Published in J Biol Chem on February 05, 2004
Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev (2009) 5.64
Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Biochem Pharmacol (2009) 1.76
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. AAPS J (2009) 1.68
Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism. J Neurosci (2005) 1.59
beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Arch Gen Psychiatry (2009) 1.53
Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expression. Br J Pharmacol (2009) 1.45
Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Mol Pharmacol (2010) 1.28
Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation. Psychopharmacology (Berl) (2005) 1.14
The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors. J Neurosci (2009) 1.13
Differential regulation of alpha7 nicotinic receptor gene (CHRNA7) expression in schizophrenic smokers. J Mol Neurosci (2009) 1.03
Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. Alcohol Clin Exp Res (2012) 0.99
Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. J Pharmacol Exp Ther (2012) 0.99
Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93
A neurocomputational hypothesis for nicotine addiction. Proc Natl Acad Sci U S A (2006) 0.92
Pharmacological chaperoning: a primer on mechanism and pharmacology. Pharmacol Res (2014) 0.92
Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology (2015) 0.89
Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation. Biochem Pharmacol (2007) 0.89
Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons. J Neurochem (2011) 0.88
Choline promotes nicotinic receptor alpha4 + beta2 up-regulation. J Biol Chem (2010) 0.84
Cellular responses to nicotinic receptor activation are decreased after prolonged exposure to galantamine in human neuroblastoma cells. Br J Pharmacol (2005) 0.84
Cellular events in nicotine addiction. Semin Cell Dev Biol (2009) 0.83
Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br J Pharmacol (2005) 0.82
Desensitization of neuronal nicotinic receptors of human neuroblastoma SH-SY5Y cells during short or long exposure to nicotine. Br J Pharmacol (2005) 0.81
Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation. Mol Pharmacol (2011) 0.81
Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption. Front Hum Neurosci (2014) 0.80
Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain. J Neurochem (2014) 0.80
Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors. Neuropharmacology (2014) 0.78
Nicotine withdrawal. Curr Top Behav Neurosci (2015) 0.78
Chronic nicotine alters nicotinic receptor-induced presynaptic Ca2+ responses in isolated nerve terminals. Neurochem Res (2007) 0.78
Intra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors. Neuropharmacology (2013) 0.78
The concept of allosteric interaction and its consequences for the chemistry of the brain. J Biol Chem (2013) 0.77
Endogenously expressed muscarinic receptors in HEK293 cells augment up-regulation of stably expressed α4β2 nicotinic receptors. J Biol Chem (2011) 0.77
Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol (2008) 12.96
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature (2008) 5.77
BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol (2010) 5.75
Conscious, preconscious, and subliminal processing: a testable taxonomy. Trends Cogn Sci (2006) 4.66
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol (2008) 4.55
Experimental and theoretical approaches to conscious processing. Neuron (2011) 4.28
A community-driven global reconstruction of human metabolism. Nat Biotechnol (2013) 3.89
Systems Biology Markup Language (SBML) Level 2 Version 5: Structures and Facilities for Model Definitions. J Integr Bioinform (2015) 3.61
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov (2009) 3.26
A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature (2006) 3.04
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature (2011) 3.00
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci (2003) 2.85
Controlled vocabularies and semantics in systems biology. Mol Syst Biol (2011) 2.79
A neuronal network model linking subjective reports and objective physiological data during conscious perception. Proc Natl Acad Sci U S A (2003) 2.79
Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors. Neuron (2006) 2.69
MIRIAM Resources: tools to generate and resolve robust cross-references in Systems Biology. BMC Syst Biol (2007) 2.56
The EBI RDF platform: linked open data for the life sciences. Bioinformatics (2014) 2.55
Identifiers.org and MIRIAM Registry: community resources to provide persistent identification. Nucleic Acids Res (2011) 2.48
Reproducible computational biology experiments with SED-ML--the Simulation Experiment Description Markup Language. BMC Syst Biol (2011) 2.40
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism. Biophys J (2005) 2.33
Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov (2006) 2.23
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula. Neuron (2011) 2.23
The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences. J Neurobiol (2002) 2.20
Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci (2002) 2.05
Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron (2005) 1.89
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue. Proc Natl Acad Sci U S A (2010) 1.81
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites. Proc Natl Acad Sci U S A (2002) 1.78
