Published in J Cell Sci on March 01, 2004
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26
Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol (2007) 2.33
Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol Cell Biol (2004) 2.31
Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol (2009) 2.21
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev Cell (2010) 1.87
Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61
Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60
Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood (2008) 1.52
Rho GTPases in hematopoiesis and hemopathies. Blood (2009) 1.37
Generation and characterization of Rac3 knockout mice. Mol Cell Biol (2005) 1.37
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci (2008) 1.32
Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis. Mol Cell Biol (2009) 1.29
Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages. J Cell Sci (2009) 1.28
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A (2009) 1.27
Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. J Cell Biol (2009) 1.23
Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J Cell Biol (2007) 1.21
Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A (2008) 1.20
S100A4 regulates macrophage chemotaxis. Mol Biol Cell (2010) 1.19
p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration. Blood (2005) 1.13
Phosphorylation of p130Cas initiates Rac activation and membrane ruffling. BMC Cell Biol (2008) 1.12
Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol (2006) 1.12
Osteoclast motility: putting the brakes on bone resorption. Ageing Res Rev (2009) 1.12
Critical roles for Rac GTPases in T-cell migration to and within lymph nodes. Blood (2010) 1.11
The unique N-terminus of R-ras is required for Rac activation and precise regulation of cell migration. Mol Biol Cell (2005) 1.11
CSF-1 receptor signaling in myeloid cells. Cold Spring Harb Perspect Biol (2014) 1.10
Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol (2005) 1.10
Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2009) 1.09
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Oncogene (2009) 1.07
Rac activation by the T-cell receptor inhibits T cell migration. PLoS One (2010) 1.03
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms. Am J Pathol (2012) 0.99
Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J Biol Chem (2011) 0.99
Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation. J Neuroinflammation (2014) 0.97
Macrophage Migration and Its Regulation by CSF-1. Int J Cell Biol (2012) 0.93
Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging. Cell Death Dis (2013) 0.92
Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development (2009) 0.91
Nox2 is required for macrophage chemotaxis towards CSF-1. PLoS One (2013) 0.89
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol (2011) 0.88
Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12. Mol Cell Biol (2013) 0.88
Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent. PLoS One (2010) 0.88
Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages. J Biol Chem (2011) 0.87
Human macrophage ATP7A is localized in the trans-Golgi apparatus, controls intracellular copper levels, and mediates macrophage responses to dermal wounds. Inflammation (2012) 0.86
Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity. Calcif Tissue Int (2010) 0.86
Ruffles limit diffusion in the plasma membrane during macropinosome formation. J Cell Sci (2011) 0.86
Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis. Arch Biochem Biophys (2011) 0.86
Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages. J Biol Chem (2009) 0.84
PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol (2011) 0.82
Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis (2013) 0.81
Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis. Free Radic Biol Med (2015) 0.78
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases. Open Rheumatol J (2012) 0.78
The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis. PLoS One (2014) 0.77
Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells. Biol Open (2015) 0.77
Interaction of crk with Myosin-1c participates in fibronectin-induced cell spreading. Int J Biol Sci (2013) 0.77
Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression. Cell Adh Migr (2015) 0.76
Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells. Mol Cell Biol (2016) 0.75
Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. PLoS One (2016) 0.75
Optical Tools To Study the Isoform-Specific Roles of Small GTPases in Immune Cells. J Immunol (2016) 0.75
The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis. Sci Rep (2017) 0.75
Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol (2008) 8.99
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol (2007) 8.92
Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol (2003) 8.68
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00
Rho GTPases in cancer cell biology. FEBS Lett (2008) 4.47
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature (2008) 3.19
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med (2009) 3.12
Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains. Nat Cell Biol (2006) 3.08
Rho GTPases and the regulation of endothelial permeability. Vascul Pharmacol (2002) 2.88
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood (2004) 2.84
Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res (2004) 2.83
Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol (2008) 2.62
RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol (2011) 2.59
RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42
Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science (2004) 2.20
Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol (2003) 2.14
Roles of Rho/ROCK and MLCK in TNF-alpha-induced changes in endothelial morphology and permeability. J Cell Physiol (2007) 2.03
Crossing the endothelial barrier during metastasis. Nat Rev Cancer (2013) 2.00
