Published in Nucleic Acids Res on June 04, 2004
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function. Nucleic Acids Res (2004) 1.54
Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides. Nucleic Acids Res (2005) 1.27
Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res (2013) 1.14
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein. Nucleic Acids Res (2010) 1.00
A chemical synthesis of LNA-2,6-diaminopurine riboside, and the influence of 2'-O-methyl-2,6-diaminopurine and LNA-2,6-diaminopurine ribosides on the thermodynamic properties of 2'-O-methyl RNA/RNA heteroduplexes. Nucleic Acids Res (2007) 0.95
Aptamers and the next generation of diagnostic reagents. Proteomics Clin Appl (2012) 0.90
Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2',4'-bridged nucleosides. Nucleic Acids Res (2008) 0.90
DNA mimics for the rapid identification of microorganisms by fluorescence in situ hybridization (FISH). Int J Mol Sci (2008) 0.87
NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer. Nucleic Acids Res (2007) 0.86
Molecular beacons of xeno-nucleic acid for detecting nucleic acid. Theranostics (2013) 0.86
In vitro selection of BNA (LNA) aptamers. Artif DNA PNA XNA (2013) 0.81
Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers. Int J Mol Sci (2016) 0.78
Inhibition of HIV Replication by Cyclic and Hairpin PNAs Targeting the HIV-1 TAR RNA Loop. J Nucleic Acids (2012) 0.77
Delivery systems for in vivo use of nucleic Acid drugs. Drug Target Insights (2007) 0.75
Aptamers against pathogenic microorganisms. Crit Rev Microbiol (2015) 0.75
siRNA-directed inhibition of HIV-1 infection. Nat Med (2002) 6.36
LNA: a versatile tool for therapeutics and genomics. Trends Biotechnol (2003) 3.90
Tackling Tat. J Mol Biol (1999) 3.13
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc Natl Acad Sci U S A (2000) 3.04
Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res (2002) 2.58
A loop-loop "kissing" complex is the essential part of the dimer linkage of genomic HIV-1 RNA. Proc Natl Acad Sci U S A (1996) 2.56
Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon. RNA (1996) 2.45
Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA. J Virol (1997) 2.30
Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids. J Am Chem Soc (2002) 1.88
Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity. Chemistry (2000) 1.72
Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA. Arch Biochem Biophys (1999) 1.66
Effects of RNA secondary structure on cellular antisense activity. Nucleic Acids Res (2000) 1.60
Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design. Nucleic Acids Res (2002) 1.52
A retroviral RNA kissing complex containing only two G.C base pairs. Proc Natl Acad Sci U S A (2000) 1.50
Single nucleotide polymorphism genotyping using locked nucleic acid (LNA). Expert Rev Mol Diagn (2003) 1.43
The conformations of locked nucleic acids (LNA). J Mol Recognit (2000) 1.41
Design and characterization of decoy oligonucleotides containing locked nucleic acids. Nucleic Acids Res (2002) 1.40
In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides. Nucleic Acids Res (2003) 1.38
Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription. RNA (2001) 1.34
Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides. Biochemistry (2001) 1.33
Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA. Chem Biol (2002) 1.30
In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1. RNA (1999) 1.24
Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing. Proc Natl Acad Sci U S A (2002) 1.21
Multiple biological roles associated with the repeat (R) region of the HIV-1 RNA genome. Adv Pharmacol (2000) 1.16
Is a closing "GA pair" a rule for stable loop-loop RNA complexes? J Biol Chem (2000) 1.16
Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication. J Biol Chem (2003) 1.11
Structure, recognition and discrimination in RNA aptamer complexes with cofactors, amino acids, drugs and aminoglycoside antibiotics. J Biotechnol (2000) 1.11
Structure of TAR RNA complexed with a Tat-TAR interaction nanomolar inhibitor that was identified by computational screening. Chem Biol (2002) 1.06
Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction. Nucleosides Nucleotides Nucleic Acids (2001) 1.05
Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions. Biochem J (2001) 1.04
Association of an RNA kissing complex analyzed using 2-aminopurine fluorescence. Nucleic Acids Res (2001) 1.02
Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development. Curr Opin Mol Ther (2001) 1.01
Molecular dynamics reveals the stabilizing role of loop closing residues in kissing interactions: comparison between TAR-TAR* and TAR-aptamer. Nucleic Acids Res (2003) 0.97
Application of PNA and LNA oligomers to chemotherapy. Curr Opin Investig Drugs (2001) 0.93
Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription. Proc Natl Acad Sci U S A (2002) 0.91
2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription. Biochemistry (2002) 0.90
Aptamers: selected oligonucleotides for therapy. Curr Opin Mol Ther (2000) 0.86
RNA as a target for drug design, the example of Tat-TAR interaction. Curr Top Med Chem (2002) 0.86
Inhibition of HIV tat-TAR interactions by an antisense oligo-2'-O-methylribonucleoside methylphosphonate. Bioorg Med Chem Lett (2003) 0.84
Interactions of hairpin oligo-2'-O-methylribonucleotides containing methylphosphonate linkages with HIV TAR RNA. Antisense Nucleic Acid Drug Dev (2003) 0.82
Synthetic oligonucleotides as RNA mimetics: 2'-modified Rnas and N3'-->P5' phosphoramidates. Cell Mol Life Sci (2000) 0.81
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res (2007) 5.67
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A (2009) 2.00
MicroRNAs in liver disease. Gastroenterology (2012) 1.76
Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res (2009) 1.72
A boost for the emerging field of RNA nanotechnology. ACS Nano (2011) 1.17
SPC3042: a proapoptotic survivin inhibitor. Mol Cancer Ther (2008) 1.15
Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process. J Biol Chem (2011) 1.08
Monomeric nucleoprotein of influenza A virus. PLoS Pathog (2013) 1.07
Antisense oligonucleotides targeted to the domain IIId of the hepatitis C virus IRES compete with 40S ribosomal subunit binding and prevent in vitro translation. Nucleic Acids Res (2003) 1.06
Aptamers targeted to an RNA hairpin show improved specificity compared to that of complementary oligonucleotides. Biochemistry (2006) 1.02
Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex. Proc Natl Acad Sci U S A (2008) 0.99
Molecular dynamics reveals the stabilizing role of loop closing residues in kissing interactions: comparison between TAR-TAR* and TAR-aptamer. Nucleic Acids Res (2003) 0.97
Apical loop-internal loop interactions: a new RNA-RNA recognition motif identified through in vitro selection against RNA hairpins of the hepatitis C virus mRNA. Biochemistry (2002) 0.97
Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus. Antimicrob Agents Chemother (2013) 0.96
Selective inhibitory DNA aptamers of the human RNase H1. Nucleic Acids Res (2003) 0.95
Aptamers: a new class of oligonucleotides in the drug discovery pipeline? Curr Opin Pharmacol (2009) 0.93
Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern. Nucleic Acid Ther (2013) 0.91
Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription. Proc Natl Acad Sci U S A (2002) 0.91
2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription. Biochemistry (2002) 0.90
Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding. PLoS One (2012) 0.89
The application of locked nucleic acids in the treatment of cancer. IDrugs (2006) 0.89
Use of dynamic combinatorial chemistry for the identification of covalently appended residues that stabilize oligonucleotide complexes. Angew Chem Int Ed Engl (2004) 0.87
Endogenous expression of an anti-TAR aptamer reduces HIV-1 replication. RNA Biol (2006) 0.87
Exploring TAR-RNA aptamer loop-loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance. Nucleic Acids Res (2008) 0.87
SELEX and dynamic combinatorial chemistry interplay for the selection of conjugated RNA aptamers. Org Biomol Chem (2006) 0.87
NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer. Nucleic Acids Res (2007) 0.86
General strategy for ordered noncovalent protein assembly on well-defined nanoscaffolds. Biomacromolecules (2013) 0.86
