Published in Science on June 18, 2004
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
Single Holliday junctions are intermediates of meiotic recombination. Cell (2006) 3.15
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89
Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. Mol Cell (2010) 2.49
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Blood (2012) 2.48
Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis. Chromosome Res (2007) 2.22
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol (2005) 2.00
DNA-damage repair; the good, the bad, and the ugly. EMBO J (2008) 1.89
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat Res (2009) 1.80
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma (2011) 1.78
MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis. PLoS Genet (2008) 1.76
Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc Natl Acad Sci U S A (2008) 1.62
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev (2005) 1.60
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell (2013) 1.57
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol Cell Biol (2009) 1.50
GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution. Genes Dev (2010) 1.44
Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates? EMBO J (2007) 1.42
Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res (2012) 1.40
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol Cell (2014) 1.34
Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. J Cell Biol (2008) 1.31
The role of AtMUS81 in DNA repair and its genetic interaction with the helicase AtRecQ4A. Nucleic Acids Res (2006) 1.28
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res (2006) 1.26
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. PLoS Genet (2010) 1.21
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene (2008) 1.20
Multiple-pathway analysis of double-strand break repair mutations in Drosophila. PLoS Genet (2007) 1.20
Rad54, the motor of homologous recombination. DNA Repair (Amst) (2010) 1.18
Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis. Genetics (2007) 1.16
Initiation of DNA interstrand cross-link repair in mammalian cells. Environ Mol Mutagen (2010) 1.09
Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis. PLoS Genet (2013) 1.06
DNA double-strand break repair in Caenorhabditis elegans. Chromosoma (2010) 1.00
Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy. Curr Cancer Drug Targets (2009) 1.00
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J (2015) 1.00
Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle. Environ Mol Mutagen (2010) 0.99
Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes. Chromosoma (2013) 0.95
Making the most of a little: dosage effects in eukaryotic telomere length maintenance. Chromosome Res (2005) 0.95
Holliday junction resolvases. Cold Spring Harb Perspect Biol (2014) 0.94
The search for a human Holliday junction resolvase. Biochem Soc Trans (2009) 0.93
Genetic and functional interactions between Mus81-Mms4 and Rad27. Nucleic Acids Res (2010) 0.92
Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage. Nucleic Acids Res (2013) 0.91
Human Rad54 protein stimulates human Mus81-Eme1 endonuclease. Proc Natl Acad Sci U S A (2008) 0.91
The multifunctional SNM1 gene family: not just nucleases. Future Oncol (2010) 0.91
Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance. Mol Cells (2014) 0.89
Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic and Molecular Analysis. Genome Dyn Stab (2008) 0.88
Two distinct MUS81-EME1 complexes from Arabidopsis process Holliday junctions. Plant Physiol (2009) 0.87
HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell Death Differ (2012) 0.87
DNA damage repair machinery and HIV escape from innate immune sensing. Front Microbiol (2014) 0.87
Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae. Mutat Res (2007) 0.86
Resolving RAD51C function in late stages of homologous recombination. Cell Div (2007) 0.85
Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1. Cell Div (2011) 0.85
Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. PLoS Genet (2011) 0.84
Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination. Cancer Res (2013) 0.83
Substrate specificity of the MUS81-EME2 structure selective endonuclease. Nucleic Acids Res (2013) 0.83
Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein. DNA Repair (Amst) (2014) 0.82
Deconstructing meiosis one kinase at a time: polo pushes past pachytene. Genes Dev (2008) 0.82
Inhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines. Onco Targets Ther (2014) 0.82
Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach. Cancer Inform (2012) 0.82
Multiple Mechanisms Contribute To Telomere Maintenance. J Cancer Biol Res (2013) 0.80
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Biochem Biophys Res Commun (2008) 0.80
The SMX DNA Repair Tri-nuclease. Mol Cell (2017) 0.79
A physiological significance of the functional interaction between Mus81 and Rad27 in homologous recombination repair. Nucleic Acids Res (2015) 0.78
Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway. Cancer Med (2015) 0.77
Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation. Oncogene (2016) 0.76
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget (2015) 0.75
Modeling the study of DNA damage responses in mice. Methods Mol Biol (2015) 0.75
Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation. Int J Radiat Oncol Biol Phys (2016) 0.75
Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair. Nucleic Acids Res (2014) 0.75
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell (2006) 7.33
RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature (2011) 6.03
DNA double-strand break repair: all's well that ends well. Annu Rev Genet (2006) 5.59
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
Regulation of cancer cell migration and bone metastasis by RANKL. Nature (2006) 5.27
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell (2003) 4.96
Progesterone induces adult mammary stem cell expansion. Nature (2010) 4.69
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01
Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol (2004) 3.96
PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res (2009) 3.95
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol (2004) 3.94
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev (2003) 3.79
Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science (2005) 3.64
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol (2007) 3.38
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science (2004) 3.20
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature (2005) 3.09
A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell (2011) 3.08
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07
Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet (2004) 2.96
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Chromosomal translocations induced at specified loci in human stem cells. Proc Natl Acad Sci U S A (2009) 2.73
The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiol Biomarkers Prev (2005) 2.71
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol (2010) 2.65
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev (2005) 2.59
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J (2002) 2.45
Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol (2005) 2.44
Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science (2011) 2.43
Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med (2011) 2.33
Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res (2007) 2.32
The safety of dose-dense doxorubicin and cyclophosphamide followed by paclitaxel with trastuzumab in HER-2/neu overexpressed/amplified breast cancer. J Clin Oncol (2008) 2.28
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation. PLoS Genet (2011) 2.22
Counting RAD51 proteins disassembling from nucleoprotein filaments under tension. Nature (2008) 2.21
DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase. Cell Cycle (2009) 2.21
Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol (2006) 2.21
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J (2004) 2.18
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science (2011) 2.17
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet (2009) 2.15
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov (2013) 2.15
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (2012) 2.14
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol (2005) 2.13
Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. J Cell Biol (2003) 2.12
Collaboration and competition between DNA double-strand break repair pathways. FEBS Lett (2010) 2.11
Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. Proc Natl Acad Sci U S A (2006) 2.10
Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol (2007) 2.10
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
Phase II trial of bicalutamide in patients with androgen receptor-positive, estrogen receptor-negative metastatic Breast Cancer. Clin Cancer Res (2013) 2.09
Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state. Circulation (2007) 2.03
Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. DNA Repair (Amst) (2006) 2.03
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A (2005) 2.03
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res (2005) 2.02
MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res (2011) 2.01
ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair. J Biol Chem (2002) 1.97
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proc Natl Acad Sci U S A (2008) 1.97
CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J (2003) 1.96
Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability. Oncogene (2004) 1.95
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol (2010) 1.92
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol (2007) 1.87
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev (2004) 1.84
Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. Mol Cell (2005) 1.84
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
Anti-proliferative activity of silver nanoparticles. BMC Cell Biol (2009) 1.80
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene (2004) 1.79
A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood (2005) 1.78
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77
Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovasc Res (2005) 1.77
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest (2005) 1.76
Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J Clin Invest (2010) 1.75
Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis. Immunity (2012) 1.75
Homeostatic control of recombination is implemented progressively in mouse meiosis. Nat Cell Biol (2012) 1.73