Published in Mol Cell Biol on September 01, 2004
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. Cancer Res (2009) 1.21
B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization. Mol Biol Cell (2007) 1.15
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice. PLoS One (2011) 1.05
RhoE Is required for keratinocyte differentiation and stratification. Mol Biol Cell (2008) 1.05
Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway. Mol Biol Cell (2007) 1.04
Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells. PLoS One (2010) 1.01
A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets. Int J Cancer (2011) 0.95
Low-dose chemotherapeutic agents regulate small Rho GTPase activity in dendritic cells. J Immunother (2008) 0.92
Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling. Proc Natl Acad Sci U S A (2013) 0.91
Rnd3 coordinates early steps of cortical neurogenesis through actin-dependent and -independent mechanisms. Nat Commun (2013) 0.91
RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. J Biol Chem (2009) 0.91
Rnd3 regulates lung cancer cell proliferation through notch signaling. PLoS One (2014) 0.90
Regulation of the microRNA 200b (miRNA-200b) by transcriptional regulators PEA3 and ELK-1 protein affects expression of Pin1 protein to control anoikis. J Biol Chem (2013) 0.87
Newcastle disease virus interaction in targeted therapy against proliferation and invasion pathways of glioblastoma multiforme. Biomed Res Int (2014) 0.86
Rnd3 induces stress fibres in endothelial cells through RhoB. Biol Open (2012) 0.85
Function and regulation of Rnd proteins in cortical projection neuron migration. Front Neurosci (2015) 0.85
Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling. Cancer Res (2014) 0.85
The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression. J Biol Chem (2013) 0.83
Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res (2014) 0.83
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell Death Dis (2014) 0.82
Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells. Cell Death Dis (2014) 0.82
The GTPase-deficient Rnd proteins are stabilized by their effectors. J Biol Chem (2012) 0.81
Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer. Autophagy (2016) 0.79
High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer. Oxid Med Cell Longev (2015) 0.79
Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity. Cancer Med (2015) 0.79
RhoE promotes metastasis in gastric cancer through a mechanism dependent on enhanced expression of CXCR4. PLoS One (2013) 0.79
RhoE is required for contact inhibition and negatively regulates tumor initiation and progression. Oncotarget (2015) 0.78
Viability reduction and Rac1 gene downregulation of heterogeneous ex-vivo glioma acute slice infected by the oncolytic Newcastle disease virus strain V4UPM. Biomed Res Int (2013) 0.77
Pathophysiological Functions of Rnd3/RhoE. Compr Physiol (2015) 0.77
Rnd3 as a Novel Target to Ameliorate Microvascular Leakage. J Am Heart Assoc (2016) 0.76
RhoE is regulated by cyclic AMP and promotes fusion of human BeWo choriocarcinoma cells. PLoS One (2012) 0.75
RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion. Oncotarget (2016) 0.75
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Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes. Mol Biol Cell (2003) 1.18
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Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene. Oncogene (1999) 0.98
Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells. Oncogene (2002) 0.97
Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer (2000) 0.89
Identification of genes involved in estrogenic action in the human prostate using microarray analysis. Genomics (2004) 0.86
Rnd proteins: a new family of Rho-related proteins that interfere with the assembly of filamentous actin structures and cell adhesion. Prog Mol Subcell Biol (1999) 0.85
Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol (2008) 8.99
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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature (2008) 3.19
Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains. Nat Cell Biol (2006) 3.08
Rho GTPases and the regulation of endothelial permeability. Vascul Pharmacol (2002) 2.88
Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res (2004) 2.83
RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol (2011) 2.59
RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42
Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol (2003) 2.14
Roles of Rho/ROCK and MLCK in TNF-alpha-induced changes in endothelial morphology and permeability. J Cell Physiol (2007) 2.03
Crossing the endothelial barrier during metastasis. Nat Rev Cancer (2013) 2.00
Phosphoinositide 3-kinases in cell migration. Biol Cell (2009) 1.95
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell (2013) 1.90
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J Cell Sci (2004) 1.88
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J Biol Chem (2002) 1.88
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology (2004) 1.82
Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding. Curr Biol (2007) 1.75
IQGAP1 promotes cell motility and invasion. J Biol Chem (2003) 1.72
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci (2006) 1.70
Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A (2006) 1.64
Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res (2002) 1.63
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol Cell (2003) 1.53
Adherens junctions connect stress fibres between adjacent endothelial cells. BMC Biol (2010) 1.52
Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells. PLoS One (2010) 1.49
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J (2007) 1.48
