PubRank

Gabriele Varani

Author PubWeight™ 108.24‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Design of a novel globular protein fold with atomic-level accuracy. Science 2003 13.06
2 RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol 2007 5.33
3 The structure and function of small nucleolar ribonucleoproteins. Nucleic Acids Res 2007 2.50
4 Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. J Am Chem Soc 2008 2.26
5 Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. EMBO J 2003 2.01
6 Protein families and RNA recognition. FEBS J 2005 1.65
7 The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nat Struct Mol Biol 2005 1.52
8 High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J Mol Biol 2006 1.49
9 Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J 2006 1.49
10 The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection. Cell 2007 1.46
11 Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots". J Mol Biol 2004 1.37
12 Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein. Proc Natl Acad Sci U S A 2009 1.33
13 Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. Nat Struct Mol Biol 2010 1.32
14 A conserved RNA structure within the HCV IRES eIF3-binding site. Nat Struct Biol 2002 1.31
15 An all-atom, distance-dependent scoring function for the prediction of protein-DNA interactions from structure. Proteins 2007 1.28
16 Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 1.27
17 A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys. Nucleic Acids Res 2004 1.27
18 A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins. FEBS J 2007 1.26
19 NMR studies of dynamics in RNA and DNA by 13C relaxation. Biopolymers 2007 1.24
20 Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus. Biochemistry 2007 1.20
21 How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape. Nucleic Acids Res 2009 1.20
22 The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. J Biol Chem 2006 1.20
23 Real-time multidimensional NMR follows RNA folding with second resolution. Proc Natl Acad Sci U S A 2010 1.18
24 13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. J Mol Biol 2005 1.18
25 Hydration dependent dynamics in RNA. J Biomol NMR 2009 1.17
26 A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III. EMBO J 2004 1.12
27 Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements. J Am Chem Soc 2004 1.11
28 TAR RNA recognition by a cyclic peptidomimetic of Tat protein. Biochemistry 2005 1.09
29 Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal. J Mol Biol 2002 1.07
30 Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein. J Mol Biol 2005 1.07
31 How arginine-rich domains coordinate mRNA maturation events. RNA Biol 2007 1.07
32 The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Res 2003 1.06
33 Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone). Chem Biol 2009 1.06
34 The structure of an enzyme-activating fragment of human telomerase RNA. RNA 2005 1.06
35 Engineering RNA-binding proteins for biology. FEBS J 2013 1.06
36 γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org Biomol Chem 2011 1.06
37 Validation of automated docking programs for docking and database screening against RNA drug targets. J Med Chem 2004 1.05
38 Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies. Biochemistry 2007 1.05
39 Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site. J Am Chem Soc 2008 1.05
40 Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein. Nucleic Acids Res 2010 1.00
41 Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1. J Mol Biol 2010 1.00
42 The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. J Mol Biol 2007 0.99
43 Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. PLoS Pathog 2011 0.97
44 High-resolution structural validation of the computational redesign of human U1A protein. Structure 2006 0.96
45 Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA. Angew Chem Int Ed Engl 2007 0.95
46 Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. J Med Chem 2009 0.94
47 Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR. Nucleic Acids Res 2005 0.94
48 Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Mol Biochem Parasitol 2006 0.93
49 Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution. J Mol Biol 2006 0.93
50 Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals. J Mol Biol 2007 0.93
51 The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochem J 2011 0.91
52 13C relaxation studies of the DNA target sequence for hhai methyltransferase reveal unique motional properties. Biochemistry 2008 0.91
53 Theory of nonrigid rotational motion applied to NMR relaxation in RNA. J Phys Chem A 2011 0.91
54 Intermediate rate atomic trajectories of RNA by solid-state NMR spectroscopy. J Am Chem Soc 2010 0.89
55 A model for C74 addition by CCA-adding enzymes: C74 addition, like C75 and A76 addition, does not involve tRNA translocation. J Biol Chem 2006 0.89
56 Contrasting views of the internal dynamics of the HhaI methyltransferase target DNA reported by solution and solid-state NMR spectroscopy. J Am Chem Soc 2006 0.87
57 How a rotavirus hijacks the human protein synthesis machinery. Nat Struct Biol 2002 0.87
58 The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. Genes Dev 2011 0.87
59 Slow exchange model of nonrigid rotational motion in RNA for combined solid-state and solution NMR studies. J Phys Chem B 2010 0.86
60 Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase. Nucleic Acids Res 2003 0.85
61 A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments. J Mol Biol 2011 0.85
62 Molecular dynamics simulation of the RNA complex of a double-stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration. Biophys J 2002 0.85
63 Furanose dynamics in the HhaI methyltransferase target DNA studied by solution and solid-state NMR relaxation. J Phys Chem B 2008 0.85
64 Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chem Biol Drug Des 2008 0.85
65 Identification of the optimal third generation antifolate against P. falciparum and P. vivax. Mol Biochem Parasitol 2005 0.83
66 The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme. J Mol Biol 2009 0.83
67 Independent alignment of RNA for dynamic studies using residual dipolar couplings. J Biomol NMR 2012 0.82
68 A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication. Chem Commun (Camb) 2013 0.82
69 Decoding RNA motional codes. Trends Biochem Sci 2006 0.82
70 Cell-free selection of RNA-binding proteins using in vitro compartmentalization. Nucleic Acids Res 2008 0.82
71 Nop10 is a conserved H/ACA snoRNP molecular adaptor. Biochemistry 2008 0.82
72 miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure. RNA 2014 0.82
73 The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae. Mol Biosyst 2014 0.81
74 Finding the missing code of RNA recognition by PUF proteins. Chem Biol 2011 0.81
75 Examining the relationship between RNA function and motion using nuclear magnetic resonance. Wiley Interdiscip Rev RNA 2011 0.81
76 13C/15N-19F intermolecular REDOR NMR study of the interaction of TAR RNA with Tat peptides. J Am Chem Soc 2010 0.81
77 Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping. Chem Biol Drug Des 2010 0.80
78 Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase. Mol Biochem Parasitol 2005 0.80
79 Structural and biochemical analysis of the assembly and function of the yeast pre-mRNA 3' end processing complex CF I. Proc Natl Acad Sci U S A 2012 0.79
80 Elucidating molecular motion through structural and dynamic filters of energy-minimized conformer ensembles. J Phys Chem B 2014 0.79
81 Molecular dynamics simulations identify time scale of conformational changes responsible for conformational selection in molecular recognition of HIV-1 transactivation responsive RNA. J Am Chem Soc 2014 0.78
82 Aminoglycoside antibiotics bind to the influenza A virus RNA promoter. Mol Biosyst 2012 0.78
83 GFT projection NMR for efficient (1)H/ (13)C sugar spin system identification in nucleic acids. J Biomol NMR 2012 0.77
84 Correction to "Theory of nonrigid rotational motion applied to NMR relaxation in RNA". J Phys Chem A 2012 0.77
85 Structural biology: RNA switches function. Nature 2006 0.76
86 Locking out viral replication. Nat Chem Biol 2009 0.76
87 Splicing factor 1 in the pocket. Structure 2003 0.76
88 Preparation of RNA samples with narrow line widths for solid state NMR investigations. J Magn Reson 2012 0.76
89 Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 0.75
90 Ultraslow Domain Motions in HIV-1 TAR RNA Revealed by Solid-State Deuterium NMR. J Phys Chem B 2016 0.75
91 1H, 13C and 15N resonance assignments of URNdesign, a computationally redesigned RRM protein. J Biomol NMR 2005 0.75
92 Interactions of protein side chains with RNA defined with REDOR solid state NMR. J Biomol NMR 2011 0.75