Published in Development on October 01, 2005
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol (2006) 2.43
Implications and challenges of connexin connections to cancer. Nat Rev Cancer (2010) 1.85
Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling. Mol Biol Cell (2011) 1.63
The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet (2007) 1.61
Cell-cell communication in the osteoblast/osteocyte lineage. Arch Biochem Biophys (2008) 1.52
Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1). J Bone Miner Res (2008) 1.51
Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun Signal (2009) 1.49
Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys (2012) 1.45
Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia. Proc Natl Acad Sci U S A (2007) 1.33
Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues. Biochim Biophys Acta (2011) 1.32
Consequences for enamel development and mineralization resulting from loss of function of ameloblastin or enamelin. Eur J Oral Sci (2009) 1.25
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol Biol Cell (2007) 1.23
The tight junction protein CAR regulates cardiac conduction and cell-cell communication. J Exp Med (2008) 1.23
Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis. J Bone Miner Res (2011) 1.23
Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. Mol Biol Cell (2009) 1.22
Gap junctions couple astrocytes and oligodendrocytes. J Mol Neurosci (2008) 1.16
Connexins and pannexins: Coordinating cellular communication in the testis and epididymis. Spermatogenesis (2011) 1.13
Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence. Can J Physiol Pharmacol (2010) 1.10
Zebrafish short fin mutations in connexin43 lead to aberrant gap junctional intercellular communication. FEBS Lett (2007) 1.08
Gap junctions and hemichannels in signal transmission, function and development of bone. Biochim Biophys Acta (2011) 1.08
Gap junctions in inherited human disorders of the central nervous system. Biochim Biophys Acta (2011) 1.05
ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. Am J Physiol Cell Physiol (2012) 1.05
The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade. J Bone Miner Res (2013) 1.04
The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter. Bone (2011) 1.02
Dysregulation of cell adhesion proteins and cardiac arrhythmogenesis. Clin Med Res (2006) 1.01
Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration. Dev Biol (2012) 1.00
Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A (2009) 0.99
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells. Proc Natl Acad Sci U S A (2012) 0.99
Interaction of connexin43 and protein kinase C-delta during FGF2 signaling. BMC Biochem (2010) 0.98
Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria. Am J Physiol Cell Physiol (2010) 0.98
Gap junctions in inherited human disease. Pflugers Arch (2010) 0.97
Ultrasound biomicroscopy in small animal research: applications in molecular and preclinical imaging. J Biomed Biotechnol (2011) 0.95
Premature osteoblast clustering by enamel matrix proteins induces osteoblast differentiation through up-regulation of connexin 43 and N-cadherin. PLoS One (2011) 0.95
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Exp Hematol (2010) 0.94
Gap junctional regulation of signal transduction in bone cells. FEBS Lett (2014) 0.93
Gap junction intercellular communication: a review of a potential platform to modulate craniofacial tissue engineering. J Biomed Mater Res B Appl Biomater (2009) 0.93
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. Biomed Res Int (2015) 0.92
Connexin 43 channels are essential for normal bone structure and osteocyte viability. J Bone Miner Res (2015) 0.91
A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse. Biol Reprod (2009) 0.91
Bioelectric signaling regulates size in zebrafish fins. PLoS Genet (2014) 0.91
Molecular mechanisms of osteoblast/osteocyte regulation by connexin43. Calcif Tissue Int (2013) 0.91
A nonsense mutation in the first transmembrane domain of connexin 43 underlies autosomal recessive oculodentodigital syndrome. J Med Genet (2006) 0.90
Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects. Hum Mutat (2011) 0.88
Evaluating the role of connexin43 in congenital heart disease: Screening for mutations in patients with outflow tract anomalies and the analysis of knock-in mouse models. J Cardiovasc Dis Res (2011) 0.88
Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia. Mol Biol Cell (2012) 0.88
The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice. Biochem J (2013) 0.87
Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system? Front Pharmacol (2013) 0.87
Novel mutations in GJA1 cause oculodentodigital syndrome. J Dent Res (2008) 0.87
Reduction of electrical coupling between microvascular endothelial cells by NO depends on connexin37. Am J Physiol Heart Circ Physiol (2009) 0.86
Role of connexins in human congenital heart disease: the chicken and egg problem. Front Pharmacol (2013) 0.86
Determining how defects in connexin43 cause skeletal disease. Genesis (2012) 0.85
Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia. Dis Model Mech (2009) 0.85
Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body. Invest Ophthalmol Vis Sci (2009) 0.85
Connexin diversity in the heart: insights from transgenic mouse models. Front Pharmacol (2013) 0.84
CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN. Actual osteol (2011) 0.84
The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants. Biochem J (2010) 0.84
Connexin43 modulates post-natal cortical bone modeling and mechano-responsiveness. Bonekey Rep (2013) 0.83
Connexin43 modulation of osteoblast/osteocyte apoptosis: a potential therapeutic target? J Bone Miner Res (2008) 0.82
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more. Cell Mol Life Sci (2015) 0.81
Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. J Biol Chem (2015) 0.81
A dominant connexin43 mutant does not have dominant effects on gap junction coupling in astrocytes. Neuron Glia Biol (2011) 0.81
Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures. Mol Biol Cell (2015) 0.80
The effect of mechanical stimulation on mineralization in differentiating osteoblasts in collagen-I scaffolds. Tissue Eng Part A (2014) 0.79
A case of oculodentodigital dysplasia syndrome with novel GJA1 gene mutation. Jpn J Ophthalmol (2009) 0.79
Connexins in the skeleton. Semin Cell Dev Biol (2015) 0.78
Characterization of gap junction proteins in the bladder of Cx43 mutant mouse models of oculodentodigital dysplasia. J Membr Biol (2012) 0.78
Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens. Exp Hematol (2011) 0.78
