Published in J Biol Chem on February 19, 2004
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
Gap-junction channels dysfunction in deafness and hearing loss. Antioxid Redox Signal (2009) 1.39
The role of connexins in ear and skin physiology - functional insights from disease-associated mutations. Biochim Biophys Acta (2012) 1.34
Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease. Mol Cell Neurosci (2007) 1.24
Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models. Brain Res (2009) 1.20
Altered gating properties of functional Cx26 mutants associated with recessive non-syndromic hearing loss. Hum Genet (2004) 1.17
Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects. J Neurosci (2009) 1.15
Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss - A Common Hereditary Deafness. Front Cell Neurosci (2015) 0.97
GJB2 Gene Mutations in Syndromic Skin Diseases with Sensorineural Hearing Loss. Curr Genomics (2011) 0.96
Dominant connexin26 mutants associated with human hearing loss have trans-dominant effects on connexin30. Neurobiol Dis (2010) 0.96
Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner. J Cell Sci (2009) 0.96
Dominant Cx26 mutants associated with hearing loss have dominant-negative effects on wild type Cx26. Mol Cell Neurosci (2010) 0.92
Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Biochem Biophys Res Commun (2005) 0.88
Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo. J Biol Chem (2013) 0.85
The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants. Biochem J (2010) 0.84
Conformational maturation and post-ER multisubunit assembly of gap junction proteins. Mol Biol Cell (2009) 0.83
Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures. Mol Biol Cell (2015) 0.80
Connexins and gap junctions in the inner ear--it's not just about K⁺ recycling. Cell Tissue Res (2014) 0.80
Connexin channels in congenital skin disorders. Semin Cell Dev Biol (2016) 0.79
Connexin26 Mutations Causing Palmoplantar Keratoderma and Deafness Interact with Connexin43, Modifying Gap Junction and Hemichannel Properties. J Invest Dermatol (2016) 0.78
Differentiation of organotypic epidermis in the presence of skin disease-linked dominant-negative Cx26 mutants and knockdown Cx26. J Membr Biol (2007) 0.77
Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function. PLoS One (2014) 0.76
Human diseases associated with connexin mutations. Biochim Biophys Acta (2017) 0.75
Connexinopathies: a structural and functional glimpse. BMC Cell Biol (2016) 0.75
Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations. BMC Cell Biol (2016) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Multicolor and electron microscopic imaging of connexin trafficking. Science (2002) 5.60
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci (2007) 2.41
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (2005) 1.93
Implications and challenges of connexin connections to cancer. Nat Rev Cancer (2010) 1.85
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem (2011) 1.76
The biochemistry and function of pannexin channels. Biochim Biophys Acta (2012) 1.70
Gap junction remodeling in skin repair following wounding and disease. Physiology (Bethesda) (2013) 1.49
Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res (2006) 1.48
Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43. J Biol Chem (2005) 1.46
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis. J Mol Med (Berl) (2015) 1.45
Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell (2009) 1.45
Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. J Biol Chem (2002) 1.37
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells. J Biol Chem (2003) 1.32
Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture. Breast Cancer Res (2005) 1.27
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol Biol Cell (2007) 1.23
Evaluation of mammary gland development and function in mouse models. J Vis Exp (2011) 1.22
Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci (2005) 1.21
Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction. Circ Res (2011) 1.21
Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res (2005) 1.17
Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol (2007) 1.15
Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma. J Biol Chem (2006) 1.10
Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia. J Biol Chem (2007) 1.10
Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules. Exp Cell Res (2002) 1.09
Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface. J Cell Sci (2004) 1.09
Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants. Cell Commun Adhes (2006) 1.07
ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. J Bone Miner Res (2008) 1.03
Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem (2010) 1.03
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1. Cancer Res (2010) 1.01
Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. J Bone Miner Res (2011) 0.99
Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia. Dev Biol (2008) 0.97
Mechanisms linking connexin mutations to human diseases. Cell Tissue Res (2014) 0.97
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. J Cell Sci (2010) 0.97
S-nitrosylation inhibits pannexin 1 channel function. J Biol Chem (2012) 0.96
Expression of pannexin isoforms in the systemic murine arterial network. J Vasc Res (2012) 0.95
Diverse subcellular distribution profiles of pannexin 1 and pannexin 3. Cell Commun Adhes (2008) 0.94
Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Carcinogenesis (2006) 0.94
Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype. J Biol Chem (2012) 0.94
Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovasc Res (2008) 0.93
The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress. Invest Ophthalmol Vis Sci (2008) 0.93
Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques. J Cell Sci (2009) 0.92
A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse. Biol Reprod (2009) 0.91
Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proc Natl Acad Sci U S A (2008) 0.91
Connexin levels regulate keratinocyte differentiation in the epidermis. J Biol Chem (2007) 0.89
Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout. J Comp Neurol (2013) 0.89
Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia. Mol Biol Cell (2012) 0.88
Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects. Hum Mutat (2011) 0.88
The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice. Biochem J (2013) 0.87
Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40. Free Radic Biol Med (2010) 0.87
Transport and function of cx26 mutants involved in skin and deafness disorders. Cell Commun Adhes (2003) 0.85
Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo. J Biol Chem (2013) 0.85
Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia. Dis Model Mech (2009) 0.85
The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants. Biochem J (2010) 0.84
Pannexin1 and Pannexin3 exhibit distinct localization patterns in human skin appendages and are regulated during keratinocyte differentiation and carcinogenesis. Cell Commun Adhes (2012) 0.84
Beta3 integrins facilitate matrix interactions during transendothelial migration of PC3 prostate tumor cells. Prostate (2005) 0.83
The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation. Exp Dermatol (2012) 0.82
Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat. Mol Reprod Dev (2011) 0.82
Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain. J Biol Chem (2011) 0.82
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms. Cell Commun Adhes (2003) 0.82
Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol Reprod (2010) 0.82
Mutations in Cx30 that are linked to skin disease and non-syndromic hearing loss exhibit several distinct cellular pathologies. J Cell Sci (2014) 0.81
A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. Prostate (2006) 0.80
The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol (2011) 0.79
The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia. J Invest Dermatol (2011) 0.79
An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels. Dis Model Mech (2014) 0.78
Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms. J Cell Sci (2013) 0.78
Differentiation of organotypic epidermis in the presence of skin disease-linked dominant-negative Cx26 mutants and knockdown Cx26. J Membr Biol (2007) 0.77
CELLULAR SMALL TALK. Sci Am (2015) 0.77
Rat epidermal keratinocytes as an organotypic model for examining the role of Cx43 and Cx26 in skin differentiation. Cell Commun Adhes (2006) 0.77
Myogenic bladder defects in mouse models of human oculodentodigital dysplasia. Biochem J (2014) 0.77
Ocular pathology relevant to glaucoma in a Gja1(Jrt/+) mouse model of human oculodentodigital dysplasia. Invest Ophthalmol Vis Sci (2011) 0.77
Critical Role of Cx40 in Reduced Endothelial Electrical Coupling by Lipopolysaccharide and Hypoxia-Reoxygenation. J Vasc Res (2016) 0.76
Optical and biochemical dissection of connexin and disease-linked connexin mutants in 3D organotypic epidermis. Methods Mol Biol (2010) 0.76
Gap junctions and cancer: communicating for 50 years. Nat Rev Cancer (2016) 0.75
Introductory paper of the special issue on gap junctions in honor of Ross Johnson. J Membr Biol (2012) 0.75