Published in Proc Natl Acad Sci U S A on February 21, 2007
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet (2009) 5.65
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature (2011) 5.49
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol (2008) 3.02
Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One (2008) 2.96
Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol (2010) 2.85
Genomic location analysis by ChIP-Seq. J Cell Biochem (2009) 2.44
Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. J Biol Chem (2012) 1.89
Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq. Nucleic Acids Res (2010) 1.81
A unique DNA binding domain converts T-cell factors into strong Wnt effectors. Mol Cell Biol (2007) 1.70
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells. Clin Cancer Res (2012) 1.68
Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development (2009) 1.59
Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell (2009) 1.51
NHERF-2 maintains endothelial homeostasis. Blood (2012) 1.47
A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol Cell Biol (2008) 1.42
A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice. Dig Dis Sci (2015) 1.40
A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. Proc Natl Acad Sci U S A (2009) 1.37
A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib. Blood (2009) 1.36
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells. J Biol Chem (2009) 1.35
An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1. Proc Natl Acad Sci U S A (2009) 1.26
Multiple Wnt/ß-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. PLoS One (2011) 1.05
Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J (2014) 1.05
Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas. EMBO Mol Med (2010) 1.01
Genomic insights into WNT/β-catenin signaling. Trends Pharmacol Sci (2013) 1.00
Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. Cancer Res (2016) 0.91
Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer. PLoS One (2014) 0.90
Localization of TFIIB binding regions using serial analysis of chromatin occupancy. BMC Mol Biol (2007) 0.88
The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways. Exp Cell Res (2011) 0.88
Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics (2010) 0.87
A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells. Cell Cycle (2015) 0.87
Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene. PLoS One (2014) 0.85
The Myc 3' Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol (2012) 0.83
Generation of high quality chromatin immunoprecipitation DNA template for high-throughput sequencing (ChIP-seq). J Vis Exp (2013) 0.83
Identification of neuronal target genes for CCAAT/enhancer binding proteins. Mol Cell Neurosci (2008) 0.83
Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer. World J Biol Chem (2015) 0.82
Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability. BMC Genomics (2012) 0.82
Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2. Eur J Hum Genet (2014) 0.80
The myc 3' wnt-responsive element suppresses colonic tumorigenesis. Mol Cell Biol (2014) 0.80
The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation. Differentiation (2011) 0.79
β-Catenin and peroxisome proliferator-activated receptor-δ coordinate dynamic chromatin loops for the transcription of vascular endothelial growth factor A gene in colon cancer cells. J Biol Chem (2012) 0.78
Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells. J Biol Chem (2012) 0.78
The Myc 3' Wnt responsive element regulates neutrophil recruitment after acute colonic injury in mice. Dig Dis Sci (2013) 0.76
The MYC 3' Wnt-Responsive Element Drives Oncogenic MYC Expression in Human Colorectal Cancer Cells. Cancers (Basel) (2016) 0.76
Role of the Wnt signaling molecules in the tooth. Jpn Dent Sci Rev (2016) 0.75
Evidence for a Circadian Effect on the Reduction of Human Growth Hormone Gene Expression in Response to Excess Caloric Intake. J Biol Chem (2016) 0.75
Expression and Splice Variant Analysis of Human TCF4 Transcription Factor in Esophageal Cancer. J Cancer (2015) 0.75
Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell (2004) 16.15
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 10.95
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A (1999) 10.75
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science (1990) 9.90
Gene expression profiles in normal and cancer cells. Science (1997) 9.65
Advanced sequencing technologies: methods and goals. Nat Rev Genet (2004) 9.31
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29
Using the transcriptome to annotate the genome. Nat Biotechnol (2002) 9.04
Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. Nat Methods (2004) 7.93
ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments. Genomics (2004) 7.21
Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev (2005) 7.21
Reliability and reproducibility issues in DNA microarray measurements. Trends Genet (2005) 6.79
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell (2006) 6.49
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem (2006) 6.32
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell (1999) 5.12
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J (1991) 4.90
Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science (2005) 4.61
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A (1999) 4.35
Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev (1997) 3.80
Beta-catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sci U S A (1997) 3.79
LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell (1997) 3.63
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell (2002) 3.37
An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell (2004) 3.30
High-resolution genome-wide mapping of histone modifications. Nat Biotechnol (2004) 2.69
Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat (1993) 2.63
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40
Fast chromatin immunoprecipitation assay. Nucleic Acids Res (2006) 2.39
N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts. Mol Cell Biol (1990) 2.24
Chromatin immunoprecipitation assay. Biotechniques (2004) 1.68
Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A (2006) 1.67
Secreted and cell surface genes expressed in benign and malignant colorectal tumors. Cancer Res (2001) 1.64
An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. J Biol Chem (2006) 1.21
Epithelial stem cells and their niche: there's no place like home. Stem Cells (2005) 1.09
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 6.61
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A (2008) 3.98
