Published in J Membr Biol on July 20, 2007
Dominant Cx26 mutants associated with hearing loss have dominant-negative effects on wild type Cx26. Mol Cell Neurosci (2010) 0.92
Getting under the skin of epidermal morphogenesis. Nat Rev Genet (2002) 4.54
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
Connexins 26, 30, and 43: differences among spontaneous, chronic, and accelerated human wound healing. J Invest Dermatol (2004) 1.61
trans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation. J Cell Sci (2001) 1.54
Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res (2006) 1.48
Targeting connexin43 expression accelerates the rate of wound repair. Curr Biol (2003) 1.48
Roles of Met-34, Cys-64, and Arg-75 in the assembly of human connexin 26. Implication for key amino acid residues for channel formation and function. J Biol Chem (2002) 1.45
Connexin mediates gap junction-independent resistance to cellular injury. J Neurosci (2003) 1.38
Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. J Biol Chem (2002) 1.37
The gap junction-independent tumor-suppressing effect of connexin 43. J Biol Chem (2003) 1.35
Dual functions for connexins: Cx43 regulates growth independently of gap junction formation. Exp Cell Res (2001) 1.27
Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30. Hum Mol Genet (2003) 1.25
Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms. J Invest Dermatol (2002) 1.21
Altered connexin expression and wound healing in the epidermis of connexin-deficient mice. J Cell Sci (2003) 1.20
Expression of gap junction proteins Cx26, Cx31.1, Cx37, and Cx43 in developing and mature rat epidermis. Dev Dyn (1994) 1.20
Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res (2005) 1.17
Connexin disorders of the skin. Clin Dermatol (2005) 1.17
Wounding alters epidermal connexin expression and gap junction-mediated intercellular communication. Mol Biol Cell (1995) 1.12
Dynamic changes in connexin expression correlate with key events in the wound healing process. Cell Biol Int (2003) 1.11
Topography of mammalian connexins in human skin. J Invest Dermatol (1994) 1.09
Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31. J Invest Dermatol (2001) 1.05
Multiple gap junction genes are utilized during rat skin and hair development. Development (1992) 1.05
Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations. J Biol Chem (2004) 1.03
Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer. Cancer Res (1999) 1.02
Upregulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium. J Invest Dermatol (1999) 0.96
Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skin. Eur J Cell Biol (1994) 0.96
Upregulation of connexin 26 between keratinocytes of psoriatic lesions. J Invest Dermatol (1998) 0.93
Vitamin C enhances differentiation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier. Histochem Cell Biol (2001) 0.92
Temporal regulation of connexin phosphorylation in embryonic and adult tissues. Biochim Biophys Acta (2005) 0.92
Expression and function of connexins in the epidermis, analyzed with transgenic mouse mutants. Eur J Cell Biol (2004) 0.92
Targeted epidermal expression of mutant Connexin 26(D66H) mimics true Vohwinkel syndrome and provides a model for the pathogenesis of dominant connexin disorders. Hum Mol Genet (2003) 0.91
Neuronal differentiation and growth control of neuro-2a cells after retroviral gene delivery of connexin43. J Biol Chem (2000) 0.91
The growth and differentiation of cultured newborn rat keratinocytes. J Invest Dermatol (1983) 0.91
Expression of gap junction proteins connexin 26 and 43 is modulated during differentiation of keratinocytes in newborn mouse epidermis. J Invest Dermatol (1993) 0.90
A preformed basal lamina alters the metabolism and distribution of hyaluronan in epidermal keratinocyte "organotypic" cultures grown on collagen matrices. Histochem Cell Biol (2000) 0.90
Differential expression of connexins during stratification of human keratinocytes. J Invest Dermatol (2000) 0.89
Changing patterns of gap junctional intercellular communication and connexin distribution in mouse epidermis and hair follicles during embryonic development. Dev Dyn (1997) 0.88
Transport and function of cx26 mutants involved in skin and deafness disorders. Cell Commun Adhes (2003) 0.85
Gap-junctional protein connexin 43 is expressed in dermis and epidermis of human skin: differential modulation by retinoids. J Invest Dermatol (1992) 0.83
Connexin gene pathology. Clin Exp Dermatol (2003) 0.83
Formation of permeability barrier in epidermal organotypic culture for studies on drug transport. J Invest Dermatol (2001) 0.82
In vivo modulation of connexins 43 and 26 of human epidermis by topical retinoic acid treatment. J Histochem Cytochem (1997) 0.82
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms. Cell Commun Adhes (2003) 0.82
Divergent effects of two sequence variants of GJB3 (G12D and R32W) on the function of connexin 31 in vitro. Exp Dermatol (2003) 0.81
The expression of gap junctional proteins during different stages of mouse skin carcinogenesis. Carcinogenesis (1995) 0.81
Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development. Dev Dyn (2005) 0.80
Changes in gap junction distribution and connexin expression pattern during human fetal skin development. J Histochem Cytochem (2002) 0.80
Connexin 26 expression and mutation analysis in epidermal disease. Cell Commun Adhes (2001) 0.80
High frequency of GJB2 gene mutations in Polish patients with prelingual nonsyndromic deafness. Genet Test (2001) 0.78
Human connexin disorders of the skin. Cell Commun Adhes (2001) 0.78
Rat epidermal keratinocytes as an organotypic model for examining the role of Cx43 and Cx26 in skin differentiation. Cell Commun Adhes (2006) 0.77
The effects of a mutant connexin 26 on epidermal differentiation. Cell Commun Adhes (2003) 0.76
Cx26 affects the in vitro reconstruction of human epidermis. Cell Commun Adhes (2001) 0.75
Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family. Eur J Hum Genet (2000) 0.75
Multicolor and electron microscopic imaging of connexin trafficking. Science (2002) 5.60
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N Engl J Med (2006) 3.59
