Localizing recent adaptive evolution in the human genome.

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Signals of recent positive selection in a worldwide sample of human populations. Genome Res (2009) 8.38

Identifying autism loci and genes by tracing recent shared ancestry. Science (2008) 7.72

Population genomics of parallel adaptation in threespine stickleback using sequenced RAD tags. PLoS Genet (2010) 7.05

African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet (2008) 6.06

Constructing genomic maps of positive selection in humans: where do we go from here? Genome Res (2009) 5.88

Patterns of positive selection in six Mammalian genomes. PLoS Genet (2008) 4.69

Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62

The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Curr Biol (2010) 4.25

Classic selective sweeps were rare in recent human evolution. Science (2011) 4.09

Pervasive hitchhiking at coding and regulatory sites in humans. PLoS Genet (2009) 4.02

cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans. Cell (2007) 3.72

Widespread genomic signatures of natural selection in hominid evolution. PLoS Genet (2009) 3.68

The role of geography in human adaptation. PLoS Genet (2009) 3.41

How culture shaped the human genome: bringing genetics and the human sciences together. Nat Rev Genet (2010) 3.21

Recent acceleration of human adaptive evolution. Proc Natl Acad Sci U S A (2007) 3.13

Darwinian and demographic forces affecting human protein coding genes. Genome Res (2009) 3.01

From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98

Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci U S A (2007) 2.81

Global distribution of genomic diversity underscores rich complex history of continental human populations. Genome Res (2009) 2.76

Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet (2008) 2.68

Identifying recent adaptations in large-scale genomic data. Cell (2013) 2.57

Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases. Proc Natl Acad Sci U S A (2009) 2.47

Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res (2008) 2.46

Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. PLoS Genet (2011) 2.44

Recent de novo origin of human protein-coding genes. Genome Res (2009) 2.36

Genomic patterns of homozygosity in worldwide human populations. Am J Hum Genet (2012) 2.30

Population genetic inference from genomic sequence variation. Genome Res (2010) 2.29

Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. Proc Natl Acad Sci U S A (2010) 2.27

Spatial patterns of variation due to natural selection in humans. Nat Rev Genet (2009) 2.18

Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14

Population differentiation as a test for selective sweeps. Genome Res (2010) 2.08

Autism and brain development. Cell (2008) 2.01

Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency. Proc Natl Acad Sci U S A (2010) 1.97

Gene regulation in primates evolves under tissue-specific selection pressures. PLoS Genet (2008) 1.86

Selective sweep at a quantitative trait locus in the presence of background genetic variation. Genetics (2008) 1.86

Comparative studies of gene expression and the evolution of gene regulation. Nat Rev Genet (2012) 1.79

Evidence of widespread selection on standing variation in Europe at height-associated SNPs. Nat Genet (2012) 1.71

"Reverse ecology" and the power of population genomics. Evolution (2008) 1.69

Targets of balancing selection in the human genome. Mol Biol Evol (2009) 1.69

Ancestral components of admixed genomes in a Mexican cohort. PLoS Genet (2011) 1.67

Patterns of polymorphism and demographic history in natural populations of Arabidopsis lyrata. PLoS One (2008) 1.63

Population genomics of rapid adaptation by soft selective sweeps. Trends Ecol Evol (2013) 1.60

Adaptive evolution of genes underlying schizophrenia. Proc Biol Sci (2007) 1.58

Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome. PLoS Genet (2011) 1.54

Genetic variation and recent positive selection in worldwide human populations: evidence from nearly 1 million SNPs. PLoS One (2009) 1.53

Natural selection and the distribution of identity-by-descent in the human genome. Genetics (2010) 1.52

High rate of recent transposable element-induced adaptation in Drosophila melanogaster. PLoS Biol (2008) 1.52

Bateman's principles and human sex roles. Trends Ecol Evol (2009) 1.52

Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genet (2008) 1.48

Natural selection and infectious disease in human populations. Nat Rev Genet (2014) 1.48

Whole-genome nucleotide diversity, recombination, and linkage disequilibrium in the model legume Medicago truncatula. Proc Natl Acad Sci U S A (2011) 1.46

A population genetic signal of polygenic adaptation. PLoS Genet (2014) 1.46

Correcting estimators of theta and Tajima's D for ascertainment biases caused by the single-nucleotide polymorphism discovery process. Genetics (2008) 1.44

