Published in Cell on January 26, 2007
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
The implications of human metabolic network topology for disease comorbidity. Proc Natl Acad Sci U S A (2008) 3.41
Scaffolds: interaction platforms for cellular signalling circuits. Trends Cell Biol (2009) 2.15
Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol (2011) 2.15
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol Cell (2011) 2.02
From genotype to phenotype: systems biology meets natural variation. Science (2008) 1.93
Signaling mechanisms controlling cell fate and embryonic patterning. Cold Spring Harb Perspect Biol (2012) 1.89
Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Mol Cell Proteomics (2010) 1.77
Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. Sci Signal (2010) 1.64
Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal (2009) 1.59
NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res (2009) 1.53
Navigating the network: signaling cross-talk in hematopoietic cells. Nat Immunol (2009) 1.48
Towards genome-scale signalling network reconstructions. Nat Rev Genet (2010) 1.39
New technology-based innovation changes surgical practice and research direction in solid cancers. Surg Endosc (2010) 1.39
Signalling scaffolds and local organization of cellular behaviour. Nat Rev Mol Cell Biol (2015) 1.35
Disease-aging network reveals significant roles of aging genes in connecting genetic diseases. PLoS Comput Biol (2009) 1.32
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics (2010) 1.32
Regulatory pathway analysis by high-throughput in situ hybridization. PLoS Genet (2007) 1.28
A network-based integrative approach to prioritize reliable hits from multiple genome-wide RNAi screens in Drosophila. BMC Genomics (2009) 1.27
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Sci Signal (2011) 1.20
Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods (2013) 1.19
An analysis of normalization methods for Drosophila RNAi genomic screens and development of a robust validation scheme. J Biomol Screen (2008) 1.07
Animal models and conserved processes. Theor Biol Med Model (2012) 0.99
Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. Oncogene (2011) 0.98
Mechanisms of tumor resistance to EGFR-targeted therapies. Expert Opin Ther Targets (2009) 0.96
Phospho-tyrosine dependent protein-protein interaction network. Mol Syst Biol (2015) 0.96
Human-specific genes may offer a unique window into human cell signaling. Sci Signal (2009) 0.95
Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Genome Res (2010) 0.94
Charting the NF-κB pathway interactome map. PLoS One (2012) 0.94
A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Genetics (2008) 0.93
Combined logical and data-driven models for linking signalling pathways to cellular response. BMC Syst Biol (2011) 0.91
Integrating computational biology and forward genetics in Drosophila. PLoS Genet (2009) 0.91
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2008) 0.90
EGFR/HER-targeted therapeutics in ovarian cancer. Future Med Chem (2012) 0.90
High-content screening of primary neurons: ready for prime time. Curr Opin Neurobiol (2009) 0.90
Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS One (2009) 0.89
Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster. BMC Genomics (2009) 0.89
Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents? Cancer Biol Ther (2010) 0.89
Quantitative phosphoproteomics of CXCL12 (SDF-1) signaling. PLoS One (2011) 0.88
Integrated phosphoproteomics analysis of a signaling network governing nutrient response and peroxisome induction. Mol Cell Proteomics (2010) 0.88
Role of ABC transporters in cancer chemotherapy. Chin J Cancer (2012) 0.87
APG: an Active Protein-Gene network model to quantify regulatory signals in complex biological systems. Sci Rep (2013) 0.86
Systems biology approach for mapping the response of human urothelial cells to infection by Enterococcus faecalis. BMC Bioinformatics (2007) 0.86
Knowledge based identification of essential signaling from genome-scale siRNA experiments. BMC Syst Biol (2009) 0.85
Network systems biology for targeted cancer therapies. Chin J Cancer (2011) 0.84
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma. Sci Rep (2014) 0.84
Resolving the network of cell signaling pathways using the evolving yeast two-hybrid system. Biotechniques (2008) 0.84
Ground state robustness as an evolutionary design principle in signaling networks. PLoS One (2009) 0.84
High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy. Mol Cell Biol (2012) 0.83
Functional characterization of the dRYBP gene in Drosophila. Genetics (2008) 0.82
Understanding quantitative genetics in the systems biology era. Int J Biol Sci (2009) 0.82
More controversy than ever - challenges and promises towards personalized treatment of gastric cancer. Ann Surg Oncol (2008) 0.81
Community of protein complexes impacts disease association. Eur J Hum Genet (2012) 0.81
Defining a modular signalling network from the fly interactome. BMC Syst Biol (2008) 0.81
A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. BMC Biol (2016) 0.79
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. Wiley Interdiscip Rev Syst Biol Med (2010) 0.79
Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation. Int J Biol Sci (2016) 0.78
EGFR as a Prognostic Marker for Gastric Cancer. World J Surg (2008) 0.77
Integrated analysis of co-expressed MAP kinase substrates in Arabidopsis thaliana. Plant Signal Behav (2009) 0.76
A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci (2015) 0.76
Online Phenotype Discovery based on Minimum Classification Error Model. Pattern Recognit (2009) 0.75
Mapping signaling pathway cross-talk in Drosophila cells. Proc Natl Acad Sci U S A (2016) 0.75
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets. BMC Biotechnol (2014) 0.75
When you are Dishevelled, fat is good and acid is bad! Nat Cell Biol (2009) 0.75
Insights to transcriptional networks by using high throughput RNAi strategies. Brief Funct Genomics (2009) 0.75
