Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells.

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A (2010) 7.31

Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells (2007) 3.71

Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture. J Neurosci (2007) 3.25

Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol (2010) 3.06

Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol (2007) 2.71

Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells (2007) 2.71

Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells (2008) 2.54

Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46

Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells (2006) 2.37

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development (2009) 2.23

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Stem Cells (2007) 2.22

Pluripotent stem cells in regenerative medicine: challenges and recent progress. Nat Rev Genet (2014) 2.12

Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc (2009) 2.11

Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.97

Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development (2009) 1.90

Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells (2010) 1.74

Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension. Nat Biotechnol (2010) 1.73

Directed differentiation of human embryonic stem cells toward chondrocytes. Nat Biotechnol (2010) 1.72

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A (2006) 1.69

The promise of human embryonic stem cells in aging-associated diseases. Aging (Albany NY) (2011) 1.49

Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One (2010) 1.48

Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol Life Sci (2011) 1.40

Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model. PLoS One (2008) 1.37

Assessment of stromal-derived inducing activity in the generation of dopaminergic neurons from human embryonic stem cells. Stem Cells (2008) 1.37

Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PLoS One (2008) 1.36

Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network. Proc Natl Acad Sci U S A (2011) 1.35

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nat Commun (2012) 1.33

Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft. Eur J Neurosci (2006) 1.32

Human pluripotent stem cells: applications and challenges in neurological diseases. Front Physiol (2012) 1.31

Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells (2012) 1.28

Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain. Cell Rep (2013) 1.26

Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. J Neurochem (2007) 1.22

Scalable culture and cryopreservation of human embryonic stem cells on microcarriers. Biotechnol Prog (2009) 1.21

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells. Integr Biol (Camb) (2012) 1.20

Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog. Endocrinology (2010) 1.19

A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo. Brain Res (2006) 1.17

Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease. Stem Cells (2006) 1.16

Engineering Stem Cell Organoids. Cell Stem Cell (2016) 1.15

Cell transplantation strategies for retinal repair. Prog Brain Res (2009) 1.14

Differentiation of neural lineage cells from human pluripotent stem cells. Methods (2008) 1.13

A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells. PLoS One (2009) 1.11

Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. J Neurosci Res (2006) 1.10

Human embryonic stem cell differentiation toward regional specific neural precursors. Stem Cells (2009) 1.10

MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model. PLoS One (2011) 1.09

Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells. Methods Mol Biol (2010) 1.09

Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells. Development (2011) 1.08

Cell sources for the regeneration of articular cartilage: the past, the horizon and the future. Int J Exp Pathol (2012) 1.06

Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders. Neurogenetics (2008) 1.06

Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain (2008) 1.06

Differentiation of neuroepithelia from human embryonic stem cells. Methods Mol Biol (2009) 1.04

Human embryonic stem cells for brain repair? Philos Trans R Soc Lond B Biol Sci (2008) 1.04

Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci (2010) 1.02

Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease. PLoS One (2012) 1.02

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nat Protoc (2011) 1.01

Stem cell-based therapeutic applications in retinal degenerative diseases. Stem Cell Rev (2011) 1.01

Engineering tissue from human embryonic stem cells. J Cell Mol Med (2008) 0.98

Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neurons. PLoS One (2008) 0.97

Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy. Cell Res (2012) 0.97

An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection. Neuropsychopharmacology (2006) 0.97

Cell-based therapies for Parkinson disease—past insights and future potential. Nat Rev Neurol (2015) 0.97

Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells. Mol Brain (2008) 0.96

A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets. Stem Cell Reports (2014) 0.96

Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Cell Death Differ (2011) 0.94

Moving stem cells to the clinic: potential and limitations for brain repair. Neuron (2015) 0.94

Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders. Front Neurosci (2010) 0.92

Pluripotent stem cells for the study of CNS development. Front Mol Neurosci (2011) 0.92

Early specification of dopaminergic phenotype during ES cell differentiation. BMC Dev Biol (2007) 0.91

Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. J Neurogenet (2014) 0.91

AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy. Diabetologia (2011) 0.90

Human stem cells as a model of motoneuron development and diseases. Ann N Y Acad Sci (2010) 0.89

Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation. Cell Rep (2015) 0.89

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. Front Cell Neurosci (2014) 0.89

Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. Stem Cells Dev (2012) 0.88

Intracerebral transplantation of differentiated human embryonic stem cells to hemiparkinsonian monkeys. Cell Transplant (2013) 0.88

Stem cell sources and therapeutic approaches for central nervous system and neural retinal disorders. Neurosurg Focus (2008) 0.87

Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain Res (2012) 0.87

Facile formation of dynamic hydrogel microspheres for triggered growth factor delivery. Acta Biomater (2010) 0.86

Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species. Front Aging Neurosci (2014) 0.86

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Mol Neurobiol (2010) 0.85

Cell-based therapies for Parkinson's disease: past, present, and future. Antioxid Redox Signal (2009) 0.85

