Published in Development on September 01, 2003
Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev (2004) 6.20
Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol (2005) 3.97
Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol (2009) 3.12
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci U S A (2007) 2.91
Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol Cell (2009) 2.47
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev (2006) 2.29
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Epigenetic programming and reprogramming during development. Nat Struct Mol Biol (2013) 2.13
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08
The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation. PLoS Genet (2006) 2.08
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol (2006) 1.97
Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo. Nat Rev Genet (2009) 1.94
Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit. J Cell Biol (2007) 1.72
MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol (2010) 1.68
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol Cell Biol (2004) 1.67
Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A (2010) 1.64
Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development. Science (2014) 1.61
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol (2004) 1.57
Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol (2012) 1.48
Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development (2008) 1.32
Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos. PLoS One (2010) 1.27
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26
Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells. Cancer Cell Int (2008) 1.26
The sperm nucleus: chromatin, RNA, and the nuclear matrix. Reproduction (2010) 1.18
Epigenetics: judge, jury and executioner of stem cell fate. Epigenetics (2012) 1.17
Epigenetic regulation in mammalian preimplantation embryo development. Reprod Biol Endocrinol (2009) 1.15
Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development. Development (2013) 1.14
X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet (2011) 1.14
Epigenetic reprogramming and development: a unique heterochromatin organization in the preimplantation mouse embryo. Brief Funct Genomics (2010) 1.11
Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging. Glia (2009) 1.09
Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte. EMBO Rep (2005) 1.05
Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development. Proc Natl Acad Sci U S A (2012) 1.03
Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development. Epigenetics Chromatin (2008) 1.00
Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos. Chromosome Res (2007) 0.96
The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution. Chromosome Res (2007) 0.95
Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Mol Med (2013) 0.92
Maternal effect genes: Findings and effects on mouse embryo development. Clin Exp Reprod Med (2014) 0.90
Establishment of epigenetic patterns in development. Chromosoma (2012) 0.90
Developmental regulation of Suz 12 localization. Chromosoma (2005) 0.89
Molecular marks for epigenetic identification of developmental and cancer stem cells. Clin Epigenetics (2010) 0.89
EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation. Mol Cell Biol (2013) 0.88
The coded functions of noncoding RNAs for gene regulation. Mol Cells (2011) 0.85
Epigenetic dynamics during preimplantation development. Reproduction (2015) 0.85
XCI in preimplantation mouse and human embryos: first there is remodelling…. Hum Genet (2011) 0.85
c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells. J Biol Chem (2014) 0.83
Poised chromatin in the mammalian germ line. Development (2014) 0.82
Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PLoS One (2013) 0.81
Acrylamide toxic effects on mouse oocyte quality and fertility in vivo. Sci Rep (2015) 0.81
Understanding the molecular circuitry of cell lineage specification in the early mouse embryo. Genes (Basel) (2011) 0.79
Cell identity in the preimplantation mammalian embryo: an epigenetic perspective from the mouse. Hum Reprod (2008) 0.79
Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development. Epigenetics (2012) 0.79
Epigenetics in preimplantation mammalian development. Theriogenology (2016) 0.78
Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. Elife (2016) 0.78
EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21. Open Biol (2016) 0.78
Dynamic expression of chromatin modifiers during developmental transitions in mouse preimplantation embryos. Sci Rep (2015) 0.77
Epigenetic reprogramming of human lung cancer cells with the extract of bovine parthenogenetic oocytes. J Cell Mol Med (2014) 0.76
Dynamics of histone H3 acetylation in the nucleosome core during mouse pre-implantation development. Epigenetics (2015) 0.76
Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development. Cell Cycle (2016) 0.76
Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis. Epigenetics (2016) 0.75
Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes. Oncotarget (2016) 0.75
PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells. Epigenetics Chromatin (2017) 0.75
PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice. Genome Biol (2017) 0.75
Epigenetic disruptions of histone signatures for the trophectoderm and inner cell mass in mouse parthenogenetic embryos. Stem Cells Dev (2014) 0.75
Chicken embryonic stem cells and primordial germ cells display different heterochromatic histone marks than their mammalian counterparts. Epigenetics Chromatin (2016) 0.75
Chromatin Memory in the Development of Human Cancers. Gene Technol (2014) 0.75
EZH2 is required for mouse oocyte meiotic maturation by interacting with and stabilizing spindle assembly checkpoint protein BubRI. Nucleic Acids Res (2016) 0.75
Genomic imprinting beyond DNA methylation: a role for maternal histones. Genome Biol (2017) 0.75
Dynamic changes in H1 subtype composition during epigenetic reprogramming. J Cell Biol (2017) 0.75
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
mRNA-Seq whole-transcriptome analysis of a single cell. Nat Methods (2009) 11.71
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature (2008) 10.11
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82
Suppression of inflammation by a synthetic histone mimic. Nature (2010) 8.80
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
Regulation of chromatin by histone modifications. Cell Res (2011) 8.44
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature (2011) 8.29
Cancer epigenetics: from mechanism to therapy. Cell (2012) 7.74
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
Epigenetic reprogramming in mouse primordial germ cells. Mech Dev (2002) 6.67
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature (2002) 6.09
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (2002) 6.05
The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol (2002) 5.67
A molecular programme for the specification of germ cell fate in mice. Nature (2002) 5.67
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51
Blimp1 is a critical determinant of the germ cell lineage in mice. Nature (2005) 5.49
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
Histone deimination antagonizes arginine methylation. Cell (2004) 5.19
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell (2004) 4.99
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem (2005) 4.78
Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem (2002) 4.70
A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev (2007) 4.69
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature (2009) 4.60
Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature (2007) 4.55
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51
An epigenetic road map for histone lysine methylation. J Cell Sci (2003) 4.43
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res (2003) 4.36
RNA-Seq analysis to capture the transcriptome landscape of a single cell. Nat Protoc (2010) 4.35
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell (2003) 4.33
An operational definition of epigenetics. Genes Dev (2009) 4.26
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
Maternal microRNAs are essential for mouse zygotic development. Genes Dev (2007) 4.16
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79
Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med (2008) 3.70
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol (2006) 3.65
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell (2003) 3.47
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46
MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res (2006) 3.36
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature (2007) 3.32
Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell (2010) 3.25
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Histone methylation: dynamic or static? Cell (2002) 3.12
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res (2008) 3.09
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08
Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev (2009) 3.02
Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01