Published in Proc Natl Acad Sci U S A on June 01, 2009
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell (2012) 4.88
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development (2011) 3.11
Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet (2012) 2.75
Direct lineage conversions: unnatural but useful? Nat Biotechnol (2011) 2.69
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol (2013) 2.06
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development (2009) 1.81
Cellular plasticity within the pancreas--lessons learned from development. Dev Cell (2010) 1.58
No evidence for β cell neogenesis in murine adult pancreas. J Clin Invest (2013) 1.54
Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS One (2012) 1.50
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol (2009) 1.46
Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab (2014) 1.45
Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci (2010) 1.40
Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes (2011) 1.30
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet (2013) 1.28
The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression. BMC Genomics (2014) 1.26
β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes (2013) 1.22
TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation. Diabetes (2012) 1.21
Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development (2010) 1.21
Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a. Proc Natl Acad Sci U S A (2010) 1.19
Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife (2013) 1.19
Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell (2010) 1.13
Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas. Cell Death Dis (2013) 1.11
Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep (2012) 1.03
De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts. Cell Rep (2014) 1.02
Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes (2012) 0.99
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A (2011) 0.99
Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol (2012) 0.98
Deconstructing pancreas developmental biology. Cold Spring Harb Perspect Biol (2012) 0.98
Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One (2012) 0.97
Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Curr Opin Organ Transplant (2010) 0.95
Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med (2012) 0.95
Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas. J Biol Chem (2013) 0.94
Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development (2011) 0.93
Differential regulation of embryonic and adult β cell replication. Cell Cycle (2012) 0.93
Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis (2012) 0.93
Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes. Cell Death Dis (2011) 0.92
Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function. Diabetes (2015) 0.91
Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol (2012) 0.91
Neurogenin3 cooperates with Foxa2 to autoactivate its own expression. J Biol Chem (2013) 0.90
Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development. Dev Biol (2011) 0.90
Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. Endocrinology (2010) 0.89
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell (2017) 0.88
An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development. PLoS Genet (2014) 0.87
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest (2016) 0.87
Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells. Genes Dev (2016) 0.87
Sox9: a master regulator of the pancreatic program. Rev Diabet Stud (2014) 0.84
The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement. Rev Diabet Stud (2010) 0.84
Endocrine-committed progenitor cells retain their differentiation potential in the absence of neurogenin-3 expression. Biochem Biophys Res Commun (2010) 0.83
Insulin producing cells established using non-integrated lentiviral vector harboring PDX1 gene. World J Stem Cells (2013) 0.82
A mouse model for monitoring islet cell genesis and developing therapies for diabetes. Dis Model Mech (2010) 0.81
Synergizing genomic analysis with biological knowledge to identify and validate novel genes in pancreatic development. Pancreas (2012) 0.81
Proliferating pancreatic beta-cells upregulate ALDH. Histochem Cell Biol (2014) 0.81
Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS One (2015) 0.81
The window period of NEUROGENIN3 during human gestation. Islets (2014) 0.81
Stem cell-based approaches for the treatment of diabetes. Stem Cells Int (2011) 0.81
Contribution of a non-β-cell source to β-cell mass during pregnancy. PLoS One (2014) 0.81
Stem cell approaches for the treatment of type 1 diabetes mellitus. Transl Res (2010) 0.80
Development and regeneration in the endocrine pancreas. ISRN Endocrinol (2012) 0.79
Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene Transduction. Diabetes (2015) 0.79
Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell mass. Islets (2012) 0.79
Reprogramming into pancreatic endocrine cells based on developmental cues. Mol Cell Endocrinol (2009) 0.79
Pancreatic Beta Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes. Diabetes (2016) 0.78
Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cells. F1000 Biol Rep (2010) 0.78
Obestatin enhances in vitro generation of pancreatic islets through regulation of developmental pathways. PLoS One (2013) 0.78
Organogenesis and functional genomics of the endocrine pancreas. Cell Mol Life Sci (2012) 0.77
Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Dev Cell (2017) 0.76
Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation. Dev Cell (2017) 0.76
β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas. J Diabetes Investig (2016) 0.75
Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol (2015) 0.75
Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Commun Signal (2016) 0.75
Stem Cells in the Treatment of Insulin-Dependent Diabetes Mellitus. Acta Naturae (2016) 0.75
In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors. Rev Diabet Stud (2014) 0.75
Beta Cell Regeneration in Adult Mice: Controversy Over the Involvement of Stem Cells. Curr Stem Cell Res Ther (2016) 0.75
Directed differentiation of progenitor cells towards an islet-cell phenotype. Am J Stem Cells (2012) 0.75
Characterization of β-cell plasticity mechanisms induced in mice by a transient source of exogenous insulin. Am J Physiol Endocrinol Metab (2013) 0.75
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 8.57
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34
Control of endodermal endocrine development by Hes-1. Nat Genet (2000) 7.71
Notch signalling controls pancreatic cell differentiation. Nature (1999) 7.18
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development (2000) 4.71
SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A (2007) 4.19
Universality and structure of the N-end rule. J Biol Chem (1989) 3.97
Attenuation of green fluorescent protein half-life in mammalian cells. Protein Eng (1999) 3.65
Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes (2000) 3.46
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev (2002) 3.22
Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell (2007) 2.68
Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol (2004) 2.68
A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol (2006) 2.62
Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis (2000) 2.48
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev (2001) 2.29
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Natl Acad Sci U S A (2004) 2.14
Defining pancreatic endocrine precursors and their descendants. Diabetes (2007) 1.65
Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol (2008) 1.55
Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells. Diabetologia (2007) 1.49
Biphasic Ngn3 expression in the developing pancreas. Dev Dyn (2008) 1.47
MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Dev Biol (2007) 1.38
Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes (2005) 1.38
Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci U S A (2005) 1.35
Impaired neural development caused by inducible expression of Axin in transgenic mice. Mech Dev (2006) 1.32
Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev (2007) 1.20
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol (2006) 1.20
Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. Biochem Biophys Res Commun (2005) 1.13
Generation of monoclonal antibodies against mouse neurogenin 3: a new immunocytochemical tool to study the pancreatic endocrine progenitor cell. Hybrid Hybridomics (2004) 0.92
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell (2006) 9.32
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell (2006) 5.19
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med (2002) 5.10
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47
Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab (2002) 4.45
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev (2005) 4.41
Recovery from diabetes in mice by beta cell regeneration. J Clin Invest (2007) 4.32
SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A (2007) 4.19
Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med (2005) 4.14
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity (2010) 4.06
Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev (2003) 4.00
Allosteric activators of glucokinase: potential role in diabetes therapy. Science (2003) 3.97
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell (2009) 3.78
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology (2007) 3.41
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A (2004) 3.40
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology (2011) 3.19
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem (2004) 3.17
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development (2011) 3.11
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08
Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology (2010) 2.73
Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71
Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell (2007) 2.68
An illustrated review of early pancreas development in the mouse. Endocr Rev (2007) 2.68
The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development (2005) 2.63
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2005) 2.60
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature (2002) 2.59
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab (2007) 2.47
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41
Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol (2008) 2.35
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol (2007) 2.32
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes (2010) 2.30
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest (2013) 2.18
Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev (2011) 2.17
Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev (2006) 2.15
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Natl Acad Sci U S A (2004) 2.14
Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron (2005) 2.12
Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol (2003) 2.12
A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. Genesis (2008) 2.10
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (2006) 2.09
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem (2003) 2.07
NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development (2005) 2.03
MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes (2010) 2.01
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development (2005) 1.98
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circ Res (2008) 1.98
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol (2008) 1.96
Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell (2010) 1.90
Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A (2009) 1.86
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem (2004) 1.86
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem (2002) 1.85
Specifying pancreatic endocrine cell fates. Mech Dev (2006) 1.84
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes (2006) 1.80
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol (2002) 1.79
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol (2008) 1.79
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell (2013) 1.79
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev (2007) 1.79
Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells. Diabetes (2007) 1.78
miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors. EMBO J (2011) 1.75
A transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation. Dev Cell (2012) 1.72
LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab (2009) 1.70
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol (2007) 1.68
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol (2008) 1.67
Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. J Bone Miner Res (2013) 1.64
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene (2003) 1.62
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol (2006) 1.61
Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn (2002) 1.61
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol (2003) 1.60
Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol (2008) 1.55
Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep (2013) 1.55
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev (2008) 1.54
Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol (2006) 1.54
Genetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 1.54
The activating receptor NKp46 is essential for the development of type 1 diabetes. Nat Immunol (2009) 1.54
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem (2005) 1.54
The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development (2007) 1.54
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J (2003) 1.51
Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol (2005) 1.50
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3. Diabetes (2011) 1.47
Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol (2009) 1.46
Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn (2003) 1.43
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis (2005) 1.42
Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia. J Biol Chem (2002) 1.42
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet (2005) 1.40