Published in J Neurosci on September 22, 2004
Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic Biol Med (2007) 2.08
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging (2006) 1.17
Rhesus macaque brain morphometry: a methodological comparison of voxel-wise approaches. Methods (2009) 1.02
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging (2006) 1.01
Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochem Res (2008) 0.95
A canine model of human aging and Alzheimer's disease. Biochim Biophys Acta (2013) 0.93
Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. Vet Clin North Am Small Anim Pract (2008) 0.90
Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci (2010) 0.87
Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Front Pharmacol (2014) 0.82
Aging in the canine and feline brain. Vet Clin North Am Small Anim Pract (2014) 0.79
Different CSF β-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease. J Neural Transm (Vienna) (2011) 0.78
Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model. J Alzheimers Dis (2008) 0.77
Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation. PeerJ (2017) 0.76
Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordr) (2005) 0.76
Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. Can Vet J (2008) 0.76
Neurobiology of the aging dog. Age (Dordr) (2010) 0.76
Young to Middle-Aged Dogs with High Amyloid-β Levels in Cerebrospinal Fluid are Impaired on Learning in Standard Cognition tests. J Alzheimers Dis (2016) 0.75
Aging of Attentiveness in Border Collies and Other Pet Dog Breeds: The Protective Benefits of Lifelong Training. Front Aging Neurosci (2017) 0.75
Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines. Age (Dordr) (2008) 0.75
Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline. Front Aging Neurosci (2016) 0.75
Effect of Skull Type on the Relative Size of Cerebral Cortex and Lateral Ventricles in Dogs. Front Vet Sci (2017) 0.75
Translational models for vascular cognitive impairment: a review including larger species. BMC Med (2017) 0.75
Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. J Comp Neurol (2008) 0.75
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (2003) 18.18
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain (2011) 9.90
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods (2005) 7.62
National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke (2006) 6.94
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement properties. Neurorehabil Neural Repair (2002) 4.47
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15
Neurobiology of exercise. Obesity (Silver Spring) (2006) 3.39
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci (2005) 3.27
Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. J Alzheimers Dis (2013) 3.10
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement (2011) 3.05
Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke (2002) 2.87
Development of a quantitative method for analysis of breast density based on three-dimensional breast MRI. Med Phys (2008) 2.84
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J Neurosci (2003) 2.63
Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. Lancet Neurol (2008) 2.62
Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci (2009) 2.48
A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurol (2013) 2.32
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A (2008) 2.29
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 2.28
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis (2009) 2.12
Gait asymmetry in community-ambulating stroke survivors. Arch Phys Med Rehabil (2008) 2.10
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem (2008) 2.04
Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol (2008) 2.03
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol (2003) 2.02
Evaluation of gait symmetry after stroke: a comparison of current methods and recommendations for standardization. Gait Posture (2009) 1.99
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
Patterned cell culture inside microfluidic devices. Lab Chip (2004) 1.89
Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc (2002) 1.81
Residual breast cancer diagnosed by MRI in patients receiving neoadjuvant chemotherapy with and without bevacizumab. Ann Surg Oncol (2009) 1.80
Imaging markers for Alzheimer disease: which vs how. Neurology (2013) 1.76
A new visual rating scale to assess strategic white matter hyperintensities within cholinergic pathways in dementia. Stroke (2005) 1.74
APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology (2009) 1.74
Microfluidic Multicompartment Device for Neuroscience Research. Langmuir (2003) 1.72
Quantitative analysis of lesion morphology and texture features for diagnostic prediction in breast MRI. Acad Radiol (2008) 1.70
The case of K.C.: contributions of a memory-impaired person to memory theory. Neuropsychologia (2005) 1.68
Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol (2011) 1.62
Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma (2005) 1.60
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation (2012) 1.57
Utility-based Quality of Life measures in Alzheimer's disease. Qual Life Res (2006) 1.55
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci (2004) 1.54
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem (2011) 1.53
Retracted Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem (2009) 1.53
Pathological complete response in triple negative poorly differentiated invasive ductal breast carcinoma detected during pregnancy. J Clin Oncol (2007) 1.51
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis (2002) 1.51
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.48
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
Cueing the personal future to reduce discounting in intertemporal choice: Is episodic prospection necessary? Hippocampus (2015) 1.46
The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging (2005) 1.44
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PLoS One (2008) 1.42
Quantification of choline-containing compounds in malignant breast tumors by 1H MR spectroscopy using water as an internal reference at 1.5 T. MAGMA (2006) 1.40
Nutrition, brain aging, and neurodegeneration. J Neurosci (2009) 1.40
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation (2008) 1.38
Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808. J Alzheimers Dis (2014) 1.36
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement (2009) 1.36
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging (2002) 1.34
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Mol Neurodegener (2010) 1.34
Monitoring the size and response of locally advanced breast cancers to neoadjuvant chemotherapy (weekly paclitaxel and epirubicin) with serial enhanced MRI. Breast Cancer Res Treat (2003) 1.34
Predicting pathologic response to neoadjuvant chemotherapy in breast cancer by using MR imaging and quantitative 1H MR spectroscopy. Radiology (2009) 1.34
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem (2003) 1.32
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32
Investigation of c9orf72 in 4 neurodegenerative disorders. Arch Neurol (2012) 1.32
Aging, the central nervous system, and mobility. J Gerontol A Biol Sci Med Sci (2013) 1.32
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis (2008) 1.31
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci (2007) 1.31
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res (2007) 1.30
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett (2004) 1.28
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26
Well-being after stroke in Canadian seniors: findings from the Canadian Study of Health and Aging. Stroke (2002) 1.24
Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging (2005) 1.24
Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice. J Neurotrauma (2007) 1.24
Selection of diagnostic features on breast MRI to differentiate between malignant and benign lesions using computer-aided diagnosis: differences in lesions presenting as mass and non-mass-like enhancement. Eur Radiol (2009) 1.24
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
A new bias field correction method combining N3 and FCM for improved segmentation of breast density on MRI. Med Phys (2011) 1.23
Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Arch Neurol (2007) 1.22
Attentional networks in normal aging and Alzheimer's disease. Neuropsychology (2006) 1.21
Diagnostic criteria for vascular cognitive disorders: a VASCOG statement. Alzheimer Dis Assoc Disord (2014) 1.21
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis (2012) 1.20
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci (2007) 1.20
Task-relevant modulation of contralateral and ipsilateral primary somatosensory cortex and the role of a prefrontal-cortical sensory gating system. Neuroimage (2002) 1.20
Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. Am J Pathol (2006) 1.20
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem (2007) 1.19