Published in Nat Genet on November 07, 2007
Butterfly genome reveals promiscuous exchange of mimicry adaptations among species. Nature (2012) 4.93
Patterns of positive selection in six Mammalian genomes. PLoS Genet (2008) 4.69
Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science (2011) 3.72
Caspar controls resistance to Plasmodium falciparum in diverse anopheline species. PLoS Pathog (2009) 2.61
The mosaic genome structure of the Wolbachia wRi strain infecting Drosophila simulans. Proc Natl Acad Sci U S A (2009) 2.48
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet (2009) 2.35
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. Genome Res (2011) 2.21
Immunity in a variable world. Philos Trans R Soc Lond B Biol Sci (2009) 2.16
Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biol (2010) 2.09
De novo transcriptome sequencing in Anopheles funestus using Illumina RNA-seq technology. PLoS One (2010) 1.95
Quantifying adaptive evolution in the Drosophila immune system. PLoS Genet (2009) 1.74
Multiple reciprocal adaptations and rapid genetic change upon experimental coevolution of an animal host and its microbial parasite. Proc Natl Acad Sci U S A (2010) 1.72
Species-wide genetic incompatibility analysis identifies immune genes as hot spots of deleterious epistasis. Cell (2014) 1.70
Introduction. Ecological immunology. Philos Trans R Soc Lond B Biol Sci (2009) 1.58
Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens. Science (2010) 1.58
Pyrosequence analysis of expressed sequence tags for Manduca sexta hemolymph proteins involved in immune responses. Insect Biochem Mol Biol (2008) 1.45
The Caenorhabditis chemoreceptor gene families. BMC Biol (2008) 1.44
Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression. Genetics (2009) 1.40
A species-specific cluster of defensin-like genes encodes diffusible pollen tube attractants in Arabidopsis. PLoS Biol (2012) 1.36
Natural selection on the Drosophila antimicrobial immune system. Curr Opin Microbiol (2008) 1.35
Adaptation and constraint at Toll-like receptors in primates. Mol Biol Evol (2010) 1.34
Distinct antimicrobial peptide expression determines host species-specific bacterial associations. Proc Natl Acad Sci U S A (2013) 1.31
Host phylogeny determines viral persistence and replication in novel hosts. PLoS Pathog (2011) 1.27
Allelic imbalance in Drosophila hybrid heads: exons, isoforms, and evolution. Mol Biol Evol (2012) 1.23
Accelerated adaptive evolution on a newly formed X chromosome. PLoS Biol (2009) 1.21
Lessons from studying insect symbioses. Cell Host Microbe (2011) 1.18
Relative roles of the cellular and humoral responses in the Drosophila host defense against three gram-positive bacterial infections. PLoS One (2011) 1.14
Sperm proteomics reveals intensified selection on mouse sperm membrane and acrosome genes. Mol Biol Evol (2010) 1.14
Neofunctionalization of young duplicate genes in Drosophila. Proc Natl Acad Sci U S A (2013) 1.14
Dynamic evolution of toll-like receptor multigene families in echinoderms. Front Immunol (2012) 1.10
Genome of Drosophila suzukii, the spotted wing drosophila. G3 (Bethesda) (2013) 1.08
Population genetic tools for dissecting innate immunity in humans. Nat Rev Immunol (2013) 1.08
The molecular evolution of four anti-malarial immune genes in the Anopheles gambiae species complex. BMC Evol Biol (2008) 1.08
Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment. Genome Biol (2014) 1.08
Discrimination of different species from the genus Drosophila by intact protein profiling using matrix-assisted laser desorption ionization mass spectrometry. BMC Evol Biol (2010) 1.05
A history of recurrent positive selection at the toll-like receptor 5 in primates. Mol Biol Evol (2009) 1.05
Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila. Mol Biol Evol (2010) 1.05
Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors. Malar J (2009) 1.05
Genotype and gene expression associations with immune function in Drosophila. PLoS Genet (2010) 1.05
High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis. Genetics (2008) 1.04
Massive expansion and functional divergence of innate immune genes in a protostome. Sci Rep (2015) 1.00
A comprehensive analysis of the Manduca sexta immunotranscriptome. Dev Comp Immunol (2012) 0.99
Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster. Front Cell Infect Microbiol (2013) 0.98
Gene expression differences underlying genotype-by-genotype specificity in a host-parasite system. Proc Natl Acad Sci U S A (2014) 0.98
Genes involved in the evolution of herbivory by a leaf-mining, Drosophilid fly. Genome Biol Evol (2012) 0.97