The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice. Psychopharmacology (Berl) (2006) 1.76
JSBML: a flexible Java library for working with SBML. Bioinformatics (2011) 1.73
Software support for SBGN maps: SBGN-ML and LibSBGN. Bioinformatics (2012) 1.69
Structure and pharmacology of pentameric receptor channels: from bacteria to brain. Structure (2012) 1.69
SBMLeditor: effective creation of models in the Systems Biology Markup language (SBML). BMC Bioinformatics (2007) 1.68
Molecular tuning of fast gating in pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A (2005) 1.58
Minimum Information About a Simulation Experiment (MIASE). PLoS Comput Biol (2011) 1.48
A neuronal model of predictive coding accounting for the mismatch negativity. J Neurosci (2012) 1.48
Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness. PLoS Biol (2005) 1.47
Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A (2011) 1.44
Executive and social behaviors under nicotinic receptor regulation. Proc Natl Acad Sci U S A (2003) 1.44
BioModels.net Web Services, a free and integrated toolkit for computational modelling software. Brief Bioinform (2009) 1.38
Altered map of visual space in the superior colliculus of mice lacking early retinal waves. J Neurosci (2005) 1.38
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc Natl Acad Sci U S A (2013) 1.32
Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors. Proc Natl Acad Sci U S A (2006) 1.32
Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor. Proc Natl Acad Sci U S A (2002) 1.32
Conformational selection or induced fit? 50 years of debate resolved. F1000 Biol Rep (2011) 1.31
Pore conformations and gating mechanism of a Cys-loop receptor. Proc Natl Acad Sci U S A (2005) 1.31
DARPP-32 is a robust integrator of dopamine and glutamate signals. PLoS Comput Biol (2006) 1.25
Designing and encoding models for synthetic biology. J R Soc Interface (2009) 1.23
Nicotine and serotonin in immune regulation and inflammatory processes: a perspective. J Leukoc Biol (2006) 1.22
BioModels Database: a repository of mathematical models of biological processes. Methods Mol Biol (2013) 1.21
SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools. BMC Syst Biol (2013) 1.20
An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors. EMBO J (2003) 1.19
An allosteric model of calmodulin explains differential activation of PP2B and CaMKII. Proc Natl Acad Sci U S A (2008) 1.18
Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta. J Comp Neurol (2003) 1.18
Monitoring protein interactions in the living cell through the fluorescence decays of the cyan fluorescent protein. Chemphyschem (2006) 1.18
Nicotine activates immature "silent" connections in the developing hippocampus. Proc Natl Acad Sci U S A (2003) 1.17
Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts. J Neurosci (2002) 1.17
Adsorption and desorption behavior of selected pesticides as influenced by decomposition of maize mulch. Chemosphere (2013) 1.17
Systems Biology Graphical Notation: Process Description language Level 1 Version 1.3. J Integr Bioinform (2015) 1.16
Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics. Proc Natl Acad Sci U S A (2007) 1.15
A gating mechanism of pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A (2013) 1.15
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J (2010) 1.12
Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice. J Physiol (2006) 1.12
Prefrontal nicotinic receptors control novel social interaction between mice. FASEB J (2011) 1.11
Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors. Proc Natl Acad Sci U S A (2010) 1.10
Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors. Neuropharmacology (2006) 1.08
Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion. Proc Natl Acad Sci U S A (2008) 1.08
Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proc Natl Acad Sci U S A (2007) 1.08
Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function. Proc Natl Acad Sci U S A (2005) 1.08
LGICdb: a manually curated sequence database after the genomes. Nucleic Acids Res (2006) 1.07
Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system. Prog Brain Res (2004) 1.05
The emergence of human consciousness: from fetal to neonatal life. Pediatr Res (2009) 1.04
Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices. Proc Natl Acad Sci U S A (2003) 1.03
Beta2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice. J Neurosci (2004) 1.02
Meredys, a multi-compartment reaction-diffusion simulator using multistate realistic molecular complexes. BMC Syst Biol (2010) 1.01
A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels. C R Biol (2005) 1.01
Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proc Natl Acad Sci U S A (2004) 1.01
Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity? J Physiol Paris (2006) 1.01
Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine. Neuropsychopharmacology (2005) 1.00
Computing phenomenologic Adair-Klotz constants from microscopic MWC parameters. BMC Syst Biol (2009) 0.99
Retrieval, alignment, and clustering of computational models based on semantic annotations. Mol Syst Biol (2011) 0.99
Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proc Natl Acad Sci U S A (2013) 0.99
Qualitative translation of relations from BioPAX to SBML qual. Bioinformatics (2012) 0.98
{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation. Am J Pathol (2009) 0.97
Live imaging of neural structure and function by fibred fluorescence microscopy. EMBO Rep (2006) 0.96