Mouse embryonic stem cells established in physiological-glucose media express the high KM Glut2 glucose transporter expressed by normal embryos. Stem Cells Transl Med (2013) 0.85

Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells. Front Neuroanat (2007) 0.84

Developmental regulation of TAC1 in peptidergic-induced human mesenchymal stem cells: implication for spinal cord injury in zebrafish. Stem Cells Dev (2011) 0.84

Biological and medical applications of a brain-on-a-chip. Exp Biol Med (Maywood) (2014) 0.84

A gutsy task: generating intestinal tissue from human pluripotent stem cells. Dig Dis Sci (2013) 0.83

Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity. Stem Cell Reports (2014) 0.83

Dopamine cell transplantation for Parkinson's disease: the importance of controlled clinical trials. Neurotherapeutics (2011) 0.83

Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy. Stem Cells Int (2012) 0.83

Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models. Stem Cells Cloning (2013) 0.83

The specification of telencephalic glutamatergic neurons from human pluripotent stem cells. J Vis Exp (2013) 0.83

Redefining Parkinson's disease research using induced pluripotent stem cells. Curr Neurol Neurosci Rep (2012) 0.82

Genetic modification of human embryonic stem cells. Biotechnol Genet Eng Rev (2007) 0.82

The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk. Neurotoxicology (2012) 0.82

Dopamine receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev (2013) 0.81

A New Experimental Model for Neuronal and Glial Differentiation Using Stem Cells Derived from Human Exfoliated Deciduous Teeth. J Mol Neurosci (2013) 0.81

Pluripotent stem cells for Parkinson's disease: progress and challenges. Stem Cell Res Ther (2013) 0.80

Development of stem cell-based therapy for Parkinson's disease. Transl Neurodegener (2015) 0.80

Long-lived engineering of glycans to direct stem cell fate. Angew Chem Int Ed Engl (2014) 0.80

Probing disorders of the nervous system using reprogramming approaches. EMBO J (2015) 0.79

Growth factors and feeder cells promote differentiation of human embryonic stem cells into dopaminergic neurons: a novel role for fibroblast growth factor-20. Front Neurosci (2008) 0.79

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60

Embryonic stem cell lines derived from human blastocysts. Science (1998) 65.53

Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 30.49

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96

Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet (2000) 9.54

In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol (2001) 9.04

Correction for liquid junction potentials in patch clamp experiments. Methods Enzymol (1992) 8.06

Specification of motoneurons from human embryonic stem cells. Nat Biotechnol (2005) 7.74

Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A (2004) 7.51

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol (2000) 6.21

Dopamine neuron agenesis in Nurr1-deficient mice. Science (1997) 5.40

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development (1995) 4.65

Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J Neurosci (1989) 3.66

Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol (2003) 3.43

FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell (1998) 3.33

Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron (2003) 3.27

Patterning the vertebrate neuraxis. Science (1996) 3.20

A role for SOX1 in neural determination. Development (1998) 2.85

Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron (1992) 2.79

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci U S A (1998) 2.76

Specification of catecholaminergic and serotonergic neurons. Nat Rev Neurosci (2002) 2.38

Dopaminergic differentiation of human embryonic stem cells. Stem Cells (2004) 2.30

Pitx3 is required for development of substantia nigra dopaminergic neurons. Proc Natl Acad Sci U S A (2003) 2.27

A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat Neurosci (2000) 2.20

Neural plate patterning: upstream and downstream of the isthmic organizer. Nat Rev Neurosci (2001) 2.06

Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J Neurosci (2001) 1.99

Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp Neurol (1997) 1.98

Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (2003) 1.90

Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development (2004) 1.86

Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture. Stem Cells (2004) 1.83

A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Proc Natl Acad Sci U S A (1997) 1.83

Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. J Neurosci (1996) 1.52

Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF. Stem Cells (2004) 1.44

Specification of dopaminergic and serotonergic neurons in the vertebrate CNS. Curr Opin Neurobiol (1999) 1.43

Early anterior/posterior patterning of the midbrain and cerebellum. Annu Rev Neurosci (2001) 1.39

Neural differentiation from embryonic stem cells: which way? Stem Cells Dev (2004) 1.37

Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons. Development (2004) 1.37

Regional specification of rodent and human neurospheres. Brain Res Dev Brain Res (2002) 1.34

Evidence for coexistence of GABA and dopamine in neurons of the rat olfactory bulb. J Comp Neurol (1987) 1.33

Catecholaminergic neurons containing GABA-like and/or glutamic acid decarboxylase-like immunoreactivities in various brain regions of the rat. Exp Brain Res (1987) 1.24

EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development (2001) 1.23

Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain. Development (2002) 1.23

Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells. Exp Neurol (2001) 1.21

A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse. Development (1988) 1.20

A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: evidence from immunohistochemistry combined with retrograde tracing. Neuroscience (1980) 1.14

Cytoarchitectural distribution of calcium binding proteins in midbrain dopaminergic regions of rats and humans. J Comp Neurol (1996) 1.08