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol (2010) 1.40
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. J Cell Sci (2008) 1.39
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells. Circ Res (2006) 1.35
Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration. J Cell Biol (2010) 1.35
Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis. Blood (2005) 1.34
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci (2008) 1.32
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol (2011) 1.30
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1. J Cell Biol (2010) 1.28
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells. J Immunol (2002) 1.25
Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1. Exp Cell Res (2003) 1.25
PAK4 is activated via PI3K in HGF-stimulated epithelial cells. J Cell Sci (2002) 1.24
Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Nat Commun (2013) 1.24
Cell migration in development and disease. Dev Cell (2002) 1.23
Rnd proteins: multifunctional regulators of the cytoskeleton and cell cycle progression. Bioessays (2010) 1.21
Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. J Cell Biol (2012) 1.20
Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration. J Biol Chem (2004) 1.20
The RhoA/ROCK-I/MLC pathway is involved in the ethanol-induced apoptosis by anoikis in astrocytes. J Cell Sci (2006) 1.20
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J (2009) 1.19
p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation. J Biol Chem (2003) 1.18
Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migration. Proc Natl Acad Sci U S A (2008) 1.17
Cell motility: braking WAVEs. Nature (2002) 1.14
RhoB affects macrophage adhesion, integrin expression and migration. Exp Cell Res (2007) 1.13
T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice. J Clin Invest (2008) 1.13
Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering. J Biol Chem (2004) 1.12
Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. J Biol Chem (2003) 1.11
PAK1 and PAK2 have different roles in HGF-induced morphological responses. Cell Signal (2009) 1.10
Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases. Eur J Immunol (2002) 1.10
SnapShot: Rho family GTPases. Cell (2007) 1.10
Rho GTPases and cell cycle control. Growth Factors (2006) 1.08
The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. J Biol Chem (2003) 1.08
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Mol Biol Cell (2006) 1.07
Rho GTPases and leucocyte-induced endothelial remodelling. Biochem J (2005) 1.07
The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis. Blood (2011) 1.07
RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line. Exp Cell Res (2006) 1.05
RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice. PLoS One (2011) 1.05
Rac activation by the T-cell receptor inhibits T cell migration. PLoS One (2010) 1.03
p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells. PLoS One (2010) 1.02
Radixin regulates cell migration and cell-cell adhesion through Rac1. J Cell Sci (2012) 1.00
Analysis of cell migration using the Dunn chemotaxis chamber and time-lapse microscopy. Methods Mol Biol (2005) 0.98
Transcriptional regulation of the small GTPase RhoB gene by TGF{beta}-induced signaling pathways. FASEB J (2009) 0.95
Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. J Biol Chem (2006) 0.94
Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization. Exp Cell Res (2005) 0.94
Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol (2012) 0.94
RhoB regulates cell migration through altered focal adhesion dynamics. Open Biol (2012) 0.93
CSF-1 and PI 3-kinase regulate podosome distribution and assembly in macrophages. Cell Motil Cytoskeleton (2006) 0.93
Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin. FEBS Lett (2006) 0.93
Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing. J Biol Chem (2006) 0.92
RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. J Biol Chem (2009) 0.91
Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation. Exp Cell Res (2009) 0.90
In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin. J Biol Chem (2009) 0.90
T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue. Blood (2008) 0.89
RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific. Circ Res (2004) 0.89
Multiple roles for RhoA during T cell transendothelial migration. Small GTPases (2010) 0.88
RhoE stimulates neurite-like outgrowth in PC12 cells through inhibition of the RhoA/ROCK-I signalling. J Neurochem (2009) 0.88
Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein. Biochemistry (2002) 0.88
Rho GTPases and cancer cell transendothelial migration. Methods Mol Biol (2012) 0.88
RhoB regulates uPAR signalling. J Cell Sci (2012) 0.87
FMNL1 promotes proliferation and migration of leukemia cells. J Leukoc Biol (2013) 0.87
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b. J Leukoc Biol (2011) 0.87
beta1-Integrins determine the dendritic morphology which enhances DC-SIGN-mediated particle capture by dendritic cells. Int Immunol (2006) 0.86
CD73 represses pro-inflammatory responses in human endothelial cells. J Inflamm (Lond) (2010) 0.85
Human endometrial stromal cell rho GTPases have opposing roles in regulating focal adhesion turnover and embryo invasion in vitro. Biol Reprod (2010) 0.85
Rnd3 induces stress fibres in endothelial cells through RhoB. Biol Open (2012) 0.85
Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclasts. Mol Biol Cell (2013) 0.84
Inhibition of ROCK by RhoE. Methods Enzymol (2006) 0.84
Neuronal polarization is impaired in mice lacking RhoE expression. J Neurochem (2012) 0.84
The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression. J Biol Chem (2013) 0.83