Published in J Mol Biol on April 23, 2004
Therapeutic antibody targeting of individual Notch receptors. Nature (2010) 4.56
Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proc Natl Acad Sci U S A (2004) 2.17
Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol (2013) 1.68
The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins. ACS Chem Biol (2009) 1.65
Engineering of recombinant crystallization chaperones. Curr Opin Struct Biol (2009) 1.53
Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A (2009) 1.40
CDR-H3 diversity is not required for antigen recognition by synthetic antibodies. J Mol Biol (2012) 1.27
Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2. J Virol (2008) 1.16
Synthetic antibody libraries focused towards peptide ligands. J Mol Biol (2008) 1.15
Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling. J Biol Chem (2010) 1.15
A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm. BMC Biotechnol (2007) 1.12
Antigen-antibody interface properties: composition, residue interactions, and features of 53 non-redundant structures. Biochim Biophys Acta (2012) 1.05
A herpes simplex virus recombinant that exhibits a single-chain antibody to HER2/neu enters cells through the mammary tumor receptor, independently of the gD receptors. J Virol (2006) 1.02
Natural and man-made V-gene repertoires for antibody discovery. Front Immunol (2012) 0.98
Antibody binding loop insertions as diversity elements. Nucleic Acids Res (2006) 0.95
Mining human antibody repertoires. MAbs (2010) 0.92
Surface display of a massively variable lipoprotein by a Legionella diversity-generating retroelement. Proc Natl Acad Sci U S A (2013) 0.92
Generic approach for the generation of stable humanized single-chain Fv fragments from rabbit monoclonal antibodies. J Biol Chem (2010) 0.88
Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity. Protein Sci (2013) 0.87
Monoclonal antibody humanness score and its applications. BMC Biotechnol (2013) 0.86
Opportunities for functional selectivity in GPCR antibodies. Biochem Pharmacol (2012) 0.86
High-throughput analysis and protein engineering using microcapillary arrays. Nat Chem Biol (2015) 0.83
The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors. PLoS Pathog (2015) 0.82
Primer extension mutagenesis powered by selective rolling circle amplification. PLoS One (2012) 0.81
Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies. J Biol Chem (2015) 0.78
An improved single-chain Fab platform for efficient display and recombinant expression. J Mol Biol (2014) 0.78
In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation. MAbs (2014) 0.78
Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration. J Biol Chem (2015) 0.77
Antibody-mediated prevention of Fusarium mycotoxins in the field. Int J Mol Sci (2008) 0.77
A two-in-one antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions. MAbs (2014) 0.77
Platform for high-throughput antibody selection using synthetically-designed antibody libraries. N Biotechnol (2015) 0.76
Engineered Autonomous Human Variable Domains. Curr Pharm Des (2016) 0.75
Understanding differences between synthetic and natural antibodies can help improve antibody engineering. MAbs (2015) 0.75
Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes. Proc Natl Acad Sci U S A (2015) 0.75
High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains. PLoS One (2015) 0.75
Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis. Front Immunol (2017) 0.75
Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell (2005) 10.68
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol (2007) 6.76
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J Biol Chem (2002) 5.63
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol (2008) 5.54
Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol (2011) 5.41
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell (2008) 5.37
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell (2003) 5.06
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science (2003) 4.56
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
Assessing validity of ICD-9-CM and ICD-10 administrative data in recording clinical conditions in a unique dually coded database. Health Serv Res (2008) 4.25
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science (2009) 3.87
Risk of COPD from exposure to biomass smoke: a metaanalysis. Chest (2010) 3.46
Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem (2005) 3.30
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nat Biotechnol (2010) 3.15
Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arterioscler Thromb Vasc Biol (2002) 3.01
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol Cell (2011) 2.88
MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Mol Cell (2007) 2.87
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochore. Mol Cell (2007) 2.82
RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell (2006) 2.77
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators. Cell (2005) 2.71
HIV-neutralizing immunoglobulin A and HIV-specific proliferation are independently associated with reduced HIV acquisition in Kenyan sex workers. AIDS (2008) 2.67
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin. Mol Biol Cell (2004) 2.60
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nat Biotechnol (2012) 2.43
Readers of histone modifications. Cell Res (2011) 2.40
Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A (2009) 2.35
Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways. PLoS Pathog (2009) 2.29
Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. Mol Cell (2010) 2.26
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Association of EGFR mutation or ALK rearrangement with expression of DNA repair and synthesis genes in never-smoker women with pulmonary adenocarcinoma. Cancer (2012) 2.24
Cse4 is part of an octameric nucleosome in budding yeast. Mol Cell (2009) 2.23
VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J (2004) 2.22
Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Neuron (2004) 2.21
An epidemiologic survey of pediatric sepsis in regional hospitals in China. Pediatr Crit Care Med (2014) 2.16
