Published in J Mol Biol on June 11, 2004
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst) (2010) 1.96
C. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression. PLoS Genet (2007) 1.47
Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. EMBO J (2006) 1.46
Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50. Genes Dev (2011) 1.45
ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex. Nucleic Acids Res (2011) 1.19
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. Nat Struct Mol Biol (2011) 1.16
The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius. BMC Mol Biol (2008) 1.10
Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair. BMC Mol Biol (2006) 1.07
Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair. Prog Biophys Mol Biol (2015) 1.07
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem (2013) 0.96
Mre11-Rad50 complex crystals suggest molecular calisthenics. DNA Repair (Amst) (2011) 0.91
Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination. Genetics (2008) 0.88
Interdependence of the rad50 hook and globular domain functions. Mol Cell (2015) 0.86
SMC complexes in bacterial chromosome condensation and segregation. Plasmid (2005) 0.85
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev (2014) 0.83
The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes. Exp Cell Res (2014) 0.82
Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain. J Biol Chem (2015) 0.80
The metagenomic telescope. PLoS One (2014) 0.79
Eukaryotic Rad50 functions as a rod-shaped dimer. Nat Struct Mol Biol (2017) 0.79
Structural studies of DNA end detection and resection in homologous recombination. Cold Spring Harb Perspect Biol (2014) 0.78
The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep (2017) 0.75
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. Q Rev Biophys (2007) 9.07
Mechanism of eukaryotic homologous recombination. Annu Rev Biochem (2008) 8.86
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS). Nat Methods (2009) 6.77
DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature (2003) 5.66
DNA double-strand break repair: all's well that ends well. Annu Rev Genet (2006) 5.59
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell (2008) 5.35
Type IV pilus structure and bacterial pathogenicity. Nat Rev Microbiol (2004) 4.29
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell (2008) 4.26
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell (2005) 4.02
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science (2009) 4.00
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol (2004) 3.94
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature (2013) 3.60
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature (2002) 3.48
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev (2011) 3.47
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol (2007) 3.38
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions. Mol Cell (2006) 3.36
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell (2004) 3.33
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science (2004) 3.20
Accurate assessment of mass, models and resolution by small-angle scattering. Nature (2013) 3.18
Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol Cell (2008) 3.15
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. Cell (2008) 3.14
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem Cell Biol (2007) 3.13
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature (2005) 3.09
5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. Proc Natl Acad Sci U S A (2009) 3.05
X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA. Cell (2005) 3.04
Mechanisms of eukaryotic DNA double strand break repair. Front Biosci (2006) 2.98
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J (2003) 2.95
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell (2009) 2.90
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law. Biopolymers (2011) 2.87
DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nat Struct Mol Biol (2004) 2.86
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature (2010) 2.79
Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. Mol Cell (2003) 2.78
Structural basis for DNA duplex separation by a superfamily-2 helicase. Nat Struct Mol Biol (2007) 2.77
SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77
A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J Biol Chem (2006) 2.69
Microbial metalloproteomes are largely uncharacterized. Nature (2010) 2.62
Structural mechanism of cytosolic DNA sensing by cGAS. Nature (2013) 2.50
Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering. Curr Opin Struct Biol (2010) 2.45
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J (2002) 2.45
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily. Cell (2011) 2.44
Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol (2005) 2.44
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev (2009) 2.43
MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell (2010) 2.40
Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell (2006) 2.39
Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J Biol Chem (2005) 2.35
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. Cell Cycle (2010) 2.32
Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res (2007) 2.32
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev (2008) 2.29
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. J Biol Chem (2004) 2.28
Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function. DNA Repair (Amst) (2006) 2.28
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J (2006) 2.27
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. DNA Repair (Amst) (2007) 2.26
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell (2006) 2.23
Counting RAD51 proteins disassembling from nucleoprotein filaments under tension. Nature (2008) 2.21
DNA base damage recognition and removal: new twists and grooves. Mutat Res (2005) 2.21
DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase. Cell Cycle (2009) 2.21
Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A (2008) 2.19
Recruitment of the recombinational repair machinery to a DNA double-strand break in yeast. Mol Cell (2003) 2.17
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Modulation of protein properties in living cells using nanobodies. Nat Struct Mol Biol (2009) 2.15
Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin. J Biol Chem (2003) 2.15
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle (2011) 2.15
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem (2007) 2.14
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14
Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies. Blood (2011) 2.13
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Mol Cell (2006) 2.13
Structural framework for the mechanism of archaeal exosomes in RNA processing. Mol Cell (2005) 2.12
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nat Genet (2009) 2.12
Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. J Cell Biol (2004) 2.12
Identification of a new cryptochrome class. Structure, function, and evolution. Mol Cell (2003) 2.11
A SIM-ultaneous role for SUMO and ubiquitin. Trends Biochem Sci (2008) 2.05
Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science (2004) 2.03
Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. J Biol Chem (2006) 2.01
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst) (2010) 1.96
CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J (2003) 1.96
Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science (2007) 1.94
Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures. Curr Opin Struct Biol (2003) 1.93
X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly. Structure (2005) 1.91
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
MDB: the Metalloprotein Database and Browser at The Scripps Research Institute. Nucleic Acids Res (2002) 1.89
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome. Mol Cell (2005) 1.89
Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome. DNA Repair (Amst) (2005) 1.88
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat Struct Mol Biol (2007) 1.87
Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature (2012) 1.86
Structural basis for H-NS-mediated trapping of RNA polymerase in the open initiation complex at the rrnB P1. J Biol Chem (2001) 1.85
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev (2004) 1.84
Accurate SAXS profile computation and its assessment by contrast variation experiments. Biophys J (2013) 1.83
Homologous DNA pairing by human recombination factors Rad51 and Rad54. J Biol Chem (2002) 1.82
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. J Mol Biol (2003) 1.82
MRE11/RAD50/NBS1: complex activities. Chromosoma (2004) 1.79
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77