The roles of JAK/STAT signaling in Drosophila immune responses.

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Immune pathways and defence mechanisms in honey bees Apis mellifera. Insect Mol Biol (2006) 3.98

An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense. Proc Natl Acad Sci U S A (2009) 2.70

JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet (2006) 2.57

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Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biol (2010) 2.09

Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol (2008) 1.85

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Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A (2008) 1.54

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White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1. J Virol (2006) 1.17

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Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. J Infect Dis (2012) 1.06

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Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway. Dev Dyn (2009) 1.06

The JAK-STAT pathway controls Plasmodium vivax load in early stages of Anopheles aquasalis infection. PLoS Negl Trop Dis (2011) 1.06

Genotype and gene expression associations with immune function in Drosophila. PLoS Genet (2010) 1.05

Multiple TGF-β superfamily signals modulate the adult Drosophila immune response. Curr Biol (2011) 0.99

JAK/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila. Dev Biol (2011) 0.99

The Anopheles innate immune system in the defense against malaria infection. J Innate Immun (2013) 0.98

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Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster. J Exp Biol (2009) 0.96

Regenerative inflammation: lessons from Drosophila intestinal epithelium in health and disease. Pathogens (2013) 0.96

Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One (2012) 0.94

Ancient cytokines, the role of astakines as hematopoietic growth factors. J Biol Chem (2010) 0.94

Reproductive status alters transcriptomic response to infection in female Drosophila melanogaster. G3 (Bethesda) (2013) 0.93

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The descent of the antibody-based immune system by gradual evolution. Proc Natl Acad Sci U S A (2004) 0.91

The epigenetic regulator G9a mediates tolerance to RNA virus infection in Drosophila. PLoS Pathog (2015) 0.91

Transcriptomic immune response of Tenebrio molitor pupae to parasitization by Scleroderma guani. PLoS One (2013) 0.90

Bacterial-modulated host immunity and stem cell activation for gut homeostasis. Genes Dev (2009) 0.90

Comparative Genomics Reveals the Origins and Diversity of Arthropod Immune Systems. Mol Biol Evol (2015) 0.90

Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway. J Biol Chem (2010) 0.88

Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway. JAKSTAT (2013) 0.88

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Making connections in insect innate immunity. Proc Natl Acad Sci U S A (2012) 0.86

Signal transduction pathways, intrinsic regulators, and the control of cell fate choice. Biochim Biophys Acta (2012) 0.86

Hematopoiesis and hematopoietic organs in arthropods. Dev Genes Evol (2013) 0.86

An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication. J Virol (2013) 0.86

Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet. Immunity (2015) 0.86

Antimicrobial autophagy: a conserved innate immune response in Drosophila. J Innate Immun (2013) 0.85

Autophagy in Drosophila: from historical studies to current knowledge. Biomed Res Int (2014) 0.85

Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteins. Dev Comp Immunol (2008) 0.85

Transcriptional profiling of Drosophila S2 cells in early response to Drosophila C virus. Virol J (2013) 0.84

Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech (2011) 0.84

Drosophila SOCS Proteins. J Signal Transduct (2011) 0.84

A novel method for infecting Drosophila adult flies with insect pathogenic nematodes. Virulence (2012) 0.83

Genome-wide transcriptional response of silkworm (Bombyx mori) to infection by the microsporidian Nosema bombycis. PLoS One (2013) 0.83

Oral vaccination of baculovirus-expressed VP28 displays enhanced protection against White Spot Syndrome Virus in Penaeus monodon. PLoS One (2011) 0.83

Identification and characterization of five transcription factors that are associated with evolutionarily conserved immune signaling pathways in the schistosome-transmitting snail Biomphalaria glabrata. Mol Immunol (2011) 0.82

Nuclear translocation of immulectin-3 stimulates hemocyte proliferation. Mol Immunol (2008) 0.82

The Drosophila melanogaster host model. J Oral Microbiol (2012) 0.82

The 'ubiquitous' reality of vector immunology. Cell Microbiol (2013) 0.82

Transcriptome analysis of fat bodies from two brown planthopper (Nilaparvata lugens) populations with different virulence levels in rice. PLoS One (2014) 0.81

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster. Elife (2016) 0.81

Drosophila E-cadherin functions in hematopoietic progenitors to maintain multipotency and block differentiation. PLoS One (2013) 0.81

Bacterial and fungal pattern recognition receptors in homologous innate signaling pathways of insects and mammals. Front Microbiol (2015) 0.81

Antioxidants maintain E-cadherin levels to limit Drosophila prohemocyte differentiation. PLoS One (2014) 0.80

Silencing of Anopheles stephensi Heme Peroxidase HPX15 Activates Diverse Immune Pathways to Regulate the Growth of Midgut Bacteria. Front Microbiol (2016) 0.80

MANF silencing, immunity induction or autophagy trigger an unusual cell type in metamorphosing Drosophila brain. Cell Mol Life Sci (2014) 0.79

The characterization of the Phlebotomus papatasi transcriptome. Insect Mol Biol (2013) 0.79

Genome-wide characterization and expression profiling of immune genes in the diamondback moth, Plutella xylostella (L.). Sci Rep (2015) 0.79

Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster. BMC Genomics (2016) 0.79

Systemic corazonin signalling modulates stress responses and metabolism in Drosophila. Open Biol (2016) 0.78

Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster. PLoS One (2012) 0.78

Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. PLoS Genet (2015) 0.78

Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model. Infect Immun (2010) 0.78

Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila. Genetics (2015) 0.78

Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation. Proc Natl Acad Sci U S A (2015) 0.77

Methylmercury tolerance is associated with the humoral stress factor gene Turandot A. Neurotoxicol Teratol (2012) 0.77

In-depth comparative transcriptome analysis of intestines of red swamp crayfish, Procambarus clarkii, infected with WSSV. Sci Rep (2016) 0.76

Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol (2015) 0.76

Extensive differences in antifungal immune response in two Drosophila species revealed by comparative transcriptome analysis. Int J Genomics (2013) 0.76

SUMO-Enriched Proteome for Drosophila Innate Immune Response. G3 (Bethesda) (2015) 0.76

Transgenerational plasticity following a dual pathogen and stress challenge in fruit flies. BMC Evol Biol (2016) 0.76

The role of peroxiredoxin 4 in inflammatory response and aging. Biochim Biophys Acta (2015) 0.76

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection. Nat Commun (2017) 0.75

Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis. Sci Rep (2017) 0.75

Evolution of Interferons and Interferon Receptors. Front Immunol (2017) 0.75

Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila. Genetics (2016) 0.75

Identification of Genes Relevant to Pesticides and Biology from Global Transcriptome Data of Monochamus alternatus Hope (Coleoptera: Cerambycidae) Larvae. PLoS One (2016) 0.75

Annotation of the Asian Citrus Psyllid Genome Reveals a Reduced Innate Immune System. Front Physiol (2016) 0.75

Characterization of Reproductive Dormancy in Male Drosophila melanogaster. Front Physiol (2016) 0.75

The RNAi pathway plays a small part in Wolbachia-mediated blocking of dengue virus in mosquito cells. Sci Rep (2017) 0.75

Taotie neurons regulate appetite in Drosophila. Nat Commun (2016) 0.75

Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila. G3 (Bethesda) (2016) 0.75

Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling. J Insect Sci (2017) 0.75

Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization. Nat Commun (2017) 0.75

Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39

The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85

An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88

Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75

The promise and perils of Wnt signaling through beta-catenin. Science (2002) 6.11

Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96

Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature (2005) 5.86

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50

Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73

A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24

Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell (2002) 4.08

Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92

Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A (2009) 3.85

Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76

Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature (2006) 3.72

Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science (2005) 3.49

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39

Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods (2006) 3.29

Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (2005) 3.28

High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet (2006) 3.22

Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20

The emergence of geometric order in proliferating metazoan epithelia. Nature (2006) 3.13

Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08

Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell (2003) 3.05

A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature (2006) 3.00

GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns (2006) 2.96

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell (2010) 2.66

Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev (2005) 2.63

Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol (2004) 2.62

Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods (2007) 2.59

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56

The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47

Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47

A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45

FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res (2006) 2.43

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26

Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21

Genetic screening for signal transduction in the era of network biology. Cell (2007) 2.19

Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13

Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell (2012) 2.06

The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell (2004) 2.06

The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev Cell (2002) 2.05

Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc (2007) 2.05

Control of the mitotic cleavage plane by local epithelial topology. Cell (2011) 2.04

Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol (2002) 2.00

Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Mol Cell (2008) 1.95

COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95

Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol (2003) 1.90

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development (2010) 1.89

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A (2009) 1.88

Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86

High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol (2005) 1.83

Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science (2005) 1.81

Drosophila and the genetics of the internal milieu. Nature (2007) 1.79

An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics (2011) 1.79

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79

In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography. Nat Methods (2007) 1.78

Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol (2011) 1.75

A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics (2003) 1.63

Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62

Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A (2010) 1.62

neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60

Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet (2008) 1.60

Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol (2013) 1.59

Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57

Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. Genome Res (2011) 1.53

Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A (2007) 1.53

Analysis of twenty-four Gal4 lines in Drosophila melanogaster. Genesis (2002) 1.51

A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A (2007) 1.50

Hedgehog signal transduction: recent findings. Curr Opin Genet Dev (2002) 1.48

RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip Rev RNA (2011) 1.48

Cellular phenotype recognition for high-content RNA interference genome-wide screening. J Biomol Screen (2008) 1.47

Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research. Oncogene (2004) 1.43

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J (2002) 1.43

Tailoring the genome: the power of genetic approaches. Nat Genet (2003) 1.43

The Hippo signaling pathway interactome. Science (2013) 1.42

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev (2002) 1.42

Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development (2009) 1.41

SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell (2007) 1.40

Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development (2002) 1.37

Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol (2003) 1.37

The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Dev Biol (2004) 1.35

Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab (2012) 1.34

False negative rates in Drosophila cell-based RNAi screens: a case study. BMC Genomics (2011) 1.34

Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC Bioinformatics (2008) 1.33

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics (2010) 1.32

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet (2013) 1.32

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell (2005) 1.31

RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development (2008) 1.30

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell (2012) 1.29

RNAiCut: automated detection of significant genes from functional genomic screens. Nat Methods (2009) 1.28

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28

Cellular processes associated with germ band retraction in Drosophila. Dev Biol (2002) 1.27

Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr Biol (2002) 1.25

A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron (2002) 1.23

Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila. Biochim Biophys Acta (2002) 1.23