Phosphoinositide 3-kinases in cell migration. Biol Cell (2009) 1.95
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell (2013) 1.90
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J Biol Chem (2002) 1.88
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol (2008) 1.83
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology (2004) 1.82
IQGAP1 promotes cell motility and invasion. J Biol Chem (2003) 1.72
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci (2006) 1.70
Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A (2006) 1.64
Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res (2002) 1.63
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells. Dev Cell (2006) 1.55
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol Cell (2003) 1.53
Adherens junctions connect stress fibres between adjacent endothelial cells. BMC Biol (2010) 1.52
Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nat Immunol (2013) 1.51
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells. PLoS One (2010) 1.49
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J (2007) 1.48
RhoE inhibits cell cycle progression and Ras-induced transformation. Mol Cell Biol (2004) 1.41
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. J Cell Sci (2008) 1.39
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell Host Microbe (2011) 1.36
Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells. Circ Res (2006) 1.35
Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration. J Cell Biol (2010) 1.35
Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis. Blood (2005) 1.34
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci (2008) 1.32
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol (2006) 1.31
Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation. Nat Immunol (2008) 1.30
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol (2011) 1.30
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1. J Cell Biol (2010) 1.28
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells. J Immunol (2002) 1.25
Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1. Exp Cell Res (2003) 1.25
PAK4 is activated via PI3K in HGF-stimulated epithelial cells. J Cell Sci (2002) 1.24
Cell migration in development and disease. Dev Cell (2002) 1.23
Rnd proteins: multifunctional regulators of the cytoskeleton and cell cycle progression. Bioessays (2010) 1.21
Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. J Cell Biol (2012) 1.20
Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration. J Biol Chem (2004) 1.20
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J (2009) 1.19
p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation. J Biol Chem (2003) 1.18
Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migration. Proc Natl Acad Sci U S A (2008) 1.17
Cell motility: braking WAVEs. Nature (2002) 1.14
RhoB affects macrophage adhesion, integrin expression and migration. Exp Cell Res (2007) 1.13
T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice. J Clin Invest (2008) 1.13
Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering. J Biol Chem (2004) 1.12
Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. J Biol Chem (2003) 1.11
PAK1 and PAK2 have different roles in HGF-induced morphological responses. Cell Signal (2009) 1.10
Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases. Eur J Immunol (2002) 1.10
SnapShot: Rho family GTPases. Cell (2007) 1.10
Rho GTPases and cell cycle control. Growth Factors (2006) 1.08
The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. J Biol Chem (2003) 1.08
CD44 involvement in autoimmune inflammations: the lesson to be learned from CD44-targeting by antibody or from knockout mice. Ann N Y Acad Sci (2007) 1.08
Rho GTPases and leucocyte-induced endothelial remodelling. Biochem J (2005) 1.07
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Mol Biol Cell (2006) 1.07
The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis. Blood (2011) 1.07
Rac activation by the T-cell receptor inhibits T cell migration. PLoS One (2010) 1.03
p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells. PLoS One (2010) 1.02
Radixin regulates cell migration and cell-cell adhesion through Rac1. J Cell Sci (2012) 1.00
Analysis of cell migration using the Dunn chemotaxis chamber and time-lapse microscopy. Methods Mol Biol (2005) 0.98
Transcriptional regulation of the small GTPase RhoB gene by TGF{beta}-induced signaling pathways. FASEB J (2009) 0.95
Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. J Biol Chem (2006) 0.94
Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol (2012) 0.94
Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization. Exp Cell Res (2005) 0.94
Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin. FEBS Lett (2006) 0.93
RhoB regulates cell migration through altered focal adhesion dynamics. Open Biol (2012) 0.93
CSF-1 and PI 3-kinase regulate podosome distribution and assembly in macrophages. Cell Motil Cytoskeleton (2006) 0.93
Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing. J Biol Chem (2006) 0.92
Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development (2009) 0.91
RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. J Biol Chem (2009) 0.91
Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation. Exp Cell Res (2009) 0.90
In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin. J Biol Chem (2009) 0.90
RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific. Circ Res (2004) 0.89
T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue. Blood (2008) 0.89
Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent. PLoS One (2010) 0.88
Rho GTPases and cancer cell transendothelial migration. Methods Mol Biol (2012) 0.88
Multiple roles for RhoA during T cell transendothelial migration. Small GTPases (2010) 0.88
Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein. Biochemistry (2002) 0.88
FMNL1 promotes proliferation and migration of leukemia cells. J Leukoc Biol (2013) 0.87
RhoB regulates uPAR signalling. J Cell Sci (2012) 0.87