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci (2007) 2.41
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (2005) 1.93
Implications and challenges of connexin connections to cancer. Nat Rev Cancer (2010) 1.85
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem (2011) 1.76
The biochemistry and function of pannexin channels. Biochim Biophys Acta (2012) 1.70
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages. PLoS Pathog (2008) 1.49
Gap junction remodeling in skin repair following wounding and disease. Physiology (Bethesda) (2013) 1.49
Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res (2006) 1.48
Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43. J Biol Chem (2005) 1.46
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis. J Mol Med (Berl) (2015) 1.45
Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell (2009) 1.45
Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. J Biol Chem (2002) 1.37
In vitro and in vivo uncaging and bioluminescence imaging by using photocaged upconversion nanoparticles. Angew Chem Int Ed Engl (2012) 1.33
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells. J Biol Chem (2003) 1.32
Marital transitions and mental health: are there gender differences in the short-term effects of marital status change? Soc Sci Med (2005) 1.30
Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture. Breast Cancer Res (2005) 1.27
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol Biol Cell (2007) 1.23
Evaluation of mammary gland development and function in mouse models. J Vis Exp (2011) 1.22
Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci (2005) 1.21
Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction. Circ Res (2011) 1.21
Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res (2005) 1.17
Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol (2007) 1.15
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol (2004) 1.13
Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma. J Biol Chem (2006) 1.10
Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia. J Biol Chem (2007) 1.10
Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface. J Cell Sci (2004) 1.09
Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules. Exp Cell Res (2002) 1.09
Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants. Cell Commun Adhes (2006) 1.07
Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations. J Biol Chem (2004) 1.03
Clinical outcomes after switching treatment from intravitreal ranibizumab to aflibercept in neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol (2013) 1.03
ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. J Bone Miner Res (2008) 1.03
Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem (2010) 1.03
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1. Cancer Res (2010) 1.01
Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. J Bone Miner Res (2011) 0.99
Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia. Dev Biol (2008) 0.97
Mechanisms linking connexin mutations to human diseases. Cell Tissue Res (2014) 0.97
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. J Cell Sci (2010) 0.97
S-nitrosylation inhibits pannexin 1 channel function. J Biol Chem (2012) 0.96
Expression of pannexin isoforms in the systemic murine arterial network. J Vasc Res (2012) 0.95
Diverse subcellular distribution profiles of pannexin 1 and pannexin 3. Cell Commun Adhes (2008) 0.94
Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype. J Biol Chem (2012) 0.94
Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Carcinogenesis (2006) 0.94
Metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (Qishen yiqi pills) in rats. Curr Drug Metab (2012) 0.94
Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovasc Res (2008) 0.93
The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress. Invest Ophthalmol Vis Sci (2008) 0.93
Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques. J Cell Sci (2009) 0.92
Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proc Natl Acad Sci U S A (2008) 0.91
A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse. Biol Reprod (2009) 0.91
Untargeted metabolic profiling reveals potential biomarkers in myocardial infarction and its application. Mol Biosyst (2010) 0.90
Mesenchymal stem cells mitigate cirrhosis through BMP7. Cell Physiol Biochem (2015) 0.89
Connexin levels regulate keratinocyte differentiation in the epidermis. J Biol Chem (2007) 0.89
Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout. J Comp Neurol (2013) 0.89
A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma. Cell Mol Immunol (2013) 0.89
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues. Oncol Lett (2012) 0.88
Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia. Mol Biol Cell (2012) 0.88
Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects. Hum Mutat (2011) 0.88
IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism. J Immunol (2003) 0.88
The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice. Biochem J (2013) 0.87
Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40. Free Radic Biol Med (2010) 0.87
Transport and function of cx26 mutants involved in skin and deafness disorders. Cell Commun Adhes (2003) 0.85
Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo. J Biol Chem (2013) 0.85
The association of APE1 -656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies. BMC Cancer (2011) 0.85
Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia. Dis Model Mech (2009) 0.85
Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2. Virology (2009) 0.85
The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants. Biochem J (2010) 0.84
Pannexin1 and Pannexin3 exhibit distinct localization patterns in human skin appendages and are regulated during keratinocyte differentiation and carcinogenesis. Cell Commun Adhes (2012) 0.84
Chemical fingerprinting and quantitative analysis of a Panax notoginseng preparation using HPLC-UV and HPLC-MS. Chin Med (2011) 0.84
An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series. BMC Ophthalmol (2014) 0.84
Beta3 integrins facilitate matrix interactions during transendothelial migration of PC3 prostate tumor cells. Prostate (2005) 0.83