Strong evidence for lineage and sequence specificity of substitution rates and patterns in Drosophila. Mol Biol Evol (2009) 0.96
Insights from natural host-parasite interactions: the Drosophila model. Dev Comp Immunol (2013) 0.95
Evolution of a cellular immune response in Drosophila: a phenotypic and genomic comparative analysis. Genome Biol Evol (2014) 0.94
Immune genes undergo more adaptive evolution than non-immune system genes in Daphnia pulex. BMC Evol Biol (2012) 0.94
Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective. BMC Genomics (2010) 0.94
X-linked variation in immune response in Drosophila melanogaster. Genetics (2009) 0.94
Signatures of rapid evolution in urban and rural transcriptomes of white-footed mice (Peromyscus leucopus) in the New York metropolitan area. PLoS One (2013) 0.93
Recognition of microbial molecular patterns and stimulation of prophenoloxidase activation by a β-1,3-glucanase-related protein in Manduca sexta larval plasma. Insect Biochem Mol Biol (2011) 0.92
Transcriptome of the plant virus vector Graminella nigrifrons, and the molecular interactions of maize fine streak rhabdovirus transmission. PLoS One (2012) 0.92
Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater. J Biol Chem (2011) 0.92
Balancing selection at a frog antimicrobial peptide locus: fluctuating immune effector alleles? Mol Biol Evol (2008) 0.92
Comparative analysis of the global transcriptome of Anopheles funestus from Mali, West Africa. PLoS One (2009) 0.91
Widespread polymorphism in the positions of stop codons in Drosophila melanogaster. Genome Biol Evol (2011) 0.91
Variation in the susceptibility of Drosophila to different entomopathogenic nematodes. Infect Immun (2015) 0.90
Transcriptomic immune response of Tenebrio molitor pupae to parasitization by Scleroderma guani. PLoS One (2013) 0.90
Positive selection in AvrP4 avirulence gene homologues across the genus Melampsora. Proc Biol Sci (2009) 0.90
The evolutionary rate variation among genes of HOG-signaling pathway in yeast genomes. Biol Direct (2010) 0.90
Comparative genomics of chemosensory protein genes reveals rapid evolution and positive selection in ant-specific duplicates. Heredity (Edinb) (2013) 0.90
Evolution of a cluster of innate immune genes (beta-defensins) along the ancestral lines of chicken and zebra finch. Immunome Res (2010) 0.90
Comparative Genomics Reveals the Origins and Diversity of Arthropod Immune Systems. Mol Biol Evol (2015) 0.90
Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes. Biol Direct (2011) 0.89
Host ecology shapes geographical variation for resistance to bacterial infection in Drosophila melanogaster. J Anim Ecol (2008) 0.89
Transcriptome of the adult female malaria mosquito vector Anopheles albimanus. BMC Genomics (2012) 0.88
Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing. BMC Genomics (2009) 0.88
Selection on an antimicrobial peptide defensin in ants. J Mol Evol (2008) 0.88
Diversity, evolution and medical applications of insect antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci (2016) 0.87
The promastigote surface antigen gene family of the Leishmania parasite: differential evolution by positive selection and recombination. BMC Evol Biol (2008) 0.87
Analysis of a normalised expressed sequence tag (EST) library from a key pollinator, the bumblebee Bombus terrestris. BMC Genomics (2010) 0.86
Adaptive evolution of a novel Drosophila lectin induced by parasitic wasp attack. Mol Biol Evol (2011) 0.86
Characterizing the infection-induced transcriptome of Nasonia vitripennis reveals a preponderance of taxonomically-restricted immune genes. PLoS One (2013) 0.86
Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles. PLoS Genet (2014) 0.85
Estimating empirical codon hidden Markov models. Mol Biol Evol (2012) 0.85
Long-term and short-term evolutionary impacts of transposable elements on Drosophila. Genetics (2012) 0.85
Expression of immune-response genes in lepidopteran host is suppressed by venom from an endoparasitoid, Pteromalus puparum. BMC Genomics (2010) 0.85
Evolutionary genetics of insect innate immunity. Brief Funct Genomics (2015) 0.85
Evidence for population-specific positive selection on immune genes of Anopheles gambiae. G3 (Bethesda) (2012) 0.84
Insect antimicrobial peptides act synergistically to inhibit a trypanosome parasite. Philos Trans R Soc Lond B Biol Sci (2016) 0.84
Adaptive evolution and functional constraint at TLR4 during the secondary aquatic adaptation and diversification of cetaceans. BMC Evol Biol (2012) 0.84
Gene duplication and ectopic gene conversion in Drosophila. Genes (Basel) (2011) 0.84
The molecular evolution of cytochrome P450 genes within and between drosophila species. Genome Biol Evol (2014) 0.83