Signatures of positive selection apparent in a small sample of human exomes. Genome Res (2010) 1.43

A genomic portrait of haplotype diversity and signatures of selection in indigenous southern African populations. PLoS Genet (2015) 1.43

Confounding between recombination and selection, and the Ped/Pop method for detecting selection. Genome Res (2008) 1.42

Fundamental concepts in genetics: genetics and the understanding of selection. Nat Rev Genet (2009) 1.41

Adaptations to new environments in humans: the role of subtle allele frequency shifts. Philos Trans R Soc Lond B Biol Sci (2010) 1.40

Sequencing and analysis of an Irish human genome. Genome Biol (2010) 1.39

Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. Am J Hum Genet (2011) 1.35

Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies. PLoS Genet (2012) 1.33

Exploring gene-culture interactions: insights from handedness, sexual selection and niche-construction case studies. Philos Trans R Soc Lond B Biol Sci (2008) 1.32

Genome sequencing reveals complex speciation in the Drosophila simulans clade. Genome Res (2012) 1.31

A genome-wide signature of positive selection in ancient and recent invasive expansions of the honey bee Apis mellifera. Proc Natl Acad Sci U S A (2008) 1.30

Darwin in mind: new opportunities for evolutionary psychology. PLoS Biol (2011) 1.29

On detecting incomplete soft or hard selective sweeps using haplotype structure. Mol Biol Evol (2014) 1.25

Genome-wide signals of positive selection in human evolution. Genome Res (2014) 1.24

Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. PLoS Genet (2010) 1.24

Human and non-human primate genomes share hotspots of positive selection. PLoS Genet (2010) 1.24

Evolutionary adaptations to dietary changes. Annu Rev Nutr (2010) 1.23

Integrating evolutionary and functional approaches to infer adaptation at specific loci. Evolution (2010) 1.21

1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans. Nucleic Acids Res (2013) 1.20

Differential gene expression in incipient species of Anopheles gambiae. Mol Ecol (2008) 1.20

A population genetics-phylogenetics approach to inferring natural selection in coding sequences. PLoS Genet (2011) 1.19

Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations? PLoS Genet (2011) 1.17

Recent human adaptation: genomic approaches, interpretation and insights. Nat Rev Genet (2013) 1.15

Positive selection in East Asians for an EDAR allele that enhances NF-kappaB activation. PLoS One (2008) 1.14

Darwin and genetics. Genetics (2009) 1.14

Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases. PLoS One (2009) 1.14

Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids. Am J Hum Genet (2012) 1.13

The timing of pigmentation lightening in Europeans. Mol Biol Evol (2012) 1.13

Detecting selective sweeps from pooled next-generation sequencing samples. Mol Biol Evol (2012) 1.13

An investigation of the statistical power of neutrality tests based on comparative and population genetic data. Mol Biol Evol (2008) 1.11

Human pigmentation genes under environmental selection. Genome Biol (2012) 1.11

Evidence for hitchhiking of deleterious mutations within the human genome. PLoS Genet (2011) 1.08

Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol (2012) 1.08

Runaway cultural niche construction. Philos Trans R Soc Lond B Biol Sci (2011) 1.07

A high resolution genome-wide scan for significant selective sweeps: an application to pooled sequence data in laying chickens. PLoS One (2012) 1.06

Detecting selective sweeps: a new approach based on hidden markov models. Genetics (2009) 1.05

Limited evidence for classic selective sweeps in African populations. Genetics (2012) 1.04

The influence of genomic context on mutation patterns in the human genome inferred from rare variants. Genome Res (2013) 1.04

Human genomic disease variants: a neutral evolutionary explanation. Genome Res (2012) 1.02

Reconstructing phylogenies and phenotypes: a molecular view of human evolution. J Anat (2008) 1.01

Risk of breast and prostate cancer is not associated with increased homozygosity in outbred populations. Eur J Hum Genet (2010) 1.01

Detecting loci under recent positive selection in dairy and beef cattle by combining different genome-wide scan methods. PLoS One (2013) 1.01

Simulation of DNA sequence evolution under models of recent directional selection. Brief Bioinform (2008) 1.01

Evolution of alternative splicing in primate brain transcriptomes. Hum Mol Genet (2010) 0.99

The landscape of human genes involved in the immune response to parasitic worms. BMC Evol Biol (2010) 0.99

Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry. BMC Evol Biol (2013) 0.99

A haplotype map of the human genome. Nature (2005) 105.70

Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64

Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics (2002) 34.50

A map of recent positive selection in the human genome. PLoS Biol (2006) 29.19

A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66

A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet (1996) 26.06

The UCSC Table Browser data retrieval tool. Nucleic Acids Res (2004) 25.12

Estimating African American admixture proportions by use of population-specific alleles. Am J Hum Genet (1998) 22.90

Detecting recent positive selection in the human genome from haplotype structure. Nature (2002) 22.00

Whole-genome patterns of common DNA variation in three human populations. Science (2005) 21.22

The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05

Calibrating a coalescent simulation of human genome sequence variation. Genome Res (2005) 15.04

Hitchhiking under positive Darwinian selection. Genetics (2000) 14.72

SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science (2005) 12.02

Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet (2004) 11.90

Natural selection on protein-coding genes in the human genome. Nature (2005) 10.84

Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science (2003) 9.20

A review of some fundamental concepts and problems of population genetics. Cold Spring Harb Symp Quant Biol (1955) 8.55

A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol (2005) 8.32

Identification of a variant associated with adult-type hypolactasia. Nat Genet (2002) 7.49

A DNA polymorphism discovery resource for research on human genetic variation. Genome Res (1998) 7.44

Detecting a local signature of genetic hitchhiking along a recombining chromosome. Genetics (2002) 7.43

Positive and negative selection on the human genome. Genetics (2001) 7.25

The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations. Genetics (2004) 7.00

Ascertainment bias in studies of human genome-wide polymorphism. Genome Res (2005) 6.63

Genomic scans for selective sweeps using SNP data. Genome Res (2005) 6.43

Simultaneous inference of selection and population growth from patterns of variation in the human genome. Proc Natl Acad Sci U S A (2005) 5.94

Adaptive protein evolution in Drosophila. Nature (2002) 5.71

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science (2005) 5.55

Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet (1998) 5.24

Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science (2003) 5.23

Genomic regions exhibiting positive selection identified from dense genotype data. Genome Res (2005) 4.81

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science (2005) 4.79

Genetic analysis of African populations: human evolution and complex disease. Nat Rev Genet (2002) 4.23

How reliable are empirical genomic scans for selective sweeps? Genome Res (2006) 4.14

The evolution of human skin coloration. J Hum Evol (2000) 4.07

Global landscape of recent inferred Darwinian selection for Homo sapiens. Proc Natl Acad Sci U S A (2005) 3.77

Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data. Genetics (2004) 3.65

Neuronal position in the developing brain is regulated by mouse disabled-1. Nature (1997) 3.60

A ruby in the rubbish: beneficial mutations, deleterious mutations and the evolution of sex. Genetics (1994) 3.55

Disentangling the effects of demography and selection in human history. Mol Biol Evol (2004) 2.97

Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa. Mol Biol Evol (2004) 2.64

A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60

Genomic signatures of positive selection in humans and the limits of outlier approaches. Genome Res (2006) 2.56

Natural selection on the olfactory receptor gene family in humans and chimpanzees. Am J Hum Genet (2003) 2.44

Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS Biol (2005) 2.37

A genome scan to detect candidate regions influenced by local natural selection in human populations. Mol Biol Evol (2003) 2.30

Conflict begets complexity: the evolution of centromeres. Curr Opin Genet Dev (2002) 2.14

Female meiosis drives karyotypic evolution in mammals. Genetics (2001) 2.14

The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis. J Invest Dermatol (1998) 2.08

Analytic review: some current problems of human population genetics. Am J Hum Genet (1973) 2.05

The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem (2004) 1.92

A method for detecting recent selection in the human genome from allele age estimates. Genetics (2003) 1.55

A scan for signatures of positive selection in candidate loci for skin pigmentation in humans. Mol Biol Evol (2006) 1.44

Positive selection on MMP3 regulation has shaped heart disease risk. Curr Biol (2004) 1.39

Brain contains two forms of synaptic vesicle protein 2. Proc Natl Acad Sci U S A (1993) 1.36

The dystrophin-associated protein complex. J Cell Sci (2002) 1.05

Genetic conflicts during meiosis and the evolutionary origins of centromere complexity. Biochem Soc Trans (2006) 1.01

