Published in J Biol Chem on February 15, 2002
Regulation of chromatin by histone modifications. Cell Res (2011) 8.44
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
Differential histone modifications mark mouse imprinting control regions during spermatogenesis. EMBO J (2007) 3.46
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37
Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol Cell Biol (2005) 2.86
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol (2003) 2.72
ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol (2007) 2.69
Open chromatin in pluripotency and reprogramming. Nat Rev Mol Cell Biol (2011) 2.69
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A (2005) 2.59
FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J (2005) 2.53
Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J (2002) 2.40
CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription. Proc Natl Acad Sci U S A (2004) 2.38
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res (2009) 2.31
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell (2005) 1.94
The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J (2002) 1.91
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J (2003) 1.89
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Proc Natl Acad Sci U S A (2002) 1.87
Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? Br J Nutr (2007) 1.85
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J (2009) 1.66
Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem J (2009) 1.59
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res (2006) 1.58
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J Biol Chem (2011) 1.55
The MTA family proteins as novel histone H3 binding proteins. Cell Biosci (2013) 1.52
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A (2004) 1.49
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Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes. EMBO J (2004) 1.42
Identifying novel proteins recognizing histone modifications using peptide pull-down assay. Methods (2006) 1.38
14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation. Mol Cell Biol (2008) 1.27
Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. Mol Cell Biol (2007) 1.25
MBD3 localizes at promoters, gene bodies and enhancers of active genes. PLoS Genet (2013) 1.22
PHD fingers: epigenetic effectors and potential drug targets. Mol Interv (2009) 1.21
Gene expression differences among primates are associated with changes in a histone epigenetic modification. Genetics (2011) 1.20
The NuRD architecture. Cell Mol Life Sci (2013) 1.18
Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc Natl Acad Sci U S A (2005) 1.15
An increasingly complex code. J Clin Invest (2002) 1.13
The ASH1 HOMOLOG 2 (ASHH2) histone H3 methyltransferase is required for ovule and anther development in Arabidopsis. PLoS One (2009) 1.12
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription. Biochemistry (2011) 1.10
S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. Cell Res (2011) 1.09
Unbiased proteomic screen for binding proteins to modified lysines on histone H3. Proteomics (2009) 1.08
Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies. Mol Cell Biol (2010) 1.07
Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas. Plant Cell (2005) 1.06
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1. EMBO J (2002) 1.04
Transcriptionally active heterochromatin in rye B chromosomes. Plant Cell (2007) 1.04
Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics (2012) 1.02
dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. EMBO J (2009) 1.01
Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments. Mol Cell Biol (2004) 1.01
Post-translational modifications of histones that influence nucleosome dynamics. Chem Rev (2014) 0.99
CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now. Biochem Soc Trans (2013) 0.98
Multivalent recognition of histone tails by the PHD fingers of CHD5. Biochemistry (2012) 0.97
Large scale analysis of co-existing post-translational modifications in histone tails reveals global fine structure of cross-talk. Mol Cell Proteomics (2014) 0.97
The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination. J Neurosci (2012) 0.95
Induced pluripotent stem cells: what lies beyond the paradigm shift. Exp Biol Med (Maywood) (2010) 0.95
Epigenetics and epilepsy. Epilepsia (2012) 0.95
CHD chromatin remodelers and the transcription cycle. Transcription (2011) 0.94
A core chromatin remodeling factor instructs global chromatin signaling through multivalent reading of nucleosome codes. Mol Cell (2013) 0.93
Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila. Genetics (2005) 0.93
Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale? Br J Nutr (2008) 0.92
cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter. J Mol Biol (2009) 0.91
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells. Nucleic Acids Res (2002) 0.89
Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. J Biol Chem (2012) 0.89
Transcriptional regulation by the Set7 lysine methyltransferase. Epigenetics (2013) 0.88
Epigenetic Reactivation of Estrogen Receptor: Promising Tools for Restoring Response to Endocrine Therapy. Mol Cell Pharmacol (2010) 0.87
Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities. Front Cell Neurosci (2013) 0.86
A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin. PLoS One (2012) 0.84
Proteomics in epigenetics: new perspectives for cancer research. Brief Funct Genomics (2013) 0.84
The WD40-repeat protein Pwp1p associates in vivo with 25S ribosomal chromatin in a histone H4 tail-dependent manner. Nucleic Acids Res (2006) 0.83
Chromatin remodeling and bivalent histone modifications in embryonic stem cells. EMBO Rep (2015) 0.83
B chromosomes of B. dichromosomatica show a reduced level of euchromatic histone H3 methylation marks. Chromosome Res (2007) 0.80
Stem cells: Escaping fates with open states. Nature (2009) 0.80
A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types. PLoS One (2013) 0.77
Characterization of histone modifications associated with DNA damage repair genes upon exposure to gamma rays in Arabidopsis seedlings. J Radiat Res (2016) 0.76
Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus. Clin Epigenetics (2016) 0.75
Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice. Sci Rep (2017) 0.75
