Published in Chembiochem on June 14, 2010
Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. PLoS Biol (2011) 2.21
Enzymatic basis of ribosomal peptide prenylation in cyanobacteria. J Am Chem Soc (2011) 1.25
Exploring protein lipidation with chemical biology. Chem Rev (2011) 1.15
The prenyl-binding protein PrBP/δ: a chaperone participating in intracellular trafficking. Vision Res (2012) 1.02
Membrane protein transport in photoreceptors: the function of PDEδ: the Proctor lecture. Invest Ophthalmol Vis Sci (2014) 0.90
Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. Biochemistry (2012) 0.88
A key role for lipoic acid synthesis during Plasmodium liver stage development. Cell Microbiol (2013) 0.87
Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions. Curr Opin Chem Biol (2012) 0.87
Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol Biol Cell (2015) 0.86
Rab GTPase prenylation hierarchy and its potential role in choroideremia disease. PLoS One (2013) 0.83
Evaluation of a cell penetrating prenylated peptide lacking an intrinsic fluorophore via in situ click reaction. Bioorg Med Chem Lett (2011) 0.81
Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence. Eukaryot Cell (2013) 0.80
S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. Plant Physiol (2013) 0.78
Type-I prenyl protease function is required in the male germline of Drosophila melanogaster. G3 (Bethesda) (2012) 0.76
All about that fat: Lipid modification of proteins in Cryptococcus neoformans. J Microbiol (2016) 0.76
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science (2010) 2.73
The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Biochemistry (2011) 2.44
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell (2004) 1.62
A toolkit and benchmark study for FRET-restrained high-precision structural modeling. Nat Methods (2012) 1.56
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol (2009) 1.50
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. EMBO J (2006) 1.39
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein Expr Purif (2002) 1.33
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol (2009) 1.29
Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci (2010) 1.28
RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol (2013) 1.26
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A (2007) 1.26
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Species-independent translational leaders facilitate cell-free expression. Nat Biotechnol (2009) 1.22
Sec2 is a highly efficient exchange factor for the Rab protein Sec4. J Mol Biol (2006) 1.18
Protein LidA from Legionella is a Rab GTPase supereffector. Proc Natl Acad Sci U S A (2011) 1.18
Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism. Biochemistry (2005) 1.16
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. PLoS One (2007) 1.15
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep (2010) 1.14
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J (2011) 1.14
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J (2006) 1.14
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J (2012) 1.14
GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol (2010) 1.12
Diels-Alder ligation and surface immobilization of proteins. Angew Chem Int Ed Engl (2005) 1.10
Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci (2011) 1.09
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A (2012) 1.09
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A (2006) 1.06
Biophysical analysis of the interaction of Rab6a GTPase with its effector domains. J Biol Chem (2008) 1.05
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases. Org Biomol Chem (2005) 1.02
Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. Elife (2013) 1.01
Oriented immobilization of farnesylated proteins by the thiol-ene reaction. Angew Chem Int Ed Engl (2010) 1.00
Site-selective protein immobilization by Staudinger ligation. Angew Chem Int Ed Engl (2006) 1.00
A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J Biol Chem (2008) 0.99
Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angew Chem Int Ed Engl (2006) 0.99
Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae. Protein Expr Purif (2005) 0.98
Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. J Biol Chem (2014) 0.97
A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. Biophys J (2006) 0.97
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. EMBO Rep (2013) 0.95
Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution. J Struct Biol (2005) 0.95
InCa-SiteFinder: a method for structure-based prediction of inositol and carbohydrate binding sites on proteins. J Mol Graph Model (2009) 0.94
A highly efficient strategy for modification of proteins at the C terminus. Angew Chem Int Ed Engl (2010) 0.94
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase. Chembiochem (2006) 0.93
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A (2014) 0.93
Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Proc Natl Acad Sci U S A (2012) 0.92
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates. Biochemistry (2002) 0.91
Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding. J Mol Biol (2008) 0.91
Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis. J Biol Chem (2009) 0.90
Direct readout of protein-protein interactions by mass spectrometry from protein-DNA microarrays. Angew Chem Int Ed Engl (2005) 0.90
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. Structure (2002) 0.90
Leishmania cell-free protein expression system. Methods (2011) 0.90
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc (2012) 0.90
A generic building block for C- and N-terminal protein-labeling and protein-immobilization. Bioorg Med Chem (2006) 0.88
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation. J Biol Chem (2009) 0.87
Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase. J Am Chem Soc (2004) 0.87
Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli. Protein Expr Purif (2008) 0.87
Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors. Chem Biol (2012) 0.87
Direct targeting of Rab-GTPase-effector interactions. Angew Chem Int Ed Engl (2014) 0.87
Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins. Biol Chem (2005) 0.87
Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers. Mol Biochem Parasitol (2007) 0.86
Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem (2012) 0.86
Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro. Chembiochem (2012) 0.86
One-pot dual-labeling of a protein by two chemoselective reactions. Angew Chem Int Ed Engl (2011) 0.85
Development of selective, potent RabGGTase inhibitors. J Med Chem (2012) 0.85
Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoan Leishmania tarentolae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.85
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro. J Am Chem Soc (2002) 0.85
Diels-Alder ligation of peptides and proteins. Chemistry (2006) 0.84
Total chemical synthesis of a functional interacting protein pair: the protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1. Proc Natl Acad Sci U S A (2003) 0.84
The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation. Elife (2013) 0.84
Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides. Bioconjug Chem (2006) 0.84
Synthesis of protein-nucleic acid conjugates by expressed protein ligation. Chem Commun (Camb) (2003) 0.84
A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins. Protein Expr Purif (2005) 0.83