Published in J Biol Chem on May 17, 2004
Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling. J Biol Chem (2007) 1.98
Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol (2006) 1.44
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41
Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2006) 1.35
Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation. PLoS One (2008) 1.24
Nucleotide signaling in nervous system development. Pflugers Arch (2006) 1.18
Basic fibroblast growth factor activates MEK/ERK cell signaling pathway and stimulates the proliferation of chicken primordial germ cells. PLoS One (2010) 1.12
Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. PLoS One (2011) 0.99
Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. Sci Signal (2009) 0.93
Progress in the reprogramming of somatic cells. Circ Res (2013) 0.92
A small molecule inhibitor of SRC family kinases promotes simple epithelial differentiation of human pluripotent stem cells. PLoS One (2013) 0.91
Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. Angew Chem Int Ed Engl (2011) 0.91
Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives. BMC Genomics (2009) 0.88
New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders. Purinergic Signal (2007) 0.87
Low concentrations of nitric oxide delay the differentiation of embryonic stem cells and promote their survival. Cell Death Dis (2010) 0.87
Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. PLoS One (2014) 0.85
Potential for pharmacological manipulation of human embryonic stem cells. Br J Pharmacol (2013) 0.85
Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells. Cancer Res (2009) 0.85
Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells. J Biol Chem (2011) 0.84
c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src. ACS Chem Biol (2013) 0.84
A scalable approach for discovering conserved active subnetworks across species. PLoS Comput Biol (2010) 0.82
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype. Cell Death Dis (2014) 0.82
Focal adhesion kinases in adhesion structures and disease. J Signal Transduct (2012) 0.81
Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal. PLoS One (2013) 0.81
The self-renewal of mouse embryonic stem cells is regulated by cell-substratum adhesion and cell spreading. Int J Biochem Cell Biol (2013) 0.80
An unexpected role for the clock protein timeless in developmental apoptosis. PLoS One (2011) 0.80
Ectopic pregnancy-derived human trophoblastic stem cells regenerate dopaminergic nigrostriatal pathway to treat parkinsonian rats. PLoS One (2012) 0.79
Serum Inter-α-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells. J Biol Chem (2014) 0.79
Discovery of consensus gene signature and intermodular connectivity defining self-renewal of human embryonic stem cells. Stem Cells (2014) 0.79
Development and application of neural stem cells for treating various human neurological diseases in animal models. Lab Anim Res (2013) 0.78
The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease. Semin Cell Dev Biol (2014) 0.77
Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res (2014) 0.77
A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation. J Cell Biol (2015) 0.76
Philadelphia chromosome-positive leukemia stem cells in acute lymphoblastic leukemia and tyrosine kinase inhibitor therapy. World J Stem Cells (2012) 0.76
Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. PLoS One (2016) 0.75
Protein kinases and associated pathways in pluripotent state and lineage differentiation. Curr Stem Cell Res Ther (2014) 0.75
The human embryonic stem cell proteome revealed by multidimensional fractionation followed by tandem mass spectrometry. Proteomics (2014) 0.75
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (2002) 15.55
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89
Retracted Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell (2013) 6.86
Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (2005) 6.14
A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell (2012) 4.49
Recovery from diabetes in mice by beta cell regeneration. J Clin Invest (2007) 4.32
A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell (2007) 4.13
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Cell Stem Cell (2013) 4.05
Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83
Extreme makeover: converting one cell into another. Cell Stem Cell (2008) 3.60
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell (2009) 3.31
Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. Cell Stem Cell (2014) 3.16
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature (2007) 3.11
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
A gene regulatory network in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 2.94
Endothelial signaling during development. Nat Med (2003) 2.83
Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev (2003) 2.58
Role of VEGF-A in vascularization of pancreatic islets. Curr Biol (2003) 2.56
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
Insulin staining of ES cell progeny from insulin uptake. Science (2003) 2.46
Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature (2011) 2.42
Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A (2005) 2.41
Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development (2003) 2.39
Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell (2009) 2.31
Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol (2012) 2.26
Single-cell transcript analysis of pancreas development. Dev Cell (2003) 2.11
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10
Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol (2004) 2.08
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol (2012) 1.90
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90
Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol (2003) 1.89
Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol (2007) 1.75
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature (2012) 1.64
How to make a functional β-cell. Development (2013) 1.58
Transcriptional dynamics of endodermal organ formation. Dev Dyn (2009) 1.58
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Differentiated human stem cells resemble fetal, not adult, β cells. Proc Natl Acad Sci U S A (2014) 1.44
A simple tool to improve pluripotent stem cell differentiation. Nat Methods (2013) 1.42
Human embryonic stem cells. Methods Enzymol (2006) 1.41
How to make beta cells? Curr Opin Cell Biol (2009) 1.31
Rapid cellular turnover in adipose tissue. PLoS One (2011) 1.26
Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes (2002) 1.23
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc Natl Acad Sci U S A (2012) 1.21
Facultative endocrine progenitor cells in the adult pancreas. Cell (2008) 1.21
Genome modification in human embryonic stem cells. J Cell Physiol (2010) 1.19
How important are adult stem cells for tissue maintenance? Cell Cycle (2004) 1.17
Wnt signaling specifies and patterns intestinal endoderm. Mech Dev (2011) 1.14
Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev (2006) 1.13
Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn (2008) 1.11
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife (2014) 1.08
Gene expression in the preimplantation embryo: in-vitro developmental changes. Reprod Biomed Online (2005) 1.03
Human embryonic stem cells: emerging technologies and practical applications. Curr Opin Genet Dev (2008) 1.01
Efficient culturing and genetic manipulation of human pluripotent stem cells. PLoS One (2011) 0.97
Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development (2013) 0.96
Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int J Dev Biol (2002) 0.86
White to brite adipocyte transition and back again. Nat Cell Biol (2013) 0.83
Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport-Brief Report. Arterioscler Thromb Vasc Biol (2015) 0.83
New tools for genome modification in human embryonic stem cells. Cell Stem Cell (2007) 0.82
Induced pluripotent stem (iPS) cells: an up-to-the-minute review. F1000 Biol Rep (2009) 0.82
Derivation of human embryonic stem cells by immunosurgery. J Vis Exp (2007) 0.82
Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med (2016) 0.81
The molecular biography of the cell. Cell (2005) 0.81
Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue. PLoS One (2011) 0.79
New findings in pancreatic and intestinal endocrine development to advance regenerative medicine. Curr Opin Endocrinol Diabetes Obes (2013) 0.78
Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells (2013) 0.77
Cbx proteins help ESCs walk the line between self-renewal and differentiation. Cell Stem Cell (2012) 0.77
Liver in a dish. Cell Res (2013) 0.75
Expression analysis of macrodactyly identifies pleiotrophin upregulation. PLoS One (2012) 0.75
Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes. Nat Commun (2016) 0.75