) 13.83
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature (1974) 13.24
High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science (1989) 8.73
Binding of immunogenic peptides to Ia histocompatibility molecules. Nature (1985) 8.39
How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol (2006) 7.57
The somatic generation of immune recognition. Eur J Immunol (1971) 6.80
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature (1992) 4.01
Correlations between T-cell specificity and the structure of the antigen receptor. Nature (1986) 3.83
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature (2010) 3.57
How the T cell repertoire becomes peptide and MHC specific. Cell (2005) 3.39
How a single T cell receptor recognizes both self and foreign MHC. Cell (2007) 3.20
Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol (2006) 3.01
Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. Nature (1987) 2.99
How T cells 'see' antigen. Nat Immunol (2005) 2.87
Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods (1995) 2.86
Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79
Development and selection of T cells: facts and puzzles. Adv Immunol (1995) 2.70
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense. Science (2002) 2.61
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat Immunol (2006) 2.57
The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nat Immunol (2005) 2.38
The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat Immunol (2009) 2.34
The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell (1997) 2.34
What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity? Trends Immunol (2003) 2.31
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity (1998) 2.31
Mouse T-cell receptor variable gene segment families. Immunogenetics (1995) 2.24
The IMGT/HLA database. Nucleic Acids Res (2008) 2.22
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity (2011) 2.11
Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity (2005) 2.03
Diverse TCRs recognize murine CD1. J Immunol (1999) 2.01
How many thymocytes audition for selection? J Exp Med (1997) 1.90
Back to central tolerance. Immunity (2004) 1.88
T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. Immunology (2009) 1.85
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity (2011) 1.84
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proc Natl Acad Sci U S A (2010) 1.60
T-cell receptor variable region gene usage in T-cell populations. Proc Natl Acad Sci U S A (1986) 1.56
Positive selection of thymocytes. Adv Immunol (1995) 1.53
A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nat Immunol (2011) 1.47
Fast on-rates allow short dwell time ligands to activate T cells. Proc Natl Acad Sci U S A (2010) 1.43
Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. Curr Opin Immunol (2009) 1.42
Control of MHC restriction by TCR Valpha CDR1 and CDR2. Science (1996) 1.40
Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire. J Exp Med (1991) 1.33
V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition. J Immunol (1994) 1.21
Allelic polymorphism in the T cell receptor and its impact on immune responses. J Exp Med (2010) 1.18
CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol (2007) 1.01
Canonical structures for the hypervariable regions of T cell alphabeta receptors. J Mol Biol (2000) 1.00
A T cell receptor V alpha region selectively expressed in CD4+ cells. J Immunol (1990) 0.93
Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8+ T cells. Eur J Immunol (2010) 0.87
Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell (2013) 3.22
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells. Nat Chem Biol (2007) 2.04
Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. J Immunol (2005) 1.98
Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor. Immunity (2008) 1.85
Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med (2009) 1.73
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry (2006) 1.68
Exacerbation of Mycobacterium tuberculosis enteritis masquerading as Crohn's disease after treatment with a tumor necrosis factor-alpha inhibitor. Am J Med (2002) 1.61
Noble metals strip peptides from class II MHC proteins. Nat Chem Biol (2006) 1.53
CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med (2002) 1.53
Class II major histocompatibility complex tetramer staining: progress, problems, and prospects. Immunology (2008) 1.47
Fast on-rates allow short dwell time ligands to activate T cells. Proc Natl Acad Sci U S A (2010) 1.43
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol (2011) 1.42
How the thymus designs antigen-specific and self-tolerant T cell receptor sequences. Proc Natl Acad Sci U S A (2008) 1.32
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat Struct Mol Biol (2012) 1.25
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc Natl Acad Sci U S A (2011) 1.23
HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimulatory microarrays. Proc Natl Acad Sci U S A (2005) 1.21
Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection. PLoS Pathog (2007) 1.20
Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins. Proc Natl Acad Sci U S A (2013) 1.19
The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. J Immunol (2007) 1.18
Model for the peptide-free conformation of class II MHC proteins. PLoS One (2008) 1.17
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harb Perspect Biol (2010) 1.16
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain. J Immunol (2004) 1.15
Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping. Biochemistry (2005) 1.13
Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle (2010) 1.12
Labeling antigen-specific CD4(+) T cells with class II MHC oligomers. J Immunol Methods (2002) 1.11
Human CD4+ T cell response to human herpesvirus 6. J Virol (2012) 1.10
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. Proc Natl Acad Sci U S A (2004) 1.09
Cutting edge: TCR engagement and triggering in the absence of large-scale molecular segregation at the T cell-APC contact site. J Immunol (2002) 1.09
The role of CD8(+) T cells in multiple sclerosis and its animal models. Curr Drug Targets Inflamm Allergy (2005) 1.08
CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement. J Immunol (2006) 1.06
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules. Proc Natl Acad Sci U S A (2002) 1.06
Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. PLoS Pathog (2013) 1.05
Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. J Immunol (2002) 1.04
An expanded self-antigen peptidome is carried by the human lymph as compared to the plasma. PLoS One (2010) 1.02
Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells. J Immunol (2014) 1.01
Pathogenic CD8 T cells in multiple sclerosis and its experimental models. Front Immunol (2012) 1.01
