Published in Trends Immunol on February 01, 2004
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (2010) 10.30
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med (2005) 4.79
The chemokine superfamily revisited. Immunity (2012) 2.83
Leukocyte migration and graft-versus-host disease. Blood (2005) 2.17
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment. Acta Neuropathol (2010) 2.12
Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator. Lab Chip (2005) 2.11
Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol (2007) 2.02
Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood (2005) 1.89
Oncolytic viruses: a novel form of immunotherapy. Expert Rev Anticancer Ther (2008) 1.78
Chemokines: novel targets for breast cancer metastasis. Cancer Metastasis Rev (2007) 1.49
Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med (2008) 1.44
Tumour necrosis factor-α inhibition can stabilize disease in progressive vitiligo. Br J Dermatol (2015) 1.42
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma. Gene Ther (2008) 1.41
A distinct chemokine axis does not account for enrichment of Foxp3(+) CD4(+) T cells in carcinogen-induced fibrosarcomas. Immunology (2015) 1.40
Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nat Rev Immunol (2009) 1.36
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. PLoS Pathog (2009) 1.35
HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. J Virol (2009) 1.28
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28
Chemokines: role in inflammation and immune surveillance. Ann Rheum Dis (2004) 1.28
CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection. J Virol (2006) 1.27
Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD). Philos Trans R Soc Lond B Biol Sci (2005) 1.26
Structural basis of chemokine receptor function--a model for binding affinity and ligand selectivity. Biosci Rep (2006) 1.26
Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J Immunol (2010) 1.24
Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin. J Cell Biol (2008) 1.23
IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma. Cancer Immunol Immunother (2008) 1.22
Measurement of cell migration in response to an evolving radial chemokine gradient triggered by a microvalve. Lab Chip (2006) 1.21
Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 (2014) 1.20
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci (2009) 1.20
Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. J Virol (2005) 1.20
Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J Clin Invest (2006) 1.18
Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation. Proc Natl Acad Sci U S A (2007) 1.18
B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J Clin Invest (2012) 1.17
Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma. Leukemia (2008) 1.16
Molecular control of physiological and pathological T-cell recruitment after mouse spinal cord injury. J Neurosci (2005) 1.16
Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis. J Transl Med (2011) 1.15
Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: role of coupled interactions and dynamics. Biochemistry (2009) 1.14
Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules. Exp Cell Res (2007) 1.10
Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J Med Chem (2012) 1.10
Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues. Mol Cell Biol (2006) 1.09
CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation. Cancer Res (2012) 1.09
CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One (2012) 1.08
CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood (2008) 1.08
CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. PLoS One (2009) 1.07
Oral inflammatory diseases and systemic inflammation: role of the macrophage. Front Immunol (2012) 1.07
Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease. Am J Pathol (2011) 1.05
Formation of B and T cell subsets require the cannabinoid receptor CB2. Immunogenetics (2006) 1.05
Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10. Clin Exp Immunol (2006) 1.05
Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. Genes Immun (2012) 1.04
Thermodynamic characterization of interleukin-8 monomer binding to CXCR1 receptor N-terminal domain. FEBS J (2007) 1.03
Modulatory effects of heparin and short-length oligosaccharides of heparin on the metastasis and growth of LMD MDA-MB 231 breast cancer cells in vivo. Br J Cancer (2007) 1.03
DARC on RBC limits lung injury by balancing compartmental distribution of CXC chemokines. Eur J Immunol (2009) 1.02
Association of serum MIP-1alpha, MIP-1beta, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus. Clin Rheumatol (2006) 1.02
Evolution of CC chemokines in teleost fish: a case study in gene duplication and implications for immune diversity. Immunogenetics (2007) 1.01
Neural circuit mechanisms of post-traumatic epilepsy. Front Cell Neurosci (2013) 0.99
The structural role of receptor tyrosine sulfation in chemokine recognition. Br J Pharmacol (2014) 0.98
Leukocyte transmigration across endothelial and extracellular matrix protein barriers in liver ischemia/reperfusion injury. Curr Opin Organ Transplant (2011) 0.97
Positive feedback may cause the biphasic response observed in the chemoattractant-induced response of Dictyostelium cells. Syst Control Lett (2006) 0.97
Roles of γδ T cells in the pathogenesis of autoimmune diseases. Clin Dev Immunol (2013) 0.96
An increased MRP8/14 expression and adhesion, but a decreased migration towards proinflammatory chemokines of type 1 diabetes monocytes. Clin Exp Immunol (2005) 0.96