Regulation of corepressor function by nuclear NADH. Science (2002) 3.83
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci (2007) 3.81
MIFlowCyt: the minimum information about a Flow Cytometry Experiment. Cytometry A (2008) 3.33
Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal models. Neurobiol Aging (2005) 3.09
A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci (2007) 2.45
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron (2002) 2.45
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell (2003) 2.42
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A (2010) 2.28
An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling. Mol Cell Neurosci (2009) 2.28
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A (2003) 2.25
Retracted Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2007) 2.09
Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc Natl Acad Sci U S A (2003) 2.03
Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum Mol Genet (2004) 1.86
A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs. PLoS Pathog (2010) 1.82
Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A (2006) 1.67
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A (2004) 1.49
Deacetylase activity is required for cAMP activation of a subset of CREB target genes. J Biol Chem (2003) 1.48
A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol Cell Biol (2008) 1.42
Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse. BMC Genomics (2010) 1.38
A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. Proc Natl Acad Sci U S A (2009) 1.37
Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci U S A (2005) 1.35
Epigenetic mechanisms and gene networks in the nervous system. J Neurosci (2005) 1.33
Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol (2011) 1.30
Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation. PLoS One (2013) 1.29
Utilizing RNA-Seq data for de novo coexpression network inference. Bioinformatics (2012) 1.28
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A (2009) 1.25
An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. J Biol Chem (2006) 1.21
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21
Renal gene and protein expression signatures for prediction of kidney disease progression. Am J Pathol (2009) 1.15
Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2. Proc Natl Acad Sci U S A (2010) 1.14
On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol Clin Exp Res (2004) 1.11
Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. J Virol (2013) 1.08
The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster. Mol Cell Biol (2002) 1.08
Role reversal: the regulation of neuronal gene expression by microRNAs. Curr Opin Neurobiol (2005) 1.06
MicroRNA pathways in neural development and plasticity. Curr Opin Neurobiol (2010) 1.04
Selection for drinking in the dark alters brain gene coexpression networks. Alcohol Clin Exp Res (2013) 1.04
Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. MBio (2013) 1.04
American Telemedicine Association's Practice Guidelines for Teledermatology. Telemed J E Health (2008) 0.99
Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems. BMC Syst Biol (2011) 0.97
Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach. Proc Natl Acad Sci U S A (2012) 0.96
DNA microarray and proteomic strategies for understanding alcohol action. Alcohol Clin Exp Res (2006) 0.94
Regulation of microRNA-375 by cAMP in pancreatic β-cells. Mol Endocrinol (2012) 0.92
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia (2007) 0.89
Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library. PLoS One (2013) 0.89
The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila. Proc Natl Acad Sci U S A (2002) 0.88
Localization of TFIIB binding regions using serial analysis of chromatin occupancy. BMC Mol Biol (2007) 0.88
Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines. Pharmacol Biochem Behav (2008) 0.87
Calmodulin-dependent protein kinase IV mediated antagonism of BMP signaling regulates lineage and survival of hematopoietic progenitors. Development (2002) 0.87
Deoxyribonucleic acid microarray analysis of gene expression pattern in the arcuate nucleus/ventromedial nucleus of hypothalamus during lactation. Endocrinology (2005) 0.86
Consensus framework for exploring microarray data using multiple clustering methods. OMICS (2007) 0.84
Differential network analysis reveals genetic effects on catalepsy modules. PLoS One (2013) 0.83
A systems framework for vaccine design. Curr Opin Immunol (2013) 0.83
Systems immunogenetics of vaccines. Semin Immunol (2013) 0.82
TandTRAQ: an open-source tool for integrated protein identification and quantitation. Bioinformatics (2007) 0.82
Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects. Physiol Genomics (2011) 0.81
Startle cue-reactivity differentiates between light and heavy smokers. Addiction (2009) 0.81
MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9. Proc Natl Acad Sci U S A (2013) 0.80
Complex genetics of interactions of alcohol and CNS function and behavior. Alcohol Clin Exp Res (2005) 0.80
The GA and the GWAS: using genetic algorithms to search for multilocus associations. IEEE/ACM Trans Comput Biol Bioinform (2011) 0.80
Genetic factors involved in risk for methamphetamine intake and sensitization. Mamm Genome (2013) 0.79
Copy number variation analysis in 98 individuals with PHACE syndrome. J Invest Dermatol (2012) 0.79
Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects. J Bone Miner Res (2015) 0.78
Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects. Alcohol Clin Exp Res (2014) 0.78
The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits. Mamm Genome (2013) 0.77
Influenza vaccination of pregnant women: attitudes and behaviors of Oregon physician prenatal care providers. Matern Child Health J (2015) 0.77
Corrigendum: miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nat Commun (2015) 0.76
Occupancy classification of position weight matrix-inferred transcription factor binding sites. PLoS One (2011) 0.75
Microcephaly genes and risk of late-onset Alzheimer disease. Alzheimer Dis Assoc Disord (2011) 0.75
Detection of expression quantitative trait Loci in complex mouse crosses: impact and alleviation of data quality and complex population substructure. Front Genet (2012) 0.75
A Simulation Framework to Investigate in vitro Viral Infection Dynamics. J Comput Sci (2013) 0.75
Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2015) 0.75
Between pathways and networks lies context: implications for precision medicine. Sci Prog (2015) 0.75