High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold. J Mol Biol (2004) 2.14
A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell (2011) 2.14
Oncogenic ERBB3 mutations in human cancers. Cancer Cell (2013) 2.06
The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol Chem (2005) 1.93
ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Nat Struct Mol Biol (2008) 1.90
Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology (2004) 1.87
Molecular recognition by a binary code. J Mol Biol (2005) 1.85
In and out: histone variant exchange in chromatin. Trends Biochem Sci (2005) 1.81
An artificial somatic-autonomic reflex pathway procedure for bladder control in children with spina bifida. J Urol (2005) 1.78
An artificial somatic-central nervous system-autonomic reflex pathway for controllable micturition after spinal cord injury: preliminary results in 15 patients. J Urol (2003) 1.73
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies. Proc Natl Acad Sci U S A (2007) 1.73
Interaction between bevacizumab and murine VEGF-A: a reassessment. Invest Ophthalmol Vis Sci (2008) 1.63
Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. J Clin Invest (2011) 1.62
Mutants of Mucor hiemalis endo-beta-N-acetylglucosaminidase show enhanced transglycosylation and glycosynthase-like activities. J Biol Chem (2007) 1.62
The MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila melanogaster X chromosome. Nat Struct Mol Biol (2008) 1.55
IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. J Allergy Clin Immunol (2007) 1.54
Clinical characteristics of Vogt-Koyanagi-Harada syndrome in Chinese patients. Ophthalmology (2006) 1.52
SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae. Genes Dev (2006) 1.51
Synthetic antibodies for specific recognition and crystallization of structured RNA. Proc Natl Acad Sci U S A (2007) 1.51
Follow-through after calling a nurse telephone advice line: a population-based study. Fam Pract (2010) 1.50
The B cell response is redundant and highly focused on V1V2 during early subtype C infection in a Zambian seroconverter. J Virol (2010) 1.49
Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study. Neuroreport (2003) 1.49
A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. PLoS Pathog (2010) 1.48
SWI/SNF-dependent chromatin remodeling of RNR3 requires TAF(II)s and the general transcription machinery. Genes Dev (2003) 1.47
Two-year outcome of high-risk benign prostate hyperplasia patients treated with transurethral prostate resection by plasmakinetic or conventional procedure. Urology (2012) 1.47
Perioperative approach in the surgical management of carotid body tumors. Ann Vasc Surg (2012) 1.47
Preferences for evidence-based practice dissemination in addiction agencies serving women: a discrete-choice conjoint experiment. Addiction (2012) 1.45
Comparison and validity of procedures coded With ICD-9-CM and ICD-10-CA/CCI. Med Care (2008) 1.42
Urodynamic investigation of cyclophosphamide-induced overactive bladder in conscious rats. Chin Med J (Engl) (2012) 1.42
Factors related to female sex workers' willingness to utilize VCT service: a qualitative study in Jinan city, northern China. AIDS Behav (2008) 1.42
Tetrahymena thermophila contains a conventional gamma-tubulin that is differentially required for the maintenance of different microtubule-organizing centers. J Cell Biol (2002) 1.42
Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. Curr Eye Res (2005) 1.41
The intrinsic contributions of tyrosine, serine, glycine and arginine to the affinity and specificity of antibodies. J Mol Biol (2008) 1.41
Validation of ICD-9-CM/ICD-10 coding algorithms for the identification of patients with acetaminophen overdose and hepatotoxicity using administrative data. BMC Health Serv Res (2007) 1.41
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
Targeting activity is required for SWI/SNF function in vivo and is accomplished through two partially redundant activator-interaction domains. Mol Cell (2003) 1.40
Efficient clustering aggregation based on data fragments. IEEE Trans Syst Man Cybern B Cybern (2012) 1.39
Synthetic therapeutic antibodies. Nat Chem Biol (2006) 1.39
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol Cell (2008) 1.38
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. J Clin Invest (2010) 1.36
Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucans. Blood (2011) 1.35
Cognitive intervention for persons with mild cognitive impairment: A meta-analysis. Ageing Res Rev (2010) 1.35
An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV. Sci China Life Sci (2013) 1.34
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci U S A (2012) 1.31
Bivalent antibody phage display mimics natural immunoglobulin. J Immunol Methods (2004) 1.30
Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy. Clin Cancer Res (2010) 1.29
Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. J Biol Chem (2003) 1.29
Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library. J Mol Biol (2006) 1.29
EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab (2013) 1.23
Seroprevalence of Toxoplasma gondii in pigs in southwestern China. Parasitol Int (2009) 1.22
Glycosynthases enable a highly efficient chemoenzymatic synthesis of N-glycoproteins carrying intact natural N-glycans. J Am Chem Soc (2009) 1.21
Rosai-Dorfman disease of multiple organs, including the epicardium: An unusual case with poor prognosis. Heart Lung (2010) 1.21
Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma. Blood (2009) 1.19
Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: optimizing methods to quantify vascular changes. Invest Ophthalmol Vis Sci (2008) 1.19
Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration. Pharm Res (2008) 1.18
Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling. J Biol Chem (2004) 1.18
Calmodulin is involved in heat shock signal transduction in wheat. Plant Physiol (2003) 1.18
Urinary arsenic metabolites in children and adults exposed to arsenic in drinking water in Inner Mongolia, China. Environ Health Perspect (2007) 1.17
Factors associated with utilization of a free HIV VCT clinic by female sex workers in Jinan City, Northern China. AIDS Behav (2011) 1.17