Published in Science on March 19, 2004
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Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science (2007) 4.03
Reconstructing immune phylogeny: new perspectives. Nat Rev Immunol (2005) 2.95
Human genetic susceptibility to infectious disease. Nat Rev Genet (2012) 2.25
Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Genetics (2004) 2.01
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The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS One (2009) 1.44
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Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum. PLoS Pathog (2010) 1.34
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An ectopic expression screen reveals the protective and toxic effects of Drosophila seminal fluid proteins. Genetics (2006) 1.11
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Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. PLoS Pathog (2009) 1.06
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Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster. Genetics (2005) 1.03
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Genetic resistance to Brucella abortus in the water buffalo (Bubalus bubalis). Infect Immun (2006) 0.97
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Genetic variation affecting host-parasite interactions: different genes affect different aspects of sigma virus replication and transmission in Drosophila melanogaster. Genetics (2008) 0.94
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Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology. Curr Opin Microbiol (2012) 0.92
Female and male genetic contributions to post-mating immune defence in female Drosophila melanogaster. Proc Biol Sci (2010) 0.92
Balancing selection at a frog antimicrobial peptide locus: fluctuating immune effector alleles? Mol Biol Evol (2008) 0.92
Effects of population structure and sex on association between serotonin receptors and Drosophila heart rate. Genetics (2004) 0.91
Big defensins, a diverse family of antimicrobial peptides that follows different patterns of expression in hemocytes of the oyster Crassostrea gigas. PLoS One (2011) 0.90
Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology. BMC Genet (2005) 0.90
Proteus mirabilis interkingdom swarming signals attract blow flies. ISME J (2012) 0.90
The cellular immune response of Daphnia magna under host-parasite genetic variation and variation in initial dose. Evolution (2012) 0.90
Host ecology shapes geographical variation for resistance to bacterial infection in Drosophila melanogaster. J Anim Ecol (2008) 0.89
Gene co-expression network analysis identifies porcine genes associated with variation in Salmonella shedding. BMC Genomics (2014) 0.89
Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing. BMC Genomics (2009) 0.88
Phagocytic ability declines with age in adult Drosophila hemocytes. Aging Cell (2014) 0.86
Ecdysone mediates the development of immunity in the Drosophila embryo. Curr Biol (2014) 0.84
The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster. PLoS Genet (2015) 0.84
Autosomal variation for male body size and sperm competition phenotypes is uncorrelated in Drosophila melanogaster. Biol Lett (2008) 0.83
Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections. Infect Immun (2014) 0.82
Perspectives on the evolutionary ecology of arthropod antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci (2016) 0.81
Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster. Pharmacogenet Genomics (2012) 0.81
Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. Mol Ecol (2011) 0.81
Expression of defense genes in Drosophila evolves under a different selective regime from expression of other genes. Evolution (2010) 0.81
Molecular evolution of a small gene family of wound inducible Kunitz trypsin inhibitors in Populus. J Mol Evol (2006) 0.80
Thorax injury lowers resistance to infection in Drosophila melanogaster. Infect Immun (2014) 0.80
Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence. Nat Commun (2015) 0.80
Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii). Immunogenetics (2015) 0.79
Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila. Curr Biol (2016) 0.78
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Clustering of Drosophila melanogaster immune genes in interplay with recombination rate. PLoS One (2008) 0.78
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The flow of antimicrobial peptide genes through a genetic barrier between Mytilus edulis and M. galloprovincialis. J Mol Evol (2009) 0.76
Immune response and gut microbial community structure in bumblebees after microbiota transplants. Proc Biol Sci (2016) 0.76
The genetic architecture of resistance to virus infection in Drosophila. Mol Ecol (2016) 0.76
Functional regulatory divergence of the innate immune system in interspecific Drosophila hybrids. Mol Biol Evol (2010) 0.76
Fruit flies like a (rotten) banana. Fly (Austin) (2008) 0.75
Survey of Global Genetic Diversity Within the Drosophila Immune System. Genetics (2016) 0.75
Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunol Res (2007) 0.75
Eco-immunology and bioinvasion: revisiting the evolution of increased competitive ability hypotheses. Evol Appl (2016) 0.75
Drosophila Genotype Influences Commensal Bacterial Levels. PLoS One (2017) 0.75
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Natural selection on protein-coding genes in the human genome. Nature (2005) 10.84
Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet (2008) 8.92
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol (2005) 8.32
Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci U S A (2011) 7.36
Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci U S A (2002) 6.95
Proportionally more deleterious genetic variation in European than in African populations. Nature (2008) 6.61
Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover. Mol Biol Evol (2002) 6.44
Genomic scans for selective sweeps using SNP data. Genome Res (2005) 6.43
Evolutionary changes in cis and trans gene regulation. Nature (2004) 6.24
Whole-genome shotgun assembly and comparison of human genome assemblies. Proc Natl Acad Sci U S A (2004) 6.08
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Recent explosive human population growth has resulted in an excess of rare genetic variants. Science (2012) 5.58
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
Localizing recent adaptive evolution in the human genome. PLoS Genet (2007) 5.11
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A (2008) 4.76
Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62
The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42
Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39
Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain. PLoS One (2008) 4.03
Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data. Genetics (2004) 3.65
Linkage disequilibrium and the mapping of complex human traits. Trends Genet (2002) 3.38
Regulatory changes underlying expression differences within and between Drosophila species. Nat Genet (2008) 3.24
Dynamic evolution of the innate immune system in Drosophila. Nat Genet (2007) 3.09
Darwinian and demographic forces affecting human protein coding genes. Genome Res (2009) 3.01
Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. Curr Biol (2004) 2.84
Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y. Science (2004) 2.80
Thrice out of Africa: ancient and recent expansions of the honey bee, Apis mellifera. Science (2006) 2.64
Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res (2008) 2.46
Evolution of protein-coding genes in Drosophila. Trends Genet (2008) 2.36
Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol (2007) 2.33
Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome. Genetics (2013) 2.17
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics (2003) 2.07
Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Genetics (2004) 2.01
Population genetics: malaria variorum. Nature (2002) 1.97
Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergence. PLoS Genet (2009) 1.97
Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Genetics (2005) 1.93
Population genetic structure of the people of Qatar. Am J Hum Genet (2010) 1.91
Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS One (2007) 1.89
Understanding the accuracy of statistical haplotype inference with sequence data of known phase. Genet Epidemiol (2007) 1.87
Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster. PLoS Pathog (2007) 1.82
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics (2003) 1.79
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Tracing the evolutionary history of Drosophila regulatory regions with models that identify transcription factor binding sites. Mol Biol Evol (2003) 1.75
The evolutionary costs of immunological maintenance and deployment. BMC Evol Biol (2008) 1.74
Low conservation of gene content in the Drosophila Y chromosome. Nature (2008) 1.72
Targets of balancing selection in the human genome. Mol Biol Evol (2009) 1.69
Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations. Am J Hum Genet (2003) 1.66
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. Am J Hum Genet (2004) 1.61
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics (2002) 1.57
Conjuring SNPs to detect associations. Nat Genet (2007) 1.57
A genome-wide approach to identifying novel-imprinted genes. Hum Genet (2007) 1.55
Origin and evolution of Y chromosomes: Drosophila tales. Trends Genet (2009) 1.53
Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet (2008) 1.53
Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res (2004) 1.52
Identification by full-coverage array CGH of human DNA copy number increases relative to chimpanzee and gorilla. Genome Res (2005) 1.51
Impact of microRNA regulation on variation in human gene expression. Genome Res (2012) 1.49
Y chromosome and other heterochromatic sequences of the Drosophila melanogaster genome: how far can we go? Genetica (2003) 1.49
Mapping multiple Quantitative Trait Loci by Bayesian classification. Genetics (2004) 1.46
Natural genetic variation in male reproductive genes contributes to nontransitivity of sperm competitive ability in Drosophila melanogaster. Mol Ecol (2012) 1.46
Independent effects of cis- and trans-regulatory variation on gene expression in Drosophila melanogaster. Genetics (2008) 1.45
Associations between sperm competition and natural variation in male reproductive genes on the third chromosome of Drosophila melanogaster. Genetics (2007) 1.45
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria. Genetics (2006) 1.44
Methods for human demographic inference using haplotype patterns from genomewide single-nucleotide polymorphism data. Genetics (2009) 1.42
Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing. Nat Genet (2011) 1.41
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern. Genome Res (2005) 1.40
Disentangling the relationship between sex-biased gene expression and X-linkage. Genome Res (2012) 1.40
Robustness of inference of haplotype block structure. J Comput Biol (2003) 1.38
Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Genome Biol Evol (2009) 1.36
Inferring genetic ancestry: opportunities, challenges, and implications. Am J Hum Genet (2010) 1.36
Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins. Genetics (2008) 1.33
Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. PLoS Genet (2012) 1.31
Genome sequencing reveals complex speciation in the Drosophila simulans clade. Genome Res (2012) 1.31
US mesothelioma patterns 1973-2002: indicators of change and insights into background rates. Eur J Cancer Prev (2008) 1.30
Optimal haplotype block-free selection of tagging SNPs for genome-wide association studies. Genome Res (2004) 1.28
Genetic incompatibilities are widespread within species. Nature (2013) 1.28
Larval rearing environment affects several post-copulatory traits in Drosophila melanogaster. Biol Lett (2007) 1.27
Molecular population genetics of inducible antibacterial peptide genes in Drosophila melanogaster. Mol Biol Evol (2003) 1.27
Rehabilitation and the single cell. Curr Opin Cell Biol (2006) 1.26
Neutral genomic regions refine models of recent rapid human population growth. Proc Natl Acad Sci U S A (2013) 1.25
Genes involved in convergent evolution of eusociality in bees. Proc Natl Acad Sci U S A (2011) 1.24
A survey for novel imprinted genes in the mouse placenta by mRNA-seq. Genetics (2011) 1.24
Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet (2013) 1.23
Specificity determinants and diversification of the Brassica self-incompatibility pollen ligand. Proc Natl Acad Sci U S A (2003) 1.23
Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism. Am J Hum Genet (2002) 1.22
The resolution of sexual antagonism by gene duplication. Genetics (2011) 1.18
Population growth inflates the per-individual number of deleterious mutations and reduces their mean effect. Genetics (2013) 1.17
Contrasting the efficacy of selection on the X and autosomes in Drosophila. Mol Biol Evol (2007) 1.16
Mining genetic epidemiology data with Bayesian networks application to APOE gene variation and plasma lipid levels. J Comput Biol (2005) 1.15
Function and evolution of DNA methylation in Nasonia vitripennis. PLoS Genet (2013) 1.14
The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Development (2006) 1.13
Sex linkage, sex-specific selection, and the role of recombination in the evolution of sexually dimorphic gene expression. Evolution (2010) 1.13
Bayesian sperm competition estimates. Genetics (2003) 1.12