A polymorphic pocket at the P10 position contributes to peptide binding specificity in class II MHC proteins. Chem Biol (2004) 1.01
Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Immunol Rev (2012) 1.00
Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance. J Immunol (2007) 0.99
Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC. J Immunol (2005) 0.99
Ligand mobility modulates immunological synapse formation and T cell activation. PLoS One (2012) 0.98
The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition. Biochemistry (2008) 0.97
HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives. J Immunol (2012) 0.97
Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis. Proc Natl Acad Sci U S A (2012) 0.97
Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding. J Biol Chem (2004) 0.97
Antigenic peptide trimming by ER aminopeptidases--insights from structural studies. Mol Immunol (2013) 0.97
Translation and validation study of Chinese versions of the neck disability index and the neck pain and disability scale. Spine (Phila Pa 1976) (2010) 0.94
Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses. J Immunol (2007) 0.94
Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity. J Mol Biol (2007) 0.93
Vaccinia peptides eluted from HLA-DR1 isolated from virus-infected cells are recognized by CD4+ T cells from a vaccinated donor. J Proteome Res (2008) 0.92
Comparison of miniscalpel-needle release, acupuncture needling, and stretching exercise to trigger point in myofascial pain syndrome. Clin J Pain (2010) 0.90
GMCSF in the absence of other cytokines sustains human dendritic cell precursors with T cell regulatory activity and capacity to differentiate into functional dendritic cells. Immunol Lett (2007) 0.90
Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Sci Rep (2012) 0.90
Stochastic simulations of a multi-group compartmental model for Johne's disease on US dairy herds with test-based culling intervention. J Theor Biol (2010) 0.90
Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides. Proc Natl Acad Sci U S A (2012) 0.89
Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy. Chembiochem (2007) 0.89
Continuous and noninvasive blood pressure measurement: a novel modeling methodology of the relationship between blood pressure and pulse wave velocity. Ann Biomed Eng (2009) 0.89
Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr D Biol Crystallogr (2010) 0.89
Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. Proc Natl Acad Sci U S A (2012) 0.88
Major histocompatibility complex and T cell interactions of a universal T cell epitope from Plasmodium falciparum circumsporozoite protein. J Biol Chem (2006) 0.88
Antigen-specific T cell phenotyping microarrays using grating coupled surface plasmon resonance imaging and surface plasmon coupled emission. Biosens Bioelectron (2011) 0.87
Examination of the highly diverse CD4(+) T-cell repertoire directed against an influenza peptide: a step towards TCR proteomics. Immunogenetics (2002) 0.86
Modulation of UvrD helicase activity by covalent DNA-protein cross-links. J Biol Chem (2010) 0.86
Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells. J Immunol (2013) 0.86
Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1. J Biol Chem (2003) 0.85
Using vaccination to prevent the invasion of Mycobacterium avium subsp. paratuberculosis in dairy herds: a stochastic simulation study. Prev Vet Med (2013) 0.84
Induced fit of an epitope peptide to a monoclonal antibody probed with a novel parallel surface plasmon resonance assay. J Biol Chem (2004) 0.84
Impact of imperfect Mycobacterium avium subsp. paratuberculosis vaccines in dairy herds: a mathematical modeling approach. Prev Vet Med (2012) 0.84
Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope. Mol Immunol (2005) 0.84
Cross-cultural adaptation, reliability, and validity of the Chinese version of the STarT Back Screening Tool in patients with low back pain. Spine (Phila Pa 1976) (2014) 0.83
Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses. PLoS One (2010) 0.83
Bi-specific MHC heterodimers for characterization of cross-reactive T cells. J Biol Chem (2010) 0.83
Presynaptic learning and memory with a persistent firing neuron and a habituating synapse: a model of short term persistent habituation. Int J Neural Syst (2012) 0.82
CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans. J Immunol (2013) 0.82
Assessing the potential impact of Salmonella vaccines in an endemically infected dairy herd. J Theor Biol (2009) 0.81
[Prediction models for the 15 years risk of new-onset hypertension in Chinese people aged from 35 to 64 years old]. Zhonghua Nei Ke Za Zhi (2014) 0.81
Genome-wide identification of bone metastasis-related microRNAs in lung adenocarcinoma by high-throughput sequencing. PLoS One (2013) 0.80
Retrospective analysis of risk factors in young patients with coronary artery disease in Guangdong and Zhejiang, China. Acta Cardiol (2009) 0.79
Identifying environmental antigens that activate myelin-specific T cells. Trends Immunol (2014) 0.79
Invasion and transmission of Salmonella Kentucky in an adult dairy herd using approximate Bayesian computation. BMC Vet Res (2013) 0.79
Intrathecal implantation of microencapsulated PC12 cells reduces cold allodynia in a rat model of neuropathic pain. Artif Organs (2010) 0.78
Carrying yourself: self antigen composition of the lymphatic fluid. Lymphat Res Biol (2013) 0.78
Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization. Curr Protoc Immunol (2014) 0.78
HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange. Front Immunol (2013) 0.77
Age at menarche, androgen concentrations, and midlife obesity: findings from the Midlife Women's Health Study. Menopause (2016) 0.75
Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39. J Immunol (2015) 0.75
Response to Garcia et al. Immunity (2012) 0.75
A "hotspot" for autoimmune T cells in type 1 diabetes. J Clin Invest (2016) 0.75
Delirium in Critically Ill Children: An International Point Prevalence Study. Crit Care Med (2017) 0.75
Model-based online learning with kernels. IEEE Trans Neural Netw Learn Syst (2013) 0.75
Cardiac output monitoring during Cesarean delivery in a patient with palliated tetralogy of Fallot. Can J Anaesth (2012) 0.75
Stochastic modeling of imperfect Salmonella vaccines in an adult dairy herd. Bull Math Biol (2014) 0.75
Boundary Constraints for Minimum Cost Control of Directed Networks. IEEE Trans Cybern (2016) 0.75
Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I. Antioxid Redox Signal (2002) 0.75
When is it safe to initiate breastfeeding for preterm infants? Adv Neonatal Care (2015) 0.75
Minimum Cost Control of Directed Networks With Selectable Control Inputs. IEEE Trans Cybern (2018) 0.75