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies. Arthritis Res Ther (2006) 0.96
Construction and validation of a Bovine Innate Immune Microarray. BMC Genomics (2005) 0.95
Differential expression of cytokines and chemokines in human monocytes induced by lipid formulations of amphotericin B. Antimicrob Agents Chemother (2005) 0.95
Chemokines in cancer development and progression and their potential as targeting molecules for cancer treatment. Mediators Inflamm (2014) 0.94
Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors. J Biol Chem (2010) 0.93
The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis. J Biol Chem (2012) 0.93
Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication. Clin Exp Immunol (2009) 0.93
SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis. FASEB J (2014) 0.92
Pericellular proteolysis in cancer. Genes Dev (2014) 0.92
Elevated ex vivo monocyte chemotactic protein-1 (CCL2) in pulmonary as compared with extra-pulmonary tuberculosis. BMC Immunol (2005) 0.91
Analysis of corneal inflammation induced by cauterisation in CCR2 and MCP-1 knockout mice. Br J Ophthalmol (2006) 0.90
Detrimental role of CC chemokine receptor 4 in murine polymicrobial sepsis. Infect Immun (2008) 0.89
The role of chemokines in severe malaria: more than meets the eye. Parasitology (2013) 0.88
Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens. PLoS Comput Biol (2012) 0.88
Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history. Genes Cells (2012) 0.87
Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet. J Gastroenterol (2010) 0.87
Antimicrobial activities of chemokines: not just a side-effect? Front Immunol (2012) 0.86
The Gαq/11 proteins contribute to T lymphocyte migration by promoting turnover of integrin LFA-1 through recycling. PLoS One (2012) 0.84
Modified skin window technique for the extended characterisation of acute inflammation in humans. Inflamm Res (2007) 0.84
Synergistic interactions between chemokine receptor elements in recognition of interleukin-8 by soluble receptor mimics. Biochemistry (2012) 0.84
In silico analysis reveals sequential interactions and protein conformational changes during the binding of chemokine CXCL-8 to its receptor CXCR1. PLoS One (2014) 0.83
Effects of radiation combined injury on hippocampal function are modulated in mice deficient in chemokine receptor 2 (CCR2). Radiat Res (2013) 0.83
Foot-and-mouth disease virus replicates only transiently in well-differentiated porcine nasal epithelial cells. J Virol (2010) 0.83
The downstream regulation of chemokine receptor signalling: implications for atherosclerosis. Mediators Inflamm (2013) 0.83
EpCAM modulates NF-κB signaling and interleukin-8 expression in breast cancer. Mol Cancer Res (2013) 0.83
Catfish CC chemokines: genomic clustering, duplications, and expression after bacterial infection with Edwardsiella ictaluri. Mol Genet Genomics (2005) 0.83
Multifaceted Impact of Host C-C Chemokine CCL2 in the Immuno-Pathogenesis of HIV-1/M. tuberculosis Co-Infection. Front Immunol (2013) 0.82
CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells. Biochim Biophys Acta (2015) 0.82
In silico identification and expression analysis of 12 novel CC chemokines in catfish. Immunogenetics (2005) 0.81
Alternative for anti-TNF antibodies for arthritis treatment. Mol Ther (2011) 0.81
Glutathione reductase is essential for host defense against bacterial infection. Free Radic Biol Med (2013) 0.81
An Ion Mobility-Mass Spectrometry Investigation of Monocyte Chemoattractant Protein-1. Int J Mass Spectrom (2009) 0.81
The role of chemokines in hepatitis C virus-mediated liver disease. Int J Mol Sci (2014) 0.81
Cardiovascular inflammation. Mediators Inflamm (2013) 0.81
Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration. J Biol Chem (2014) 0.80
Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction. Circulation (2016) 0.80
Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome. J Neuroinflammation (2014) 0.80
Targeting chemokine pathways in esophageal adenocarcinoma. Cell Cycle (2014) 0.79
The role of chemokines in mediating graft versus host disease: opportunities for novel therapeutics. Front Pharmacol (2012) 0.79
A skin-selective homing mechanism for human immune surveillance T cells. J Exp Med (2004) 1.91
A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum (2006) 1.50
Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A (2010) 1.33
Structure-function relationship between the human chemokine receptor CXCR3 and its ligands. J Biol Chem (2002) 1.28
The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice. Am J Pathol (2007) 1.27
CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses. Trends Immunol (2002) 1.26
Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation. Immunity (2005) 1.24
Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections. J Immunol (2009) 1.09
Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes. FEBS Lett (2003) 0.92
CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice. J Immunol (2013) 0.91
Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing. J Immunol (2006) 0.89
The platelet protein kinase C substrate pleckstrin binds directly to SDPR protein. Platelets (2009) 0.86
Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae). J Biol Chem (2002) 0.84
Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor. Transplantation (2005) 0.79
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett (2005) 0.78
Cupiennin 1d*: the cytolytic activity depends on the hydrophobic N-terminus and is modulated by the polar C-terminus. FEBS Lett (2002) 0.75