Embryonic stem cells for neural replacement therapy: prospects and challenges. J Hematother Stem Cell Res (2003) 1.03

Generation of tyrosine hydroxylase-producing neurons from precursors of the embryonic and adult forebrain. J Neurosci (1999) 1.02

Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activity. J Neurosci Res (2002) 0.96

Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50

Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27

Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41

Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16

The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94

ProbeMatch: rapid alignment of oligonucleotides to genome allowing both gaps and mismatches. Bioinformatics (2009) 13.34

Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21

RNA-Seq gene expression estimation with read mapping uncertainty. Bioinformatics (2009) 10.74

Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50

Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol (2003) 9.15

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74

Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell (2007) 8.59

Derivation of human embryonic stem cells in defined conditions. Nat Biotechnol (2006) 8.28

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell (2009) 8.14

Specification of motoneurons from human embryonic stem cells. Nat Biotechnol (2005) 7.74

Feeder-independent culture of human embryonic stem cells. Nat Methods (2006) 7.61

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A (2010) 7.31

Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09

Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods (2005) 6.37

BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol (2002) 6.20

Chemically defined conditions for human iPSC derivation and culture. Nat Methods (2011) 5.84

Homologous recombination in human embryonic stem cells. Nat Biotechnol (2003) 5.77

Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res (2003) 5.12

NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell (2008) 4.88

EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments. Bioinformatics (2013) 4.79

Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A (2003) 4.67

Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood (2004) 4.32

Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81

Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells (2007) 3.71

Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res (2007) 3.56

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53

Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proc Natl Acad Sci U S A (2009) 3.53

Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture. J Neurosci (2007) 3.25

Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99

Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res (2012) 2.91

Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells (2005) 2.78

Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell (2010) 2.69

Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68

Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood (2006) 2.66

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol (2011) 2.65

Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell (2012) 2.62

A mesoderm-derived precursor for mesenchymal stem and endothelial cells. Cell Stem Cell (2010) 2.58

Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells (2008) 2.54

Surface antigens of human embryonic stem cells: changes upon differentiation in culture. J Anat (2002) 2.52

Diversity of inhibitory neurotransmission through GABA(A) receptors. Trends Neurosci (2004) 2.49

Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46

High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells (2003) 2.42

Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. Proc Natl Acad Sci U S A (2011) 2.41

Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nat Methods (2011) 2.39

Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 2.29

Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner. Stem Cells Dev (2007) 2.27

Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells (2011) 2.26

Pluripotent stem cell lines. Genes Dev (2008) 2.25

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development (2009) 2.23

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Stem Cells (2007) 2.22

Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell (2008) 2.21

Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells. Endocrinology (2003) 2.15

Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann Neurol (2002) 2.15

Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc (2009) 2.11

FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell (2011) 2.11

A germ cell origin of embryonic stem cells? Development (2005) 2.09

Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol (2007) 2.08

Specification of transplantable astroglial subtypes from human pluripotent stem cells. Nat Biotechnol (2011) 2.07

Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proc Natl Acad Sci U S A (2010) 2.05

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing. Proc Natl Acad Sci U S A (2010) 2.01

Human embryonic stem cell phosphoproteome revealed by electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.95

Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood (2011) 1.92

Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development (2009) 1.90

Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc (2009) 1.83

Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat Protoc (2012) 1.74

Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res (2011) 1.72

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. J Cell Biol (2004) 1.62

Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J Virol (2003) 1.57

Regulation of neural specification from human embryonic stem cells by BMP and FGF. Stem Cells (2009) 1.53

Conserved regulation of MAP kinase expression by PUF RNA-binding proteins. PLoS Genet (2007) 1.51

A study of the relationships between oligonucleotide properties and hybridization signal intensities from NimbleGen microarray datasets. Nucleic Acids Res (2008) 1.47

Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46

The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials (2009) 1.46

Modulation of GABA(A) receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process. J Neurosci (2003) 1.46

Evaluation of de novo transcriptome assemblies from RNA-Seq data. Genome Biol (2014) 1.46

MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells (2009) 1.43

Arrays for the combinatorial exploration of cell adhesion. J Am Chem Soc (2004) 1.41

Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol Life Sci (2011) 1.40

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol (2013) 1.38

Neural differentiation from embryonic stem cells: which way? Stem Cells Dev (2004) 1.37

Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep (2013) 1.36

Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network. Proc Natl Acad Sci U S A (2011) 1.35

Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway. J Immunol (2006) 1.34

Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proc Natl Acad Sci U S A (2009) 1.29

A novel helical double-layered cobalt(II)-organic framework with tetranuclear [Co4(mu3-OH)2] clusters linked by an unsymmetrical pyridylbenzoate ligand. Inorg Chem (2007) 1.28

Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells (2012) 1.28

GABA A,slow: causes and consequences. Trends Neurosci (2010) 1.27

Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model. J Stroke Cerebrovasc Dis (2011) 1.27

Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus. Eur J Neurosci (2007) 1.27