Published in BMC Bioinformatics on June 05, 2008
Cellular heterogeneity: do differences make a difference? Cell (2010) 3.57
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59
Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A (2008) 2.03
Automated microscopy for high-content RNAi screening. J Cell Biol (2010) 1.87
Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol (2010) 1.77
RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip Rev RNA (2011) 1.48
How to understand the cell by breaking it: network analysis of gene perturbation screens. PLoS Comput Biol (2010) 1.24
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment. J Biomol Screen (2013) 1.19
An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods (2009) 1.18
Chapter 17: bioimage informatics for systems pharmacology. PLoS Comput Biol (2013) 0.95
On comparing heterogeneity across biomarkers. Cytometry A (2014) 0.83
How cells explore shape space: a quantitative statistical perspective of cellular morphogenesis. Bioessays (2014) 0.80
Joint modeling of cell and nuclear shape variation. Mol Biol Cell (2015) 0.80
Inferring signalling networks from images. J Microsc (2013) 0.76
Ens-PPI: A Novel Ensemble Classifier for Predicting the Interactions of Proteins Using Autocovariance Transformation from PSSM. Biomed Res Int (2016) 0.76
Finding the shape-shifter genes. Nat Cell Biol (2013) 0.75
Building cell models and simulations from microscope images. Methods (2015) 0.75
Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol (2005) 7.07
Estimating the support of a high-dimensional distribution. Neural Comput (2001) 5.98
Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
A prediction-based resampling method for estimating the number of clusters in a dataset. Genome Biol (2002) 5.15
Image-based multivariate profiling of drug responses from single cells. Nat Methods (2007) 3.90
Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76
Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Evaluation and comparison of gene clustering methods in microarray analysis. Bioinformatics (2006) 3.16
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature (2006) 3.00
Automatic segmentation of high-throughput RNAi fluorescent cellular images. IEEE Trans Inf Technol Biomed (2008) 2.25
Towards automated cellular image segmentation for RNAi genome-wide screening. Med Image Comput Comput Assist Interv (2005) 2.19
Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics (2007) 1.82
Determining the number of clusters using the weighted gap statistic. Biometrics (2007) 1.56
Cellular phenotype recognition for high-content RNA interference genome-wide screening. J Biomol Screen (2008) 1.47
An automated feedback system with the hybrid model of scoring and classification for solving over-segmentation problems in RNAi high content screening. J Microsc (2007) 1.21
High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles. BMC Biotechnol (2007) 1.00
Robust cluster analysis of microarray gene expression data with the number of clusters determined biologically. Bioinformatics (2003) 0.86
Cluster number selection for a small set of samples using the Bayesian Ying-Yang model. IEEE Trans Neural Netw (2002) 0.81
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75
The promise and perils of Wnt signaling through beta-catenin. Science (2002) 6.11
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature (2005) 5.86
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell (2002) 4.08
Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92
Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A (2009) 3.85
Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76
Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature (2006) 3.72
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science (2005) 3.49
Automated segmentation, classification, and tracking of cancer cell nuclei in time-lapse microscopy. IEEE Trans Biomed Eng (2006) 3.45
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods (2006) 3.29
Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (2005) 3.28
High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet (2006) 3.22
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
The emergence of geometric order in proliferating metazoan epithelia. Nature (2006) 3.13
Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell (2003) 3.05
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab (2013) 3.00
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature (2006) 3.00
GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns (2006) 2.96
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83
The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell (2010) 2.66
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev (2005) 2.63
Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol (2004) 2.62
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods (2007) 2.59
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy. Bioinformatics (2007) 2.54
Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47
The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47
A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45
FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res (2006) 2.43
3D cell nuclei segmentation based on gradient flow tracking. BMC Cell Biol (2007) 2.41
The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev (2004) 2.37
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
Towards effective and rewarding data sharing. Neuroinformatics (2003) 2.24
Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21
Genetic screening for signal transduction in the era of network biology. Cell (2007) 2.19
Towards automated cellular image segmentation for RNAi genome-wide screening. Med Image Comput Comput Assist Interv (2005) 2.19
Development of an integrated wireless sensor network micro-environmental monitoring system. ISA Trans (2008) 2.16
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13
Brain tissue segmentation based on DTI data. Neuroimage (2007) 2.06
Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. Am J Respir Cell Mol Biol (2013) 2.06
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell (2012) 2.06
The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell (2004) 2.06
The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev Cell (2002) 2.05
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc (2007) 2.05
Control of the mitotic cleavage plane by local epithelial topology. Cell (2011) 2.04
Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol (2002) 2.00
Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Mol Cell (2008) 1.95
COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95
Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage (2007) 1.92
Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol (2003) 1.90
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development (2010) 1.89
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A (2009) 1.88
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86
Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. BMC Genomics (2009) 1.86
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86
High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol (2005) 1.83
Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science (2005) 1.81
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med (2004) 1.80
Drosophila and the genetics of the internal milieu. Nature (2007) 1.79
An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics (2011) 1.79
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography. Nat Methods (2007) 1.78
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol (2011) 1.75
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. J Virol (2007) 1.73
Using manifold embedding for assessing and predicting protein interactions from high-throughput experimental data. Bioinformatics (2010) 1.65
A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics (2003) 1.63
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A (2010) 1.62
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60
Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet (2008) 1.60
Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol (2013) 1.59
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57
A computerized cellular imaging system for high content analysis in Monastrol suppressor screens. J Biomed Inform (2005) 1.55
A novel computational approach for automatic dendrite spines detection in two-photon laser scan microscopy. J Neurosci Methods (2007) 1.53
Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A (2007) 1.53
Automated neurite labeling and analysis in fluorescence microscopy images. Cytometry A (2006) 1.53