Examining crosstalk among Transforming Growth Factor β, Bone Morphogen Protein, and Wnt pathways. J Biol Chem (2016) 0.75
Co-culture Activation of MAP Kinase in Drosophila S2 Cells. Methods Mol Biol (2017) 0.75
Network analyses elucidate the role of SMYD3 in esophageal squamous cell carcinoma. FEBS Open Bio (2017) 0.75
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75
The promise and perils of Wnt signaling through beta-catenin. Science (2002) 6.11
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature (2005) 5.86
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell (2002) 4.08
Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92
Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A (2009) 3.85
Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76
Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature (2006) 3.72
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science (2005) 3.49
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods (2006) 3.29
Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (2005) 3.28
High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet (2006) 3.22
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
The emergence of geometric order in proliferating metazoan epithelia. Nature (2006) 3.13
Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell (2003) 3.05
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature (2006) 3.00
GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns (2006) 2.96
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell (2010) 2.66
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev (2005) 2.63
Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol (2004) 2.62
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods (2007) 2.59
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47
The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47
A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45
FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res (2006) 2.43
The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev (2004) 2.37
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell (2012) 2.06
The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell (2004) 2.06
The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev Cell (2002) 2.05
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc (2007) 2.05
Control of the mitotic cleavage plane by local epithelial topology. Cell (2011) 2.04
Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol (2002) 2.00
Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Mol Cell (2008) 1.95
COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95
Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol (2003) 1.90
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development (2010) 1.89
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A (2009) 1.88
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86
High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol (2005) 1.83
Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science (2005) 1.81
Drosophila and the genetics of the internal milieu. Nature (2007) 1.79
An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics (2011) 1.79
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography. Nat Methods (2007) 1.78
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol (2011) 1.75
A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics (2003) 1.63
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A (2010) 1.62
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60
Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet (2008) 1.60
Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol (2013) 1.59
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57
Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A (2007) 1.53
Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. Genome Res (2011) 1.53
Analysis of twenty-four Gal4 lines in Drosophila melanogaster. Genesis (2002) 1.51
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A (2007) 1.50
Hedgehog signal transduction: recent findings. Curr Opin Genet Dev (2002) 1.48
RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip Rev RNA (2011) 1.48
Cellular phenotype recognition for high-content RNA interference genome-wide screening. J Biomol Screen (2008) 1.47
Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research. Oncogene (2004) 1.43
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J (2002) 1.43
Tailoring the genome: the power of genetic approaches. Nat Genet (2003) 1.43
The Hippo signaling pathway interactome. Science (2013) 1.42
Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev (2002) 1.42
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development (2009) 1.41
SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell (2007) 1.40
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development (2002) 1.37
Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol (2003) 1.37
The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Dev Biol (2004) 1.35
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab (2012) 1.34
False negative rates in Drosophila cell-based RNAi screens: a case study. BMC Genomics (2011) 1.34
Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC Bioinformatics (2008) 1.33
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics (2010) 1.32
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet (2013) 1.32
BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell (2005) 1.31
RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development (2008) 1.30
Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell (2012) 1.29
RNAiCut: automated detection of significant genes from functional genomic screens. Nat Methods (2009) 1.28
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28
Cellular processes associated with germ band retraction in Drosophila. Dev Biol (2002) 1.27
Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr Biol (2002) 1.25
A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron (2002) 1.23
Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila. Biochim Biophys Acta (2002) 1.23