The hitchhiking effect of an autosomal meiotic drive gene. Genetics (2006) 0.91

Finding the missing heritability of complex diseases. Nature (2009) 67.95

The diploid genome sequence of an Asian individual. Nature (2008) 46.29

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40

The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36

Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01

Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27

Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12

Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21

The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76

Genes mirror geography within Europe. Nature (2008) 14.23

Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res (2009) 12.58

A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66

Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27

Bayes empirical bayes inference of amino acid sites under positive selection. Mol Biol Evol (2005) 11.26

Natural selection on protein-coding genes in the human genome. Nature (2005) 10.84

Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66

Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science (2003) 9.20

The use of coded PCR primers enables high-throughput sequencing of multiple homolog amplification products by 454 parallel sequencing. PLoS One (2007) 9.17

Inferring the joint demographic history of multiple populations from multidimensional SNP frequency data. PLoS Genet (2009) 9.16

Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet (2008) 8.92

Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level. Mol Biol Evol (2005) 8.74

A high-resolution map of human evolutionary constraint using 29 mammals. Nature (2011) 8.67

Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38

A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol (2005) 8.32

Multilocus methods for estimating population sizes, migration rates and divergence time, with applications to the divergence of Drosophila pseudoobscura and D. persimilis. Genetics (2004) 7.79

Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science (2009) 7.64

Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature (2010) 7.51

Demographic history and rare allele sharing among human populations. Proc Natl Acad Sci U S A (2011) 7.36

Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages. Mol Biol Evol (2002) 7.21

The evolution of gene expression levels in mammalian organs. Nature (2011) 7.16

Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci U S A (2002) 6.95

Ascertainment bias in studies of human genome-wide polymorphism. Genome Res (2005) 6.63

Proportionally more deleterious genetic variation in European than in African populations. Nature (2008) 6.61

Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover. Mol Biol Evol (2002) 6.44

Genomic scans for selective sweeps using SNP data. Genome Res (2005) 6.43

Evolutionary changes in cis and trans gene regulation. Nature (2004) 6.24

Whole-genome shotgun assembly and comparison of human genome assemblies. Proc Natl Acad Sci U S A (2004) 6.08

Simultaneous inference of selection and population growth from patterns of variation in the human genome. Proc Natl Acad Sci U S A (2005) 5.94

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77

Integration within the Felsenstein equation for improved Markov chain Monte Carlo methods in population genetics. Proc Natl Acad Sci U S A (2007) 5.64

Recent explosive human population growth has resulted in an excess of rare genetic variants. Science (2012) 5.58

Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44

Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa. Nat Commun (2011) 5.41

Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39

A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34

Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nat Biotechnol (2011) 4.84

An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84

The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet (2008) 4.79

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A (2008) 4.76

Patterns of positive selection in six Mammalian genomes. PLoS Genet (2008) 4.69

A single IGF1 allele is a major determinant of small size in dogs. Science (2007) 4.68

Genomewide SNP variation reveals relationships among landraces and modern varieties of rice. Proc Natl Acad Sci U S A (2009) 4.65

Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature (2010) 4.64

Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62

ClinGen--the Clinical Genome Resource. N Engl J Med (2015) 4.45

The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42

Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39

A Markov chain Monte Carlo approach for joint inference of population structure and inbreeding rates from multilocus genotype data. Genetics (2007) 4.31

Accuracy and power of statistical methods for detecting adaptive evolution in protein coding sequences and for identifying positively selected sites. Genetics (2004) 4.22

Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain. PLoS One (2008) 4.03

Effect of recombination on the accuracy of the likelihood method for detecting positive selection at amino acid sites. Genetics (2003) 3.89

Molecular and evolutionary history of melanism in North American gray wolves. Science (2009) 3.87

Genome-wide patterns of nucleotide polymorphism in domesticated rice. PLoS Genet (2007) 3.83

Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83

The cost of inbreeding in Arabidopsis. Nature (2002) 3.80

Ancient biomolecules from deep ice cores reveal a forested southern Greenland. Science (2007) 3.79

Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data. Genetics (2004) 3.65

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet (2007) 3.61

Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proc Natl Acad Sci U S A (2011) 3.53

Linkage disequilibrium as a signature of selective sweeps. Genetics (2004) 3.52

Comparative recombination rates in the rat, mouse, and human genomes. Genome Res (2004) 3.50

A simple genetic architecture underlies morphological variation in dogs. PLoS Biol (2010) 3.46

Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature (2013) 3.45