Candidate innate immune system gene expression in the ecological model Daphnia. Dev Comp Immunol (2011) 0.83
Drosophila innate immunity: regional and functional specialization of prophenoloxidases. BMC Biol (2015) 0.83
Haplotype structure and expression divergence at the Drosophila cellular immune gene eater. Mol Biol Evol (2010) 0.82
An effector Peptide family required for Drosophila toll-mediated immunity. PLoS Pathog (2015) 0.82
Perspectives on the evolutionary ecology of arthropod antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci (2016) 0.81
Expression of defense genes in Drosophila evolves under a different selective regime from expression of other genes. Evolution (2010) 0.81
Immune Signaling and Antimicrobial Peptide Expression in Lepidoptera. Insects (2013) 0.81
The potential for adaptive maintenance of diversity in insect antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci (2016) 0.80
Evolutionary rate patterns of genes involved in the Drosophila Toll and Imd signaling pathway. BMC Evol Biol (2013) 0.80
Functional divergence among silkworm antimicrobial peptide paralogs by the activities of recombinant proteins and the induced expression profiles. PLoS One (2011) 0.80
Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life. Front Immunol (2012) 0.80
Differentiation at the MHCIIα and Cath2 loci in sympatric Salvelinus alpinus resource morphs in Lake Thingvallavatn. PLoS One (2013) 0.80
A genomic comparison of two termites with different social complexity. Front Genet (2015) 0.79
Insect immunology and hematopoiesis. Dev Comp Immunol (2015) 0.79
Gene duplication in the genome of parasitic Giardia lamblia. BMC Evol Biol (2010) 0.78
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
A metagenomic survey of microbes in honey bee colony collapse disorder. Science (2007) 11.72
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Natural selection on protein-coding genes in the human genome. Nature (2005) 10.84
Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet (2008) 8.92
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol (2005) 8.32
Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci U S A (2011) 7.36
Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci U S A (2002) 6.95
Proportionally more deleterious genetic variation in European than in African populations. Nature (2008) 6.61
The genome of the model beetle and pest Tribolium castaneum. Nature (2008) 6.50
Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover. Mol Biol Evol (2002) 6.44
Genomic scans for selective sweeps using SNP data. Genome Res (2005) 6.43
Evolutionary changes in cis and trans gene regulation. Nature (2004) 6.24
Whole-genome shotgun assembly and comparison of human genome assemblies. Proc Natl Acad Sci U S A (2004) 6.08
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Recent explosive human population growth has resulted in an excess of rare genetic variants. Science (2012) 5.58
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species. Science (2010) 5.56
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
Localizing recent adaptive evolution in the human genome. PLoS Genet (2007) 5.11
Colony collapse disorder: a descriptive study. PLoS One (2009) 5.02
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A (2008) 4.76
Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62
Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science (2002) 4.47
The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42
Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39
Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain. PLoS One (2008) 4.03
Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data. Genetics (2004) 3.65
Linkage disequilibrium and the mapping of complex human traits. Trends Genet (2002) 3.38
Regulatory changes underlying expression differences within and between Drosophila species. Nat Genet (2008) 3.24
Darwinian and demographic forces affecting human protein coding genes. Genome Res (2009) 3.01
Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. Curr Biol (2004) 2.84
Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y. Science (2004) 2.80
Thrice out of Africa: ancient and recent expansions of the honey bee, Apis mellifera. Science (2006) 2.64
A directed screen for genes involved in Drosophila blood cell activation. Proc Natl Acad Sci U S A (2004) 2.60
Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res (2008) 2.46
Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc Natl Acad Sci U S A (2003) 2.42
Genetic basis of natural variation in D. melanogaster antibacterial immunity. Science (2004) 2.38
Evolution of protein-coding genes in Drosophila. Trends Genet (2008) 2.36
Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol (2007) 2.33
Pathogen webs in collapsing honey bee colonies. PLoS One (2012) 2.21
Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome. Genetics (2013) 2.17
Creating a buzz about insect genomes. Science (2011) 2.17
Nosema ceranae is a long-present and wide-spread microsporidian infection of the European honey bee (Apis mellifera) in the United States. J Invertebr Pathol (2007) 2.17
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes. Curr Biol (2007) 2.12
Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biol (2010) 2.09
Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics (2003) 2.07
Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Genetics (2004) 2.01
Population genetics: malaria variorum. Nature (2002) 1.97
Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees. PLoS Pathog (2009) 1.97
Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergence. PLoS Genet (2009) 1.97
De novo transcriptome sequencing in Anopheles funestus using Illumina RNA-seq technology. PLoS One (2010) 1.95
Changes in transcript abundance relating to colony collapse disorder in honey bees (Apis mellifera). Proc Natl Acad Sci U S A (2009) 1.94
Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Genetics (2005) 1.93
Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster. Proc Natl Acad Sci U S A (2009) 1.93
Population genetic structure of the people of Qatar. Am J Hum Genet (2010) 1.91
Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS One (2007) 1.89
Understanding the accuracy of statistical haplotype inference with sequence data of known phase. Genet Epidemiol (2007) 1.87
Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster. PLoS Pathog (2007) 1.82
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J (2005) 1.79
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics (2003) 1.79
Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila. Proc Natl Acad Sci U S A (2003) 1.79
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Tracing the evolutionary history of Drosophila regulatory regions with models that identify transcription factor binding sites. Mol Biol Evol (2003) 1.75
Comparative genomic analysis of the Tribolium immune system. Genome Biol (2007) 1.74
The evolutionary costs of immunological maintenance and deployment. BMC Evol Biol (2008) 1.74
Low conservation of gene content in the Drosophila Y chromosome. Nature (2008) 1.72
Systemic spread and propagation of a plant-pathogenic virus in European honeybees, Apis mellifera. MBio (2014) 1.71
Targets of balancing selection in the human genome. Mol Biol Evol (2009) 1.69
Dead or alive: deformed wing virus and Varroa destructor reduce the life span of winter honeybees. Appl Environ Microbiol (2011) 1.69
Predictive markers of honey bee colony collapse. PLoS One (2012) 1.68
Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations. Am J Hum Genet (2003) 1.66
Varroa destructor is an effective vector of Israeli acute paralysis virus in the honeybee, Apis mellifera. J Gen Virol (2010) 1.65
Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. J Leukoc Biol (2011) 1.62
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. Am J Hum Genet (2004) 1.61
Invertebrate immunity and the limits of mechanistic immunology. Nat Immunol (2005) 1.57
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics (2002) 1.57
Conjuring SNPs to detect associations. Nat Genet (2007) 1.57
Anopheles gambiae APL1 is a family of variable LRR proteins required for Rel1-mediated protection from the malaria parasite, Plasmodium berghei. PLoS One (2008) 1.55
A genome-wide approach to identifying novel-imprinted genes. Hum Genet (2007) 1.55
Weighing risk factors associated with bee colony collapse disorder by classification and regression tree analysis. J Econ Entomol (2010) 1.53
Origin and evolution of Y chromosomes: Drosophila tales. Trends Genet (2009) 1.53
Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet (2008) 1.53
Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res (2004) 1.52
Identification by full-coverage array CGH of human DNA copy number increases relative to chimpanzee and gorilla. Genome Res (2005) 1.51
Impact of microRNA regulation on variation in human gene expression. Genome Res (2012) 1.49
Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292: 246-248. 1981. J Immunol (2009) 1.49
Y chromosome and other heterochromatic sequences of the Drosophila melanogaster genome: how far can we go? Genetica (2003) 1.49
Mapping multiple Quantitative Trait Loci by Bayesian classification. Genetics (2004) 1.46
Finding the missing honey bee genes: lessons learned from a genome upgrade. BMC Genomics (2014) 1.46