PubRank

Tony Kouzarides

Author PubWeight™ 213.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Active genes are tri-methylated at K4 of histone H3. Nature 2002 15.68
2 Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol 2003 8.82
3 Regulation of chromatin by histone modifications. Cell Res 2011 8.44
4 Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 2011 8.29
5 Cancer epigenetics: from mechanism to therapy. Cell 2012 7.74
6 Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A 2002 7.67
7 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J 2002 6.37
8 Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature 2002 6.09
9 Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 2002 6.05
10 New nomenclature for chromatin-modifying enzymes. Cell 2007 5.34
11 The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci 2003 5.19
12 Histone deimination antagonizes arginine methylation. Cell 2004 5.19
13 Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell 2004 4.99
14 Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem 2005 4.78
15 The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 2002 4.70
16 JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 2009 4.60
17 Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 2007 4.55
18 The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res 2003 4.36
19 EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 2003 4.33
20 An operational definition of epigenetics. Genes Dev 2009 4.26
21 Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem 2005 4.20
22 Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol 2006 3.65
23 Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell 2003 3.47
24 Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature 2007 3.32
25 Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 2010 3.25
26 Histone methylation: dynamic or static? Cell 2002 3.12
27 Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J 2004 2.94
28 Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 2003 2.91
29 Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J Biol Chem 2002 2.89
30 Targeting epigenetic readers in cancer. N Engl J Med 2012 2.86
31 Methylation at arginine 17 of histone H3 is linked to gene activation. EMBO Rep 2001 2.83
32 Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci 2002 2.80
33 Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol 2002 2.78
34 Reversing histone methylation. Nature 2005 2.57
35 The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J 2002 2.56
36 cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. Curr Biol 2002 2.27
37 Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. Int J Dev Biol 2006 2.17
38 Proline isomerization of histone H3 regulates lysine methylation and gene expression. Cell 2006 1.93
39 Histone methylation: recognizing the methyl mark. Methods Enzymol 2004 1.85
40 Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin. J Biol Chem 2004 1.78
41 The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol 2012 1.69
42 Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe. J Biol Chem 2007 1.65
43 Acetylation of beta-catenin by CREB-binding protein (CBP). J Biol Chem 2002 1.47
44 Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell 2012 1.46
45 Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res 2002 1.45
46 Histone methylation defines epigenetic asymmetry in the mouse zygote. Int J Dev Biol 2002 1.41
47 Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics 2006 1.39
48 DNA methyltransferases get connected to chromatin. Trends Genet 2002 1.38
49 A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Dev 2010 1.37
50 Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res 2003 1.32
51 Histone H3 tail clipping regulates gene expression. Nat Struct Mol Biol 2008 1.30
52 Phosphorylation of histone H3 Thr-45 is linked to apoptosis. J Biol Chem 2009 1.26
53 LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. Nat Cell Biol 2010 1.25
54 Direct binding of INHAT to H3 tails disrupted by modifications. J Biol Chem 2004 1.22
55 Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol Cancer Ther 2005 1.15
56 A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. Mol Cell Biol 2003 1.15
57 ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. Stem Cells 2012 1.09
58 Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus. J Biol Chem 2008 1.08
59 Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome. Clin Cancer Res 2004 1.08
60 Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2. Nat Struct Mol Biol 2009 1.03
61 The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells. Genome Biol 2013 1.00
62 Crystal structure of the ENT domain of human EMSY. J Mol Biol 2005 0.97
63 Three distinct patterns of histone H3Y41 phosphorylation mark active genes. Cell Rep 2012 0.95
64 Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes. Epigenetics Chromatin 2010 0.93
65 Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. EMBO Rep 2005 0.90
66 Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1. PLoS One 2007 0.86
67 The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia. PLoS One 2012 0.80
68 Decoding the chromatin modification landscape. Cell Cycle 2011 0.79
69 Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells. J Pathol 2014 0.78
70 Nuclear JAK2. Blood 2011 0.78
71 S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo. J Cell Biochem 2014 0.76
72 The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31. Mol Cell 2014 0.75