Published in J Biol Chem on February 25, 2004
The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest (2008) 5.27
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest (2009) 3.70
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest (2012) 2.62
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci U S A (2004) 2.29
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J (2007) 2.07
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest (2005) 2.01
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest (2005) 1.84
Adipocyte CREB promotes insulin resistance in obesity. Cell Metab (2009) 1.72
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest (2008) 1.71
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest (2010) 1.70
Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene (2010) 1.68
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab (2012) 1.64
LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest (2012) 1.58
Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev (2014) 1.58
Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol Endocrinol (2010) 1.47
Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment. World J Gastroenterol (2008) 1.43
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci U S A (2009) 1.42
Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD. Circ Cardiovasc Genet (2015) 1.38
Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity. J Biol Chem (2008) 1.36
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver. Diabetes (2011) 1.28
Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression. PLoS One (2011) 1.27
Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? Biochim Biophys Acta (2011) 1.27
Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis. J Lipid Res (2010) 1.26
Molecular pathways in non-alcoholic fatty liver disease. Clin Exp Gastroenterol (2014) 1.25
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J Biol Chem (2009) 1.22
Tpk3 and Snf1 protein kinases regulate Rgt1 association with Saccharomyces cerevisiae HXK2 promoter. Nucleic Acids Res (2006) 1.16
Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol (2009) 1.07
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal (2016) 1.02
Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis. Free Radic Biol Med (2013) 0.97
Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase. Biochem J (2006) 0.96
Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem (2012) 0.96
Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone. Endocrinology (2009) 0.95
Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner. J Biol Chem (2010) 0.93
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A (2012) 0.92
Fenofibrate improves renal lipotoxicity through activation of AMPK-PGC-1α in db/db mice. PLoS One (2014) 0.92
The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways. Mol Cell Biol (2008) 0.92
O-GlcNAcylation and Metabolic Reprograming in Cancer. Front Endocrinol (Lausanne) (2014) 0.91
ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells. Proc Natl Acad Sci U S A (2014) 0.90
Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. Lab Invest (2014) 0.90
Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver disease. J Lipids (2011) 0.90
PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol Metab (2013) 0.89
N-acetylglucosamine kinase, HXK1 is involved in morphogenetic transition and metabolic gene expression in Candida albicans. PLoS One (2013) 0.89
A pathway approach to investigate the function and regulation of SREBPs. Genes Nutr (2013) 0.89
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis. Nutrients (2015) 0.87
Increasing protein at the expense of carbohydrate in the diet down-regulates glucose utilization as glucose sparing effect in rats. PLoS One (2011) 0.85
Fatty liver disease in children: eat now pay later. Hepatol Int (2010) 0.85
The short isoform of the ubiquitin ligase NEDD4L is a CREB target gene in hepatocytes. PLoS One (2013) 0.85
Differential expression of A-type and B-type lamins during hair cycling. PLoS One (2009) 0.84
Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem (2013) 0.84
Loss of sugar detection by GLUT2 affects glucose homeostasis in mice. PLoS One (2007) 0.84
A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism. Diabetes (2015) 0.83
Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores. Front Endocrinol (Lausanne) (2013) 0.82
Metabolic consequences of microRNA-122 inhibition in rainbow trout, Oncorhynchus mykiss. BMC Genomics (2014) 0.81
Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in rats. Diabetologia (2012) 0.81
Independent association between low serum amylase and non-alcoholic fatty liver disease in asymptomatic adults: a cross-sectional observational study. BMJ Open (2013) 0.81
Postprandial regulation of growth- and metabolism-related factors in zebrafish. Zebrafish (2013) 0.81
A model of insulin resistance in mice, born to diabetic pregnancy, is associated with alterations of transcription-related genes in pancreas and epididymal adipose tissue. J Obes (2010) 0.80
A very low carbohydrate ketogenic diet prevents the progression of hepatic steatosis caused by hyperglycemia in a juvenile obese mouse model. Nutr Diabetes (2012) 0.80
Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance. Cardiovasc Diabetol (2009) 0.80
Transcriptional regulation of mitochondrial glycerophosphate acyltransferase is mediated by distal promoter via ChREBP and SREBP-1. Arch Biochem Biophys (2009) 0.80
Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice. Acta Pharmacol Sin (2014) 0.80
The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals. PLoS Genet (2014) 0.79
O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing. Front Endocrinol (Lausanne) (2015) 0.79
ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β-Cell Line. PLoS One (2016) 0.79
FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance. Endocrinology (2015) 0.79
Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming". Hepat Mon (2014) 0.78
Influence of fat/carbohydrate ratio on progression of fatty liver disease and on development of osteopenia in male rats fed alcohol via total enteral nutrition (TEN). Alcohol (2014) 0.78
Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile. PLoS One (2014) 0.78
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. PLoS One (2014) 0.78
Metabolic fuel selection: the importance of being flexible. J Clin Invest (2004) 0.77
Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1α with CREB-binding protein. Diabetes (2012) 0.77
Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism. PLoS One (2014) 0.77
Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis. Elife (2016) 0.76
ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways. Oncotarget (2016) 0.76
Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression. Am J Physiol Gastrointest Liver Physiol (2015) 0.76
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J Med Genet (2016) 0.75
Effect of high-intensity exercise and high-fat diet on lipid metabolism in the liver of rats. J Exerc Nutrition Biochem (2015) 0.75
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20. Nat Commun (2017) 0.75
Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9). Cardiovasc Diabetol (2016) 0.75
Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose. Sci Rep (2016) 0.75
Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway. Int J Clin Exp Med (2015) 0.75
Effects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP. Drug Des Devel Ther (2016) 0.75
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest (2016) 0.75
BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene. Sci Rep (2017) 0.75
Conformational Characteristics of Rice Hexokinase OsHXK7 as a Moonlighting Protein involved in Sugar Signalling and Metabolism. Protein J (2017) 0.75
A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response. Cell Rep (2017) 0.75
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature (2004) 7.64
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest (2008) 5.27
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell (2006) 5.19
Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab (2002) 4.45
Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med (2005) 4.14
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity (2010) 4.06
Allosteric activators of glucokinase: potential role in diabetes therapy. Science (2003) 3.97
SREBP transcription factors: master regulators of lipid homeostasis. Biochimie (2004) 3.85
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell (2009) 3.78
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest (2009) 3.70
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A (2004) 3.40
Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest (2012) 2.62
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2005) 2.60
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature (2002) 2.59
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab (2007) 2.47
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes (2006) 2.43
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J (2002) 2.41
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol (2007) 2.32
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes (2010) 2.30
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem (2003) 2.23
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr (2007) 2.15
AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol (2002) 2.14
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc Natl Acad Sci U S A (2005) 2.13
Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol (2003) 2.12
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (2006) 2.09
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A (2009) 2.09
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem (2003) 2.07
Hepatokines: unlocking the multi-organ network in metabolic diseases. Diabetologia (2015) 2.05
Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem (2005) 2.04
MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes (2010) 2.01
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest (2005) 2.01
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circ Res (2008) 1.98
Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med (2011) 1.95
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem J (2002) 1.87
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem (2004) 1.86
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem (2002) 1.85
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest (2005) 1.84
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie (2005) 1.82
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes (2006) 1.80
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). J Cell Sci (2002) 1.79
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev (2007) 1.79
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest (2008) 1.71
Functions of AMP-activated protein kinase in adipose tissue. J Physiol (2006) 1.70
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest (2010) 1.70
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol (2007) 1.68
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol (2008) 1.67
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab (2012) 1.64
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene (2003) 1.62
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol (2006) 1.61
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol (2003) 1.60
Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. J Biol Chem (2001) 1.59
LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest (2012) 1.58
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res (2005) 1.57
Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie (2005) 1.55
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev (2008) 1.54
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem (2005) 1.54
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J (2003) 1.51
Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators. Bioorg Med Chem (2006) 1.51
Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol (2005) 1.50
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: a role for caveolar endocytosis. Traffic (2006) 1.48
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis (2005) 1.42
The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). J Biol Chem (2002) 1.41
Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett (2002) 1.41
Control of gene expression by fatty acids. J Nutr (2004) 1.41
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet (2005) 1.40
Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest (2009) 1.39
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation (2011) 1.38
Novel insights into ChREBP regulation and function. Trends Endocrinol Metab (2013) 1.38
Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass. J Clin Invest (2003) 1.37
Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet (2013) 1.37
Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes (2011) 1.37