Transcription factor FoxO1 is essential for enamel biomineralization. PLoS One (2012) 0.78
Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS One (2016) 0.78
Myogenic bladder defects in mouse models of human oculodentodigital dysplasia. Biochem J (2014) 0.77
Gap Junctions and Biophysical Regulation of Bone Cells. Clin Rev Bone Miner Metab (2010) 0.76
If the skull fits: magnetic resonance imaging and microcomputed tomography for combined analysis of brain and skull phenotypes in the mouse. Physiol Genomics (2012) 0.76
Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell (2016) 0.76
Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone. BMC Cell Biol (2016) 0.75
Advances in the Molecular Genetics of Non-syndromic Syndactyly. Curr Genomics (2015) 0.75
Connexin mutant embryonic stem cells and human diseases. World J Stem Cells (2014) 0.75
Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling. Curr Osteoporos Rep (2017) 0.75
Impact of obesity on 7,12-dimethylbenz[a]anthracene-induced altered ovarian connexin gap junction proteins in female mice. Toxicol Appl Pharmacol (2014) 0.75
Mind the Gaps in Tumor Immunity: Impact of Connexin-Mediated Intercellular Connections. Front Immunol (2017) 0.75
Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function. J Bone Miner Res (2017) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
Connexins and Pannexins in Bone and Skeletal Muscle. Curr Osteoporos Rep (2017) 0.75
Identification of human brain tumour initiating cells. Nature (2004) 38.87
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09
A mouse for all reasons. Cell (2007) 9.01
Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell (2005) 7.30
miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59
T1, T2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med (2005) 6.17
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
Multicolor and electron microscopic imaging of connexin trafficking. Science (2002) 5.60
Severe expressive-language delay related to duplication of the Williams-Beuren locus. N Engl J Med (2005) 5.37
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell (2009) 5.19
Endothelial cells and VEGF in vascular development. Nature (2005) 4.92
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development (2005) 4.89
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell (2006) 4.77
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell (2007) 4.39
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22
Retinoid signaling determines germ cell fate in mice. Science (2006) 4.17
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature (2004) 4.09
Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest (2003) 4.04
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature (2009) 3.70
Behavioral phenotypes of Disc1 missense mutations in mice. Neuron (2007) 3.68
Molecular profiling of non-small cell lung cancer and correlation with disease-free survival. Cancer Res (2002) 3.68
Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N Engl J Med (2006) 3.59
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40
Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development (2003) 3.14
Human chromosome 7: DNA sequence and biology. Science (2003) 3.02
Concise review: stem cell antigen-1: expression, function, and enigma. Stem Cells (2007) 2.97
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development (2005) 2.91
Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J (2007) 2.91
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood (2005) 2.76
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69
The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65
Ethics. The ISSCR guidelines for human embryonic stem cell research. Science (2007) 2.62
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst. Development (2010) 2.60
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes (2009) 2.58
Emerging risk factors for coronary heart disease: a summary of systematic reviews conducted for the U.S. Preventive Services Task Force. Ann Intern Med (2009) 2.56
Atelectasis causes alveolar injury in nonatelectatic lung regions. Am J Respir Crit Care Med (2006) 2.56
Crystal-associated nephropathy in patients with brushite nephrolithiasis. Kidney Int (2005) 2.51
Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods (2009) 2.51
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci (2007) 2.41
The role of FGF/Erk signaling in pluripotent cells. Development (2010) 2.40
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet (2012) 2.39
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol (2003) 2.34
Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells. Cell Stem Cell (2008) 2.31
Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol (2006) 2.27
Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol (2007) 2.26
Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. J Biol Chem (2003) 2.26
A new partner for the international knockout mouse consortium. Cell (2007) 2.23
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab (2013) 2.21
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J (2004) 2.18
Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet (2005) 2.15
Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. Blood (2002) 2.15
Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia. Am J Hum Genet (2006) 2.14
Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage. Genesis (2003) 2.14
The fetal cardiovascular response to antenatal steroids in severe early-onset intrauterine growth restriction. Am J Obstet Gynecol (2004) 2.13
MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CNS demyelination: a prospective national cohort study. Lancet Neurol (2011) 2.12
Multiple-mouse MRI. Magn Reson Med (2003) 2.10
Cell and molecular regulation of the mouse blastocyst. Dev Dyn (2006) 2.10
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol (2006) 2.10
Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice. Proc Natl Acad Sci U S A (2003) 2.09
Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A (2004) 2.08
β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell (2011) 2.07
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature (2007) 2.06
Mouse embryonic chimeras: tools for studying mammalian development. Development (2003) 2.06
Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development (2010) 2.05
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Early changes in lung gene expression due to high tidal volume. Am J Respir Crit Care Med (2003) 2.03
Stem cells. Setting standards for human embryonic stem cells. Science (2003) 1.95
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell (2008) 1.94
Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A (2011) 1.92