Studying epigenetic complexes and their inhibitors with the proteomics toolbox. Clin Epigenetics (2016) 0.75
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82
Regulation of chromatin by histone modifications. Cell Res (2011) 8.44
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature (2011) 8.29
Cancer epigenetics: from mechanism to therapy. Cell (2012) 7.74
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature (2002) 6.09
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (2002) 6.05
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
Histone deimination antagonizes arginine methylation. Cell (2004) 5.19
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell (2004) 4.99
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem (2005) 4.78
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem (2002) 4.70
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature (2009) 4.60
MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature (2003) 4.56
Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature (2007) 4.55
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res (2003) 4.36
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell (2003) 4.33
An operational definition of epigenetics. Genes Dev (2009) 4.26
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol (2006) 3.65
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell (2003) 3.47
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature (2007) 3.32
Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell (2010) 3.25
Histone methylation: dynamic or static? Cell (2002) 3.12
Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J (2004) 2.94
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91
Targeting epigenetic readers in cancer. N Engl J Med (2012) 2.86
Methylation at arginine 17 of histone H3 is linked to gene activation. EMBO Rep (2001) 2.83
Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci (2002) 2.80
Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol (2002) 2.78
Reversing histone methylation. Nature (2005) 2.57
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J (2002) 2.56
8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease. Proteomics (2007) 2.33
cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. Curr Biol (2002) 2.27
Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. Int J Dev Biol (2006) 2.17
VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. J Cell Biol (2002) 2.06
Proline isomerization of histone H3 regulates lysine methylation and gene expression. Cell (2006) 1.93
A tumour suppressor network relying on the polyamine-hypusine axis. Nature (2012) 1.85
Histone methylation: recognizing the methyl mark. Methods Enzymol (2004) 1.85
Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin. J Biol Chem (2004) 1.78
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69
Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe. J Biol Chem (2007) 1.65
Acetylation of beta-catenin by CREB-binding protein (CBP). J Biol Chem (2002) 1.47
Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell (2012) 1.46
Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res (2002) 1.45
Histone methylation defines epigenetic asymmetry in the mouse zygote. Int J Dev Biol (2002) 1.41
Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics (2006) 1.39
DNA methyltransferases get connected to chromatin. Trends Genet (2002) 1.38
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Dev (2010) 1.37
Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res (2003) 1.32
Histone H3 tail clipping regulates gene expression. Nat Struct Mol Biol (2008) 1.30
Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice. J Biol Chem (2001) 1.28
Phosphorylation of histone H3 Thr-45 is linked to apoptosis. J Biol Chem (2009) 1.26
LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. Nat Cell Biol (2010) 1.25
Direct binding of INHAT to H3 tails disrupted by modifications. J Biol Chem (2004) 1.22
EDD mediates DNA damage-induced activation of CHK2. J Biol Chem (2006) 1.21
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol Cancer Ther (2005) 1.15
A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. Mol Cell Biol (2003) 1.15
ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. Stem Cells (2012) 1.09
Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus. J Biol Chem (2008) 1.08
Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome. Clin Cancer Res (2004) 1.08
Combined in-gel tryptic digestion and CNBr cleavage for the generation of peptide maps of an integral membrane protein with MALDI-TOF mass spectrometry. Biochim Biophys Acta (2002) 1.04
Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2. Nat Struct Mol Biol (2009) 1.03
The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells. Genome Biol (2013) 1.00
Crystal structure of the ENT domain of human EMSY. J Mol Biol (2005) 0.97
Three distinct patterns of histone H3Y41 phosphorylation mark active genes. Cell Rep (2012) 0.95
Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes. Epigenetics Chromatin (2010) 0.93
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. EMBO Rep (2005) 0.90
Improved in-gel approaches to generate peptide maps of integral membrane proteins with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Mass Spectrom (2002) 0.90
Proteomic approach to the identification of voltage-dependent anion channel protein isoforms in guinea pig brain synaptosomes. Proteomics (2004) 0.88
Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma. Proteomics (2003) 0.86
Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1. PLoS One (2007) 0.86
The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia. PLoS One (2012) 0.80
Identification of caseins in goat milk. Proteomics (2002) 0.79
Decoding the chromatin modification landscape. Cell Cycle (2011) 0.79
Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells. J Pathol (2014) 0.78
Nuclear JAK2. Blood (2011) 0.78
S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo. J Cell Biochem (2014) 0.76
Fast Global Phosphoproteome Profiling of Jurkat T cells by HIFU-TiO2-SCX-LC-MS/MS. Anal Chem (2017) 0.75
John Cottrell, David Creasy & Darryl Pappin. Interview by H. Craig Mak. Nat Biotechnol (2012) 0.75
The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31. Mol Cell (2014) 0.75