Determinants of apical loop-internal loop RNA-RNA interactions involving the HCV IRES. Biochem Biophys Res Commun (2004) 0.85
Direct evidence for RNA-RNA interactions at the 3' end of the Hepatitis C virus genome using surface plasmon resonance. RNA (2013) 0.83
Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA. Biochemistry (2005) 0.83
LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1. Blood Cells Mol Dis (2007) 0.83
Nucleic acids targeted to drugs: SELEX against a quadruplex ligand. Biochimie (2011) 0.83
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity. Oligonucleotides (2007) 0.82
In vitro selection of RNA aptamers derived from a genomic human library against the TAR RNA element of HIV-1. Biochemistry (2009) 0.82
Systematic screening of LNA/2'-O-methyl chimeric derivatives of a TAR RNA aptamer. FEBS Lett (2007) 0.82
A functional selection of viral genetic elements in cultured cells to identify hepatitis C virus RNA translation inhibitors. Nucleic Acids Res (2008) 0.81
In vitro selection of DNA aptamers against the HIV-1 TAR RNA hairpin. Antisense Nucleic Acid Drug Dev (2002) 0.81
Single-cycle kinetic analysis of ternary DNA complexes by surface plasmon resonance on a decaying surface. Biochimie (2012) 0.80
HAPIscreen, a method for high-throughput aptamer identification. J Nanobiotechnology (2011) 0.80
Deciphering aromatic oligoamide foldamer-DNA interactions. Angew Chem Int Ed Engl (2011) 0.80
Bimodal loop-loop interactions increase the affinity of RNA aptamers for HIV-1 RNA structures. Biochemistry (2006) 0.80
Survivin mRNA antagonists using locked nucleic acid, potential for molecular cancer therapy. Nucleosides Nucleotides Nucleic Acids (2007) 0.80
Regulating eukaryotic gene expression with aptamers. FEBS Lett (2004) 0.80
In vitro selection procedures for identifying DNA and RNA aptamers targeted to nucleic acids and proteins. Methods Mol Biol (2005) 0.79
(99m)Tc-MAG3-aptamer for imaging human tumors associated with high level of matrix metalloprotease-9. Bioconjug Chem (2012) 0.79
Surface plasmon resonance investigation of RNA aptamer-RNA ligand interactions. Methods Mol Biol (2011) 0.78
Mutations of the SL2 dimerization sequence of the hepatitis C genome abrogate viral replication. Cell Mol Life Sci (2015) 0.78
Anti-HIV activity of steric block oligonucleotides. Ann N Y Acad Sci (2006) 0.77
Aptamers as imaging agents. Expert Opin Med Diagn (2010) 0.77
Simulated single-cycle kinetics improves the design of surface plasmon resonance assays. Talanta (2013) 0.77
Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch. Chem Commun (Camb) (2008) 0.77
Advances in binder identification and characterisation: the case of oligonucleotide aptamers. N Biotechnol (2011) 0.76
Synthesis and biological evaluation of LNA phosphoramidates. Nucleosides Nucleotides Nucleic Acids (2008) 0.76
Riboswitches based on kissing complexes for the detection of small ligands. Angew Chem Int Ed Engl (2014) 0.76
Aptamers targeting RNA molecules. Methods Mol Biol (2009) 0.76
Regulating mRNA translation with a kiss. Nucleic Acids Symp Ser (Oxf) (2008) 0.76
Specific or nonspecific protein-polyphenol interactions? Discrimination in real time by surface plasmon resonance. Chembiochem (2009) 0.76
Binding of filamentous actin and winding into fibrillar aggregates by the polyphenolic C-glucosidic ellagitannin vescalagin. Angew Chem Int Ed Engl (2011) 0.76
Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA. PLoS One (2012) 0.75
An improved design of the kissing complex-based aptasensor for the detection of adenosine. Anal Bioanal Chem (2015) 0.75
Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus. J Biomol Struct Dyn (2014) 0.75
Encapsidation of RNA-polyelectrolyte complexes with amphiphilic block copolymers: toward a new self-assembly route. J Am Chem Soc (2012) 0.75
[Hommage to Professor Claude Hélène]. Bull Cancer (2003) 0.75
Nucleic acid aptamers. Methods (2016) 0.75
Aptamer-mediated nanoparticle interactions: from oligonucleotide-protein complexes to SELEX screens. Methods Mol Biol (2015) 0.75
Comparative studies of tricyclo-DNA- and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression. Nucleosides Nucleotides Nucleic Acids (2007) 0.75