Published in Intensive Care Med on May 18, 2004
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood (2006) 1.38
Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Crit Care (2009) 1.18
Proteomics reveals age-related differences in the host immune response to sepsis. J Proteome Res (2013) 1.16
Prevalence and significance of coagulation abnormalities in community-acquired pneumonia. Mol Med (2009) 1.12
Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis. Crit Care (2006) 1.11
Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation. Thromb J (2006) 1.10
Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries. Intensive Care Med (2010) 1.00
Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore. J Biol Chem (2014) 0.99
A clinically applicable porcine model of septic and ischemia/reperfusion-induced shock and multiple organ injury. J Surg Res (2010) 0.96
Toward an operative diagnosis in sepsis: a latent class approach. BMC Infect Dis (2008) 0.88
Pre-existing atrial fibrillation and risk of arterial thromboembolism and death following pneumonia: a population-based cohort study. BMJ Open (2014) 0.86
Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice. PLoS One (2011) 0.83
A randomized clinical trial of unfractioned heparin for treatment of sepsis (the HETRASE study): design and rationale [NCT00100308]. Trials (2006) 0.83
Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns. Eur J Pediatr (2006) 0.81
Early diagnostic markers of sepsis after oesophagectomy (including thromboelastography). BMC Anesthesiol (2012) 0.81
Novel biomarkers for early prediction of sepsis-induced disseminated intravascular coagulation in a mouse cecal ligation and puncture model. J Inflamm (Lond) (2013) 0.81
Is Familial Mediterranean Fever a thrombotic disease or not? Eur J Pediatr (2007) 0.80
Microcirculatory changes in term newborns with suspected infection: an observational prospective study. Int J Pediatr (2013) 0.79
Bronchoalveolar Activation of Coagulation and Inhibition of Fibrinolysis during Ventilator-Associated Lung Injury. Crit Care Res Pract (2012) 0.79
Pre-existing atrial fibrillation and risk of arterial thromboembolism and death in intensive care unit patients: a population-based cohort study. Crit Care (2015) 0.76
Sepsis: a review for the neurohospitalist. Neurohospitalist (2012) 0.76
The melding of nanomedicine in thrombosis imaging and treatment: a review. Future Sci OA (2016) 0.75
Analysis of the influence of antithrombin on microvascular thrombosis: anti-inflammation is crucial for anticoagulation. Intensive Care Med Exp (2015) 0.75
Year in review 2005: Critical Care - resource management. Crit Care (2006) 0.75
Should β-blockers be used in septic shock? Crit Care (2014) 0.75
Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis. J Intensive Care (2017) 0.75
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Mortality after surgery in Europe: a 7 day cohort study. Lancet (2012) 9.96
Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med (2010) 8.58
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med (2004) 5.90
Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med (2002) 5.84
Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA (2010) 5.80
Sepsis definitions: time for change. Lancet (2013) 5.63
Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology (2015) 5.52
Circulatory shock. N Engl J Med (2013) 4.95
Sepsis biomarkers: a review. Crit Care (2010) 4.76
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med (2004) 4.56
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07
Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med (2003) 4.04
Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med (2005) 3.97
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Pulse pressure variations to predict fluid responsiveness: influence of tidal volume. Intensive Care Med (2005) 3.81
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65
High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58
The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med (2006) 3.53
Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet (2009) 3.38
Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med (2011) 3.34
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09
Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med (2007) 3.06
C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest (2003) 2.95
Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest (2008) 2.90
Let us use the pulmonary artery catheter correctly and only when we need it. Crit Care Med (2005) 2.83
Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions. Crit Care Med (2010) 2.83
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study. Crit Care Med (2006) 2.74
Do all nonsurvivors of cardiogenic shock die with a low cardiac index? Chest (2003) 2.73
Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med (2005) 2.73
Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med (2013) 2.72
Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med (2009) 2.68
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48
Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med (2006) 2.47
Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med (2006) 2.40
Ethics and end-of-life care for adults in the intensive care unit. Lancet (2010) 2.40
Management of bleeding following major trauma: a European guideline. Crit Care (2007) 2.40
Antibiotic strategies in severe nosocomial sepsis: why do we not de-escalate more often? Crit Care Med (2012) 2.39
Host-pathogen interactions in sepsis. Lancet Infect Dis (2007) 2.35
Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med (2004) 2.33
Severe sepsis in cirrhosis. Hepatology (2009) 2.33
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31
Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med (2008) 2.27
The prognostic value of muscle StO2 in septic patients. Intensive Care Med (2007) 2.25
Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit Care Med (2003) 2.23
Gamma-globulin levels in patients with community-acquired septic shock. Shock (2009) 2.21
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17
A large-bolus injection, but not continuous infusion of sodium selenite improves outcome in peritonitis. Shock (2009) 2.17
Sepsis: time to reconsider the concept. Crit Care Med (2008) 2.17
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care (2010) 2.11
Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med (2010) 2.11
Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality? Transfusion (2009) 2.11
Randomized, controlled clinical trials in sepsis: has methodological quality improved over time? Crit Care Med (2002) 2.10
The Surviving Sepsis Campaign: raising awareness to reduce mortality. Crit Care (2003) 2.07
High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safety. Crit Care Med (2006) 2.07
Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis*. Crit Care Med (2012) 2.06
Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med (2010) 2.05
Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med (2003) 2.05
Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med (2003) 2.01
An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study. Intensive Care Med (2006) 2.00
Multicenter, randomized, controlled trials evaluating mortality in intensive care: doomed to fail? Crit Care Med (2008) 2.00
Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Crit Care Med (2003) 1.98
Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care (2011) 1.91
Monitoring the microcirculation in the critically ill patient: current methods and future approaches. Intensive Care Med (2010) 1.88
Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J (2004) 1.86
Molecular biology of inflammation and sepsis: a primer. Crit Care Med (2009) 1.86
The impact of hospital and ICU organizational factors on outcome in critically ill patients: results from the Extended Prevalence of Infection in Intensive Care study. Crit Care Med (2015) 1.85
Coagulation abnormalities in critically ill patients. Crit Care (2006) 1.84
Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents (2011) 1.80
Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77
Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients. Intensive Care Med (2010) 1.77
Global prospective epidemiologic and surveillance study of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Crit Care Med (2014) 1.77
Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care (2012) 1.76
Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial. Crit Care Med (2016) 1.76
Relative adrenal insufficiency in patients with septic shock: comparison of low-dose and conventional corticotropin tests. Crit Care Med (2005) 1.72
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med (2004) 1.72
Ventriculostomy-related infections in critically ill patients: a 6-year experience. J Neurosurg (2005) 1.71
The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction. Intensive Care Med (2002) 1.71
Characteristics and outcomes of cancer patients in European ICUs. Crit Care (2009) 1.70
Does a higher positive end expiratory pressure decrease mortality in acute respiratory distress syndrome? A systematic review and meta-analysis. Anesthesiology (2009) 1.68
Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study. Crit Care (2013) 1.66
Post mortem examination in the intensive care unit: still useful? Intensive Care Med (2004) 1.66
Sublingual and muscular microcirculatory alterations after cardiac arrest: a pilot study. Resuscitation (2011) 1.63
Antibiotic usage and resistance: gaining or losing ground on infections in critically ill patients? JAMA (2009) 1.63